 Thrombomodulin
"Thrombomodulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cell surface glycoprotein of endothelial cells that binds thrombin and serves as a cofactor in the activation of protein C and its regulation of blood coagulation.
| Descriptor ID |
D018180
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| MeSH Number(s) |
D12.776.395.550.625.800.800 D12.776.543.550.625.800.800 D12.776.543.750.750.850.800
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Thrombomodulin".
Below are MeSH descriptors whose meaning is more specific than "Thrombomodulin".
This graph shows the total number of publications written about "Thrombomodulin" by people in UAMS Profiles by year, and whether "Thrombomodulin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2023 | 0 | 1 | 1 | | 2020 | 1 | 0 | 1 | | 2016 | 2 | 0 | 2 | | 2015 | 1 | 1 | 2 | | 2014 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2008 | 2 | 0 | 2 | | 2007 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2004 | 1 | 1 | 2 | | 2003 | 2 | 0 | 2 | | 2002 | 1 | 0 | 1 |
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Below are the most recent publications written about "Thrombomodulin" by people in Profiles over the past ten years.
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Maeso-D?az R, Du K, Pan C, Guy CD, Oh SH, Chen T, Wang L, Ko DC, Tang L, Dutta RK, Jun JH, Suzuki A, Abdelmalek MF, Wang XF, Diehl AM. Targeting senescent hepatocytes using the thrombomodulin-PAR1 inhibitor vorapaxar ameliorates NAFLD progression. Hepatology. 2023 10 01; 78(4):1209-1222.
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Sadhukhan R, Leung JWC, Garg S, Krager KJ, Savenka AV, Basnakian AG, Pathak R. Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose. Sci Rep. 2020 05 07; 10(1):7734.
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Pathak R, Ghosh SP, Zhou D, Hauer-Jensen M. The Vitamin E Analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM). Int J Mol Sci. 2016 Nov 18; 17(11).
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Pathak R, Wang J, Garg S, Aykin-Burns N, Petersen KU, Hauer-Jensen M. Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model. Radiat Res. 2016 08; 186(2):112-20.
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Pathak R, Shao L, Ghosh SP, Zhou D, Boerma M, Weiler H, Hauer-Jensen M. Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice. PLoS One. 2015; 10(4):e0122511.
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Iwase H, Ekser B, Satyananda V, Bhama J, Hara H, Ezzelarab M, Klein E, Wagner R, Long C, Thacker J, Li J, Zhou H, Jiang M, Nagaraju S, Zhou H, Veroux M, Bajona P, Wijkstrom M, Wang Y, Phelps C, Klymiuk N, Wolf E, Ayares D, Cooper DK. Pig-to-baboon heterotopic heart transplantation--exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens. Xenotransplantation. 2015 May-Jun; 22(3):211-20.
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Swaminathan S, Rosner MH, Okusa MD. Emerging therapeutic targets of sepsis-associated acute kidney injury. Semin Nephrol. 2015 Jan; 35(1):38-54.
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Pathak R, Shao L, Chafekar SM, Feng W, Ponnappan U, Fink LM, Zhou D, Hauer-Jensen M. IKK? regulates endothelial thrombomodulin in a Klf2-dependent manner. J Thromb Haemost. 2014 Sep; 12(9):1533-1544.
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