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Yuet-Kin Leung

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPharmacology & Toxicology, College of Medicine
DivisionPharmacology Aging Research
Address200 South Cedar
Mail Slot # 611
Little Rock AR 72202
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Leung YK, Biesiada J, Govindarajah V, Ying J, Kendler A, Medvedovic M, Ho SM. Low-Dose Bisphenol A in a Rat Model of Endometrial Cancer: A CLARITY-BPA Study. Environ Health Perspect. 2020 12; 128(12):127005. PMID: 33296240.
      View in: PubMed
    2. Padala KP, Padala PR, Leung YK, Dennis RA, Ho SM. Open Burn Pit Exposure and Concern About the COVID-19 Pandemic. Prim Care Companion CNS Disord. 2020 11 05; 22(6). PMID: 33166097.
      View in: PubMed
    3. Lakkaniga NR, Gunaganti N, Zhang L, Belachew B, Frett B, Leung YK, Li HY. Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation. Eur J Med Chem. 2020 Nov 15; 206:112691. PMID: 32823007.
      View in: PubMed
    4. Wongsurawat T, Jenjaroenpun P, De Loose A, Alkam D, Ussery DW, Nookaew I, Leung YK, Ho SM, Day JD, Rodriguez A. A novel Cas9-targeted long-read assay for simultaneous detection of IDH1/2 mutations and clinically relevant MGMT methylation in fresh biopsies of diffuse glioma. Acta Neuropathol Commun. 2020 06 20; 8(1):87. PMID: 32563269.
      View in: PubMed
    5. Lu Y, Liu X, Zhang E, Kopras EJ, Smith EP, Astreinidis A, Li C, Leung YK, Ho SM, Yu JJ. Estrogen activates pyruvate kinase M2 and increases the growth of TSC2-deficient cells. PLoS One. 2020; 15(2):e0228894. PMID: 32078667.
      View in: PubMed
    6. Langevin SM, Kuhnell D, Niu L, Biesiada J, Leung YK, Deka R, Chen A, Medvedovic M, Kelsey KT, Kasper S, Zhang X. Comprehensive mapping of the methylation landscape of 16 CpG-dense regions in oral and pharyngeal squamous cell carcinoma. Epigenomics. 2019 07; 11(9):987-1002. PMID: 31215230.
      View in: PubMed
    7. Khanal T, Leung YK, Jiang W, Timchenko N, Ho SM, Kim K. NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries. FASEB J. 2019 07; 33(7):8335-8348. PMID: 30991008.
      View in: PubMed
    8. Xie C, Leung YK, Chen A, Long DX, Hoyo C, Ho SM. Differential methylation values in differential methylation analysis. Bioinformatics. 2019 04 01; 35(7):1094-1097. PMID: 30184051.
      View in: PubMed
    9. Leung YK, Chan QK, Ng CF, Ma FM, Tse HM, To KF, Maranchie J, Ho SM, Lau KM. Correction: Hsa-miRNA-765 as a Key Mediator for Inhibiting Growth, Migration and Invasion in Fulvestrant-Treated Prostate Cancer. PLoS One. 2019; 14(3):e0214184. PMID: 30883603.
      View in: PubMed
    10. Dworatzek E, Mahmoodzadeh S, Schriever C, Kusumoto K, Kramer L, Santos G, Fliegner D, Leung YK, Ho SM, Zimmermann WH, Lutz S, Regitz-Zagrosek V. Sex-specific regulation of collagen I and III expression by 17ß-Estradiol in cardiac fibroblasts: role of estrogen receptors. Cardiovasc Res. 2019 02 01; 115(2):315-327. PMID: 30016401.
      View in: PubMed
    11. Leung YK, Ouyang B, Niu L, Xie C, Ying J, Medvedovic M, Chen A, Weihe P, Valvi D, Grandjean P, Ho SM. Identification of sex-specific DNA methylation changes driven by specific chemicals in cord blood in a Faroese birth cohort. Epigenetics. 2018; 13(3):290-300. PMID: 29560787.
