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Jesus Delgado-Calle

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPhysiology & Cell Biology, College of Medicine
Address325 S. Elm St.
Mail Slot # 505
Little Rock AR 72205
ORCID ORCID Icon0000-0002-2083-2774 Additional info
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    Other Roles
    Director, Bone Imaging Core, Center for Musculoskeletal Disease Research

    Collapse Overview 

    Collapse Teaching 

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    Collapse research activities and funding
    P20GM125503     (OBRIEN, CHARLES A)Apr 1, 2023 - Jan 31, 2028
    NIH/Nat. Inst. of General Medical Sciences
    Center for Musculoskeletal Disease Research (CMDR)
    Role: Co-Investigator
    Seeds of Sciences     (Jesus Delgado-Calle)Mar 1, 2023 - Feb 29, 2024
    UAMS Cancer Institute
    haracterization of the Senescent Secretome of the Bone Metastatic Tumor Niche
    Role: Principle Investigator
         (Jesus Delgado-Calle)Nov 15, 2022 - Nov 14, 2023
    UAMS Musculoskeletal Hub)
    Role of Extrachromosomal DNA in Bone
    Role: Principle Investigator
    R01AR080116     (G. David Roodman)Apr 1, 2022 - Mar 31, 2027
    NIH/NIAMS
    Osteoclast-Osteocyte Interaction's in Paget's Disease.
    Role: Co-Investigator
    R01 CA241677     (DELGADO-CALLE, JESUS)Mar 1, 2022 - Feb 28, 2028
    NIH/National Institutes of Health - Pass Through: Indiana University
    Osteoclast-Osteocyte Interaction's in Paget's Disease- Sub with Indiana University
    Role: Principal Investigator
    R01 CA241677-03     (DELGADO-CALLE, JESUS)Mar 1, 2022 - Feb 28, 2028
    NIH/National Institutes of Health - Pass Through: Indiana University
    Osteoclast-Osteocyte Interaction's in Paget's Disease- Sub with Indiana University
    Role: Principal Investigator
    R01AR080116     (DELGADO-CALLE, JESUS)Feb 22, 2022 - Dec 31, 2026
    NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases - Pass Through: Indiana University
    Osteoclast-Osteocyte Interaction's in Paget's Disease- Sub with Indiana University
    Role: Principal Investigator
         (Jesus Delgado-Calle)Sep 1, 2021 - Aug 31, 2023
    Arkansas Breast Cancer Research Program
    Pathological Cross-talk Between Senescent Osteocytes and Breast Cancer Cells in Bone Metastasis.
    Role: Principle Investigator
    R37CA251763     (DELGADO-CALLE, JESUS)Sep 1, 2020 - May 31, 2025
    NIH
    Bone-Targeted Therapies to Improve Bone Health and Prevent Relapse in Multiple Myeloma
    Role: Principal Investigator
    R37CA251763     (DELGADO-CALLE, JESUS)Sep 1, 2020 - May 31, 2025
    NIH/Nat. Cancer Institute
    Bone-Targeted Therapies to Improve Bone Health and Prevent Relapse in Multiple Myeloma
    Role: Principal Investigator
    R01CA241677     (DELGADO-CALLE, JESUS)Jul 1, 2020 - Feb 28, 2025
    NIH/Nat. Cancer Institute - Pass Through: Indiana University
    Manipulating the N-end Rule Protein Degradation Pathway to Build Bone and Decrease Tumor Growth in Multiple Myeloma Bone Disease
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Sabol HM, Ashby C, Adhikari M, Anloague A, Kaur J, Khan S, Choudhury SR, Schinke C, Palmieri M, Barnes CL, Ambrogini E, Nookaew I, Delgado-Calle J. A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma. Haematologica. 2024 08 01; 109(8):2606-2618. PMID: 38385272.
      View in: PubMed
    2. Marino S, Petrusca DN, Bishop RT, Anderson JL, Sabol HM, Ashby C, Layer JH, Cesarano A, Dav? UP, Perna F, Delgado-Calle J, Chirgwin JM, Roodman GD. Pharmacologic targeting of the p62 ZZ domain enhances both anti-tumor and bone-anabolic effects of bortezomib in multiple myeloma. Haematologica. 2024 05 01; 109(5):1501-1513. PMID: 37981834.
      View in: PubMed
    3. Adhikari M, Kaur J, Sabol HM, Anloague A, Khan S, Kurihara N, Diaz-delCastillo M, Andreasen CM, Barnes CL, Stambough JB, Palmieri M, Reyes-Castro O, Ambrogini E, Almeida M, O'Brien CA, Nookaw I, Delgado-Calle J. Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis. Res Sq. 2024 Mar 14. PMID: 38558984.
