 In Situ Hybridization, Fluorescence
"In Situ Hybridization, Fluorescence" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
| Descriptor ID |
D017404
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| MeSH Number(s) |
E01.370.225.500.620.670.325.350 E01.370.225.750.600.670.325.350 E05.200.500.620.670.325.350 E05.200.750.600.670.325.350 E05.393.285.350 E05.393.661.475.350
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| Concept/Terms |
In Situ Hybridization, Fluorescence- In Situ Hybridization, Fluorescence
- Hybridization in Situ, Fluorescent
- FISH Technique
- FISH Techniques
- Technique, FISH
- Techniques, FISH
- Fluorescent in Situ Hybridization
- FISH Technic
- FISH Technics
- Technic, FISH
- Technics, FISH
- Hybridization in Situ, Fluorescence
- In Situ Hybridization, Fluorescent
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Below are MeSH descriptors whose meaning is more general than "In Situ Hybridization, Fluorescence".
Below are MeSH descriptors whose meaning is more specific than "In Situ Hybridization, Fluorescence".
This graph shows the total number of publications written about "In Situ Hybridization, Fluorescence" by people in UAMS Profiles by year, and whether "In Situ Hybridization, Fluorescence" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2024 | 1 | 2 | 3 | | 2023 | 0 | 2 | 2 | | 2022 | 1 | 3 | 4 | | 2021 | 0 | 2 | 2 | | 2020 | 0 | 5 | 5 | | 2019 | 1 | 4 | 5 | | 2018 | 1 | 1 | 2 | | 2017 | 3 | 2 | 5 | | 2016 | 1 | 6 | 7 | | 2015 | 1 | 9 | 10 | | 2014 | 1 | 12 | 13 | | 2013 | 1 | 9 | 10 | | 2012 | 0 | 4 | 4 | | 2011 | 1 | 12 | 13 | | 2010 | 0 | 4 | 4 | | 2009 | 1 | 6 | 7 | | 2008 | 1 | 5 | 6 | | 2007 | 0 | 4 | 4 | | 2006 | 1 | 10 | 11 | | 2005 | 2 | 9 | 11 | | 2004 | 2 | 7 | 9 | | 2003 | 1 | 5 | 6 | | 2002 | 1 | 6 | 7 | | 2001 | 1 | 0 | 1 | | 2000 | 0 | 2 | 2 | | 1999 | 2 | 1 | 3 | | 1998 | 0 | 2 | 2 | | 1997 | 2 | 0 | 2 | | 1996 | 0 | 2 | 2 |
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Below are the most recent publications written about "In Situ Hybridization, Fluorescence" by people in Profiles over the past ten years.
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Binz RL, Pathak R. G-Banding and Molecular Cytogenetics Detect Novel Translocations and Cryptic Aberrations in Human Immortal Endothelial Cells. Int J Mol Sci. 2024 Jul 20; 25(14).
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Binz RL, Burns K, Pathak R. Protocol for preparation and staining of chromosomes isolated from mouse and human tissues for conventional and molecular cytogenetic analysis. STAR Protoc. 2024 Mar 15; 5(1):102897.
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Mezzacappa FM, Smith FK, Zhang W, Gard A, Cabuk FK, Gonzalez-Gomez I, Monforte HL, Liang J, Singh O, Quezado MM, Aldape KD, Gokden M, Bridge JA, Chen J. Potential prognostic determinants for FET::CREB fusion-positive intracranial mesenchymal tumor. Acta Neuropathol Commun. 2024 Jan 30; 12(1):17.
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Langston RG, Pinckard-Dover H, Guzman G, Wardell CP, Gokden M, Morris TW, Day JD, Rodriguez A. Intracranial hematolymphoid malignancies: A case series with molecular characterization. Clin Neurol Neurosurg. 2023 10; 233:107928.
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Mohan M, Gong Z, Ashby TC, Al Hadidi S, Thanendrarajan S, Schinke C, Alapat D, Shaughnessy JD, Zhan F, van Rhee F, Sawyer JR, Tian E, Zangari M. Concomitant deletion of the short arm (del(1p13.3)) and amplification or gain (1q21) of chromosome 1 by fluorescence in situ hybridization are associated with a poor clinical outcome in multiple myeloma. Cancer. 2023 08 15; 129(16):2491-2498.
