 Hypoplastic Left Heart Syndrome
"Hypoplastic Left Heart Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A condition caused by underdevelopment of the whole left half of the heart. It is characterized by hypoplasia of the left cardiac chambers (HEART ATRIUM; HEART VENTRICLE), the AORTA, the AORTIC VALVE, and the MITRAL VALVE. Severe symptoms appear in early infancy when DUCTUS ARTERIOSUS closes.
| Descriptor ID |
D018636
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| MeSH Number(s) |
C14.240.400.625 C14.280.400.625 C16.131.240.400.625
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hypoplastic Left Heart Syndrome".
Below are MeSH descriptors whose meaning is more specific than "Hypoplastic Left Heart Syndrome".
This graph shows the total number of publications written about "Hypoplastic Left Heart Syndrome" by people in UAMS Profiles by year, and whether "Hypoplastic Left Heart Syndrome" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 3 | 0 | 3 | | 2023 | 4 | 0 | 4 | | 2022 | 3 | 1 | 4 | | 2021 | 2 | 0 | 2 | | 2020 | 4 | 0 | 4 | | 2018 | 4 | 0 | 4 | | 2017 | 6 | 0 | 6 | | 2016 | 6 | 0 | 6 | | 2015 | 5 | 0 | 5 | | 2014 | 1 | 0 | 1 | | 2013 | 2 | 1 | 3 | | 2012 | 2 | 0 | 2 | | 2011 | 1 | 1 | 2 | | 2010 | 2 | 0 | 2 | | 2009 | 2 | 1 | 3 | | 2007 | 2 | 0 | 2 | | 2004 | 1 | 0 | 1 | | 2003 | 1 | 1 | 2 | | 2002 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 |
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Below are the most recent publications written about "Hypoplastic Left Heart Syndrome" by people in Profiles over the past ten years.
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Bleiweis MS, Co-Vu J, Philip J, Fudge JC, Vyas HV, Pitkin AD, Janelle GM, Sullivan KJ, DeGroff CJ, Gupta D, Coppola JA, Pietra BBA, Fricker FJ, Cruz Beltr?n SC, Peek GJ, Jacobs JP. Comprehensive Approach to the Management of Patients With Hypoplastic Left Heart Syndrome: Analysis of 100 Consecutive Neonates. Ann Thorac Surg. 2025 01; 119(1):169-177.
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Ittleman B, Lowenstein S, Edwards LA, Caris E, Bhat A, Conwell J, Lewin M, Arya B. Fetal Echocardiographic Evaluation of Tricuspid Valve and Right Ventricular Function Including Global Longitudinal Strain in Hypoplastic Left Heart Syndrome and Association with Postnatal Outcomes. Pediatr Cardiol. 2025 Mar; 46(3):553-561.
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Qasim A, Doan TT, Furtun BY, Binsalamah Z, Adachi I, Morris SA. Labyrinthine cor triatriatum sinister in fetal hypoplastic left heart syndrome is associated with poor outcomes. Prenat Diagn. 2024 06; 44(6-7):758-772.
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Mahle WT, Keesari R, Trachtenberg F, Newburger JW, Lim H, Edelson J, Jeewa A, Lal A, Kindel SJ, Burns KM, Lang S, Bainton J, Carboni M, Villa CR, Richmond M, Henderson H, Menteer J, Pizarro C, Goldberg CS. School age and adolescent heart failure following the Norwood procedure. J Heart Lung Transplant. 2024 03; 43(3):453-460.
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Blue EE, White JJ, Dush MK, Gordon WW, Wyatt BH, White P, Marvin CT, Helle E, Ojala T, Priest JR, Jenkins MM, Almli LM, Reefhuis J, Pangilinan F, Brody LC, McBride KL, Garg V, Shaw GM, Romitti PA, Nembhard WN, Browne ML, Werler MM, Kay DM, Mital S, Chong JX, Nascone-Yoder NM, Bamshad MJ. Rare variants in CAPN2 increase risk for isolated hypoplastic left heart syndrome. HGG Adv. 2023 10 12; 4(4):100232.
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Cunningham TW, Bai S, Krawczeski CD, Spencer JD, Phelps C, Yates AR. Acute kidney injury in hypoplastic left heart syndrome patients following the comprehensive stage two palliation. Cardiol Young. 2024 Mar; 34(3):552-558.
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Detterich J, Taylor MD, Slesnick TC, DiLorenzo M, Hlavacek A, Lam CZ, Sachdeva S, Lang SM, Campbell MJ, Gerardin J, Whitehead KK, Rathod RH, Cartoski M, Menon S, Trachtenberg F, Gongwer R, Newburger J, Goldberg C, Dorfman AL. Cardiac Magnetic Resonance Imaging to Determine Single Ventricle Function in a Pediatric Population is Feasible in a Large Trial Setting: Experience from the Single Ventricle Reconstruction Trial Longitudinal Follow up. Pediatr Cardiol. 2023 Oct; 44(7):1454-1461.
