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Narasimhan Rajaram

TitleAssociate Professor - Engineering
Institution@uark.edu
DepartmentBMEG | Biomedical Engineering
Address1 University of Arkansas
Fayetteville AR 72701
Phone+1 (479) 5757282
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Mordi A, Karunakaran V, Marium Mim U, Marple E, Rajaram N. Design and Validation of a Multimodal Diffuse Reflectance and Spatially Offset Raman Spectroscopy System for In?Vivo Applications. J Biophotonics. 2025 Mar; 18(3):e202400333. PMID: 39721981.
      View in: PubMed
    2. Karunakaran V, Dadgar S, Paidi SK, Mordi AF, Lowe WA, Mim UM, Ivers JD, Rodriguez Troncoso JI, McPeake JA, Fernandes A, Tripathi SD, Barman I, Rajaram N. Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy. ACS Omega. 2024 Oct 22; 9(42):43025-43033. PMID: 39464461.
      View in: PubMed
    3. Drewke EE, Brand RL, Geels CG, Jensen HK, Wong K, Sanders JD, Rajaram N. Noncontact Diffuse Reflectance Spectroscopy of Synovial Fluid Samples for Rapid Identification of Infections. J Biophotonics. 2024 Nov; 17(11):e202400213. PMID: 39233380.
      View in: PubMed
    4. Ivers JD, Puvvada N, Quick CM, Rajaram N. Investigating the relationship between hypoxia, hypoxia-inducible factor 1, and the optical redox ratio in response to radiation therapy. Biophotonics Discov. 2024 Apr; 1(1). PMID: 40109884.
      View in: PubMed
    5. Jenkins SV, Shah S, Jamshidi-Parsian A, Mortazavi A, Kristian H, Boysen G, Vang KB, Griffin RJ, Rajaram N, Dings RPM. Acquired Radiation Resistance Induces Thiol-dependent Cisplatin Cross-resistance. Radiat Res. 2024 02 01; 201(2):174-187. PMID: 38329819.
      View in: PubMed
    6. Sharma M, Brown AW, Powell NM, Rajaram N, Tong L, Mourani PM, Schootman M. Racial and skin color mediated disparities in pulse oximetry in infants and young children. Paediatr Respir Rev. 2024 Jun; 50:62-72. PMID: 38233229.
      View in: PubMed
    7. Rodriguez Troncoso J, Marium Mim U, Ivers JD, Paidi SK, Harper MG, Nguyen KG, Ravindranathan S, Rebello L, Lee DE, Zaharoff DA, Barman I, Rajaram N. Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy. Biomed Opt Express. 2023 Dec 01; 14(12):6114-6126. PMID: 38420330.
      View in: PubMed
    8. Jules A, Means D, Troncoso JR, Fernandes A, Dadgar S, Siegel ER, Rajaram N. Diffuse Reflectance Spectroscopy of Changes in Tumor Microenvironment in Response to Different Doses of Radiation. Radiat Res. 2022 12 01; 198(6):545-552. PMID: 36240754.
      View in: PubMed
    9. Paidi SK, Troncoso JR, Harper MG, Liu Z, Nguyen KG, Ravindranathan S, Rebello L, Lee DE, Ivers JD, Zaharoff DA, Rajaram N, Barman I. Raman spectroscopy reveals phenotype switches in breast cancer metastasis. Theranostics. 2022; 12(12):5351-5363. PMID: 35910801.
      View in: PubMed
    10. Bess SN, Greening GJ, Rajaram N, Muldoon TJ. Macrophage-targeted anti-CCL2 immunotherapy enhances tumor sensitivity to 5-fluorouracil in a Balb/c-CT26 murine colon carcinoma model measured using diffuse reflectance spectroscopy. BMC Immunol. 2022 04 23; 23(1):20. PMID: 35461243.
      View in: PubMed
    11. Paidi SK, Rodriguez Troncoso J, Raj P, Monterroso Diaz P, Ivers JD, Lee DE, Avaritt NL, Gies AJ, Quick CM, Byrum SD, Tackett AJ, Rajaram N, Barman I. Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy. Cancer Res. 2021 11 15; 81(22):5745-5755. PMID: 34645610.