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Binz RL, Pathak R. Molecular Cytogenetics Reveals Mosaicism in Human Umbilical Vein Endothelial Cells. Genes (Basel). 2022 06 03; 13(6).
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Wilcock DM, McMurtry V, Coleman JF, Kim JT, Khalili P, Deftereos G, Albertson D, Gulbahce EH, Liu T, Sirohi D. Histopathological Correlation of Chromosome 12 Polysomy by Fluorescence in Situ Hybridization in Adipocytic Neoplasms. Int J Surg Pathol. 2022 Oct; 30(7):734-742.
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Ramos JM. Fluorescent In Situ Hybridization (FISH). Methods Mol Biol. 2022; 2422:179-189.
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Grushko TA, Filiaci VL, Montag AG, Apushkin M, Gomez MJ, Monovich L, Ramirez NC, Schwab C, Kesterson JP, Seward SM, Method MW, Olopade OI, Fleming GF, Birrer MJ. Effects of Slide Storage on Detection of Molecular Markers by IHC and FISH in Endometrial Cancer Tissues From a Clinical Trial: An NRG Oncology/GOG Pilot Study. Appl Immunohistochem Mol Morphol. 2022 01 01; 30(1):27-35.
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Campbell K, Bridge JA, DiMaio D, Wilson J, Shalin SC, Gardner JM. Dermatofibrosarcoma protuberans with platelet-derived growth factor-D rearrangement; two cases with morphologically distinct presentations. J Cutan Pathol. 2022 Mar; 49(3):274-277.
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Williamson SR, Al-Obaidy KI, Cheng L, Smith SC, Cox RM, McKenney JK, Gokden N, Phillips CL, Giannico GA, Gallan AJ, Przybycin CG, Grignon DJ. Distal Tubular Hyperplasia: A Proposal for a Unique Form of Renal Tubular Proliferation Distinct From Papillary Adenoma. Am J Surg Pathol. 2021 04 01; 45(4):516-522.
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Costa LJ, Usmani SZ. Defining and Managing High-Risk Multiple Myeloma: Current Concepts. J Natl Compr Canc Netw. 2020 12; 18(12):1730-1737.
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Pina-Oviedo S, Bellamy WT, Gokden M. Analysis of primary central nervous system large B-cell lymphoma in the era of high-grade B-cell lymphoma: Detection of two cases with MYC and BCL6 rearrangements in a cohort of 12 cases. Ann Diagn Pathol. 2020 Oct; 48:151610.
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El Jamal SM, Salama A, Marcellino BK, Abulsayen HA, Zhou X, Hassan M, Firpo-Betancourt A, Saad AG. Myeloid Sarcoma of the Testis in Children: Clinicopathologic and Immunohistochemical Characteristics With KMT2A (MLL) Gene Rearrangement Correlation. Appl Immunohistochem Mol Morphol. 2020 08; 28(7):501-507.
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Wu X, Cai H, Qiu Y, Li J, Zhou DB, Cao XX. ETV6-ACSL6 fusion gene in myeloid neoplasms: clinical spectrum, current practice, and outcomes. Orphanet J Rare Dis. 2020 07 28; 15(1):192.
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Soong D, Stratford J, Avet-Loiseau H, Bahlis N, Davies F, Dispenzieri A, Sasser AK, Schecter JM, Qi M, Brown C, Jones W, Keats JJ, Auclair D, Chiu C, Powers J, Schaffer M. CNV Radar: an improved method for somatic copy number alteration characterization in oncology. BMC Bioinformatics. 2020 Mar 06; 21(1):98.
