 Phenytoin
"Phenytoin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An anticonvulsant that is used in a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
| Descriptor ID |
D010672
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| MeSH Number(s) |
D03.383.129.308.432.555.730
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| Concept/Terms |
Phenytoin- Phenytoin
- Diphenylhydantoin
- Fenitoin
- 5,5-Diphenylhydantoin
Epamin- Epamin
- Phizer Brand of Phenytoin
- Phenytoin Phizer Brand
Epanutin- Epanutin
- Pfizer Brand of Phenytoin
- Phenytoin Pfizer Brand
Dilantin- Dilantin
- Park Davis brand of Phenytoin
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Below are MeSH descriptors whose meaning is more general than "Phenytoin".
Below are MeSH descriptors whose meaning is more specific than "Phenytoin".
This graph shows the total number of publications written about "Phenytoin" by people in UAMS Profiles by year, and whether "Phenytoin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2019 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2003 | 0 | 1 | 1 | | 2000 | 1 | 0 | 1 | | 1990 | 1 | 0 | 1 |
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Below are the most recent publications written about "Phenytoin" by people in Profiles over the past ten years.
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Kang YJ, Clement EM, Sumsky SL, Xiang Y, Park IH, Santaniello S, Greenfield LJ, Garcia-Rill E, Smith BN, Lee SH. The critical role of persistent sodium current in hippocampal gamma oscillations. Neuropharmacology. 2020 01 01; 162:107787.
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Hirashima R, Michimae H, Takemoto H, Sasaki A, Kobayashi Y, Itoh T, Tukey RH, Fujiwara R. Induction of the UDP-Glucuronosyltransferase 1A1 during the Perinatal Period Can Cause Neurodevelopmental Toxicity. Mol Pharmacol. 2016 09; 90(3):265-74.
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Tanaka T, Litofsky NS. Anti-epileptic drugs in pediatric traumatic brain injury. Expert Rev Neurother. 2016 10; 16(10):1229-34.
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