      View in: PubMed
    4. Tenshin H, Delgado-Calle J, Windle JJ, Roodman GD, Chirgwin JM, Kurihara N. Osteocytes and Paget's Disease of Bone. Curr Osteoporos Rep. 2024 04; 22(2):266-272. PMID: 38457001.
      View in: PubMed
    5. Garc?a-S?nchez D, Gonz?lez-Gonz?lez A, ?lvarez-Iglesias I, Dujo-Guti?rrez MD, Bolado-Carrancio A, Certo M, P?rez-N??ez MI, Riancho JA, Rodr?guez-Rey JC, Delgado-Calle J, P?rez-Campo FM. Engineering a Pro-Osteogenic Secretome through the Transient Silencing of the Gene Encoding Secreted Frizzled Related Protein 1. Int J Mol Sci. 2023 Aug 03; 24(15). PMID: 37569774.
      View in: PubMed
    6. Miyagawa K, Tenshin H, Mulcrone PL, Delgado-Calle J, Subler MA, Windle JJ, Chirgwin JM, Roodman GD, Kurihara N. Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to pagetic lesion formation. JCI Insight. 2023 07 24; 8(14). PMID: 37338990.
      View in: PubMed
    7. Delgado-Calle J, Roodman GD. Doubling Down on Wnt Signaling to Overcome Myeloma Bone Disease. J Bone Miner Res. 2023 06; 38(6):812-813. PMID: 37277117.
      View in: PubMed
    8. Anloague A, Delgado-Calle J. Osteocytes: New Kids on the Block for Cancer in Bone Therapy. Cancers (Basel). 2023 May 07; 15(9). PMID: 37174109.
      View in: PubMed
    9. Schinke C, Weinhold N, Delgado-Calle J. Editorial: The role of the bone marrow microenvironment in multiple myeloma evolution and therapy. Front Oncol. 2023; 13:1157555. PMID: 36895479.
      View in: PubMed
    10. Wanchai V, Jenjaroenpun P, Leangapichart T, Arrey G, Burnham CM, T?mmler MC, Delgado-Calle J, Regenberg B, Nookaew I. CReSIL: accurate identification of extrachromosomal circular DNA from long-read sequences. Brief Bioinform. 2022 11 19; 23(6). PMID: 36198068.
      View in: PubMed
    11. Sabol HM, Amorim T, Ashby C, Halladay D, Anderson J, Cregor M, Sweet M, Nookaew I, Kurihara N, Roodman GD, Bellido T, Delgado-Calle J. Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction. Neoplasia. 2022 06; 28:100785. PMID: 35390742.
      View in: PubMed
    12. Delgado-Calle J, McAndrews K, Wu G, Orr AL, Ferrari A, Tu X, Srinivasan V, Roodman GD, Ebetino FH, Boeckman RK, Bellido T. The Notch pathway regulates the bone gain induced by PTH anabolic signaling. FASEB J. 2022 03; 36(3):e22196. PMID: 35137455.
      View in: PubMed
    13. Chen J, Cuevas PL, Dworan JS, Dawid I, Turkkahraman H, Tran K, Delgado-Calle J, Bellido T, Gorski JP, Liu B, Brunski JB, Helms JA. Wnt/?-catenin Signaling Controls Maxillofacial Hyperostosis. J Dent Res. 2022 07; 101(7):793-801. PMID: 35114849.
      View in: PubMed
    14. Sabol HM, Ferrari AJ, Adhikari M, Amorim T, McAndrews K, Anderson J, Vigolo M, Lehal R, Cregor M, Khan S, Cuevas PL, Helms JA, Kurihara N, Srinivasan V, Ebetino FH, Boeckman RK, Roodman GD, Bellido T, Delgado-Calle J. Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity. Cancer Res. 2021 10 01; 81(19):5102-5114. PMID: 34348968.
      View in: PubMed
    15. Delgado-Calle J, Bellido T. The osteocyte as a signaling cell. Physiol Rev. 2022 01 01; 102(1):379-410. PMID: 34337974.
      View in: PubMed
    16. Sabol HM, Delgado-Calle J. The multifunctional role of Notch signaling in multiple myeloma. J Cancer Metastasis Treat. 2021; 7. PMID: 34778567.
      View in: PubMed
    17. Adhikari M, Delgado-Calle J. Role of Osteocytes in Cancer Progression in the Bone and the Associated Skeletal Disease. Curr Osteoporos Rep. 2021 06; 19(3):247-255. PMID: 33818732.