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Varma A, Sui D, Milton DR, Tang G, Saini N, Hasan O, Mukherjee A, Joseph JJ, Bashir Q, Rondon G, Srour S, Popat UR, Hosing CM, Nieto Y, Kebriaei P, Alousi AM, Ahmed S, Mehta R, Khouri IF, Ahmed H, Iyer S, Weber DM, Thomas SK, Manasanch E, Lee HC, Patel K, Ciurea SO, Shpall EJ, Orlowski RZ, Champlin RE, Qazilbash MH. Outcome of Multiple Myeloma with Chromosome 1q Gain and 1p Deletion after Autologous Hematopoietic Stem Cell Transplantation: Propensity Score Matched Analysis. Biol Blood Marrow Transplant. 2020 04; 26(4):665-671.
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Kushnir VM, Mullady DK, Das K, Lang G, Hollander TG, Murad FM, Jackson SA, Toney NA, Finkelstein SD, Edmundowicz SA. The Diagnostic Yield of Malignancy Comparing Cytology, FISH, and Molecular Analysis of Cell Free Cytology Brush Supernatant in Patients With Biliary Strictures Undergoing Endoscopic Retrograde Cholangiography (ERC): A Prospective Study. J Clin Gastroenterol. 2019 10; 53(9):686-692.
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Sawyer JR, Tian E, Walker BA, Wardell C, Lukacs JL, Sammartino G, Bailey C, Schinke CD, Thanendrarajan S, Davies FE, Morgan GJ, Barlogie B, Zangari M, van Rhee F. An acquired high-risk chromosome instability phenotype in multiple myeloma: Jumping 1q Syndrome. Blood Cancer J. 2019 08 09; 9(8):62.
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Mikulasova A, Ashby C, Tytarenko RG, Qu P, Rosenthal A, Dent JA, Ryan KR, Bauer MA, Wardell CP, Hoering A, Mavrommatis K, Trotter M, Deshpande S, Yaccoby S, Tian E, Keats J, Auclair D, Jackson GH, Davies FE, Thakurta A, Morgan GJ, Walker BA. Microhomology-mediated end joining drives complex rearrangements and overexpression of MYC and PVT1 in multiple myeloma. Haematologica. 2020 04; 105(4):1055-1066.
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Farra C, Fedda F, Tfayli A, Tawil A, Zaatari G, Ashkar H, Issa G, Boulos F. The Impact of Partial Weak Staining in Normal Breast Epithelium on the Reliability of Immunohistochemistry Results in HercepTest-positive Breast Cancer. Clin Breast Cancer. 2019 10; 19(5):340-344.
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Larsen CP, Bonsib SM, Beggs ML, Wilson JD. Fluorescence in situ hybridization for the diagnosis of NPHP1 deletion-related nephronophthisis on renal biopsy. Hum Pathol. 2018 11; 81:71-77.
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Tian E. Fluorescence In Situ Hybridization (FISH) in Multiple Myeloma. Methods Mol Biol. 2018; 1792:55-69.
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Walker BA. Whole Exome Sequencing in Multiple Myeloma to Identify Somatic Single Nucleotide Variants and Key Translocations Involving Immunoglobulin Loci and MYC. Methods Mol Biol. 2018; 1792:71-95.
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Sadhukhan R, Chowdhury P, Ghosh S, Ghosh U. Expression of Telomere-Associated Proteins is Interdependent to Stabilize Native Telomere Structure and Telomere Dysfunction by G-Quadruplex Ligand Causes TERRA Upregulation. Cell Biochem Biophys. 2018 Jun; 76(1-2):311-319.
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Sun M, Zhang H, Li G, Guy CJ, Wang X, Lu X, Gong F, Lee J, Hassed S, Li S. Molecular characterization of 20 small supernumerary marker chromosome cases using array comparative genomic hybridization and fluorescence in situ hybridization. Sci Rep. 2017 09 04; 7(1):10395.
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Pina-Oviedo S, Miranda RN, Lin P, Manning JT, Medeiros LJ. Follicular lymphoma with hyaline-vascular Castleman-like features: analysis of 6 cases and review of the literature. Hum Pathol. 2017 10; 68:136-146.
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Row RH, Martin BL. itFISH: Enhanced Staining by Iterative Fluorescent In Situ Hybridization. Zebrafish. 2017 12; 14(6):578-580.