      View in: PubMed
    12. Alexander J, Teague AM, Chen J, Aston CE, Leung YK, Chernausek S, Simmons RA, Pinney SE. Offspring sex impacts DNA methylation and gene expression in placentae from women with diabetes during pregnancy. PLoS One. 2018; 13(2):e0190698. PMID: 29470513.
      View in: PubMed
    13. Khanal T, Choi K, Leung YK, Wang J, Kim D, Janakiram V, Cho SG, Puga A, Ho SM, Kim K. Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer. Sci Rep. 2017 09 06; 7(1):10662. PMID: 28878246.
      View in: PubMed
    14. Chen T, Lu L, Xu C, Lin X, Leung YK, Ho SM, Ruan XZ, Lian X. Inhibition Role of Atherogenic Diet on Ethyl Carbamate Induced Lung Tumorigenesis in C57BL/6J Mice. Sci Rep. 2017 07 05; 7(1):4723. PMID: 28680122.
      View in: PubMed
    15. Leung YK, Govindarajah V, Cheong A, Veevers J, Song D, Gear R, Zhu X, Ying J, Kendler A, Medvedovic M, Belcher S, Ho SM. Gestational high-fat diet and bisphenol A exposure heightens mammary cancer risk. Endocr Relat Cancer. 2017 07; 24(7):365-378. PMID: 28487351.
      View in: PubMed
    16. Tarapore P, Hennessy M, Song D, Ying J, Ouyang B, Govindarajah V, Leung YK, Ho SM. Data on spermatogenesis in rat males gestationally exposed to bisphenol A and high fat diets. Data Brief. 2016 Dec; 9:812-817. PMID: 27872877.
      View in: PubMed
    17. Tarapore P, Hennessy M, Song D, Ying J, Ouyang B, Govindarajah V, Leung YK, Ho SM. High butter-fat diet and bisphenol A additively impair male rat spermatogenesis. Reprod Toxicol. 2017 03; 68:191-199. PMID: 27658648.
      View in: PubMed
    18. Xu Z, Taylor JA, Leung YK, Ho SM, Niu L. oxBS-MLE: an efficient method to estimate 5-methylcytosine and 5-hydroxymethylcytosine in paired bisulfite and oxidative bisulfite treated DNA. Bioinformatics. 2016 12 01; 32(23):3667-3669. PMID: 27522082.
      View in: PubMed
    19. Zhou Z, Kennell C, Lee JY, Leung YK, Tarapore P. Calcium phosphate-polymer hybrid nanoparticles for enhanced triple negative breast cancer treatment via co-delivery of paclitaxel and miR-221/222 inhibitors. Nanomedicine. 2017 02; 13(2):403-410. PMID: 27520723.
      View in: PubMed
    20. Cheong A, Zhang X, Cheung YY, Tang WY, Chen J, Ye SH, Medvedovic M, Leung YK, Prins GS, Ho SM. DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk. Epigenetics. 2016 09; 11(9):674-689. PMID: 27415467.
      View in: PubMed
    21. Ho SM, Cheong A, Adgent MA, Veevers J, Suen AA, Tam NNC, Leung YK, Jefferson WN, Williams CJ. Environmental factors, epigenetics, and developmental origin of reproductive disorders. Reprod Toxicol. 2017 03; 68:85-104. PMID: 27421580.
      View in: PubMed
    22. Rizzardi AE, Zhang X, Vogel RI, Kolb S, Geybels MS, Leung YK, Henriksen JC, Ho SM, Kwak J, Stanford JL, Schmechel SC. Quantitative comparison and reproducibility of pathologist scoring and digital image analysis of estrogen receptor ß2 immunohistochemistry in prostate cancer. Diagn Pathol. 2016 Jul 11; 11(1):63. PMID: 27401406.
