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Kiran Kumar Adepu

TitlePost Doctoral Fellow
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPeds Pediatrics, College of Medicine
DivisionPeds Developmental Nutrition
Address1212 Marshall Street
Mail Slot # 512-20B
Little Rock AR 72202
ORCID ORCID Icon0000-0001-6612-1823 Additional info
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    Collapse Overview 
    Collapse overview
    Kiran Kumar has a Ph.D. degree in Biotechnology (specialization in protein chemistry and enzymology) from one of the reputed Institutes in India, Indian Institute of Technology (IIT) Guwahati. He has a vast Postdoctoral Research experience from Pennsylvania State University, Pennsylvania and Brookhaven National Laboratory, New York, NY, USA focusing on different metalloproteins, their biochemical, molecular, biophysical & structure-functions. He worked on several novel proteins and enzymes and their biochemical, structural, and molecular research during doctoral and postdoctoral training. He also worked with different Biotech & Probiotic Industries in the position of Group Leader & Head Research and Development. He was also associated several years with Non-profit Research Organization in different research & administrative positions (Senior Scientist to Head of the Division) leading several research scientists, research groups and technical teams. He worked with a broad range of microbial systems, protein chemistry and structure-function of enzymes for bioenergy and food bioprocessing applications.

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    Collapse Affiliation 
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    Indian Institute of Technology Delhi

    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Head (Research & Development) - Probiotics
    Grasmicrobe Pvt Ltd, India
    2019-2020

    Head - Bioconversion Technology Division
    Sardar Patel Renewable Energy Research Institute, India
    2018-2019

    Principal Scientist - Bioconversion Technology Division
    Sardar Patel Renewable Energy Research Institute, India
    2016-2019

    Senior Scientist - Bioconversion Technology Division
    Sardar Patel Renewable Energy Research Institute, India
    2013-2016

    Group Leader - Enzyme Product Development
    Codon Biosciences Pvt. Ltd, India
    2012-2013

    Collapse education and training
    Indian Institute of Technology Guwahati, IndiaDoctorate05/2009Protein Biochemistry
    Kakatiya University, IndiaMasters06/2003Clinical Biochemistry
    Kakatiya University, IndiaBacherlors04/2000Biology
    Pennsylvania State University, USAPostdoctoral Fellow10/2011Protein Biochemistry
    Brookhaven National Laboratory, USAResearch Associate01/2012Macromolecular Crystallography
    Collapse awards and honors
    2020World Top 2% Scientist, Stanford University, USA
    2019World Top 2% Scientist, Stanford University, USA
    2004 - 2009MHRD Fellowship, Indian Institute of Technology Guwahati
    1997 - 2000University Rank Award, Kakatiya University
    2001 - 2003University Gold Medal Award, Kakatiya University

    Collapse Teaching 
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    Teaching Assistant,
    Indian Institute of Technology Guwahati, India
    2004-2008

    Lecturer
    Swatha Junior College, India
    2000-2001


    Collapse Research 
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    I have a strong record of formal training in basic biochemistry from my bachelor and master’s programs. As a graduate in biotechnology, I was trained in developing complex membrane-bound redox proteins from microbial sources, characterize its functional properties towards its potential applications, synthesis of industrially important products, enzyme-based biosensors and biofuel cells. During my postdoctoral training, I had gained immense experience in several biochemical, biophysical, molecular expression tools, focused on protein crystallization of metallo-proteins, denovo crystal structure determination of novel iron-sulfur protein containing both eukaryotic and prokaryotic subunits from the archaebacterial with key cellular functions. Being part of industrial research, I was involved in design and development of cellulose degrading enzymes, novel green solvents, micro-algae and its deployment towards bio-renewable energy research, and probiotic gut microbiota towards increasing innate health immunity. Currently, I am actively involved in research projects pertaining to muscle physiology, work that complements collaborative studies examining protein-ligand interactions of different cellular metabolites. Having broad experience in multi- and inter-disciplinary research skills in structural and functional biology, I am able to collaborate with investigators in various fields. My focus is to develop in vitro based research experimentations in understanding cellular physiology and approaches that provide a strong scientific premise connecting in silico and in vivo research. Thus, my overall research program addresses research, design, development and deployment. This unique skillset and approach will be applied in the current application considering its focus on myoglobin structural-functional biochemistry and implications toward intermediary metabolism of cellular metabolites in pathophysiological conditions.

