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Kiran Kumar Adepu

TitlePost Doctoral Fellow
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPeds Pediatrics, College of Medicine
DivisionPeds Developmental Nutrition
Address1212 Marshall Street
Mail Slot # 512-20B
Little Rock AR 72202
ORCID ORCID Icon0000-0001-6612-1823 Additional info
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    Collapse Overview 
    Collapse overview
    Kiran Kumar has a Ph.D. degree in Biotechnology (specialization in protein chemistry and enzymology) from one of the reputed Institutes in India, Indian Institute of Technology (IIT) Guwahati. He has a vast Postdoctoral Research experience from Pennsylvania State University, Pennsylvania and Brookhaven National Laboratory, New York, NY, USA focusing on different metalloproteins, their biochemical, molecular, biophysical & structure-functions. He worked on several novel proteins and enzymes and their biochemical, structural, and molecular research during doctoral and postdoctoral training. He also worked with different Biotech & Probiotic Industries in the position of Group Leader & Head Research and Development. He was also associated several years with Non-profit Research Organization in different research & administrative positions (Senior Scientist to Head of the Division) leading several research scientists, research groups and technical teams. He worked with a broad range of microbial systems, protein chemistry and structure-function of enzymes for bioenergy and food bioprocessing applications.


    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Head (Research & Development) - Probiotics
    Grasmicrobe Pvt Ltd, India
    2019-2020

    Head - Bioconversion Technology Division
    Sardar Patel Renewable Energy Research Institute, India
    2018-2019

    Principal Scientist - Bioconversion Technology Division
    Sardar Patel Renewable Energy Research Institute, India
    2016-2019

    Senior Scientist - Bioconversion Technology Division
    Sardar Patel Renewable Energy Research Institute, India
    2013-2016

    Group Leader - Enzyme Product Development
    Codon Biosciences Pvt. Ltd, India
    2012-2013

    Collapse education and training
    Indian Institute of Technology Guwahati, IndiaDoctorate05/2009Protein Biochemistry
    Kakatiya University, IndiaMasters06/2003Clinical Biochemistry
    Kakatiya University, IndiaBacherlors04/2000Biology
    Pennsylvania State University, USAPostdoctoral Fellow10/2011Protein Biochemistry
    Brookhaven National Laboratory, USAResearch Associate01/2012Macromolecular Crystallography
    Collapse awards and honors
    2004 - 2009MHRD Fellowship, Indian Institute of Technology Guwahati
    1997 - 2000University Rank Award, Kakatiya University
    2001 - 2003University Gold Medal Award, Kakatiya University

    Collapse Teaching 
    Collapse teaching overview
    Teaching Assistant,
    Indian Institute of Technology Guwahati, India
    2004-2008

    Lecturer
    Swatha Junior College, India
    2000-2001


    Collapse Research 
    Collapse research activities and funding
    GR0371754450     (Sree V Chintapalli)Oct 1, 2021 - Sep 30, 2023
    ACRI/ABI
    Effect of lactate on myoglobin oxygenation and deoxygenation A novel study in understanding energy deficit in failing heart conditions (USD $75,000)
    Role Description: The goal of the study is to explore the novel physiological functions of myoglobin in cellular metabolite transportation. The findings will bring out cellular understandings on acute myocardial ischemia conditions accompanied with lactic acidosis.
    Role: Co-Investigator

    DST/TDT/AGRO-52/2019(C)     (Shahab Fatima)Feb 25, 2020 - Feb 24, 2022
    DST
    Sustainable processing of agroresidual waste to produce acoustic materials and bio-renewable chemicals using green solvents (USD $104,000)
    Role Description: The goal of this study is to design and develop socio-economic sustainability of rice straw biomass into high value chemicals from natural deep eutectic solvent pretreated agro-residues and evaluate the production of acoustic materials towards circular bioeconomy.
    Role: Co-Investigator