      View in: PubMed
    18. Chen J, Yuan X, Pilawski I, Liu X, Delgado-Calle J, Bellido T, Turkkahraman H, Helms JA. Molecular Basis for Craniofacial Phenotypes Caused by Sclerostin Deletion. J Dent Res. 2021 03; 100(3):310-317. PMID: 33078679.
      View in: PubMed
    19. Mulcrone PL, Edwards SKE, Petrusca DN, Haneline LS, Delgado-Calle J, Roodman GD. Osteocyte Vegf-a contributes to myeloma-associated angiogenesis and is regulated by Fgf23. Sci Rep. 2020 10 14; 10(1):17319. PMID: 33057033.
      View in: PubMed
    20. Miyagawa K, Ohata Y, Delgado-Calle J, Teramachi J, Zhou H, Dempster DD, Subler MA, Windle JJ, Chirgwin JM, Roodman GD, Kurihara N. Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo. JCI Insight. 2020 03 26; 5(6). PMID: 32078587.
      View in: PubMed
    21. Bellido T, Delgado-Calle J. Ex Vivo Organ Cultures as Models to Study Bone Biology. JBMR Plus. 2020 Mar; 4(3). PMID: 32161838.
      View in: PubMed
    22. Delgado-Calle J, Kurihara N, Atkinson EG, Nelson J, Miyagawa K, Galmarini CM, Roodman GD, Bellido T. Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts. Oncotarget. 2019 Apr 12; 10(28):2709-2721. PMID: 31105871.
      View in: PubMed
    23. Fern?ndez AF, Bay?n GF, Urdinguio RG, Tora?o EG, Garc?a MG, Carella A, Petrus-Reurer S, Ferrero C, Martinez-Camblor P, Cubillo I, Garc?a-Castro J, Delgado-Calle J, P?rez-Campo FM, Riancho JA, Bueno C, Men?ndez P, Mentink A, Mareschi K, Claire F, Fagnani C, Medda E, Toccaceli V, Brescianini S, Moran S, Esteller M, Stolzing A, de Boer J, Nistic? L, Stazi MA, Fraga MF. Corrigendum: H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells. Genome Res. 2019 04; 29(4):710.2. PMID: 30936177.
      View in: PubMed
    24. Atkinson EG, Delgado-Calle J. The Emerging Role of Osteocytes in Cancer in Bone. JBMR Plus. 2019 Mar; 3(3):e10186. PMID: 30918922.
      View in: PubMed
    25. Marino S, Bishop RT, de Ridder D, Delgado-Calle J, Reagan MR. 2D and 3D In Vitro Co-Culture for Cancer and Bone Cell Interaction Studies. Methods Mol Biol. 2019; 1914:71-98. PMID: 30729461.
      View in: PubMed
    26. Delgado-Calle J, Hancock B, Likine EF, Sato AY, McAndrews K, Sanudo C, Bruzzaniti A, Riancho JA, Tonra JR, Bellido T. MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production. FASEB J. 2018 05; 32(5):2878-2890. PMID: 29401593.
      View in: PubMed
    27. McDonald MM, Delgado-Calle J. Sclerostin: an Emerging Target for the Treatment of Cancer-Induced Bone Disease. Curr Osteoporos Rep. 2017 12; 15(6):532-541. PMID: 28956252.
      View in: PubMed
    28. Delgado-Calle J, Anderson J, Cregor MD, Condon KW, Kuhstoss SA, Plotkin LI, Bellido T, Roodman GD. Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth. Leukemia. 2017 12; 31(12):2686-2694. PMID: 28529307.
      View in: PubMed
    29. Delgado-Calle J, Bellido T. New Insights Into the Local and Systemic Functions of Sclerostin: Regulation of Quiescent Bone Lining Cells and Beige Adipogenesis in Peripheral Fat Depots. J Bone Miner Res. 2017 05; 32(5):889-891. PMID: 28370281.
      View in: PubMed
    30. Delgado-Calle J. Osteoclasts Control Lipid Secretion to Regulate Breast Cancer Bone Metastasis. Endocrinology. 2017 03 01; 158(3):458-460. PMID: 28430916.
      View in: PubMed
    31. Delgado-Calle J, Tu X, Pacheco-Costa R, McAndrews K, Edwards R, Pellegrini GG, Kuhlenschmidt K, Olivos N, Robling A, Peacock M, Plotkin LI, Bellido T. Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor. J Bone Miner Res. 2017 Mar; 32(3):522-535. PMID: 27704638.