      View in: PubMed
    23. Miller M, Bailey B, Govindarajah V, Levin L, Metzger T, Pinney SM, Leung YK, Ho SM. A community survey on knowledge of the impact of environmental and epigenetic factors on health and disease. Perspect Public Health. 2016 Nov; 136(6):345-352. PMID: 26941233.
      View in: PubMed
    24. Schade GR, Holt SK, Zhang X, Song D, Wright JL, Zhao S, Kolb S, Lam HM, Levin L, Leung YK, Ho SM, Stanford JL. Prostate Cancer Expression Profiles of Cytoplasmic ERß1 and Nuclear ERß2 are Associated with Poor Outcomes following Radical Prostatectomy. J Urol. 2016 06; 195(6):1760-6. PMID: 26804755.
      View in: PubMed
    25. Stevenson M, Alexander B, Baxter CS, Leung YK. Evaluating Endocrine Disruption Activity of Deposits on Firefighting Gear Using a Sensitive and High Throughput Screening Method. J Occup Environ Med. 2015 Dec; 57(12):e153-7. PMID: 26641839.
      View in: PubMed
    26. Govindarajah V, Leung YK, Ying J, Gear R, Bornschein RL, Medvedovic M, Ho SM. In utero exposure of rats to high-fat diets perturbs gene expression profiles and cancer susceptibility of prepubertal mammary glands. J Nutr Biochem. 2016 Mar; 29:73-82. PMID: 26895667.
      View in: PubMed
    27. Martinez AM, Cheong A, Ying J, Xue J, Kannan K, Leung YK, Thomas MA, Ho SM. Effects of High-Butterfat Diet on Embryo Implantation in Female Rats Exposed to Bisphenol A. Biol Reprod. 2015 Dec; 93(6):147. PMID: 26510865.
      View in: PubMed
    28. Panchanathan R, Liu H, Leung YK, Ho SM, Choubey D. Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells. Mol Cell Endocrinol. 2015 Nov 05; 415:45-55. PMID: 26277401.
      View in: PubMed
    29. Ho SM, Cheong A, Lam HM, Hu WY, Shi GB, Zhu X, Chen J, Zhang X, Medvedovic M, Leung YK, Prins GS. Exposure of Human Prostaspheres to Bisphenol A Epigenetically Regulates SNORD Family Noncoding RNAs via Histone Modification. Endocrinology. 2015 Nov; 156(11):3984-95. PMID: 26248216.
      View in: PubMed
    30. Zhou Z, Badkas A, Stevenson M, Lee JY, Leung YK. Herceptin conjugated PLGA-PHis-PEG pH sensitive nanoparticles for targeted and controlled drug delivery. Int J Pharm. 2015 Jun 20; 487(1-2):81-90. PMID: 25865568.
      View in: PubMed
    31. Yang WS, Chadalapaka G, Cho SG, Lee SO, Jin UH, Jutooru I, Choi K, Leung YK, Ho SM, Safe S, Kim K. The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis. Neoplasia. 2014 Dec; 16(12):1059-69. PMID: 25499219.
      View in: PubMed
    32. Leung YK, Chan QK, Ng CF, Ma FM, Tse HM, To KF, Maranchie J, Ho SM, Lau KM. Hsa-miRNA-765 as a key mediator for inhibiting growth, migration and invasion in fulvestrant-treated prostate cancer. PLoS One. 2014; 9(5):e98037. PMID: 24837491.
      View in: PubMed
    33. Knower KC, To SQ, Leung YK, Ho SM, Clyne CD. Endocrine disruption of the epigenome: a breast cancer link. Endocr Relat Cancer. 2014 Apr; 21(2):T33-55. PMID: 24532474.
      View in: PubMed
    34. Langevin SM, Pinney SM, Leung YK, Ho SM. Does epigenetic drift contribute to age-related increases in breast cancer risk? Epigenomics. 2014; 6(4):367-9. PMID: 25333845.
      View in: PubMed
    35. Lee MT, Ho SM, Tarapore P, Chung I, Leung YK. Estrogen receptor ß isoform 5 confers sensitivity of breast cancer cell lines to chemotherapeutic agent-induced apoptosis through interaction with Bcl2L12. Neoplasia. 2013 Nov; 15(11):1262-71. PMID: 24339738.