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Pathak R, Koturbash I, Hauer-Jensen M. Detection of Inter-chromosomal Stable Aberrations by Multiple Fluorescence In Situ Hybridization (mFISH) and Spectral Karyotyping (SKY) in Irradiated Mice. J Vis Exp. 2017 01 11; (119).
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Gonda TA, Viterbo D, Gausman V, Kipp C, Sethi A, Poneros JM, Gress F, Park T, Khan A, Jackson SA, Blauvelt M, Toney N, Finkelstein SD. Mutation Profile and Fluorescence In Situ Hybridization Analyses Increase Detection of Malignancies in Biliary Strictures. Clin Gastroenterol Hepatol. 2017 Jun; 15(6):913-919.e1.
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Cornell RF, D'Souza A, Kassim AA, Costa LJ, Innis-Shelton RD, Zhang MJ, Huang J, Abidi M, Aiello J, Akpek G, Bashey A, Bashir Q, Cerny J, Comenzo R, Diaz MA, Freytes C, Gale RP, Ganguly S, Hamadani M, Hashmi S, Holmberg L, Hossain N, Kamble RT, Kharfan-Dabaja M, Kindwall-Keller T, Kyle R, Kumar S, Lazarus H, Lee C, Maiolino A, Marks DI, Meehan K, Mikhael J, Nath R, Nishihori T, Olsson RF, Ramanathan M, Saad A, Seo S, Usmani S, Vesole D, Vij R, Vogl D, Wirk BM, Yared J, Krishnan A, Mark T, Nieto Y, Hari P. Maintenance versus Induction Therapy Choice on Outcomes after Autologous Transplantation for Multiple Myeloma. Biol Blood Marrow Transplant. 2017 Feb; 23(2):269-277.
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Sawyer JR, Tian E, Shaughnessy JD, Epstein J, Swanson CM, Stangeby C, Hale CL, Parr L, Lynn M, Sammartino G, Lukacs JL, Stein C, Bailey C, Zangari M, Davies FE, Van Rhee F, Barlogie B, Morgan GJ. Hyperhaploidy is a novel high-risk cytogenetic subgroup in multiple myeloma. Leukemia. 2017 03; 31(3):637-644.
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Njei B, McCarty TR, Varadarajulu S, Navaneethan U. Systematic review with meta-analysis: endoscopic retrograde cholangiopancreatography-based modalities for the diagnosis of cholangiocarcinoma in primary sclerosing cholangitis. Aliment Pharmacol Ther. 2016 12; 44(11-12):1139-1151.
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Scott EC, Hari P, Sharma M, Le-Rademacher J, Huang J, Vogl D, Abidi M, Beitinjaneh A, Fung H, Ganguly S, Hildebrandt G, Holmberg L, Kalaycio M, Kumar S, Kyle R, Lazarus H, Lee C, Maziarz RT, Meehan K, Mikhael J, Nishihori T, Ramanathan M, Usmani S, Tay J, Vesole D, Wirk B, Yared J, Savani BN, Gasparetto C, Krishnan A, Mark T, Nieto Y, D'Souza A. Post-Transplant Outcomes in High-Risk Compared with Non-High-Risk Multiple Myeloma: A CIBMTR Analysis. Biol Blood Marrow Transplant. 2016 10; 22(10):1893-1899.
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Abbi KK, Silverman M, Farooq U, Tricot A, Dozeman L, Nadiminti K, Krasowski MD, Tricot GJ. Potential pitfalls of serum free light chain analysis to assess treatment response for multiple myeloma. Br J Haematol. 2016 08; 174(4):536-40.
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Graham RP, Arnold CA, Naini BV, Lam-Himlin DM. Basaloid Squamous Cell Carcinoma of the Anus Revisited. Am J Surg Pathol. 2016 Mar; 40(3):354-60.
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Wu SP, Pfeiffer RM, Ahn IE, Mailankody S, Sonneveld P, van Duin M, Munshi NC, Walker BA, Morgan G, Landgren O. Impact of Genes Highly Correlated with MMSET Myeloma on the Survival of Non-MMSET Myeloma Patients. Clin Cancer Res. 2016 Aug 15; 22(16):4039-44.
