 Antipsychotic Agents
"Antipsychotic Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
| Descriptor ID |
D014150
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| MeSH Number(s) |
D27.505.696.277.950.040 D27.505.954.427.210.950.040 D27.505.954.427.700.872.331
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| Concept/Terms |
Antipsychotic Agents- Antipsychotic Agents
- Agents, Antipsychotic
- Antipsychotics
- Major Tranquilizers
- Tranquilizers, Major
- Tranquillizing Agents, Major
- Agents, Major Tranquillizing
- Major Tranquillizing Agents
- Neuroleptic Drugs
- Drugs, Neuroleptic
- Neuroleptics
- Tranquilizing Agents, Major
- Agents, Major Tranquilizing
- Major Tranquilizing Agents
- Antipsychotic Drugs
- Drugs, Antipsychotic
- Neuroleptic Agents
- Agents, Neuroleptic
Antipsychotic Effect- Antipsychotic Effect
- Effect, Antipsychotic
- Antipsychotic Effects
- Effects, Antipsychotic
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Below are MeSH descriptors whose meaning is more general than "Antipsychotic Agents".
Below are MeSH descriptors whose meaning is more specific than "Antipsychotic Agents".
This graph shows the total number of publications written about "Antipsychotic Agents" by people in UAMS Profiles by year, and whether "Antipsychotic Agents" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2025 | 1 | 0 | 1 | | 2024 | 1 | 0 | 1 | | 2023 | 1 | 0 | 1 | | 2022 | 4 | 1 | 5 | | 2020 | 1 | 2 | 3 | | 2019 | 1 | 1 | 2 | | 2018 | 3 | 1 | 4 | | 2017 | 2 | 3 | 5 | | 2016 | 5 | 3 | 8 | | 2015 | 4 | 3 | 7 | | 2014 | 4 | 1 | 5 | | 2013 | 10 | 1 | 11 | | 2012 | 5 | 1 | 6 | | 2011 | 5 | 0 | 5 | | 2010 | 2 | 1 | 3 | | 2009 | 5 | 2 | 7 | | 2008 | 4 | 0 | 4 | | 2007 | 4 | 2 | 6 | | 2006 | 8 | 3 | 11 | | 2005 | 3 | 0 | 3 | | 2004 | 6 | 3 | 9 | | 2003 | 10 | 1 | 11 | | 2002 | 6 | 1 | 7 | | 2001 | 1 | 0 | 1 | | 2000 | 2 | 0 | 2 | | 1999 | 3 | 3 | 6 | | 1998 | 3 | 0 | 3 | | 1997 | 1 | 2 | 3 | | 1996 | 2 | 0 | 2 | | 1995 | 7 | 0 | 7 | | 1994 | 2 | 1 | 3 | | 1993 | 1 | 0 | 1 | | 1992 | 2 | 0 | 2 | | 1991 | 1 | 0 | 1 | | 1990 | 2 | 0 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Antipsychotic Agents" by people in Profiles over the past ten years.
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Kaul I, Claxton A, Sawchak S, Sauder C, Brannan SK, Raj E, Ruan S, Konis G, Brown D, Cutler AJ, Marcus R. Safety and Tolerability of Xanomeline and Trospium Chloride in Schizophrenia: Pooled Results From the 5-Week, Randomized, Double-Blind, Placebo-Controlled EMERGENT Trials. J Clin Psychiatry. 2025 Feb 26; 86(1).
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Den J, Nelson N, Klimberg VS. Analysis of the incidence and outcomes of breast cancer in women with schizophrenia. Am J Surg. 2025 Jan; 239:116050.
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Furr Stimming E, Claassen DO, Kayson E, Goldstein J, Mehanna R, Zhang H, Liang GS, Haubenberger D. Safety and efficacy of valbenazine for the treatment of chorea associated with Huntington's disease (KINECT-HD): a phase 3, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2023 06; 22(6):494-504.
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Cohen BM, Singh T, ?ng?r D, Konstantin GE, Gardner ME. Clinical phenotypes of five patients with psychotic disorders carrying rare schizophrenia-associated loss-of-function variants. Schizophr Res. 2022 Dec; 250:100-103.
