 Iron
"Iron" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
| Descriptor ID |
D007501
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| MeSH Number(s) |
D01.268.556.412 D01.268.956.287 D01.552.544.412
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Iron".
Below are MeSH descriptors whose meaning is more specific than "Iron".
This graph shows the total number of publications written about "Iron" by people in UAMS Profiles by year, and whether "Iron" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2024 | 1 | 1 | 2 | | 2023 | 1 | 1 | 2 | | 2022 | 2 | 6 | 8 | | 2021 | 2 | 0 | 2 | | 2020 | 1 | 3 | 4 | | 2019 | 0 | 1 | 1 | | 2018 | 3 | 1 | 4 | | 2017 | 2 | 3 | 5 | | 2016 | 2 | 2 | 4 | | 2015 | 3 | 5 | 8 | | 2014 | 6 | 0 | 6 | | 2013 | 3 | 2 | 5 | | 2011 | 2 | 1 | 3 | | 2010 | 0 | 3 | 3 | | 2009 | 2 | 0 | 2 | | 2008 | 2 | 2 | 4 | | 2007 | 2 | 2 | 4 | | 2006 | 4 | 1 | 5 | | 2005 | 1 | 0 | 1 | | 2004 | 2 | 0 | 2 | | 2003 | 3 | 0 | 3 | | 2001 | 1 | 0 | 1 | | 2000 | 1 | 0 | 1 | | 1999 | 1 | 1 | 2 | | 1997 | 0 | 1 | 1 | | 1995 | 1 | 0 | 1 | | 1993 | 2 | 0 | 2 | | 1990 | 0 | 1 | 1 |
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Below are the most recent publications written about "Iron" by people in Profiles over the past ten years.
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Kwon JH, Kang R, Lee SM, Hahm TS, Cho HS, Jin G, Ko JS. Effect of high-dose intravenous iron injection on hepatic function in a rat model of cirrhosis. J Int Med Res. 2024 May; 52(5):3000605241253733.
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Jiang H, Wang L, Zhang Q, Wang S, Jia L, Cheng H, Wang J, Li X, Xie Y, Wang Y, Hu M, Guo J, Li Q, Peng Z, Wang M, Xie Y, Li T, Wang Y, Geng BD, Swaminathan S, Bergsagel PL, Liu Z. Bone marrow stromal cells dictate lanosterol biosynthesis and ferroptosis of multiple myeloma. Oncogene. 2024 May; 43(21):1644-1653.
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Hussein SM, Sofoluwe A, Paleja A, Duhme-Klair A, Thomas MS. Identification of a system for hydroxamate xenosiderophore-mediated iron transport in Burkholderia cenocepacia. Microbiology (Reading). 2024 01; 170(1).
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Le J, Pan G, Zhang C, Chen Y, Tiwari AK, Qin JJ. Targeting ferroptosis in gastric cancer: Strategies and opportunities. Immunol Rev. 2024 Jan; 321(1):228-245.
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Jiang HB, Hutchins DA, Ma W, Zhang RF, Wells M, Jiao N, Wang Y, Chai F. Natural ocean iron fertilization and climate variability over geological periods. Glob Chang Biol. 2023 Dec; 29(24):6856-6866.
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Dzakovich MP, Debelo H, Albertsen MC, Che P, Jones TJ, Simon MK, Zhao ZY, Glassman K, Ferruzzi MG. Trait stacking simultaneously enhances provitamin A carotenoid and mineral bioaccessibility in biofortified Sorghum bicolor. Food Funct. 2023 Jul 31; 14(15):7053-7065.
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Ali SA, Razzaq S, Aziz S, Allana A, Ali AA, Naeem S, Khowaja N, Ur Rehman F. Role of iron in the reduction of anemia among women of reproductive age in low-middle income countries: insights from systematic review and meta-analysis. BMC Womens Health. 2023 04 17; 23(1):184.
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Leal EC, Carvalho E. Heme Oxygenase-1 as Therapeutic Target for Diabetic Foot Ulcers. Int J Mol Sci. 2022 Oct 10; 23(19).
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Yang N, Lin YA, Merkel CA, DeMers MA, Qu PP, Webb EA, Fu FX, Hutchins DA. Molecular mechanisms underlying iron and phosphorus co-limitation responses in the nitrogen-fixing cyanobacterium Crocosphaera. ISME J. 2022 12; 16(12):2702-2711.
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Joffr? E, Xiao X, Correia MSP, Nookaew I, Sasse S, Globisch D, Zhu B, Sj?ling ?. Analysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors. Microbiol Spectr. 2022 08 31; 10(4):e0175521.
