 Clozapine
"Clozapine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
| Descriptor ID |
D003024
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| MeSH Number(s) |
D03.494.240.220
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Clozapine".
Below are MeSH descriptors whose meaning is more specific than "Clozapine".
This graph shows the total number of publications written about "Clozapine" by people in UAMS Profiles by year, and whether "Clozapine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2022 | 1 | 0 | 1 | | 2016 | 2 | 0 | 2 | | 2014 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 | | 2009 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2003 | 0 | 2 | 2 | | 2001 | 1 | 0 | 1 | | 1999 | 1 | 1 | 2 | | 1998 | 1 | 0 | 1 | | 1996 | 1 | 1 | 2 | | 1995 | 0 | 1 | 1 | | 1993 | 1 | 0 | 1 | | 1992 | 2 | 0 | 2 | | 1991 | 1 | 0 | 1 |
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Below are the most recent publications written about "Clozapine" by people in Profiles over the past ten years.
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Cohen BM, Singh T, ?ng?r D, Konstantin GE, Gardner ME. Clinical phenotypes of five patients with psychotic disorders carrying rare schizophrenia-associated loss-of-function variants. Schizophr Res. 2022 Dec; 250:100-103.
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Das A, Minner R, Krain L, Spollen J. Delirium on clozapine: A tale of friend turned foe-A case report. Int J Psychiatry Med. 2021 11; 56(6):446-458.
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Hao L, Ben-David O, Babb SM, Futerman AH, Cohen BM, Buttner EA. Clozapine Modulates Glucosylceramide, Clears Aggregated Proteins, and Enhances ATG8/LC3 in Caenorhabditis elegans. Neuropsychopharmacology. 2017 Mar; 42(4):951-962.
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Saur T, Cohen BM, Ma Q, Babb SM, Buttner EA, Yao WD. Acute and chronic effects of clozapine on cholinergic transmission in cultured mouse superior cervical ganglion neurons. J Neurogenet. 2016 Sep - Dec; 30(3-4):297-305.
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