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Bleiweis MS, Philip J, Fudge JC, Vyas HV, Peek GJ, Pitkin AD, Janelle GM, Sullivan KJ, Stukov Y, Nixon CS, Sharaf OM, Neal D, Jacobs JP. Support with Single Ventricle-Ventricular Assist Device (sVAD) in Patients with Functionally Univentricular Circulation Prior to Fontan Operation. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2023; 26:26-39.
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Loomba RS, Dyamenahalli U, Savorgnan F, Acosta S, Villarreal E, Farias JS, Wong J, Flores S. Association of Immediate Postoperative Hemodynamic and Laboratory Values in Predicting Norwood Admission Outcomes. Pediatr Cardiol. 2024 Aug; 45(6):1232-1241.
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Bleiweis MS, Peek GJ, Philip J, Fudge JC, Sullivan KJ, Co-Vu J, DeGroff C, Vyas HV, Gupta D, Shih R, Pietra BBA, Fricker FJ, Cruz Beltran SC, Arnold MA, Wesley MC, Pitkin AD, Hernandez-Rivera JF, Lopez-Colon D, Barras WE, Stukov Y, Sharaf OM, Neal D, Nixon CS, Jacobs JP. A Comprehensive Approach to the Management of Patients With HLHS and Related Malformations: An Analysis of 83 Patients (2015-2021). World J Pediatr Congenit Heart Surg. 2022 09; 13(5):664-675.
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Bleiweis MS, Philip J, Peek GJ, Fudge JC, Sullivan KJ, Co-Vu J, Gupta D, Shih R, Pietra BBA, Fricker FJ, Vyas HV, Hernandez-Rivera JF, Powers ER, Nixon CS, Falasa M, Jacobs JP. Palliation Plus Ventricular Assist Device Insertion in 15 Neonates and Infants With Functionally Univentricular Circulation. Ann Thorac Surg. 2022 10; 114(4):1412-1418.
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Hill MA, Mitchell MB, Rajab TK. Mitral Valve Anatomy in Patients With Native Aortic Root Thrombosis After Norwood Palliation. Ann Thorac Surg. 2022 09; 114(3):1089-1090.
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Gilmore A, Davis JA, Low S, Chisolm J, Kelly J, Hone E, Bai S, McConnell P, Galantowicz M, Cua CL. Incidence of and Risk Factors for Aortic Arch Interventions After the Comprehensive Stage II Procedure for Hypoplastic Left Heart Syndrome. Pediatr Cardiol. 2022 Feb; 43(2):426-434.
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Bleiweis MS, Philip J, Peek GJ, Fudge JC, Sullivan KJ, Co-Vu J, Gupta D, Fricker FJ, Vyas HV, Ebraheem M, Powers ER, Falasa M, Jacobs JP. Combined Hybrid Procedure and VAD Insertion in 9 High-Risk Neonates and Infants With HLHS. Ann Thorac Surg. 2022 09; 114(3):809-816.
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Cunningham TW, Tan Y, Krawczeski CD, Spencer JD, Bai S, Phelps C, Yates AR. Incidence and impact of acute kidney injury in patients with hypoplastic left heart syndrome following the hybrid stage 1 palliation. Cardiol Young. 2021 Feb; 31(3):414-420.
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Rajab TK, Mitchell MB. Native Aortic Root Thrombosis After Norwood Palliation for Hypoplastic Left Heart Syndrome. Ann Thorac Surg. 2021 07; 112(1):147-154.
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Spigel ZA, Kalustian A, Ghanayem N, Imamura M, Adachi I, McKenzie ED, Heinle J, Caldarone CA, Binsalamah ZM. Predictors of Transplant-Free Survival After the Norwood Procedure. Ann Thorac Surg. 2021 08; 112(2):638-644.
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Spigel ZA, Kalustian AB, Binsalamah ZM, Caldarone CA, Imamura M, Adachi I, Heinle JS, McKenzie ED. Recurrent Pulmonary Artery Interventions Following the Norwood Procedure Are Not Associated With Conduit Type. Semin Thorac Cardiovasc Surg. 2021 Spring; 33(1):195-201.
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Buelow MW, Rudd N, Tanem J, Simpson P, Bartz P, Hill G. Reintervention following stage 1 palliation: A report from the NPC-QIC Registry. Congenit Heart Dis. 2018 Nov; 13(6):919-926.
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Prodhan P, Tang X, Gossett J, Beam B, Simsic J, Ghanayem N, ElHassan NO. Gastrostomy tube placement among infants with hypoplastic left heart syndrome undergoing stage 1 palliation. Congenit Heart Dis. 2018 Jul; 13(4):519-527.
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Menon SC, Al-Dulaimi R, McCrindle BW, Goldberg DJ, Sachdeva R, Goldstein BH, Seery T, Uzark KC, Chelliah A, Butts R, Henderson H, Johnson T, Williams RV. Delayed puberty and abnormal anthropometry and its associations with quality of life in young Fontan survivors: A multicenter cross-sectional study. Congenit Heart Dis. 2018 May; 13(3):463-469.
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ElHassan NO, Tang X, Gossett J, Zakaria D, Ross A, Kona SK, Prodhan P. Necrotizing Enterocolitis in Infants with Hypoplastic Left Heart Syndrome Following Stage 1 Palliation or Heart Transplant. Pediatr Cardiol. 2018 Apr; 39(4):774-785.