    GSBTM/JDR&D/604/2019/303     (Adepu Kiran Kumar)Mar 19, 2019 - Mar 18, 2021
    GSBTM
    Next generation bio-ligin nanoparticle synthesis from lignocellulosic agro-residual waste materials using natural deep eutectic solvents (YSD $53,000)
    Role Description: The goal of this study is to design, develop and characterize the lignin nanoparticles and nanofibrils synthesized from novel green solvents pretreated rice straw biomass and enhance the overall economic viability of processes involved in bioconversion of agro-residual waste materials.
    Role: Principle Investigator

    BT/PR11014/PBD/26/404/2014     (Madhuri Narra)Jul 18, 2017 - Jul 18, 2020
    DBT
    Refinement and demonstration of an integrated process technology for conversion of crop residues into ethanol and methane for use as transport fuels (USD $209,000)
    Role Description: The goal of the study is to optimize the process of second generation biofuels using microbial and enzymatic treatment methods of conversion of agricultural waste biomass residues into value added products and demonstrate the feasibility of the technology for industrial application using comprehensive techno-economic analysis.
    Role: Co-Investigator

    BT/PR8991/PBD/26/392/2013     (Kiran Kumar Adepu)Nov 1, 2016 - Oct 31, 2019
    DBT
    Design and development of pilot scale cultivation and harvesting systems of oleaginous microalgae from west coast of India for biodiesel production (USD $78,000)
    Role Description: The goal of this study is to translation of lab-grown robust high oil-yielding microalga from indoor bench-scale to outdoor pilot-scale mass production in diary industrial effluent in a zero-waste circular economy. Major outcomes of the project were extraction of microalgal oil for renewable fuels, generation of irrigation acceptable water, recycle and reuse of microalgal-treated dairy effluent, and utilization of microalga as aqua-feed supplement.
    Role: Principle Investigator

    BT/PR12368/PBD/26/431/2014     (Kiran Kumar Adepu)Apr 1, 2016 - Jun 30, 2019
    DBT
    Development of a cost-effective green technology for lignocellulosic biomass pretreatment using natural deep eutectic solvents (USD $126,000)
    Role Description: The goal of this study is to design and develop novel green bio-based solvents that are renewable, biodegradable, sustainable and cost-effective and utilize them in the pretreatment processes of agro-residual biomass for production of high-quality cellulose, lignin and xylan derivatives.
    Role: Principle Investigator