    Collapse research activities and funding
    GR0371754450     (Sree V Chintapalli)Oct 1, 2021 - Sep 30, 2023
    ACRI/ABI Investigator-Initiated Research Grant
    Effect of lactate on myoglobin oxygenation and deoxygenation A novel study in understanding energy deficit in failing heart conditions (USD $75,000)
    Role Description: The goal of the study is to explore the novel physiological functions of myoglobin in cellular metabolite transportation. The findings will bring out cellular understandings on acute myocardial ischemia conditions accompanied with lactic acidosis.
    Role: Co-Investigator

    DST/TDT/AGRO-52/2019(C)     (Shahab Fatima)Feb 25, 2020 - Feb 24, 2022
    Department of Science and Technology - Technology Development Program (DST-TDP)
    Sustainable processing of agroresidual waste to produce acoustic materials and bio-renewable chemicals using green solvents (USD $104,000)
    Role Description: The goal of this study is to design and develop socio-economic sustainability of rice straw biomass into high value chemicals from natural deep eutectic solvent pretreated agro-residues and evaluate the production of acoustic materials towards circular bioeconomy.
    Role: Co-Investigator

    GSBTM/JDR&D/604/2019/303     (Kiran Kumar Adepu)Mar 19, 2019 - Mar 18, 2021
    Gujarat State Biotechnology Mission - Department of Science and Technology (GSBTM-DST)
    Next generation bio-ligin nanoparticle synthesis from lignocellulosic agro-residual waste materials using natural deep eutectic solvents (USD $53,000)
    Role Description: The goal of this study is to design, develop and characterize the lignin nanoparticles and nanofibrils synthesized from novel green solvents pretreated rice straw biomass and enhance the overall economic viability of processes involved in bioconversion of agro-residual waste materials.
    Role: Principle Investigator

    BT/PR11014/PBD/26/404/2014     (Madhuri Narra)Jul 18, 2017 - Jul 18, 2020
    Department of Biotechnology (DBT)
    Refinement and demonstration of an integrated process technology for conversion of crop residues into ethanol and methane for use as transport fuels (USD $209,000)
    Role Description: The goal of the study is to optimize the process of second generation biofuels using microbial and enzymatic treatment methods of conversion of agricultural waste biomass residues into value added products and demonstrate the feasibility of the technology for industrial application using comprehensive techno-economic analysis.
    Role: Co-Investigator

    BT/PR8991/PBD/26/392/2013     (Kiran Kumar Adepu)Nov 1, 2016 - Oct 31, 2019
    Department of Biotechnology (DBT)
    Design and development of pilot scale cultivation and harvesting systems of oleaginous microalgae from west coast of India for biodiesel production (USD $78,000)
    Role Description: The goal of this study is to translation of lab-grown robust high oil-yielding microalga from indoor bench-scale to outdoor pilot-scale mass production in diary industrial effluent in a zero-waste circular economy. Major outcomes of the project were extraction of microalgal oil for renewable fuels, generation of irrigation acceptable water, recycle and reuse of microalgal-treated dairy effluent, and utilization of microalga as aqua-feed supplement.
    Role: Principle Investigator

    BT/PR12368/PBD/26/431/2014     (Kiran Kumar Adepu)Apr 1, 2016 - Jun 30, 2019
    Department of Biotechnology (DBT)
    Development of a cost-effective green technology for lignocellulosic biomass pretreatment using natural deep eutectic solvents (USD $126,000)
    Role Description: The goal of this study is to design and develop novel green bio-based solvents that are renewable, biodegradable, sustainable and cost-effective and utilize them in the pretreatment processes of agro-residual biomass for production of high-quality cellulose, lignin and xylan derivatives.
    Role: Principle Investigator