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Philip J, Gupta D, Bleiweis MS, Pietra BA, Vyas HV. Hypoplastic left heart in Turner's syndrome: a primary indication for transplant? Cardiol Young. 2018 Mar; 28(3):458-460.
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Zakaria D, Tang X, Bhakta R, ElHassan NO, Prodhan P. Chromosomal Abnormalities Affect the Surgical Outcome in Infants with Hypoplastic Left Heart Syndrome: A Large Cohort Analysis. Pediatr Cardiol. 2018 Jan; 39(1):11-18.
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Plymale JM, Frommelt PC, Nugent M, Simpson P, Tweddell JS, Shillingford AJ. The Infant with Aortic Arch Hypoplasia and Small Left Heart Structures: Echocardiographic Indices of Mitral and Aortic Hypoplasia Predicting Successful Biventricular Repair. Pediatr Cardiol. 2017 Aug; 38(6):1296-1304.
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Goreczny S, Qureshi SA, Rosenthal E, Krasemann T, Nassar MS, Anderson DR, Morgan GJ. Comparison of self-expandable and balloon-expanding stents for hybrid ductal stenting in hypoplastic left heart complex. Cardiol Young. 2017 Jul; 27(5):837-845.
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Hinkle KA, Wilkes J, McFadden M, Williams RV, Minich LL, Menon SC. A multi-institutional study of factors affecting resource utilisation following the Fontan operation. Cardiol Young. 2017 May; 27(4):739-746.
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Tadphale SD, Tang X, ElHassan NO, Beam B, Prodhan P. Cavopulmonary Anastomosis During Same Hospitalization as Stage 1 Norwood/Hybrid Palliative Surgery. Ann Thorac Surg. 2017 Apr; 103(4):1285-1291.
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Goreczny S, Morgan GJ, Dryzek P, Moll JA, Moszura T. Initial experience with live three-dimensional image overlay for ductal stenting in hypoplastic left heart syndrome. EuroIntervention. 2016 Dec 20; 12(12):1527-1533.
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Prodhan P, Agarwal A, ElHassan NO, Bolin EH, Beam B, Garcia X, Gaies M, Tang X. Tracheostomy Among Infants With Hypoplastic Left Heart Syndrome Undergoing Cardiac Operations: A Multicenter Analysis. Ann Thorac Surg. 2017 Apr; 103(4):1308-1314.
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Tomita-Mitchell A, Stamm KD, Mahnke DK, Kim MS, Hidestrand PM, Liang HL, Goetsch MA, Hidestrand M, Simpson P, Pelech AN, Tweddell JS, Benson DW, Lough JW, Mitchell ME. Impact of MYH6 variants in hypoplastic left heart syndrome. Physiol Genomics. 2016 12 01; 48(12):912-921.
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Lara DA, Ethen MK, Canfield MA, Nembhard WN, Morris SA. A population-based analysis of mortality in patients with Turner syndrome and hypoplastic left heart syndrome using the Texas Birth Defects Registry. Congenit Heart Dis. 2017 Jan; 12(1):105-112.
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Collins RT, Doshi P, Onukwube J, Fram RY, Robbins JM. Risk Factors for Increased Hospital Resource Utilization and In-Hospital Mortality in Adults With Single Ventricle Congenital Heart Disease. Am J Cardiol. 2016 08 01; 118(3):453-62.
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Kyle WB, Denfield SW, Valdes SO, Penny DJ, Bolin EH, Lopez KN. Assessing ST Segment Changes and Ischemia During Exercise Stress Testing in Patients with Hypoplastic Left Heart Syndrome and Fontan Palliation. Pediatr Cardiol. 2016 Mar; 37(3):545-51.
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Murphy MO, Bellsham-Revell H, Morgan GJ, Krasemann T, Rosenthal E, Qureshi SA, Salih C, Austin CB, Anderson DR. Hybrid Procedure for Neonates With Hypoplastic Left Heart Syndrome at High-Risk for Norwood: Midterm Outcomes. Ann Thorac Surg. 2015 Dec; 100(6):2286-90; discussion 2291-2.
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Bolin EH, Maskatia SA, Tate AL, Petit CJ. Older Age at Completion of Fontan Procedure Is Associated with Improved Percentage of Predicted Maximum Oxygen Uptake. Tex Heart Inst J. 2015 Aug; 42(4):333-40.
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Johnson JT, Sleeper LA, Chen S, Ohye RG, Gaies MG, Williams IA, Sachdeva R, Pruetz JD, Tatum GH, Thacker D, Brunetti MA, Frommelt MA, Jacobs JP, Kirsh JA, Lambert LM, Newburger JW, Pemberton VL, Zyblewski SC, Divanovic AA, Pinto NM. Associations Between Day of Admission and Day of Surgery on Outcome and Resource Utilization in Infants With Hypoplastic Left Heart Syndrome Who Underwent Stage I Palliation (from the Single Ventricle Reconstruction Trial). Am J Cardiol. 2015 Oct 15; 116(8):1263-9.
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