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Dunn MG, Close RM, McKee SG, Cordero R, Japa IF, Lowenthal ED. Evaluation of iron intake in preschool children in a setting with high anemia burden. Int Health. 2022 Jul 01; 14(4):450-451.
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Chumble A, Brush P, Muzaffar A, Tanaka T. The Effects of Preoperative Administration of Erythropoietin in Pediatric Patients Undergoing Cranial Vault Remodeling for Craniosynostosis. J Craniofac Surg. 2022 Jul-Aug 01; 33(5):1424-1427.
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Das BK, Wang L, Fujiwara T, Zhou J, Aykin-Burns N, Krager KJ, Lan R, Mackintosh SG, Edmondson R, Jennings ML, Wang X, Feng JQ, Barrientos T, Gogoi J, Kannan A, Gao L, Xing W, Mohan S, Zhao H. Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton. Elife. 2022 06 27; 11.
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Ippolito JR, Piccolo BD, Robeson MS, Barney DE, Ali J, Singh P, Hennigar SR. Iron deficient diets modify the gut microbiome and reduce the severity of enteric infection in a mouse model of S. Typhimurium-induced enterocolitis. J Nutr Biochem. 2022 09; 107:109065.
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Butt AT, Banyard CD, Haldipurkar SS, Agnoli K, Mohsin MI, Vitovski S, Paleja A, Tang Y, Lomax R, Ye F, Green J, Thomas MS. The Burkholderia cenocepacia iron starvation s factor, OrbS, possesses an on-board iron sensor. Nucleic Acids Res. 2022 04 22; 50(7):3709-3726.
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Uyoga MA, Mzembe G, Stoffel NU, Moretti D, Zeder C, Phiri K, Sabatier M, Hays NP, Zimmermann MB, Mwangi MN. Iron Bioavailability from Infant Cereals Containing Whole Grains and Pulses: A Stable Isotope Study in Malawian Children. J Nutr. 2022 03 03; 152(3):826-834.
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Yu YC, Luu HN, Wang R, Thomas CE, Glynn NW, Youk AO, Behari J, Yuan JM. Serum Biomarkers of Iron Status and Risk of Hepatocellular Carcinoma Development in Patients with Nonalcoholic Fatty Liver Disease. Cancer Epidemiol Biomarkers Prev. 2022 01; 31(1):230-235.
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Rashid T, Abdulkadir A, Nasrallah IM, Ware JB, Liu H, Spincemaille P, Romero JR, Bryan RN, Heckbert SR, Habes M. DEEPMIR: a deep neural network for differential detection of cerebral microbleeds and iron deposits in MRI. Sci Rep. 2021 07 08; 11(1):14124.
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Ali SA, Ali SA, Razzaq S, Khowaja N, Gutkind S, Raheman FU, Suhail N. Predictors of iron consumption for at least 90?days during pregnancy: Findings from National Demographic Health Survey, Pakistan (2017-2018). BMC Pregnancy Childbirth. 2021 May 03; 21(1):352.
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Adetola OY, Kruger J, Ferruzzi MG, Hamaker BR, Taylor JRN. Potential of moringa leaf and baobab fruit food-to-food fortification of wholegrain maize porridge to improve iron and zinc bioaccessibility. Int J Food Sci Nutr. 2022 Feb; 73(1):15-27.
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Ghaffarieh A, Ciolino JB. Potential of Application of Iron Chelating Agents in Ophthalmic Diseases. Semin Ophthalmol. 2021 May 19; 36(4):157-161.
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Ali SA, Abbasi Z, Shahid B, Moin G, Hambidge KM, Krebs NF, Westcott JE, McClure EM, Goldenberg RL, Saleem S. Prevalence and determinants of anemia among women of reproductive age in Thatta Pakistan: Findings from a cross-sectional study. PLoS One. 2020; 15(9):e0239320.
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Hawco NJ, Fu F, Yang N, Hutchins DA, John SG. Independent iron and light limitation in a low-light-adapted Prochlorococcus from the deep chlorophyll maximum. ISME J. 2021 01; 15(1):359-362.
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Kruger J, Taylor JRN, Ferruzzi MG, Debelo H. What is food-to-food fortification? A working definition and framework for evaluation of efficiency and implementation of best practices. Compr Rev Food Sci Food Saf. 2020 11; 19(6):3618-3658.