    VVN/EAAI/DRET/LBT /2017/1     (Kiran Kumar Adepu)Apr 1, 2016 - Mar 30, 2019
    Indian Council of Agricultural Research (ICAR-AICRP (EAAI))
    Development of a cost-effective pilotscale microalgal post-harvesting technology
    Role Description: The goal of the study is to design and develop an effective low-cost downstream processing of microalgae for generating value added products in a circular economy
    Role: Principle Investigator

    CRP/VVN/2015/3     (Kiran Kumar Adepu)Apr 1, 2015 - Mar 31, 2018
    Indian Council of Agricultural Research (ICAR-CRP (EA))
    Development of a cost-effective green technology for pilot-scale production of cellulosic ethanol from lignocellulosic biomass using natural deep eutectic solvents
    Role Description: The goal of the study is to design and develop a simple process for production of bioethanol and other value added products from agro-residual waste materials using novel green solvents in a circular economy
    Role: Principle Investigator

    CRP/VVN/2015/1     (Madhuri Narra)Apr 1, 2015 - Mar 31, 2018
    Indian Council of Agricultural Research (ICAR-CRP (EA))
    Techno-economic evaluation of SPRERI cellulosic ethanol technology using selected crop residues and development of scale-up system
    Role Description: The goal of the study is to comprehensively evaluate the process/technology for production of bioethanol from crop residues
    Role: Co-Investigator

    GUJCOST/MRP/2014- 15/1290     (Kiran Kumar Adepu)Dec 30, 2014 - Jan 29, 2016
    Gujarat Council of Science and Technology - Department of Science and Technology (GUJCOST-DST)
    Bioremediation of dairy wastewater by microalgae
    Role Description: The goal of the study is to test the feasibility of dairy effluents in microalgal growth and simultaneous bio-remediation process.
    Role: Principle Investigator

    VVN/RES/DRET/LBT/ 2014/4     (Kiran Kumar Adepu)Apr 2, 2014 - Mar 31, 2016
    Indian Council of Agricultural Research (ICAR-AICRP (EAAI))
    Development of a semi fed-batch method for high-solids biomass saccharification for cellulosic ethanol production
    Role Description: The goal of the study is to investigate different modes of glucose production from green solvent treated agro-residual waste materials towards bioethanol production
    Role: Principle Investigator

    VVN/EAAI/DRET/LBT /2014/1     (Kiran Kumar Adepu)Apr 1, 2014 - Mar 31, 2016
    Indian Council of Agricultural Research (ICAR-AICRP (EAAI))
    Development of a flat-plate photobioreactor for cultivation of marine microalgae
    Role Description: The goal of this study is to design and develop a flat-pate photobioreactor for mass cultivation of enriched microalga isolated from marine sources
    Role: Principle Investigator

    VVN/RES/DRET/LBT/ 2014/1     (Kiran Kumar Adepu)Apr 1, 2014 - Mar 31, 2016
    Indian Council of Agricultural Research (ICAR-AICRP (EAAI))
    Development of low cost cultivation system using dairy wastewater/fertilizer for the growth of microalgae under waste water open race-way pond conditions
    Role Description: The goal of the study is the design and develop different cost-effective processes for microalgal cultivation using cheap or waste organic sources
    Role: Principle Investigator

    VVN/RES/DRET/LBT/ 2014/3     (Kiran Kumar Adepu)Apr 1, 2014 - Mar 31, 2016
    Indian Council of Agricultural Research (ICAR-AICRP (EAAI))
    Studies on developing a next generation green solvent for cellulosic biomass pretreatment
    Role Description: The goal of the study is toe investigate the feasibility of novel green solvents in extraction of value added products from agro-residual waste biomaterials
    Role: Principle Investigator

