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Roy Morello

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPhysiology & Cell Biology, College of Medicine
Address211-2 Biomedical Research I
325 S. Elm St.
Mail Slot # 505
Little Rock AR 72205
Phone501-526-4090
ORCID ORCID Icon0000-0003-1604-4879 Additional info
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentGenetics, College of Medicine
    DivisionGenetics Faculty

    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentOrthopaedics, College of Medicine


    Collapse Overview 

    Collapse Affiliation 
    Collapse member of
    UAMS IACUC
    American Society of Human Genetics (ASHG)
    American Society for Bone and Mineral Research (ASBMR)
    Center for Musculoskeletal and Disease Research (CMDR) at UAMS
    Collapse collaborator
    John L. Carroll
    Intawat Nookaew
    Sergey Leikin
    Charles O'Brien
    Anne-Karina Perl

    Collapse Biography 
    Collapse awards and honors
    2022 - 2024Innovation award, American Lung Association

    Collapse Teaching 

    Collapse Research 
    Collapse research activities and funding
    1 R01 HL166748-01     (Roy Morello)Sep 1, 2023 - Jun 30, 2027
    NIH/NHLBI
    Lung developmental defects caused by type I collagen mutations in mouse models of osteogenesis imperfecta.
    Role Description: The goal of this project is to tease out the contribution of intrinsic vs. extrinsic factors underlying the impaired breathing function in OI and to identify the alveolar cellular/molecular changes caused by type I collagen defects in animal models of OI.
    Role: Principal Investigator
    2P20GM125503     (OBRIEN, CHARLES A)Apr 1, 2023 - Jun 30, 2028
    NIH/Nat. Inst. of General Medical Sciences
    Center for Musculoskeletal Disease Research (CMDR)
    Role: Principal Investigator
    IA-941372     (Roy Morello)Jul 1, 2022 - Jun 30, 2024
    American Lung Association
    Elucidating the role of type I collagen mutations on respiratory function in osteogenesis imperfecta.
    Role Description: The goal of this project is to tease out the contribution of intrinsic vs. extrinsic factors underlying the impaired breathing function in OI and to identify the alveolar cellular/molecular changes caused by type I collagen defects in animal models of OI.
    Role: Principal Investigator
    R03HD097559     (MORELLO, ROY)Jan 11, 2019 - Dec 31, 2020
    NIH/Nat. Inst. of Child Health & Human Development
    Primary lung defects in mouse models of osteogenesis imperfecta
    Role: Principal Investigator
         (Morello, Roy)Jan 1, 2019 - Dec 31, 2020
    UAMS Research Scholar Pilot Grant Award in Child Health
    Respiratory Function in Animal Models of Skeletal Dysplasias
    Role: Principal Investigator
         (Morello, Roy)Jan 1, 2018 - Dec 31, 2018
    UAMS 2018 Medical Research Endowment award
    Lung alterations in recessive Osteogenesis Imperfecta due to loss of the prolyl 3-hydroxylation complex
    Role: Principal Investigator
    117-1006842     (MORELLO, ROY)Jul 1, 2015 - Jun 30, 2016
    UAMS College of Medicine
    Morello Startup
    Role: Principal Investigator
    R01AI119380     (SMELTZER, MARK S)Jun 15, 2015 - Aug 31, 2026
    NIH
    Defining the role of post-translational regulation by extracellular proteases in the pathogenesis of Staphylococcus aureus osteomyelitis
    Role: Co-Investigator
    R43AR066388     (RADIN, DAVID)Jun 1, 2014 - May 31, 2016
    NIH
    Targeted Enzyme Replacement Therapy for Rare Forms of Osteogenesis Imperfecta
    Role: Co-Principal Investigator
    R01AR060823     (MORELLO, ROY)Sep 17, 2012 - Jul 31, 2018
    NIH
    Role of the Leprecan Genes in Skeletal Formation
    Role: Principal Investigator
         (Morello, Roy)Jan 1, 2012 - Jun 30, 2013
    UAMS 2012 Medical Research Endowment award
    Matrix-mediated effects on Bone Marrow Stromal Cells (BMSCs)
    Role: Principal Investigator
         (Morello, Roy)Dec 1, 2010 - Nov 30, 2011
    ASBMR Junior Faculty Osteoporosis Research Award
    Sc65, a novel osteoporosis related gene
    Role: Principal Investigator
         (Morello, Roy)Jan 1, 2007 - Dec 31, 2008
    OSTEOGENESIS IMPERFECTA FOUNDATION - Michael Geisman Research Fellowship
    Role of collagen prolyl 3-hydroxylation in Osteogenesis imperfecta
    Role: Principal Investigator
    R03AR051459     (MORELLO, ROY)Sep 26, 2005 - Aug 31, 2009
    NIH
    Crtap function during skeletal homeostasis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Dimori M, Toulany M, Sultana LS, Onal M, Thostenson JD, Carroll JL, O'Brien CA, Morello R. A new Col1a1 conditional knock-in mouse model to study osteogenesis imperfecta. J Bone Miner Res. 2024 Nov 20. PMID: 39566076.
