 Introns
"Introns" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Sequences of DNA in the genes that are located between the EXONS. They are transcribed along with the exons but are removed from the primary gene transcript by RNA SPLICING to leave mature RNA. Some introns code for separate genes.
| Descriptor ID |
D007438
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| MeSH Number(s) |
G05.360.340.024.220.400 G05.360.340.024.340.137.515
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| Concept/Terms |
Introns- Introns
- Intron
- Intervening Sequences
- Sequences, Intervening
- Intervening Sequence
- Sequence, Intervening
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Below are MeSH descriptors whose meaning is more general than "Introns".
Below are MeSH descriptors whose meaning is more specific than "Introns".
This graph shows the total number of publications written about "Introns" by people in UAMS Profiles by year, and whether "Introns" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2023 | 0 | 1 | 1 | | 2022 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2017 | 2 | 1 | 3 | | 2016 | 1 | 2 | 3 | | 2015 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 | | 2011 | 0 | 1 | 1 | | 2010 | 1 | 1 | 2 | | 2009 | 0 | 3 | 3 | | 2008 | 2 | 0 | 2 | | 2005 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2003 | 0 | 3 | 3 | | 2002 | 0 | 2 | 2 | | 2001 | 0 | 2 | 2 | | 2000 | 0 | 1 | 1 | | 1999 | 0 | 2 | 2 | | 1997 | 0 | 1 | 1 | | 1992 | 0 | 1 | 1 | | 1991 | 0 | 1 | 1 |
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Below are the most recent publications written about "Introns" by people in Profiles over the past ten years.
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Islam MR, Nagar P, Neetole ST, Wan L, Rahman MA. RNA Splicing in Cancer and Targeted Therapies. Genes (Basel). 2023 Oct 29; 14(11).
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Gao Y, Lin KT, Jiang T, Yang Y, Rahman MA, Gong S, Bai J, Wang L, Sun J, Sheng L, Krainer AR, Hua Y. Systematic characterization of short intronic splicing-regulatory elements in SMN2 pre-mRNA. Nucleic Acids Res. 2022 01 25; 50(2):731-749.
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Haertle L, Barrio S, Munawar U, Han S, Zhou X, Vogt C, Fern?ndez RA, Bittrich M, Ruiz-Heredia Y, Da Vi? M, Zovko J, Garitano-Trojaola A, Bolli N, Ruckdeschel A, St?hmer T, Chatterjee M, Kull M, Kr?nke J, Agirre X, Martin-Subero JI, Raab P, Einsele H, Rasche L, Martinez-Lopez J, Haaf T, Kort?m KM. Cereblon enhancer methylation and IMiD resistance in multiple myeloma. Blood. 2021 11 04; 138(18):1721-1726.
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Silverstein S, Veerapandiyan A, Hayes-Rosen C, Ming X, Kornitzer J. A novel intronic homozygous mutation in the AMT gene of a patient with nonketotic hyperglycinemia and hyperammonemia. Metab Brain Dis. 2019 02; 34(1):373-376.
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Ahsan KB, Masuda A, Rahman MA, Takeda JI, Nazim M, Ohkawara B, Ito M, Ohno K. SRSF1 suppresses selection of intron-distal 5' splice site of DOK7 intron 4 to generate functional full-length Dok-7 protein. Sci Rep. 2017 09 05; 7(1):10446.
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Wight PA. Effects of Intron 1 Sequences on Human PLP1 Expression: Implications for PLP1-Related Disorders. ASN Neuro. 2017 Jul-Aug; 9(4):1759091417720583.
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Knight Johnson A, Schaefer GB, Lee J, Hu Y, Del Gaudio D. Alu-mediated deletion of PIGL in a Patient with CHIME syndrome. Am J Med Genet A. 2017 May; 173(5):1378-1382.
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Gilbert KM, Blossom SJ, Erickson SW, Broadfoot B, West K, Bai S, Li J, Cooney CA. Chronic exposure to trichloroethylene increases DNA methylation of the Ifng promoter in CD4+ T cells. Toxicol Lett. 2016 Oct 17; 260:1-7.
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Raisingani M, Contreras MF, Prasad K, Pappas JG, Kluge ML, Shah B, David R. Unusual phenotype of congenital adrenal hyperplasia (CAH) with a novel mutation of the CYP21A2 gene. J Pediatr Endocrinol Metab. 2016 Jul 01; 29(7):867-71.
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Shibata A, Okuno T, Rahman MA, Azuma Y, Takeda J, Masuda A, Selcen D, Engel AG, Ohno K. IntSplice: prediction of the splicing consequences of intronic single-nucleotide variations in the human genome. J Hum Genet. 2016 Jul; 61(7):633-40.
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Starlard-Davenport A, Orloff MS, Dhakal I, Penney RB, Kadlubar SA. Genotypic and allelic variability in CYP19A1 among populations of African and European ancestry. PLoS One. 2015; 10(2):e0117347.
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Mirabella F, Murison A, Aronson LI, Wardell CP, Thompson AJ, Hanrahan SJ, Fok JH, Pawlyn C, Kaiser MF, Walker BA, Davies FE, Morgan GJ. A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex. PLoS One. 2014; 9(6):e99493.
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