      View in: PubMed
    36. Lee MT, Leung YK, Chung I, Tarapore P, Ho SM. Estrogen receptor ß (ERß1) transactivation is differentially modulated by the transcriptional coregulator Tip60 in a cis-acting element-dependent manner. J Biol Chem. 2013 Aug 30; 288(35):25038-25052. PMID: 23857583.
      View in: PubMed
    37. Lee MT, Ouyang B, Ho SM, Leung YK. Differential expression of estrogen receptor beta isoforms in prostate cancer through interplay between transcriptional and translational regulation. Mol Cell Endocrinol. 2013 Aug 25; 376(1-2):125-35. PMID: 23806560.
      View in: PubMed
    38. Brunst KJ, Leung YK, Ryan PH, Khurana Hershey GK, Levin L, Ji H, Lemasters GK, Ho SM. Forkhead box protein 3 (FOXP3) hypermethylation is associated with diesel exhaust exposure and risk for childhood asthma. J Allergy Clin Immunol. 2013 Feb; 131(2):592-4.e1-3. PMID: 23260754.
      View in: PubMed
    39. Leung YK, Lee MT, Lam HM, Tarapore P, Ho SM. Estrogen receptor-beta and breast cancer: translating biology into clinical practice. Steroids. 2012 Jun; 77(7):727-37. PMID: 22465878.
      View in: PubMed
    40. Lam HM, Suresh Babu CV, Wang J, Yuan Y, Lam YW, Ho SM, Leung YK. Phosphorylation of human estrogen receptor-beta at serine 105 inhibits breast cancer cell migration and invasion. Mol Cell Endocrinol. 2012 Jul 06; 358(1):27-35. PMID: 22370157.
      View in: PubMed
    41. Ho SM, Johnson A, Tarapore P, Janakiram V, Zhang X, Leung YK. Environmental epigenetics and its implication on disease risk and health outcomes. ILAR J. 2012; 53(3-4):289-305. PMID: 23744968.
      View in: PubMed
    42. Ho SM, Lee MT, Lam HM, Leung YK. Estrogens and prostate cancer: etiology, mediators, prevention, and management. Endocrinol Metab Clin North Am. 2011 Sep; 40(3):591-614, ix. PMID: 21889723.
      View in: PubMed
    43. Leung YK, Ho SM. Estrogen receptor ß: switching to a new partner and escaping from estrogen. Sci Signal. 2011 Apr 12; 4(168):pe19. PMID: 21487104.
      View in: PubMed
    44. Ouyang B, Leung YK, Wang V, Chung E, Levin L, Bracken B, Cheng L, Ho SM. a-Methylacyl-CoA racemase spliced variants and their expression in normal and malignant prostate tissues. Urology. 2011 Jan; 77(1):249.e1-7. PMID: 21195844.
      View in: PubMed
    45. Leung YK, Lam HM, Wu S, Song D, Levin L, Cheng L, Wu CL, Ho SM. Estrogen receptor beta2 and beta5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion. Endocr Relat Cancer. 2010 Sep; 17(3):675-89. PMID: 20501637.
      View in: PubMed
    46. Zhang X, Wu M, Xiao H, Lee MT, Levin L, Leung YK, Ho SM. Methylation of a single intronic CpG mediates expression silencing of the PMP24 gene in prostate cancer. Prostate. 2010 May 15; 70(7):765-76. PMID: 20054818.
      View in: PubMed
    47. Haynes EN, Heckel P, Ryan P, Roda S, Leung YK, Sebastian K, Succop P. Environmental manganese exposure in residents living near a ferromanganese refinery in Southeast Ohio: a pilot study. Neurotoxicology. 2010 Sep; 31(5):468-74. PMID: 19879291.