      View in: PubMed
    32. Delgado-Calle J, Sato AY, Bellido T. Role and mechanism of action of sclerostin in bone. Bone. 2017 03; 96:29-37. PMID: 27742498.
      View in: PubMed
    33. Tora?o EG, Bay?n GF, Del Real ?, Sierra MI, Garc?a MG, Carella A, Belmonte T, Urdinguio RG, Cubillo I, Garc?a-Castro J, Delgado-Calle J, P?rez-Campo FM, Riancho JA, Fraga MF, Fern?ndez AF. Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells. J Transl Med. 2016 07 08; 14(1):207. PMID: 27393146.
      View in: PubMed
    34. Sato AY, Cregor M, Delgado-Calle J, Condon KW, Allen MR, Peacock M, Plotkin LI, Bellido T. Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin. J Bone Miner Res. 2016 10; 31(10):1791-1802. PMID: 27163932.
      View in: PubMed
    35. P?rez-Campo FM, May T, Zauers J, Sa?udo C, Delgado-Calle J, Arozamena J, Berciano MT, Lafarga M, Riancho JA. Generation and characterization of two immortalized human osteoblastic cell lines useful for epigenetic studies. J Bone Miner Metab. 2017 Mar; 35(2):150-160. PMID: 27038990.
      View in: PubMed
    36. Delgado-Calle J, Anderson J, Cregor MD, Hiasa M, Chirgwin JM, Carlesso N, Yoneda T, Mohammad KS, Plotkin LI, Roodman GD, Bellido T. Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma. Cancer Res. 2016 Mar 01; 76(5):1089-100. PMID: 26833121.
      View in: PubMed
    37. Delgado-Calle J, Bellido T. Osteocytes and Skeletal Pathophysiology. Curr Mol Biol Rep. 2015 Dec; 1(4):157-167. PMID: 26693137.
      View in: PubMed
    38. Tu X, Delgado-Calle J, Condon KW, Maycas M, Zhang H, Carlesso N, Taketo MM, Burr DB, Plotkin LI, Bellido T. Osteocytes mediate the anabolic actions of canonical Wnt/?-catenin signaling in bone. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):E478-86. PMID: 25605937.
      View in: PubMed
    39. Delgado-Calle J, Bellido T, Roodman GD. Role of osteocytes in multiple myeloma bone disease. Curr Opin Support Palliat Care. 2014 Dec; 8(4):407-13. PMID: 25289928.
      View in: PubMed
    40. Garmilla-Ezquerra P, Sa?udo C, Delgado-Calle J, P?rez-Nu?ez MI, Sumillera M, Riancho JA. Analysis of the bone microRNome in osteoporotic fractures. Calcif Tissue Int. 2015 Jan; 96(1):30-7. PMID: 25432767.
      View in: PubMed
    41. Fern?ndez AF, Bay?n GF, Urdinguio RG, Tora?o EG, Garc?a MG, Carella A, Petrus-Reurer S, Ferrero C, Martinez-Camblor P, Cubillo I, Garc?a-Castro J, Delgado-Calle J, P?rez-Campo FM, Riancho JA, Bueno C, Men?ndez P, Mentink A, Mareschi K, Claire F, Fagnani C, Medda E, Toccaceli V, Brescianini S, Moran S, Esteller M, Stolzing A, de Boer J, Nistic? L, Stazi MA, Fraga MF. H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells. Genome Res. 2015 Jan; 25(1):27-40. PMID: 25271306.
      View in: PubMed
    42. P?rez-Campo FM, Sa?udo C, Delgado-Calle J, Arozamena J, Zarrabeitia MT, Riancho JA. A Sclerostin super-producer cell line derived from the human cell line SaOS-2: a new tool for the study of the molecular mechanisms driving Sclerostin expression. Calcif Tissue Int. 2014 Aug; 95(2):194-9. PMID: 24913258.
      View in: PubMed
    43. Ben-awadh AN, Delgado-Calle J, Tu X, Kuhlenschmidt K, Allen MR, Plotkin LI, Bellido T. Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes. Endocrinology. 2014 Aug; 155(8):2797-809. PMID: 24877630.
      View in: PubMed
    44. Delgado-Calle J, Riancho JA, Klein-Nulend J. Nitric oxide is involved in the down-regulation of SOST expression induced by mechanical loading. Calcif Tissue Int. 2014 Apr; 94(4):414-22. PMID: 24322886.