      View in: PubMed
    12. Troncoso JR, Diaz PM, Lee DE, Quick CM, Rajaram N. Longitudinal monitoring of tumor response to immune checkpoint inhibitors using noninvasive diffuse reflectance spectroscopy. Biomed Opt Express. 2021 Jul 01; 12(7):3982-3991. PMID: 34457393.
      View in: PubMed
    13. Vohra N, Chavez T, Troncoso JR, Rajaram N, Wu J, Coan PN, Jackson TA, Bailey K, El-Shenawee M. Mammary tumors in Sprague Dawley rats induced by N-ethyl-N-nitrosourea for evaluating terahertz imaging of breast cancer. J Med Imaging (Bellingham). 2021 Mar; 8(2):023504. PMID: 33928181.
      View in: PubMed
    14. Dadgar S, Greene E, Dhamad A, Mallmann B, Dridi S, Rajaram N. Diffuse reflectance spectroscopy reveals heat stress-induced changes in hemoglobin concentration in chicken breast. Sci Rep. 2021 02 11; 11(1):3649. PMID: 33574480.
      View in: PubMed
    15. Dadgar S, Troncoso JR, Siegel ER, Curry NM, Griffin RJ, Dings RPM, Rajaram N. Spectroscopic investigation of radiation-induced reoxygenation in radiation-resistant tumors. Neoplasia. 2021 01; 23(1):49-57. PMID: 33220616.
      View in: PubMed
    16. Lee DE, Brown JL, Rosa-Caldwell ME, Perry RA, Brown LA, Haynie WS, Washington TA, Wiggs MP, Rajaram N, Greene NP. Cancer-induced Cardiac Atrophy Adversely Affects Myocardial Redox State and Mitochondrial Oxidative Characteristics. JCSM Rapid Commun. 2021 Jan-Jun; 4(1):3-15. PMID: 33693448.
      View in: PubMed
    17. Mundo AI, Greening GJ, Fahr MJ, Hale LN, Bullard EA, Rajaram N, Muldoon TJ. Diffuse reflectance spectroscopy to monitor murine colorectal tumor progression and therapeutic response (Erratum). J Biomed Opt. 2020 04; 25(4):1. PMID: 32323510.
      View in: PubMed
    18. Mundo AI, Greening GJ, Fahr MJ, Hale LN, Bullard EA, Rajaram N, Muldoon TJ. Diffuse reflectance spectroscopy to monitor murine colorectal tumor progression and therapeutic response. J Biomed Opt. 2020 03; 25(3):1-16. PMID: 32141266.
      View in: PubMed
    19. Dadgar S, Rajaram N. Optical Imaging Approaches to Investigating Radiation Resistance. Front Oncol. 2019; 9:1152. PMID: 31750246.
      View in: PubMed
    20. Greene E, Flees J, Dadgar S, Mallmann B, Orlowski S, Dhamad A, Rochell S, Kidd M, Laurendon C, Whitfield H, Brearley C, Rajaram N, Walk C, Dridi S. Quantum Blue Reduces the Severity of Woody Breast Myopathy via Modulation of Oxygen Homeostasis-Related Genes in Broiler Chickens. Front Physiol. 2019; 10:1251. PMID: 31632293.
      View in: PubMed
    21. Lee DE, Perry RA, Brown JL, Rosa-Caldwell ME, Brown LA, Haynie WS, Rajaram N, Washington TA, Greene NP. Mitochondrial mRNA translation initiation contributes to oxidative metabolism in the myocardia of aged, obese mice. Exp Gerontol. 2019 07 01; 121:62-70. PMID: 30928679.
      View in: PubMed
    22. Paidi SK, Diaz PM, Dadgar S, Jenkins SV, Quick CM, Griffin RJ, Dings RPM, Rajaram N, Barman I. Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment. Cancer Res. 2019 04 15; 79(8):2054-2064. PMID: 30819665.