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Vorland CJ, Mestre LM, Mendis SS, Brown AW. Within-group comparisons led to unsubstantiated conclusions in "Low-phytate wholegrain bread instead of high-phytate wholegrain bread in a total diet context did not improve iron status of healthy Swedish females: a 12-week, randomized, parallel-design intervention Study". Eur J Nutr. 2020 09; 59(6):2813-2814.
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Tiwari AKM, Mahdi AA, Mishra S, Parveen H, Fatima G. Effect of iron and folate supplementation on Pb levels in pregnant anemic women: a prospective study. Free Radic Res. 2020 Sep; 54(8-9):662-669.
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Scindia Y, Wlazlo E, Ghias E, Cechova S, Loi V, Leeds J, Ledesma J, Helen C, Swaminathan S. Modulation of iron homeostasis with hepcidin ameliorates spontaneous murine lupus nephritis. Kidney Int. 2020 07; 98(1):100-115.
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Menon LP, Weinstein RS. Iron replacement ameliorates hypophosphatemia in autosomal dominant hypophosphatemic rickets: A review of the role of iron. Bone. 2020 02; 131:115137.
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Agnoli K, Haldipurkar SS, Tang Y, Butt AT, Thomas MS. Distinct Modes of Promoter Recognition by Two Iron Starvation s Factors with Overlapping Promoter Specificities. J Bacteriol. 2019 02 01; 201(3).
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Qiu GW, Lou WJ, Sun CY, Yang N, Li ZK, Li DL, Zang SS, Fu FX, Hutchins DA, Jiang HB, Qiu BS. Outer Membrane Iron Uptake Pathways in the Model Cyanobacterium Synechocystis sp. Strain PCC 6803. Appl Environ Microbiol. 2018 10 01; 84(19).
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Urbaniak A, Basta P, Ast K, Woloszyn A, Kurianska-Woloszyn J, Latour E, Skarpanska-Stejnborn A. The impact of supplementation with pomegranate fruit (Punica granatum L.) juice on selected antioxidant parameters and markers of iron metabolism in rowers. J Int Soc Sports Nutr. 2018 Jul 24; 15(1):35.
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Wang L, Fang B, Fujiwara T, Krager K, Gorantla A, Li C, Feng JQ, Jennings ML, Zhou J, Aykin-Burns N, Zhao H. Deletion of ferroportin in murine myeloid cells increases iron accumulation and stimulates osteoclastogenesis in vitro and in vivo. J Biol Chem. 2018 06 15; 293(24):9248-9264.
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Dreval K, Tryndyak V, Kindrat I, Twaddle NC, Orisakwe OE, Mudalige TK, Beland FA, Doerge DR, Pogribny IP. Cellular and Molecular Effects of Prolonged Low-Level Sodium Arsenite Exposure on Human Hepatic HepaRG Cells. Toxicol Sci. 2018 04 01; 162(2):676-687.
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Peng Y, Shinde DN, Valencia CA, Mo JS, Rosenfeld J, Truitt Cho M, Chamberlin A, Li Z, Liu J, Gui B, Brockhage R, Basinger A, Alvarez-Leon B, Heydemann P, Magoulas PL, Lewis AM, Scaglia F, Gril S, Chong SC, Bower M, Monaghan KG, Willaert R, Plona MR, Dineen R, Milan F, Hoganson G, Powis Z, Helbig KL, Keller-Ramey J, Harris B, Anderson LC, Green T, Sukoff Rizzo SJ, Kaylor J, Chen J, Guan MX, Sellars E, Sparagana SP, Gibson JB, Reinholdt LG, Tang S, Huang T. Biallelic mutations in the ferredoxin reductase gene cause novel mitochondriopathy with optic atrophy. Hum Mol Genet. 2017 12 15; 26(24):4937-4950.
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Butt AT, Thomas MS. Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species. Front Cell Infect Microbiol. 2017; 7:460.
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Kindrat I, Dreval K, Shpyleva S, Tryndyak V, de Conti A, Mudalige TK, Chen T, Erstenyuk AM, Beland FA, Pogribny IP. Effect of methapyrilene hydrochloride on hepatic intracellular iron metabolism in vivo and in vitro. Toxicol Lett. 2017 Nov 05; 281:65-73.
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Liu Z, Nemec-Bakk A, Khaper N, Chen A. Sensitive Electrochemical Detection of Nitric Oxide Release from Cardiac and Cancer Cells via a Hierarchical Nanoporous Gold Microelectrode. Anal Chem. 2017 08 01; 89(15):8036-8043.
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McKee SG, Close R, Lowenthal E. Evaluation of Iron Deficiency Anemia in a Pediatric Clinic in the Dominican Republic. Ann Glob Health. 2017 May - Aug; 83(3-4):550-556.