      View in: PubMed
    45. Garc?a-Ibarbia C, Delgado-Calle J, Casafont I, Velasco J, Arozamena J, P?rez-N??ez MI, Alonso MA, Berciano MT, Ortiz F, P?rez-Castrill?n JL, Fern?ndez AF, Fraga MF, Zarrabeitia MT, Riancho JA. Contribution of genetic and epigenetic mechanisms to Wnt pathway activity in prevalent skeletal disorders. Gene. 2013 Dec 15; 532(2):165-72. PMID: 24096177.
      View in: PubMed
    46. Delgado-Calle J, Arozamena J, P?rez-L?pez J, Bolado-Carrancio A, Sa?udo C, Agudo G, de la Vega R, Alonso MA, Rodr?guez-Rey JC, Riancho JA. Role of BMPs in the regulation of sclerostin as revealed by an epigenetic modifier of human bone cells. Mol Cell Endocrinol. 2013 Apr 30; 369(1-2):27-34. PMID: 23415712.
      View in: PubMed
    47. Delgado-Calle J, Fern?ndez AF, Sainz J, Zarrabeitia MT, Sa?udo C, Garc?a-Renedo R, P?rez-N??ez MI, Garc?a-Ibarbia C, Fraga MF, Riancho JA. Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis. Arthritis Rheum. 2013 Jan; 65(1):197-205. PMID: 23124911.
      View in: PubMed
    48. Delgado-Calle J, Riancho JA. The role of DNA methylation in common skeletal disorders. Biology (Basel). 2012 Nov 22; 1(3):698-713. PMID: 24832515.
      View in: PubMed
    49. Garc?a-Renedo RJ, Carranza-Bencano A, Delgado-Calle J, N??ez-Samper M, Llanos-Alc?zar LF. [Disruption of anterointernal weight bearing: sequelae of surgical treatment of hallux valgus]. Acta Ortop Mex. 2012 Nov-Dec; 26(6):393-7. PMID: 24712209.
      View in: PubMed
    50. Delgado-Calle J, Garmilla P, Riancho JA. Do epigenetic marks govern bone mass and homeostasis? Curr Genomics. 2012 May; 13(3):252-63. PMID: 23115526.
      View in: PubMed
    51. Delgado-Calle J, Sa?udo C, Bolado A, Fern?ndez AF, Arozamena J, Pascual-Carra MA, Rodriguez-Rey JC, Fraga MF, Bonewald L, Riancho JA. DNA methylation contributes to the regulation of sclerostin expression in human osteocytes. J Bone Miner Res. 2012 Apr; 27(4):926-37. PMID: 22162201.
      View in: PubMed
    52. Delgado-Calle J, Sa?udo C, Fern?ndez AF, Garc?a-Renedo R, Fraga MF, Riancho JA. Role of DNA methylation in the regulation of the RANKL-OPG system in human bone. Epigenetics. 2012 Jan 01; 7(1):83-91. PMID: 22207352.
      View in: PubMed
    53. Delgado-Calle J, Arozamena J, Garc?a-Renedo R, Garc?a-Ibarbia C, Pascual-Carra MA, Gonz?lez-Mac?as J, Riancho JA. Osteocyte deficiency in hip fractures. Calcif Tissue Int. 2011 Oct; 89(4):327-34. PMID: 21874545.
      View in: PubMed
    54. Riancho JA, Delgado-Calle J. [Osteoblast-osteoclast interaction mechanisms]. Reumatol Clin. 2011 Sep; 7 Suppl 2:S1-4. PMID: 21924211.
      View in: PubMed
    55. Delgado-Calle J, Sa?udo C, S?nchez-Verde L, Garc?a-Renedo RJ, Arozamena J, Riancho JA. Epigenetic regulation of alkaline phosphatase in human cells of the osteoblastic lineage. Bone. 2011 Oct; 49(4):830-8. PMID: 21700004.
      View in: PubMed
    56. C?rcamo-Orive I, Gaztelumendi A, Delgado J, Tejados N, Dorronsoro A, Fern?ndez-Rueda J, Pennington DJ, Trigueros C. Regulation of human bone marrow stromal cell proliferation and differentiation capacity by glucocorticoid receptor and AP-1 crosstalk. J Bone Miner Res. 2010 Oct; 25(10):2115-25. PMID: 20499359.
      View in: PubMed
    57. C?rcamo-Orive I, Tejados N, Delgado J, Gaztelumendi A, Otaegui D, Lang V, Trigueros C. ERK2 protein regulates the proliferation of human mesenchymal stem cells without affecting their mobilization and differentiation potential. Exp Cell Res. 2008 May 01; 314(8):1777-88. PMID: 18378228.
      View in: PubMed
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