      View in: PubMed
    23. Vohra N, Bowman T, Diaz PM, Rajaram N, Bailey K, El-Shenawee M. Pulsed Terahertz Reflection Imaging of tumors in a spontaneous model of breast cancer. Biomed Phys Eng Express. 2018 Nov; 4(6). PMID: 31275612.
      View in: PubMed
    24. Ravindranathan S, Nguyen KG, Kurtz SL, Frazier HN, Smith SG, Koppolu BP, Rajaram N, Zaharoff DA. Tumor-derived granulocyte colony-stimulating factor diminishes efficacy of breast tumor cell vaccines. Breast Cancer Res. 2018 10 22; 20(1):126. PMID: 30348199.
      View in: PubMed
    25. Vargas I, Alhallak K, Kolenc OI, Jenkins SV, Griffin RJ, Dings RPM, Rajaram N, Quinn KP. Rapid quantification of mitochondrial fractal dimension in individual cells. Biomed Opt Express. 2018 Nov 01; 9(11):5269-5279. PMID: 30460127.
      View in: PubMed
    26. Greening G, Mundo A, Rajaram N, Muldoon TJ. Sampling depth of a diffuse reflectance spectroscopy probe for in-vivo physiological quantification of murine subcutaneous tumor allografts. J Biomed Opt. 2018 08; 23(8):1-14. PMID: 30152204.
      View in: PubMed
    27. Diaz PM, Jenkins SV, Alhallak K, Semeniak D, Griffin RJ, Dings RPM, Rajaram N. Quantitative diffuse reflectance spectroscopy of short-term changes in tumor oxygenation after radiation in a matched model of radiation resistance. Biomed Opt Express. 2018 Aug 01; 9(8):3794-3804. PMID: 30338156.
      View in: PubMed
    28. Lee DE, Alhallak K, Jenkins SV, Vargas I, Greene NP, Quinn KP, Griffin RJ, Dings RPM, Rajaram N. A Radiosensitizing Inhibitor of HIF-1 alters the Optical Redox State of Human Lung Cancer Cells In Vitro. Sci Rep. 2018 06 11; 8(1):8815. PMID: 29891977.
      View in: PubMed
    29. Dadgar S, Troncoso JR, Rajaram N. Optical spectroscopic sensing of tumor hypoxia. J Biomed Opt. 2018 06; 23(6):1-6. PMID: 29873205.
      View in: PubMed
    30. Martinez AF, McCachren SS, Lee M, Murphy HA, Zhu C, Crouch BT, Martin HL, Erkanli A, Rajaram N, Ashcraft KA, Fontanella AN, Dewhirst MW, Ramanujam N. Metaboloptics: Visualization of the tumor functional landscape via metabolic and vascular imaging. Sci Rep. 2018 03 08; 8(1):4171. PMID: 29520098.
      View in: PubMed
    31. Bowman T, Chavez T, Khan K, Wu J, Chakraborty A, Rajaram N, Bailey K, El-Shenawee M. Pulsed terahertz imaging of breast cancer in freshly excised murine tumors. J Biomed Opt. 2018 02; 23(2):1-13. PMID: 29446263.
      View in: PubMed
    32. Alhallak K, Jenkins SV, Lee DE, Greene NP, Quinn KP, Griffin RJ, Dings RPM, Rajaram N. Optical imaging of radiation-induced metabolic changes in radiation-sensitive and resistant cancer cells. J Biomed Opt. 2017 06 01; 22(6):60502. PMID: 28622395.
      View in: PubMed
    33. Greening GJ, Rajaram N, Muldoon TJ. Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis. J Vis Exp. 2016 10 17; (116). PMID: 27805585.
      View in: PubMed
    34. Lam NT, Muldoon TJ, Quinn KP, Rajaram N, Balachandran K. Valve interstitial cell contractile strength and metabolic state are dependent on its shape. Integr Biol (Camb). 2016 10 10; 8(10):1079-1089. PMID: 27713997.