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Cerimele JM, Johnson M, Blanchard BE, Russo J, Un?tzer J, Fortney JC. Bipolar disorder in primary care: Medication treatment by co-located psychiatrists versus primary care clinicians supported by psychiatrists. Gen Hosp Psychiatry. 2022 Sep-Oct; 78:108-110.
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Coralic Z, Rader ES, Vinson DR, Wilson MP. Haloperidol Versus Ziprasidone With Concomitant Medications and Other Predictors of Physical Restraint Duration in the Emergency Department. J Emerg Med. 2022 05; 62(5):636-647.
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Choo TH, Xu Q, Budimirovic D, Lozano R, Esler AN, Frye RE, Andrews H, Velinov M. Height and BMI in fragile X syndrome: A?longitudinal assessment. Obesity (Silver Spring). 2022 03; 30(3):743-750.
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Katz IR, Rogers MP, Lew R, Thwin SS, Doros G, Ahearn E, Ostacher MJ, DeLisi LE, Smith EG, Ringer RJ, Ferguson R, Hoffman B, Kaufman JS, Paik JM, Conrad CH, Holmberg EF, Boney TY, Huang GD, Liang MH. Lithium Treatment in the Prevention of Repeat Suicide-Related Outcomes in Veterans With Major Depression or Bipolar Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2022 01 01; 79(1):24-32.
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Das A, Minner R, Krain L, Spollen J. Delirium on clozapine: A tale of friend turned foe-A case report. Int J Psychiatry Med. 2021 11; 56(6):446-458.
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Schneider A, Mullinax S, Hall N, Acheson A, Oliveto AH, Wilson MP. Intramuscular medication for treatment of agitation in the emergency department: A systematic review of controlled trials. Am J Emerg Med. 2021 08; 46:193-199.
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Meltzer HY, Share DB, Jayathilake K, Salomon RM, Lee MA. Lurasidone Improves Psychopathology and Cognition in Treatment-Resistant Schizophrenia. J Clin Psychopharmacol. 2020 May-Jun; 40(3):240-249.
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Gupta HV. Teaching Video NeuroImages: Tardive diaphragmatic tremor. Neurology. 2020 02 11; 94(6):e656.
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Cohen BM. Evidence-Based Drug Treatment of Acute Depression in Bipolar Disorder. JAMA Psychiatry. 2019 12 01; 76(12):1314-1315.
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Cole JB, Klein LR, Mullinax SZ, Nordstrom KD, Driver BE, Wilson MP. Study Enrollment When "Preconsent" Is Utilized for a Randomized Clinical Trial of Two Treatments for Acute Agitation in the Emergency Department. Acad Emerg Med. 2019 05; 26(5):559-566.
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Chouinard VA, Henderson DC, Dalla Man C, Valeri L, Gray BE, Ryan KP, Cypess AM, Cobelli C, Cohen BM, ?ng?r D. Impaired insulin signaling in unaffected siblings and patients with first-episode psychosis. Mol Psychiatry. 2019 10; 24(10):1513-1522.
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Gressler LE, Martin BC, Hudson TJ, Painter JT. Relationship between concomitant benzodiazepine-opioid use and adverse outcomes among US veterans. Pain. 2018 03; 159(3):451-459.
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Patatanian E, Claborn MK. Drug-Induced Restless Legs Syndrome. Ann Pharmacother. 2018 07; 52(7):662-672.
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Pyne JM, Fischer EP, Mittal D, Owen R. A Patient-Centered Antipsychotic Medication Adherence Intervention: Results From a Randomized Controlled Trial. J Nerv Ment Dis. 2018 02; 206(2):142-148.
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Lewandowski KE, Sperry SH, Cohen BM, Norris LA, Fitzmaurice GM, Ongur D, Keshavan MS. Treatment to Enhance Cognition in Bipolar Disorder (TREC-BD): Efficacy of a Randomized Controlled Trial of Cognitive Remediation Versus Active Control. J Clin Psychiatry. 2017 Nov/Dec; 78(9):e1242-e1249.
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Gondim FAA, Arag?o AP, Holanda Filha JG, Messias ELM. Hikikomori in Brazil: 29 years of Voluntary social Withdrawal. Asian J Psychiatr. 2017 Dec; 30:163-164.
