 MAP Kinase Kinase 4
"MAP Kinase Kinase 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES and the RETINOID X RECEPTORS. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to cellular stress.
| Descriptor ID |
D048670
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| MeSH Number(s) |
D08.811.913.696.620.682.700.565.400 D08.811.913.696.620.682.725.200.400 D12.644.360.440.400 D12.776.476.440.400
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| Concept/Terms |
MAP Kinase Kinase 4- MAP Kinase Kinase 4
- JNK Kinase
- JNK-Activating Protein Kinase
- JNK Activating Protein Kinase
- Protein Kinase, JNK-Activating
- JNKK1 Protein Kinase
- Kinase, JNKK1 Protein
- Protein Kinase, JNKK1
- Jun Amino-Terminal Kinase Kinase
- Jun Amino Terminal Kinase Kinase
- Stress-Activated Protein Kinase Kinase 1
- Stress Activated Protein Kinase Kinase 1
- Mitogen-Activated Protein Kinase Kinase 4
- Mitogen Activated Protein Kinase Kinase 4
- SAP Kinase Kinase 1
- SAP Kinase-Extracellular Signal-Regulated Kinase Kinase 1
- SAP Kinase Extracellular Signal Regulated Kinase Kinase 1
- SAPK-ERK Kinase 1
- SAPK ERK Kinase 1
- SEK1 Protein Kinase
- Protein Kinase, SEK1
- JN Kinase Kinase
- MEK4 Protein Kinase
- Protein Kinase, MEK4
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Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase 4".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase 4".
This graph shows the total number of publications written about "MAP Kinase Kinase 4" by people in UAMS Profiles by year, and whether "MAP Kinase Kinase 4" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2022 | 0 | 2 | 2 | | 2016 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 | | 2012 | 1 | 1 | 2 | | 2011 | 0 | 3 | 3 | | 2009 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2004 | 1 | 1 | 2 | | 2003 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2000 | 1 | 1 | 2 | | 1998 | 0 | 2 | 2 | | 1996 | 1 | 0 | 1 |
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Below are the most recent publications written about "MAP Kinase Kinase 4" by people in Profiles over the past ten years.
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Najjar RS, Knapp D, Wanders D, Feresin RG. Raspberry and blackberry act in a synergistic manner to improve cardiac redox proteins and reduce NF-?B and SAPK/JNK in mice fed a high-fat, high-sucrose diet. Nutr Metab Cardiovasc Dis. 2022 07; 32(7):1784-1796.
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Raghavan S, Kundumani-Sridharan V, Kumar S, White CW, Das KC. Thioredoxin Prevents Loss of UCP2 in Hyperoxia via MKK4-p38 MAPK-PGC1a Signaling and Limits Oxygen Toxicity. Am J Respir Cell Mol Biol. 2022 03; 66(3):323-336.
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Maroso M, Szabo GG, Kim HK, Alexander A, Bui AD, Lee SH, Lutz B, Soltesz I. Cannabinoid Control of Learning and Memory through HCN Channels. Neuron. 2016 Mar 02; 89(5):1059-73.
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Kundumani-Sridharan V, Subramani J, Das KC. Thioredoxin Activates MKK4-NF?B Pathway in a Redox-dependent Manner to Control Manganese Superoxide Dismutase Gene Expression in Endothelial Cells. J Biol Chem. 2015 Jul 10; 290(28):17505-19.
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