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Kuiper R, van Duin M, van Vliet MH, Broijl A, van der Holt B, El Jarari L, van Beers EH, Mulligan G, Avet-Loiseau H, Gregory WM, Morgan G, Goldschmidt H, Lokhorst HM, Sonneveld P. Prediction of high- and low-risk multiple myeloma based on gene expression and the International Staging System. Blood. 2015 Oct 22; 126(17):1996-2004.
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Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P. Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group. J Clin Oncol. 2015 Sep 10; 33(26):2863-9.
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Abdallah AO, Bansal M, Kemp SA, Schichman SA, Xiang Z. A unique presentation of unilateral pleural effusion in a patient with a high-grade plasma cell neoplasm. Leuk Lymphoma. 2015; 56(10):2989-91.
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Caponetti GC, Dave BJ, Perry AM, Smith LM, Jain S, Meyer PN, Bast M, Bierman PJ, Bociek RG, Vose JM, Armitage JO, Aoun P, Fu K, Greiner TC, Chan WC, Sanger WG, Weisenburger DD. Isolated MYC cytogenetic abnormalities in diffuse large B-cell lymphoma do not predict an adverse clinical outcome. Leuk Lymphoma. 2015; 56(11):3082-9.
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Nanaji NM, Chen QC, Singh Z, Ross DD, Elman AH, Zou YS. Concomitant bone marrow involvement by plasma cell myeloma and primary myelodysplastic syndrome with biclonal complex chromosome anomalies. Leuk Lymphoma. 2015; 56(8):2470-2.
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Lai YY, Huang XJ, Li J, Zou P, Xu ZF, Sun H, Shao ZH, Zhou DB, Chen FP, Liu ZG, Zhu HL, Wu DP, Wang C, Zhang Y, Li Y, Hou M, Du X, Wang X, Li W, Lai YR, Zhou J, Zhou YH, Fang MY, Qiu L, Wang XM, Zhang GS, Jiang M, Liang YM, Zhang LS, Chen XQ, Bai H, Lin JY. Standardized fluorescence in situ hybridization testing based on an appropriate panel of probes more effectively identifies common cytogenetic abnormalities in myelodysplastic syndromes than conventional cytogenetic analysis: a multicenter prospective study of 2302 patients in China. Leuk Res. 2015 May; 39(5):530-5.
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Xiang Z, Abdallah AO, Govindarajan R, Mehta P, Emanuel PD, Papenhausen P, Schichman SA. MYC amplification in multiple marker chromosomes and EZH2 microdeletion in a man with acute myeloid leukemia. Cancer Genet. 2015 Mar; 208(3):96-100.
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Parra-Herran C, Quick CM, Howitt BE, Dal Cin P, Quade BJ, Nucci MR. Inflammatory myofibroblastic tumor of the uterus: clinical and pathologic review of 10 cases including a subset with aggressive clinical course. Am J Surg Pathol. 2015 Feb; 39(2):157-68.
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Sanmann JN, Pickering DL, Golden DM, Stevens JM, Hempel TE, Althof PA, Wiggins ML, Starr LJ, Dav? BJ, Sanger WG. Assessing the utility of confirmatory studies following identification of large-scale genomic imbalances by microarray. Genet Med. 2015 Nov; 17(11):875-9.
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Bhutani M, Landgren O, Usmani SZ. Multiple myeloma: is it time for biomarker-driven therapy? Am Soc Clin Oncol Educ Book. 2015; e493-503.
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Pawlyn C, Melchor L, Murison A, Wardell CP, Brioli A, Boyle EM, Kaiser MF, Walker BA, Begum DB, Dahir NB, Proszek P, Gregory WM, Drayson MT, Jackson GH, Ross FM, Davies FE, Morgan GJ. Coexistent hyperdiploidy does not abrogate poor prognosis in myeloma with adverse cytogenetics and may precede IGH translocations. Blood. 2015 Jan 29; 125(5):831-40.
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