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Wilson MP, Nordstrom K, Hopper A, Porter A, Castillo EM, Vilke GM. Risperidone in the Emergency Setting is Associated with More Hypotension in Elderly Patients. J Emerg Med. 2017 Nov; 53(5):735-739.
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Yeo QM, Wiley TL, Smith MN, Hammond DA. Oral Agents for the Management of Agitation and Agitated Delirium in Critically Ill Patients. Crit Care Nurs Q. 2017 Oct/Dec; 40(4):344-362.
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Painter JT, Owen R, Henderson KL, Bauer MS, Mittal D, Hudson TJ. Analysis of the Appropriateness of Off-Label Antipsychotic Use for Mental Health Indications in a Veteran Population. Pharmacotherapy. 2017 Apr; 37(4):438-446.
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Kirchner JE, Woodward EN, Smith JL, Curran GM, Kilbourne AM, Owen RR, Bauer MS. Implementation Science Supports Core Clinical Competencies: An Overview and Clinical Example. Prim Care Companion CNS Disord. 2016 Dec 08; 18(6).
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Huang JH, Park H, Iaconelli J, Berkovitch SS, Watmuff B, McPhie D, ?ng?r D, Cohen BM, Clish CB, Karmacharya R. Unbiased Metabolite Profiling of Schizophrenia Fibroblasts under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines. J Proteome Res. 2017 02 03; 16(2):481-493.
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Hao L, Ben-David O, Babb SM, Futerman AH, Cohen BM, Buttner EA. Clozapine Modulates Glucosylceramide, Clears Aggregated Proteins, and Enhances ATG8/LC3 in Caenorhabditis elegans. Neuropsychopharmacology. 2017 Mar; 42(4):951-962.
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Saur T, Cohen BM, Ma Q, Babb SM, Buttner EA, Yao WD. Acute and chronic effects of clozapine on cholinergic transmission in cultured mouse superior cervical ganglion neurons. J Neurogenet. 2016 Sep - Dec; 30(3-4):297-305.
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Wilson MP, Vilke GM, Hayden SR, Nordstrom K. Psychiatric Emergencies for Clinicians: Emergency Department Management of Neuroleptic Malignant Syndrome. J Emerg Med. 2016 Jul; 51(1):66-9.
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D'Onofrio S, Urbano FJ, Messias E, Garcia-Rill E. Lithium decreases the effects of neuronal calcium sensor protein 1 in pedunculopontine neurons. Physiol Rep. 2016 Mar; 4(6).
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Farrell MS, McCorvy JD, Huang XP, Urban DJ, White KL, Giguere PM, Doak AK, Bernstein AI, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt WS, Norwood AP, Webster KA, Gannon BM, Miller GW, Porter JH, Shoichet BK, Fantegrossi WE, Wetsel WC, Roth BL. In Vitro and In Vivo Characterization of the Alkaloid Nuciferine. PLoS One. 2016; 11(3):e0150602.
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An T, Choi J, Kim A, Lee JH, Nam Y, Park J, Sun Bk, Suh H, Kim CJ, Hwang SJ. Sustained release of risperidone from biodegradable microspheres prepared by in-situ suspension-evaporation process. Int J Pharm. 2016 Apr 30; 503(1-2):8-15.
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Campillo A, Castillo E, Vilke GM, Hopper A, Ryan V, Wilson MP. First-generation Antipsychotics Are Often Prescribed in the Emergency Department but Are Often Not Administered with Adjunctive Medications. J Emerg Med. 2015 Dec; 49(6):901-6.
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Hinds A, Coulter L, Hudson J, Seaton V. Screening for diabetes in patients receiving second-generation atypical antipsychotics. Am J Health Syst Pharm. 2015 Sep 01; 72(17 Suppl 2):S70-3.
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Aman M, Rettiganti M, Nagaraja HN, Hollway JA, McCracken J, McDougle CJ, Tierney E, Scahill L, Arnold LE, Hellings J, Posey DJ, Swiezy NB, Ghuman J, Grados M, Shah B, Vitiello B. Tolerability, Safety, and Benefits of Risperidone in Children and Adolescents with Autism: 21-Month Follow-up After 8-Week Placebo-Controlled Trial. J Child Adolesc Psychopharmacol. 2015 Aug; 25(6):482-93.
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