    VVN/RES/DRET/BCT/ 2014/1     (Madhuri Narra)Apr 1, 2014 - Mar 31, 2016
    Indian Council of Agricultural Research (ICAR-AICRP (EAAI))
    Production of economically viable and low cost cellulases using cheap lignocellulosic biomass or by coculturing method
    Role Description: The goal of the study is to explore the feasibility of in-house produced cellulose degrading enzymes using agro-residual waste materials and compare with the commercially available enzymes
    Role: Co-Investigator

    VVN/RES/DRET/BCT/ 2012/3     (Kiran Kumar Adepu)Apr 1, 2013 - Mar 28, 2014
    Indian Council of Agricultural Research (ICAR-AICRP (EAAI))
    Use of mutagenesis to improve economics of cellulose production by an in-house fungal isolate
    Role Description: The goal of the study is to mutate the cellulose producing filamentous fungi for selection of highly efficient cellulase strains towards bioprocessing and biotransformation
    Role: Principle Investigator

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    1. Adepu KK, Bhandari D, Anishkin A, Adams SH, Chintapalli SV. Myoglobin-Pyruvate Interactions: Binding Thermodynamics, Structure-Function Relationships, and Impact on Oxygen Release Kinetics. Int J Mol Sci. 2022 Aug 06; 23(15). PMID: 35955898.
      View in: PubMed
    2. Adepu KK, Kachhap S, Bhandari D, Anishkin A, Chintapalli SV. Computational insights on molecular interactions of acifran with GPR109A and GPR109B. J Mol Model. 2022 Jul 28; 28(8):237. PMID: 35900600.
      View in: PubMed
    3. Adepu KK, Bhandari D, Anishkin A, Adams SH, Chintapalli SV. Myoglobin Interaction with Lactate Rapidly Releases Oxygen: Studies on Binding Thermodynamics, Spectroscopy, and Oxygen Kinetics. Int J Mol Sci. 2022 Apr 26; 23(9). PMID: 35563138.
      View in: PubMed
    4. Adepu KK, Kachhap S, Anishkin A, Chintapalli SV. Structural and Energetic Insights Into the Interaction of Niacin With the GPR109A Receptor. Bioinform Biol Insights. 2021; 15:11779322211056122. PMID: 34866904.
      View in: PubMed
    5. Kumar AK*, Sharma S, Dixit G, Shah E, Patel A, Boczkaj G. Techno-economic evaluation of natural deep eutectic solvent based biorefinery in different scenarios. Biofuels Bioproducts Biorefinery. 2020; 14(4):746-763.
    6. Kasturi Dutta, Angana Sarkar, Kumar AK, Achlesh Daverey. Preface to the first International Conference on Bioprocess for Sustainable Environment and Energy (ICBSEE-2018). Biocatalysis and Agricultural Biotechnology. 2020; 23:101465.
    7. Kumar AK*, Shaishav Sharma, Gaurav Dixit, Ekta Shah, Aesha Patel. Techno-economic analysis of microalgae production with simultaneous dairy effluent treatment using a pilot-scale High Volume V-shape pond system. Renewable Energy. 2020; 145:1620-1632.
    8. Shaishav Sharma, Ekta Shah, Deepti Davla, Gaurav Dixit, Aesha Patel, Kumar AK*. Effect of microalga-based diet on oxidative stress enzymes of African catfish, Clarias gariepinus. International Aquatic Research. 2019; 11(4):377-387.
    9. Preeti Sant, Shaishav Sharma, Aesha Patel, Ekta Shah, Gaurav Dixit, Reshma L Patel, Arti Pamnani, Kumar AK*. Microalgae for industrial wastewater treatment and biodiesel production. Recent Scientific Research. 2019.
    10. Kumar AK*, S Sharma, E Shah, BS Parikh, A Patel, G Dixit, S Gupta, JM Divecha. Cultivation of Ascochloris sp. ADW007-enriched microalga in raw dairy wastewater for enhanced biomass and lipid productivity. International Journal of Environmental Science and Technology. 2019; 16(2):943-954.