      View in: PubMed
    48. Hess-Wilson JK, Webb SL, Daly HK, Leung YK, Boldison J, Comstock CE, Sartor MA, Ho SM, Knudsen KE. Unique bisphenol A transcriptome in prostate cancer: novel effects on ERbeta expression that correspond to androgen receptor mutation status. Environ Health Perspect. 2007 Nov; 115(11):1646-53. PMID: 18007998.
      View in: PubMed
    49. Mak P, Leung YK, Tang WY, Harwood C, Ho SM. Apigenin suppresses cancer cell growth through ERbeta. Neoplasia. 2006 Nov; 8(11):896-904. PMID: 17132221.
      View in: PubMed
    50. Ho SM, Leung YK, Chung I. Estrogens and antiestrogens as etiological factors and therapeutics for prostate cancer. Ann N Y Acad Sci. 2006 Nov; 1089:177-93. PMID: 17261766.
      View in: PubMed
    51. Leung YK, Mak P, Hassan S, Ho SM. Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling. Proc Natl Acad Sci U S A. 2006 Aug 29; 103(35):13162-7. PMID: 16938840.
      View in: PubMed
    52. Leung YK, Gao Y, Lau KM, Zhang X, Ho SM. ICI 182,780-regulated gene expression in DU145 prostate cancer cells is mediated by estrogen receptor-beta/NFkappaB crosstalk. Neoplasia. 2006 Apr; 8(4):242-9. PMID: 16756716.
      View in: PubMed
    53. Leung YK, Ho JW. Deciphering signaling control by phosphoproteome using mass spectrometry. Protein Pept Lett. 2006; 13(5):467-9. PMID: 16800799.
      View in: PubMed
    54. Leung YK, Lau KM, Mobley J, Jiang Z, Ho SM. Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis. Cancer Res. 2005 May 01; 65(9):3726-34. PMID: 15867368.
      View in: PubMed
    55. Ho JW, Song JZ, Leung YK. Activation of p53 by specific agents in potential cancer therapy. Curr Med Chem Anticancer Agents. 2005 Mar; 5(2):131-5. PMID: 15777220.
      View in: PubMed
    56. Leung YK, Wong KF, Lee HK, Ho JW. Cloning and characterization of chironomidae ferrochelatase: copper activation of the purified ferrochelatase. Mol Cell Biochem. 2004 Jul; 262(1-2):225-31. PMID: 15532727.
      View in: PubMed
    57. Zhu X, Leav I, Leung YK, Wu M, Liu Q, Gao Y, McNeal JE, Ho SM. Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis. Am J Pathol. 2004 Jun; 164(6):2003-12. PMID: 15161636.
      View in: PubMed
    58. Tam NN, Gao Y, Leung YK, Ho SM. Androgenic regulation of oxidative stress in the rat prostate: involvement of NAD(P)H oxidases and antioxidant defense machinery during prostatic involution and regrowth. Am J Pathol. 2003 Dec; 163(6):2513-22. PMID: 14633623.
      View in: PubMed
    59. Leung YK, Ng TB, Ho JW. Transcriptional regulation of fosl-1 by licorice in rat Clone 9 cells. Life Sci. 2003 Oct 31; 73(24):3109-21. PMID: 14550851.
      View in: PubMed
    60. Lau KM, Tam NN, Thompson C, Cheng RY, Leung YK, Ho SM. Age-associated changes in histology and gene-expression profile in the rat ventral prostate. Lab Invest. 2003 May; 83(5):743-57. PMID: 12746483.
      View in: PubMed
    61. Ho JW, Leung YK, Chan CP. Herbal medicine in the treatment of cancer. Curr Med Chem Anticancer Agents. 2002 Mar; 2(2):209-14. PMID: 12678744.
      View in: PubMed
    62. Leung YK, Ho JW. Induction of UDP-glucuronosyltransferase 1A8 mRNA by 3-methylcholanthene in rat hepatoma cells. Biochem Pharmacol. 2002 Feb 15; 63(4):767-75. PMID: 11992647.
      View in: PubMed
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