      View in: PubMed
    2. Warren A, Porter RM, Reyes-Castro O, Ali MM, Marques-Carvalho A, Kim HN, Gatrell LB, Schipani E, Nookaew I, O'Brien CA, Morello R, Almeida M. The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice. Nat Commun. 2023 06 17; 14(1):3616. PMID: 37330524.
      View in: PubMed
    3. Dimori M, Pokrovskaya ID, Liu S, Sherrill JT, Gomez-Acevedo H, Fu Q, Storrie B, Lupashin VV, Morello R. A Rab33b missense mouse model for Smith-McCort dysplasia shows bone resorption defects and altered protein glycosylation. Front Genet. 2023; 14:1204296. PMID: 37359363.
      View in: PubMed
    4. Dimori M, Fett J, Leikin S, Otsuru S, Thostenson JD, Carroll JL, Morello R. Distinct type I collagen alterations cause intrinsic lung and respiratory defects of variable severity in mouse models of osteogenesis imperfecta. J Physiol. 2023 01; 601(2):355-379. PMID: 36285717.
      View in: PubMed
    5. Esteban-Lopez M, Wilson KJ, Myhr C, Kaftanovskaya EM, Henderson MJ, Southall NT, Xu X, Wang A, Hu X, Barnaeva E, Ye W, George ER, Sherrill JT, Ferrer M, Morello R, Agoulnik IU, Marugan JJ, Agoulnik AI. Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2. Commun Biol. 2022 11 04; 5(1):1183. PMID: 36333465.
      View in: PubMed
    6. Fett J, Dimori M, Carroll JL, Morello R. Haploinsufficiency of Col5a1 causes intrinsic lung and respiratory changes in a mouse model of classical Ehlers-Danlos syndrome. Physiol Rep. 2022 04; 10(8):e15275. PMID: 35439366.
      View in: PubMed
    7. Wee NK, Sims NA, Morello R. The Osteocyte Transcriptome: Discovering Messages Buried Within Bone. Curr Osteoporos Rep. 2021 12; 19(6):604-615. PMID: 34757588.
      View in: PubMed
    8. Marom R, Rabenhorst BM, Morello R. Osteogenesis imperfecta: an update on clinical features and therapies. Eur J Endocrinol. 2020 Oct; 183(4):R95-R106. PMID: 32621590.
      View in: PubMed
    9. Xu H, Lenhart SA, Chu EY, Chavez MB, Wimer HF, Dimori M, Somerman MJ, Morello R, Foster BL, Hatch NE. Dental and craniofacial defects in the Crtap-/- mouse model of osteogenesis imperfecta type VII. Dev Dyn. 2020 07; 249(7):884-897. PMID: 32133710.