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Xia J, Xu H, Zhang X, Allamargot C, Coleman KL, Nessler R, Frech I, Tricot G, Zhan F. Multiple Myeloma Tumor Cells are Selectively Killed by Pharmacologically-dosed Ascorbic Acid. EBioMedicine. 2017 Apr; 18:41-49.
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Chakravarti A, Camp K, McNabb DS, Pinto I. The Iron-Dependent Regulation of the Candida albicans Oxidative Stress Response by the CCAAT-Binding Factor. PLoS One. 2017; 12(1):e0170649.
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Juvvadi PR. Balancing iron and calcium: Flavin carrier family proteins in Aspergillus fumigatus virulence. Virulence. 2017 08 18; 8(6):621-624.
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Swaminathan S. Gadolinium toxicity: Iron and ferroportin as central targets. Magn Reson Imaging. 2016 Dec; 34(10):1373-1376.
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Swaminathan S. Iron, hormesis, and protection in acute kidney injury. Kidney Int. 2016 07; 90(1):16-7.
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Charlton JR, Pearl VM, Denotti AR, Lee JB, Swaminathan S, Scindia YM, Charlton NP, Baldelomar EJ, Beeman SC, Bennett KM. Biocompatibility of ferritin-based nanoparticles as targeted MRI contrast agents. Nanomedicine. 2016 08; 12(6):1735-45.
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Raber J, Allen AR, Sharma S, Allen B, Rosi S, Olsen RH, Davis MJ, Eiwaz M, Fike JR, Nelson GA. Effects of Proton and Combined Proton and (56)Fe Radiation on the Hippocampus. Radiat Res. 2016 Jan; 185(1):20-30.
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Allen AR, Raber J, Chakraborti A, Sharma S, Fike JR. (56)Fe Irradiation Alters Spine Density and Dendritic Complexity in the Mouse Hippocampus. Radiat Res. 2015 Dec; 184(6):586-94.
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Bose C, Megyesi JK, Shah SV, Hiatt KM, Hall KA, Karaduta O, Swaminathan S. Evidence Suggesting a Role of Iron in a Mouse Model of Nephrogenic Systemic Fibrosis. PLoS One. 2015; 10(8):e0136563.
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Nzabarushimana E, Prior S, Miousse IR, Pathak R, Allen AR, Latendresse J, Olsen RH, Raber J, Hauer-Jensen M, Nelson GA, Koturbash I. Combined exposure to protons and (56)Fe leads to overexpression of Il13 and reactivation of repetitive elements in the mouse lung. Life Sci Space Res (Amst). 2015 Nov; 7:1-8.
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Bertrand EM, McCrow JP, Moustafa A, Zheng H, McQuaid JB, Delmont TO, Post AF, Sipler RE, Spackeen JL, Xu K, Bronk DA, Hutchins DA, Allen AE. Phytoplankton-bacterial interactions mediate micronutrient colimitation at the coastal Antarctic sea ice edge. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):9938-43.
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Casper C, Chaturvedi S, Munshi N, Wong R, Qi M, Schaffer M, Bandekar R, Hall B, van de Velde H, Vermeulen J, Reddy M, van Rhee F. Analysis of Inflammatory and Anemia-Related Biomarkers in a Randomized, Double-Blind, Placebo-Controlled Study of Siltuximab (Anti-IL6 Monoclonal Antibody) in Patients With Multicentric Castleman Disease. Clin Cancer Res. 2015 Oct 01; 21(19):4294-304.
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Gu Z, Wang H, Xia J, Yang Y, Jin Z, Xu H, Shi J, De Domenico I, Tricot G, Zhan F. Decreased ferroportin promotes myeloma cell growth and osteoclast differentiation. Cancer Res. 2015 Jun 01; 75(11):2211-21.
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Scindia Y, Dey P, Thirunagari A, Liping H, Rosin DL, Floris M, Okusa MD, Swaminathan S. Hepcidin Mitigates Renal Ischemia-Reperfusion Injury by Modulating Systemic Iron Homeostasis. J Am Soc Nephrol. 2015 Nov; 26(11):2800-14.
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Ellwood MJ, Hutchins DA, Lohan MC, Milne A, Nasemann P, Nodder SD, Sander SG, Strzepek R, Wilhelm SW, Boyd PW. Iron stable isotopes track pelagic iron cycling during a subtropical phytoplankton bloom. Proc Natl Acad Sci U S A. 2015 Jan 06; 112(1):E15-20.
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