    11. Kumar AK, Sharma S, Patel A, Dixit G, Shah E. Comprehensive evaluation of microalgal based dairy effluent treatment process for clean water generation and other value added products. Int J Phytoremediation. 2019; 21(6):519-530. PMID: 30666880.
      View in: PubMed
    12. Sharma S, Kumar AK*. Role of Natural Deep Eutectic Solvents (NADES) in the Pretreatment of Lignocellulosic Biomass for an Integrated Biorefinery and Bioprocessing Concept. Recent Advancements in Biofuels and Bioenergy Utilization. 2018; 73-109.
    13. Kumar AK*, Sharma S, Shah E, Patel A,. Technical assessment of natural deep eutectic solvent (NADES) mediated biorefinery process: A case study. Journal of Molecular Liquids. 2018; 260:313-322.
    14. Prakash D, Walters KA, Martinie RJ, McCarver AC, Kumar AK, Lessner DJ, Krebs C, Golbeck JH, Ferry JG. Toward a mechanistic and physiological understanding of a ferredoxin:disulfide reductase from the domains Archaea and Bacteria. J Biol Chem. 2018 06 15; 293(24):9198-9209. PMID: 29720404.
      View in: PubMed
    15. Kumar AK*, Shah E, Patel A, Sharma S, Dixit G . Physico-chemical characterization and evaluation of neat and aqueous mixtures of choline chloride?+?lactic acid for lignocellulosic biomass fractionation, enzymatic hydrolysis and fermentation. Journal of Molecular Liquids. 2018; 271:540-549.
    16. Kumar AK*, Bhumika S Parikh, Michael A Cotta. Application of natural deep eutectic solvents in biomass pretreatment, enzymatic saccharification and cellulosic ethanol production. Materials Today: Proceedings. 2018; 5(11):23057-23063.
    17. Patel H, Kumar AK, Shah A. Purification and characterization of novel bi-functional GH3 family ß-xylosidase/ß-glucosidase from Aspergillus niger ADH-11. Int J Biol Macromol. 2018 Apr 01; 109:1260-1269. PMID: 29174354.
      View in: PubMed
    18. Ekta Shah, Aesha Patel, Shaishav Sharma, Gaurav Dixit, Kumar AK*. Dairy Effluent to Irrigation Water: A Holistic Bioremediation Process Using Microalgal Treatment. International Journal of Research. 2017; 4(13):895-902.
    19. Aesha Patel, Ekta Shah, Shaishav Sharma, Gaurav Dixit, Kumar AK*. Lignocellulosic Agroresidual Waste Materials to Liquid Biofuels – A Green Technology Process. International Journal of Research. 2017; 4(13):824-849.
    20. Kumar AK, Sharma S. Recent updates on different methods of pretreatment of lignocellulosic feedstocks: a review. Bioresour Bioprocess. 2017; 4(1):7. PMID: 28163994.
      View in: PubMed
    21. Kumar AK*, Bhumika S Parikh, Ekta Shah, Lewis Z Liu, Michael A Cotta. Cellulosic ethanol production from green solvent-pretreated rice straw. Biocatalysis and Agricultural Biotechnology. 2016; 7:14-23.
    22. Yenugudhati D, Prakash D, Kumar AK, Kumar RS, Yennawar NH, Yennawar HP, Ferry JG. Structural and Biochemical Characterizations of Methanoredoxin from Methanosarcina acetivorans, a Glutaredoxin-Like Enzyme with Coenzyme M-Dependent Protein Disulfide Reductase Activity. Biochemistry. 2016 Jan 19; 55(2):313-21. PMID: 26684934.
      View in: PubMed
    23. DK Chapla, BS Parikh, ZL Liu, MA Cotta, Kumar AK*. Enhanced cellulosic ethanol production from mild-alkali pretreated rice straw in SSF using Clavispora NRRL Y-50464. Journal of Biobased Materials and Bioenergy. 2015; 9(4):381-388.
    24. Kumar AK*, Bhumika S Parikh, Surendra P Singh, Deval Shah. Use of combined UV and chemical mutagenesis treatment of Aspergillus terreus D34 for hyper-production of cellulose-degrading enzymes and enzymatic hydrolysis of mild-alkali pretreated rice straw. Bioresources and Bioprocessing. 2015; 2(1):1-11.