    Collapse Outreach 

    Collapse Bibliographic 
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    The links below are provided by the researcher to provide access to external online bibliographies that they keep independently from the Profiles System.
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Kumar AK*, Sharma S, Dixit G, Shah E, Patel A, Boczkaj G. Techno-economic evaluation of natural deep eutectic solvent based biorefinery in different scenarios. Biofuels Bioproducts Biorefinery. 2020; 14(4):746-763.
    2. Kasturi Dutta, Angana Sarkar, Kumar AK, Achlesh Daverey. Preface to the first International Conference on Bioprocess for Sustainable Environment and Energy (ICBSEE-2018). Biocatalysis and Agricultural Biotechnology. 2020; 23:101465.
    3. Kumar AK*, Shaishav Sharma, Gaurav Dixit, Ekta Shah, Aesha Patel. Techno-economic analysis of microalgae production with simultaneous dairy effluent treatment using a pilot-scale High Volume V-shape pond system. Renewable Energy. 2020; 145:1620-1632.
    4. Shaishav Sharma, Ekta Shah, Deepti Davla, Gaurav Dixit, Aesha Patel, Kumar AK*. Effect of microalga-based diet on oxidative stress enzymes of African catfish, Clarias gariepinus. International Aquatic Research. 2019; 11(4):377-387.
    5. Preeti Sant, Shaishav Sharma, Aesha Patel, Ekta Shah, Gaurav Dixit, Reshma L Patel, Arti Pamnani, Kumar AK*. Microalgae for industrial wastewater treatment and biodiesel production. Recent Scientific Research. 2019.
    6. Kumar AK*, S Sharma, E Shah, BS Parikh, A Patel, G Dixit, S Gupta, JM Divecha. Cultivation of Ascochloris sp. ADW007-enriched microalga in raw dairy wastewater for enhanced biomass and lipid productivity. International Journal of Environmental Science and Technology. 2019; 16(2):943-954.
    7. Kumar AK, Sharma S, Patel A, Dixit G, Shah E. Comprehensive evaluation of microalgal based dairy effluent treatment process for clean water generation and other value added products. Int J Phytoremediation. 2019; 21(6):519-530. PMID: 30666880.
      View in: PubMed
    8. Sharma S, Kumar AK*. Role of Natural Deep Eutectic Solvents (NADES) in the Pretreatment of Lignocellulosic Biomass for an Integrated Biorefinery and Bioprocessing Concept. Recent Advancements in Biofuels and Bioenergy Utilization. 2018; 73-109.
    9. Kumar AK*, Sharma S, Shah E, Patel A,. Technical assessment of natural deep eutectic solvent (NADES) mediated biorefinery process: A case study. Journal of Molecular Liquids. 2018; 260:313-322.
    10. Prakash D, Walters KA, Martinie RJ, McCarver AC, Kumar AK, Lessner DJ, Krebs C, Golbeck JH, Ferry JG. Toward a mechanistic and physiological understanding of a ferredoxin:disulfide reductase from the domains Archaea and Bacteria. J Biol Chem. 2018 06 15; 293(24):9198-9209. PMID: 29720404.
      View in: PubMed
    11. Kumar AK*, Shah E, Patel A, Sharma S, Dixit G . Physico-chemical characterization and evaluation of neat and aqueous mixtures of choline chloride?+?lactic acid for lignocellulosic biomass fractionation, enzymatic hydrolysis and fermentation. Journal of Molecular Liquids. 2018; 271:540-549.
    12. Kumar AK*, Bhumika S Parikh, Michael A Cotta. Application of natural deep eutectic solvents in biomass pretreatment, enzymatic saccharification and cellulosic ethanol production. Materials Today: Proceedings. 2018; 5(11):23057-23063.
    13. Patel H, Kumar AK, Shah A. Purification and characterization of novel bi-functional GH3 family ß-xylosidase/ß-glucosidase from Aspergillus niger ADH-11. Int J Biol Macromol. 2018 Apr 01; 109:1260-1269. PMID: 29174354.
      View in: PubMed
    14. Ekta Shah, Aesha Patel, Shaishav Sharma, Gaurav Dixit, Kumar AK*. Dairy Effluent to Irrigation Water: A Holistic Bioremediation Process Using Microalgal Treatment. International Journal of Research. 2017; 4(13):895-902.
    15. Aesha Patel, Ekta Shah, Shaishav Sharma, Gaurav Dixit, Kumar AK*. Lignocellulosic Agroresidual Waste Materials to Liquid Biofuels – A Green Technology Process. International Journal of Research. 2017; 4(13):824-849.
    16. Kumar AK, Sharma S. Recent updates on different methods of pretreatment of lignocellulosic feedstocks: a review. Bioresour Bioprocess. 2017; 4(1):7. PMID: 28163994.
      View in: PubMed
    17. Kumar AK*, Bhumika S Parikh, Ekta Shah, Lewis Z Liu, Michael A Cotta. Cellulosic ethanol production from green solvent-pretreated rice straw. Biocatalysis and Agricultural Biotechnology. 2016; 7:14-23.