      View in: PubMed
    10. Dimori M, Heard-Lipsmeyer ME, Byrum SD, Mackintosh SG, Kurten RC, Carroll JL, Morello R. Respiratory defects in the CrtapKO mouse model of osteogenesis imperfecta. Am J Physiol Lung Cell Mol Physiol. 2020 04 01; 318(4):L592-L605. PMID: 32022592.
      View in: PubMed
    11. Zimmerman SM, Dimori M, Heard-Lipsmeyer ME, Morello R. The Osteocyte Transcriptome Is Extensively Dysregulated in Mouse Models of Osteogenesis Imperfecta. JBMR Plus. 2019 Jul; 3(7):e10171. PMID: 31372585.
      View in: PubMed
    12. Bow A, Newby S, Rifkin R, Jackson BK, Matavosian A, Griffin C, King W, Alghazali K, Madhi A, Berryhill SB, Morello R, Hecht S, Biris AS, Anderson DE, Bourdo SE, Dhar M. Evaluation of a Polyurethane Platform for Delivery of Nanohydroxyapatite and Decellularized Bone Particles in a Porous Three-Dimensional Scaffold. ACS Appl Bio Mater. 2019; 5(2):1815-1829.
    13. O'Brien CA, Morello R. Modeling Rare Bone Diseases in Animals. Curr Osteoporos Rep. 2018 08; 16(4):458-465. PMID: 29802575.
      View in: PubMed
    14. Zimmerman SM, Heard-Lipsmeyer ME, Dimori M, Thostenson JD, Mannen EM, O'Brien CA, Morello R. Loss of RANKL in osteocytes dramatically increases cancellous bone mass in the osteogenesis imperfecta mouse (oim). Bone Rep. 2018 Dec; 9:61-73. PMID: 30105276.
      View in: PubMed
    15. Morello R. Osteogenesis imperfecta and therapeutics. Matrix Biol. 2018 10; 71-72:294-312. PMID: 29540309.
      View in: PubMed
    16. Zimmerman SM, Besio R, Heard-Lipsmeyer ME, Dimori M, Castagnola P, Swain FL, Gaddy D, Diekman AB, Morello R. Expression characterization and functional implication of the collagen-modifying Leprecan proteins in mouse gonadal tissue and mature sperm. AIMS Genet. 2018; 5(1):24-40. PMID: 30417103.
      View in: PubMed
    17. Mohan M, Samant RS, Yoon D, Buros AF, Branca A, Montgomery CO, Nicholas R, Suva LJ, Morello R, Thanendrarajan S, Schinke C, Yaccoby S, van Rhee F, Davies FE, Morgan GJ, Zangari M. Extensive Remineralization of Large Pelvic Lytic Lesions Following Total Therapy Treatment in Patients With Multiple Myeloma. J Bone Miner Res. 2017 Jun; 32(6):1261-1266. PMID: 28240368.
      View in: PubMed
    18. Hudson DM, Weis M, Rai J, Joeng KS, Dimori M, Lee BH, Morello R, Eyre DR. P3h3-null and Sc65-null Mice Phenocopy the Collagen Lysine Under-hydroxylation and Cross-linking Abnormality of Ehlers-Danlos Syndrome Type VIA. J Biol Chem. 2017 03 03; 292(9):3877-3887. PMID: 28115524.
      View in: PubMed
    19. Loughran AJ, Gaddy D, Beenken KE, Meeker DG, Morello R, Zhao H, Byrum SD, Tackett AJ, Cassat JE, Smeltzer MS. Impact of sarA and Phenol-Soluble Modulins on the Pathogenesis of Osteomyelitis in Diverse Clinical Isolates of Staphylococcus aureus. Infect Immun. 2016 09; 84(9):2586-94. PMID: 27354444.
      View in: PubMed
    20. Heard ME, Besio R, Weis M, Rai J, Hudson DM, Dimori M, Zimmerman SM, Kamykowski JA, Hogue WR, Swain FL, Burdine MS, Mackintosh SG, Tackett AJ, Suva LJ, Eyre DR, Morello R. Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation. PLoS Genet. 2016 Apr; 12(4):e1006002. PMID: 27119146.