    25. Kumar AK, Parikh BS, Pravakar M. Natural deep eutectic solvent mediated pretreatment of rice straw: bioanalytical characterization of lignin extract and enzymatic hydrolysis of pretreated biomass residue. Environ Sci Pollut Res Int. 2016 May; 23(10):9265-75. PMID: 26032452.
      View in: PubMed
    26. Kumar AK. UV mutagenesis treatment for improved production of endoglucanase and ß-glucosidase from newly isolated thermotolerant actinomycetes, Streptomyces griseoaurantiacus. Bioresources and Bioprocessing. 2015; 2(1):1-10.
    27. Kumar AK, Kumar RS, Yennawar NH, Yennawar HP, Ferry JG. Structural and Biochemical Characterization of a Ferredoxin:Thioredoxin Reductase-like Enzyme from Methanosarcina acetivorans. Biochemistry. 2015 May 19; 54(19):3122-8. PMID: 25915695.
      View in: PubMed
    28. Kumar AK*, BS Parikh. Cellulose-degrading enzymes from Aspergillus terreus D34 and enzymatic saccharification of mild-alkali and dilute-acid pretreated lignocellulosic biomass residues. Bioresources and Bioprocessing. 2015; 2(7):1-13.
    29. Madhuri Narra, Garima Dixit, Jyoti Divecha, Kumar AK, Datta Madamwar, Amita R Shah. Production, purification and characterization of a novel GH 12 family endoglucanase from Aspergillus terreus and its application in enzymatic degradation of delignified rice straw. International Biodeterioration and Biodegradation. 2014; 88:150-161.
    30. Goswami P, Chinnadayyala SS, Chakraborty M, Kumar AK, Kakoti A. An overview on alcohol oxidases and their potential applications. Appl Microbiol Biotechnol. 2013 May; 97(10):4259-75. PMID: 23525937.
      View in: PubMed
    31. Ankana Kakoti, Kumar AK, Pranab Goswami. Microsome-bound alcohol oxidase catalyzed production of carbonyl compounds from alcohol substrates. Journal of Molecular Catalysis B: Enzymatic. 2012; 78:98-104.
    32. Kumar AK, Yennawar NH, Yennawar HP, Ferry JG. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a novel plant-type ferredoxin/thioredoxin reductase-like protein from Methanosarcina acetivorans. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 01; 67(Pt 7):775-8. PMID: 21795791.
      View in: PubMed
    33. Kumar AK, Vatsyayan P, Goswami P. Production of lipid and fatty acids during growth of Aspergillus terreus on hydrocarbon substrates. Appl Biochem Biotechnol. 2010 Mar; 160(5):1293-300. PMID: 19507060.
      View in: PubMed
    34. Kumar AK. Characteristics and application potential of an alcohol oxidase from the hydrocarbondegrading fungus aspergillus terrrus. 2009.
    35. Kumar AK, Goswami P. Dissociation and reconstitution studies of a broad substrate specific multimeric alcohol oxidase protein produced by Aspergillus terreus. J Biochem. 2009 Feb; 145(2):259-65. PMID: 19060312.
      View in: PubMed
    36. Kumar AK, Goswami P. Purification and properties of a novel broad substrate specific alcohol oxidase from Aspergillus terreus MTCC 6324. Biochim Biophys Acta. 2008 Nov; 1784(11):1552-9. PMID: 18639656.
      View in: PubMed
    37. Vatsyayan P, Kumar AK, Goswami P, Goswami P. Broad substrate Cytochrome P450 monooxygenase activity in the cells of Aspergillus terreus MTCC 6324. Bioresour Technol. 2008 Jan; 99(1):68-75. PMID: 17251009.
      View in: PubMed
    38. Kumar AK, Goswami P. Functional characterization of alcohol oxidases from Aspergillus terreus MTCC 6324. Appl Microbiol Biotechnol. 2006 Oct; 72(5):906-11. PMID: 16547701.
      View in: PubMed
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