      View in: PubMed
    35. Alhallak K, Rebello LG, Muldoon TJ, Quinn KP, Rajaram N. Optical redox ratio identifies metastatic potential-dependent changes in breast cancer cell metabolism. Biomed Opt Express. 2016 Nov 01; 7(11):4364-4374. PMID: 27895979.
      View in: PubMed
    36. Greening GJ, James HM, Dierks MK, Vongkittiargorn N, Osterholm SM, Rajaram N, Muldoon TJ. Towards monitoring dysplastic progression in the oral cavity using a hybrid fiber-bundle imaging and spectroscopy probe. Sci Rep. 2016 05 25; 6:26734. PMID: 27220821.
      View in: PubMed
    37. Greening GJ, Rajaram N, Muldoon TJ. In vivo measurement of non-keratinized squamous epithelium using a spectroscopic microendoscope with multiple source-detector separations. Proc SPIE Int Soc Opt Eng. 2016 Feb 13; 9715. PMID: 27134337.
      View in: PubMed
    38. Greening GJ, James HM, Powless AJ, Hutcheson JA, Dierks MK, Rajaram N, Muldoon TJ. Fiber-bundle microendoscopy with sub-diffuse reflectance spectroscopy and intensity mapping for multimodal optical biopsy of stratified epithelium. Biomed Opt Express. 2015 Dec 01; 6(12):4934-50. PMID: 26713207.
      View in: PubMed
    39. Holdaway J, Levitt P, Fang J, Rajaram N. Mobility and health sector development in China and India. Soc Sci Med. 2015 Apr; 130:268-76. PMID: 25734612.
      View in: PubMed
    40. Rajaram N, Reesor AF, Mulvey CS, Frees AE, Ramanujam N. Non-invasive, simultaneous quantification of vascular oxygenation and glucose uptake in tissue. PLoS One. 2015; 10(1):e0117132. PMID: 25635865.
      View in: PubMed
    41. Frees AE, Rajaram N, McCachren SS, Fontanella AN, Dewhirst MW, Ramanujam N. Delivery-corrected imaging of fluorescently-labeled glucose reveals distinct metabolic phenotypes in murine breast cancer. PLoS One. 2014; 9(12):e115529. PMID: 25526261.
      View in: PubMed
    42. Lim L, Nichols B, Migden MR, Rajaram N, Reichenberg JS, Markey MK, Ross MI, Tunnell JW. Clinical study of noninvasive in vivo melanoma and nonmelanoma skin cancers using multimodal spectral diagnosis. J Biomed Opt. 2014; 19(11):117003. PMID: 25375350.
      View in: PubMed
    43. Fontanella AN, Schroeder T, Hochman DW, Chen RE, Hanna G, Haglund MM, Rajaram N, Frees AE, Secomb TW, Palmer GM, Dewhirst MW. Quantitative mapping of hemodynamics in the lung, brain, and dorsal window chamber-grown tumors using a novel, automated algorithm. Microcirculation. 2013 Nov; 20(8):724-35. PMID: 23781901.
      View in: PubMed
    44. Rajaram N, Frees AE, Fontanella AN, Zhong J, Hansen K, Dewhirst MW, Ramanujam N. Delivery rate affects uptake of a fluorescent glucose analog in murine metastatic breast cancer. PLoS One. 2013; 8(10):e76524. PMID: 24204635.
      View in: PubMed
    45. Barrott JJ, Hughes PF, Osada T, Yang XY, Hartman ZC, Loiselle DR, Spector NL, Neckers L, Rajaram N, Hu F, Ramanujam N, Vaidyanathan G, Zalutsky MR, Lyerly HK, Haystead TA. Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells. Chem Biol. 2013 Sep 19; 20(9):1187-97. PMID: 24035283.
      View in: PubMed
    46. Zhong J, Rajaram N, Brizel DM, Frees AE, Ramanujam N, Batinic-Haberle I, Dewhirst MW. Radiation induces aerobic glycolysis through reactive oxygen species. Radiother Oncol. 2013 Mar; 106(3):390-6. PMID: 23541363.