      View in: PubMed
    21. Morello R and Haddad R. Recessive Osteogenesis Imperfecta: rER Genes Take the Stage. Chapter 7. Transitional Care in Osteogenesis Imperfecta: Advances in Biology, Technology, and Clinical Practice. Edited by Peter A. Smith, Frank Rauch, Gerald F. Harris. Shriners Hospitals for Children. Chicago, IL. 2015.
    22. Gruenwald K, Castagnola P, Besio R, Dimori M, Chen Y, Akel NS, Swain FL, Skinner RA, Eyre DR, Gaddy D, Suva LJ, Morello R. Sc65 is a novel endoplasmic reticulum protein that regulates bone mass homeostasis. J Bone Miner Res. 2014 Mar; 29(3):666-75. PMID: 23959653.
      View in: PubMed
    23. Homan EP, Lietman C, Grafe I, Lennington J, Morello R, Napierala D, Jiang MM, Munivez EM, Dawson B, Bertin TK, Chen Y, Lua R, Lichtarge O, Hicks J, Weis MA, Eyre D, Lee BH. Differential effects of collagen prolyl 3-hydroxylation on skeletal tissues. PLoS Genet. 2014 Jan; 10(1):e1004121. PMID: 24465224.
      View in: PubMed
    24. Morello R, Haddad R. Transitional Care in Osteogenesis Imperfecta: Advances in Biology, Technology, and Clinical Practice. Recessive Osteogenesis Imperfecta: eER Genes Take the Stage. 2013.
    25. Homan EP, Lee B, Morello R. Osteogenesis Imperfecta: a Translational Approach to Brittle Bone Disease. Recessive Osteogenesis Imperfecta Due to Mutations in CRTAP, LEPRE1 and PPIB. 2013; 14.
    26. Morello R, Esposito PW. Osteogenesis. Osteogenesis imperfecta. 2012; 9.
    27. Homan EP, Rauch F, Grafe I, Lietman C, Doll JA, Dawson B, Bertin T, Napierala D, Morello R, Gibbs R, White L, Miki R, Cohn DH, Crawford S, Travers R, Glorieux FH, Lee B. Mutations in SERPINF1 cause osteogenesis imperfecta type VI. J Bone Miner Res. 2011 Dec; 26(12):2798-803. PMID: 21826736.
      View in: PubMed
    28. Ben Amor IM, Rauch F, Gruenwald K, Weis M, Eyre DR, Roughley P, Glorieux FH, Morello R. Severe Osteogenesis Imperfecta Caused by a Small In-Frame Deletion in CRTAP. Amer J Med Genet. 2011; 155A(11):2865-70.
    29. Monticone M, Panfoli I, Ravera S, Puglisi R, Jiang MM, Morello R, Candiani S, Tonachini L, Biticchi R, Fabiano A, Cancedda R, Boitani C, Castagnola P. The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and cellular respiration. J Cell Physiol. 2010 Nov; 225(3):767-76. PMID: 20568109.
      View in: PubMed
    30. Morello R, Rauch F. Role of cartilage-associated protein in skeletal development. Curr Osteoporos Rep. 2010 Jun; 8(2):77-83. PMID: 20425614.
      View in: PubMed
    31. Gabbay KH, Bohren KM, Morello R, Bertin TK, Liu J, Vogel P. Delineation of the ascorbate synthesis pathway and the role of mild ascorbate deficiency in osteoporosis. J. Biol. Chem. 2010.
    32. Baldridge D, Lennington J, Weis M, Homan EP, Jiang MM, Munivez E, Keene DR, Hogue WR, Pyott S, Byers PH, Krakow D, Cohn DH, Eyre DR, Lee B, Morello R. Generalized connective tissue disease in Crtap-/- mouse. PLoS One. 2010 May 11; 5(5):e10560. PMID: 20485499.