    18. Yenugudhati D, Prakash D, Kumar AK, Kumar RS, Yennawar NH, Yennawar HP, Ferry JG. Structural and Biochemical Characterizations of Methanoredoxin from Methanosarcina acetivorans, a Glutaredoxin-Like Enzyme with Coenzyme M-Dependent Protein Disulfide Reductase Activity. Biochemistry. 2016 Jan 19; 55(2):313-21. PMID: 26684934.
      View in: PubMed
    19. DK Chapla, BS Parikh, ZL Liu, MA Cotta, Kumar AK*. Enhanced cellulosic ethanol production from mild-alkali pretreated rice straw in SSF using Clavispora NRRL Y-50464. Journal of Biobased Materials and Bioenergy. 2015; 9(4):381-388.
    20. Kumar AK*, Bhumika S Parikh, Surendra P Singh, Deval Shah. Use of combined UV and chemical mutagenesis treatment of Aspergillus terreus D34 for hyper-production of cellulose-degrading enzymes and enzymatic hydrolysis of mild-alkali pretreated rice straw. Bioresources and Bioprocessing. 2015; 2(1):1-11.
    21. Kumar AK, Parikh BS, Pravakar M. Natural deep eutectic solvent mediated pretreatment of rice straw: bioanalytical characterization of lignin extract and enzymatic hydrolysis of pretreated biomass residue. Environ Sci Pollut Res Int. 2016 May; 23(10):9265-75. PMID: 26032452.
      View in: PubMed
    22. Kumar AK. UV mutagenesis treatment for improved production of endoglucanase and ß-glucosidase from newly isolated thermotolerant actinomycetes, Streptomyces griseoaurantiacus. Bioresources and Bioprocessing. 2015; 2(1):1-10.
    23. Kumar AK, Kumar RS, Yennawar NH, Yennawar HP, Ferry JG. Structural and Biochemical Characterization of a Ferredoxin:Thioredoxin Reductase-like Enzyme from Methanosarcina acetivorans. Biochemistry. 2015 May 19; 54(19):3122-8. PMID: 25915695.
      View in: PubMed
    24. Kumar AK*, BS Parikh. Cellulose-degrading enzymes from Aspergillus terreus D34 and enzymatic saccharification of mild-alkali and dilute-acid pretreated lignocellulosic biomass residues. Bioresources and Bioprocessing. 2015; 2(7):1-13.
    25. Madhuri Narra, Garima Dixit, Jyoti Divecha, Kumar AK, Datta Madamwar, Amita R Shah. Production, purification and characterization of a novel GH 12 family endoglucanase from Aspergillus terreus and its application in enzymatic degradation of delignified rice straw. International Biodeterioration and Biodegradation. 2014; 88:150-161.
    26. Goswami P, Chinnadayyala SS, Chakraborty M, Kumar AK, Kakoti A. An overview on alcohol oxidases and their potential applications. Appl Microbiol Biotechnol. 2013 May; 97(10):4259-75. PMID: 23525937.
      View in: PubMed
    27. Ankana Kakoti, Kumar AK, Pranab Goswami. Microsome-bound alcohol oxidase catalyzed production of carbonyl compounds from alcohol substrates. Journal of Molecular Catalysis B: Enzymatic. 2012; 78:98-104.
    28. Kumar AK, Yennawar NH, Yennawar HP, Ferry JG. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a novel plant-type ferredoxin/thioredoxin reductase-like protein from Methanosarcina acetivorans. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 01; 67(Pt 7):775-8. PMID: 21795791.
      View in: PubMed
    29. Kumar AK, Vatsyayan P, Goswami P. Production of lipid and fatty acids during growth of Aspergillus terreus on hydrocarbon substrates. Appl Biochem Biotechnol. 2010 Mar; 160(5):1293-300. PMID: 19507060.
      View in: PubMed
    30. Kumar AK. Characteristics and application potential of an alcohol oxidase from the hydrocarbondegrading fungus aspergillus terrrus. 2009.
    31. Kumar AK, Goswami P. Dissociation and reconstitution studies of a broad substrate specific multimeric alcohol oxidase protein produced by Aspergillus terreus. J Biochem. 2009 Feb; 145(2):259-65. PMID: 19060312.
      View in: PubMed
    32. Kumar AK, Goswami P. Purification and properties of a novel broad substrate specific alcohol oxidase from Aspergillus terreus MTCC 6324. Biochim Biophys Acta. 2008 Nov; 1784(11):1552-9. PMID: 18639656.
      View in: PubMed
    33. Vatsyayan P, Kumar AK, Goswami P, Goswami P. Broad substrate Cytochrome P450 monooxygenase activity in the cells of Aspergillus terreus MTCC 6324. Bioresour Technol. 2008 Jan; 99(1):68-75. PMID: 17251009.
      View in: PubMed
    34. Kumar AK, Goswami P. Functional characterization of alcohol oxidases from Aspergillus terreus MTCC 6324. Appl Microbiol Biotechnol. 2006 Oct; 72(5):906-11. PMID: 16547701.
      View in: PubMed
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