      View in: PubMed
    47. Yu B, Shah A, Wang B, Rajaram N, Wang Q, Ramanujam N, Palmer GM, Dewhirst MW. Measuring tumor cycling hypoxia and angiogenesis using a side-firing fiber optic probe. J Biophotonics. 2014 Jul; 7(7):552-64. PMID: 23242854.
      View in: PubMed
    48. Liu C, Rajaram N, Vishwanath K, Jiang T, Palmer GM, Ramanujam N. Experimental validation of an inverse fluorescence Monte Carlo model to extract concentrations of metabolically relevant fluorophores from turbid phantoms and a murine tumor model. J Biomed Opt. 2012 Jul; 17(7):077012. PMID: 22894524.
      View in: PubMed
    49. Nichols BS, Rajaram N, Tunnell JW. Performance of a lookup table-based approach for measuring tissue optical properties with diffuse optical spectroscopy. J Biomed Opt. 2012 May; 17(5):057001. PMID: 22612140.
      View in: PubMed
    50. Bish SF, Rajaram N, Nichols B, Tunnell JW. Development of a noncontact diffuse optical spectroscopy probe for measuring tissue optical properties. J Biomed Opt. 2011 Dec; 16(12):120505. PMID: 22191909.
      View in: PubMed
    51. Zaman RT, Rajaram N, Nichols BS, Rylander HG, Wang T, Tunnell JW, Welch AJ. Changes in morphology and optical properties of sclera and choroidal layers due to hyperosmotic agent. J Biomed Opt. 2011 Jul; 16(7):077008. PMID: 21806288.
      View in: PubMed
    52. Barman I, Dingari NC, Rajaram N, Tunnell JW, Dasari RR, Feld MS. Rapid and accurate determination of tissue optical properties using least-squares support vector machines. Biomed Opt Express. 2011 Feb 15; 2(3):592-9. PMID: 21412464.
      View in: PubMed
    53. Zaman RT, Rajaram N, Walsh A, Oliver J, Rylander HG, Tunnell JW, Welch AJ, Mahadevan-Jansen A. Variation of fluorescence in tissue with temperature. Lasers Surg Med. 2011 Jan; 43(1):36-42. PMID: 21254141.
      View in: PubMed
    54. Lim L, Nichols B, Rajaram N, Tunnell JW. Probe pressure effects on human skin diffuse reflectance and fluorescence spectroscopy measurements. J Biomed Opt. 2011 Jan-Feb; 16(1):011012. PMID: 21280899.
      View in: PubMed
    55. Rajaram N, Reichenberg JS, Migden MR, Nguyen TH, Tunnell JW. Pilot clinical study for quantitative spectral diagnosis of non-melanoma skin cancer. Lasers Surg Med. 2010 Dec; 42(10):716-27. PMID: 21246575.
      View in: PubMed
    56. Rajaram N, Gopal A, Zhang X, Tunnell JW. Experimental validation of the effects of microvasculature pigment packaging on in vivo diffuse reflectance spectroscopy. Lasers Surg Med. 2010 Sep; 42(7):680-8. PMID: 20740619.
      View in: PubMed
    57. Rajaram N, Aramil TJ, Lee K, Reichenberg JS, Nguyen TH, Tunnell JW. Design and validation of a clinical instrument for spectral diagnosis of cutaneous malignancy. Appl Opt. 2010 Jan 10; 49(2):142-52. PMID: 20062500.
      View in: PubMed
    58. Rajaram N, Nguyen TH, Tunnell JW. Lookup table-based inverse model for determining optical properties of turbid media. J Biomed Opt. 2008 Sep-Oct; 13(5):050501. PMID: 19021373.
      View in: PubMed
    59. Zaman RT, Diagaradjane P, Wang JC, Schwartz J, Rajaram N, Gill-Sharp KL, Cho SH, Rylander HG, Payne JD, Krishnan S, Tunnell JW. In Vivo Detection of Gold Nanoshells in Tumors Using Diffuse Optical Spectroscopy. IEEE J Sel Top Quantum Electron. 2007 Nov-Dec; 13(6):1715-1720. PMID: 33859459.
      View in: PubMed
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