      View in: PubMed
    33. Gabbay KH, Bohren KM, Morello R, Bertin T, Liu J, Vogel P. Ascorbate synthesis pathway: dual role of ascorbate in bone homeostasis. J Biol Chem. 2010 Jun 18; 285(25):19510-20. PMID: 20410296.
      View in: PubMed
    34. Fratz-Zelman N, Morello R, Lee B, Rauch F, Glorieux FH, Misof BM, Klaushofer K, Roschger P. CRTAP deficiency leads to abnormally high bone matrix mineralization in a murine model and in children with Osteogenesis Imperfecta type VII. BONE. 2010; (46):820-826.
    35. Ferlin A, Pepe A, Gianesello L, Garolla A, Feng S, Facciolli A, Morello R, Agoulnik AI, Foresta C. New roles for INSL3 in adults. Ann N Y Acad Sci. 2009; 1160:215-8.
    36. Ferlin A, Pepe A, Gianesello L, Garolla A, Feng S, Facciolli A, Morello R, Agoulnik AI, Foresta C. New roles for INSL3 in adults. Ann N Y Acad Sci. 2009 Apr; 1160:215-8. PMID: 19416191.
      View in: PubMed
    37. Morello R, Scott DA, and Lee B. Nail-patella syndrome. Chapter 31. Genetic diseases of the kidney. Edited by Richard P. Lifton, Stefan Somlo, Gerhard H. Giebisch and Donald W. Seldin. Elsevier. 2009.
    38. Baldridge D, Schwarze U, Morello R, Lennington J, Bertin TK, Pace JM, Pepin MG, Weis M, Eyre DR, Walsh J, Lambert D, Green A, Robinson H, Michelson M, Houge G, Lindman C, Martin J, Ward J, Lemyre E, Mitchell JJ, Krakow D, Rimoin DL, Cohn DH, Byers PH, Lee B. CRTAP and LEPRE1 mutations in recessive osteogenesis imperfecta. Hum Mutat. 2008 Dec; 29(12):1435-42. PMID: 18566967.
      View in: PubMed
    39. Morello R, Bertin TK, Schlaubitz S, Shaw CA, Kakuru S, Munivez E, Hermanns P, Chen Y, Zabel B, Lee B. Brachy-syndactyly caused by loss of Sfrp2 function. J Cell Physiol. 2008 Oct; 217(1):127-37. PMID: 18446812.
      View in: PubMed
    40. Ferlin A, Pepe A, Gianesello L, Garolla A, Feng S, Giannini S, Zaccolo M, Facciolli A, Morello R, Agoulnik AI, Foresta C. Mutations in the insulin-like factor 3 receptor are associated with osteoporosis. J Bone Miner Res. 2008 May; 23(5):683-93. PMID: 18433302.
      View in: PubMed
    41. Napierala D, Sam K, Morello R, Zheng Q, Munivez E, Shivdasani RA, Lee B. Uncoupling of chondrocyte differentiation and perichondrial mineralization underlies the skeletal dysplasia in tricho-rhino-phalangeal syndrome. Hum Mol Genet. 2008 Jul 15; 17(14):2244-54. PMID: 18424451.
      View in: PubMed
    42. Barnes AM, Chang W, Morello R, Cabral WA, Weis M, Eyre DR, Leikin S, Makareeva E, Kuznetsova N, Uveges TE, Ashok A, Flor AW, Mulvihill JJ, Wilson PL, Sundaram UT, Lee B, Marini JC. Deficiency of cartilage-associated protein in recessive lethal osteogenesis imperfecta. N Engl J Med. 2006 Dec 28; 355(26):2757-64. PMID: 17192541.
      View in: PubMed
    43. Morello R, Bertin TK, Chen Y, Hicks J, Tonachini L, Monticone M, Castagnola P, Rauch F, Glorieux FH, Vranka J, B?chinger HP, Pace JM, Schwarze U, Byers PH, Weis M, Fernandes RJ, Eyre DR, Yao Z, Boyce BF, Lee B. CRTAP is required for prolyl 3- hydroxylation and mutations cause recessive osteogenesis imperfecta. Cell. 2006 Oct 20; 127(2):291-304. PMID: 17055431.
      View in: PubMed
    44. Kang JS, Wang XP, Miner JH, Morello R, Sado Y, Abrahamson DR, Borza DB. Loss of alpha3/alpha4(IV) Collagen from the Glomerular Basement Membrane Induces a Strain-Dependent Isoform Switch to alpha5alpha6(IV) Collagen Associated with Longer Renal Survival in Col4a3-/- Alport Mice. J Am Soc Nephrol. 2006; (7):1962-1969.
    45. Tavella S, Biticchi R, Morello R, Castagnola P, Musante V, Costa D, Cancedda R, Garofalo S. Forced chondrocyte expression of Sonic hedge-hog impairs joint formation affecting proliferation and apoptosis. Matrix Biol. 2006; 7(25):389-397.
    46. Dreyer SD, Naruse T, Morello R, Zabel B, Winterpacht A, Johnson RL, Lee B, and Oberg KC. Lmx1b expression during joint and tendon formation: localization and evaluation of potential downstream targets. Gene Expr Patterns. 2004; (4):397-405.
    47. Zheng Q, Zhou G, Morello R, Chen Y, Garcia-Rojas X, Lee B. Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo. J Cell Biol. 2003 Sep 01; 162(5):833-42. PMID: 12952936.
      View in: PubMed
    48. Lee B and Morello R. LMX1B and the Nail Patella Syndrome. Chapter 58. Molecular basis of inborn errors of development. Oxford University Press. 2003.
    49. Hamano Y, Grunkemeyer JA, Sudhakar A, Zeisberg M, Cosgrove D, Morello R, Lee B, Sugimoto H, Kalluri R. Determinants of vascular permeability in the kidney glomerulus. J Biol Chem. 2002 Aug 23; 277(34):31154-62. PMID: 12039968.
      View in: PubMed
    50. Morello R, Lee B. Insight into podocyte differentiation from the study of human genetic disease: nail-patella syndrome and transcriptional regulation in podocytes. Pediatr Res. 2002 May; 51(5):551-8. PMID: 11978876.
      View in: PubMed
    51. *Miner JH, *Morello R, Andrews KL, Li C, Antignac C, Shaw AS, and Lee B. Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation. J Clin Invest. 2002; (109):1065-1072.
    52. Morello R, Zhou G, Dreyer SD, Harvey SJ, Ninomiya Y, Thorner PS, Miner JH, Cole W, Winterpacht A, Zabel B, Oberg KC, and Lee B. Regulation of glomerular basement membrane collagen expression by LMX1B provides a basis for renal disease in Nail Patella syndrome. Nat Genet. 2001; (27):205-209.
    53. Dreyer SD, Morello R, German MS, Zabel B, Winterpacht A, Lunstrum GP, Horton WA, Oberg KC, and Lee B. LMX1B transactivation and expression in nail-patella syndrome. Hum Mol Genet. 2000; 7(9):1067-1074.
    54. Morello R, Tonachini L, Monticone M, Viggiano L, Rocchi M, Cancedda R, and Castagnola P. cDNA cloning, characterization and chromosome mapping of Crtap encoding the mouse cartilage associated protein. Matrix Biol. 1999; (18):319-324.
    55. Tonachini L, Morello R, Monticone M, Skaug J, Scherer SW, Cancedda R, and Castagnola P. . cDNA cloning, characterization and chromosome mapping of the gene encoding Human Cartilage Associated Protein (CRTAP). Cytogenet Cell Genet. 1999; 3-4(87):191-194.
    56. Castagnola P, Gennari M, Morello R, Tonachini L, Marin O, Gaggero A, and Cancedda R. Cartilage Associated Protein (CASP) is a novel developmentally regulated chick embryo protein. J Cell Sci. 1997; (110):1351-1359.
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