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Yuet-Kin Leung

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPharmacology & Toxicology, College of Medicine
Address200 South Cedar
Mail Slot # 611
Little Rock AR 72202
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    Collapse Affiliation 
    Collapse member of
    UAMS Winthrop P. Rockefeller Cancer Institute

    Collapse Biography 
    Collapse education and training
    Executive Healthcare Leadership Institute, Sam M. Walton College of Business, University of Arkansas06/2024Executive Healthcare Leadership

    Collapse Teaching 

    Collapse Research 
    Collapse research activities and funding
    Award #2217824     (HO, SHUK-MEI)Aug 1, 2022 - Jul 31, 2028
    National Science Foundation - Pass Through: Louisiana Tech University
    NSF, RII Track-2 FEC: Facilitating Ubiquitous Technology Utilizing Resilient Eco-friendly Sensors (FUTURE Sensors)
    Role: Co-Investigator
    W81XWH-22-1-0152     (Ho, Shuk-Mei)May 1, 2022 - Apr 30, 2026
    DOD
    DNA methylation markers associated with exposure and adverse health outcomes in Veterans exposed to airborne hazards from open burn pits
    Role: Co-Investigator
    R01ES032675     (Ho/Leung)Apr 29, 2022 - Apr 28, 2027
    NIH
    RNA modifications by paternal exposure to arsenic and intergenerational effects on sperm quality
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Shahror RA, Shosha E, Ji MH, Morris CA, Wild M, Zaman B, Mitchell CD, Tetelbom P, Leung YK, Phillips PH, Sallam AA, Fouda AY. Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology. Transl Vis Sci Technol. 2024 Aug 01; 13(8):30. PMID: 39163016.
      View in: PubMed
    2. Cortes-Ramirez SA, Ho SM, Leung YK. Endocrine-Disrupting Chemicals: A Looming Threat to Current and Future Generations. Int J Mol Sci. 2024 Jul 27; 25(15). PMID: 39125790.
      View in: PubMed
    3. Puvvula J, Braun JM, DeFranco EA, Ho SM, Leung YK, Huang S, Zhang X, Vuong AM, Kim SS, Percy Z, Calafat AM, Botelho JC, Chen A. Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells. Epigenetics Commun. 2024; 4(1):4. PMID: 38962689.
      View in: PubMed
    4. Leung YK, Lee SG, Wang J, Guruvaiah P, Rusch NJ, Ho SM, Park C, Kim K. The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/?-catenin Signaling via Epigenetic Dysregulation that Enhances Sp1-? catenin-p300 Interactions in Hepatocellular Carcinoma. Adv Sci (Weinh). 2024 Aug; 11(29):e2308539. PMID: 38790135.
      View in: PubMed
    5. Puvvula J, Manz KE, Braun JM, Pennell KD, DeFranco EA, Ho SM, Leung YK, Huang S, Vuong AM, Kim SS, Percy ZP, Bhashyam P, Lee R, Jones DP, Tran V, Kim DV, Chen A. Maternal and newborn metabolomic changes associated with urinary polycyclic aromatic hydrocarbon metabolite concentrations at delivery: an untargeted approach. Metabolomics. 2023 Dec 14; 20(1):6. PMID: 38095785.
      View in: PubMed
    6. Wang X, DeFilippis RA, Weldemichael T, Gunaganti N, Tran P, Leung YK, Shah NP, Li HY. An imidazo[1,2-a]pyridine-pyridine derivative potently inhibits FLT3-ITD and FLT3-ITD secondary mutants, including gilteritinib-resistant FLT3-ITD/F691L. Eur J Med Chem. 2024 Jan 15; 264:115977. PMID: 38056299.
      View in: PubMed
    7. Tu SM, Chen JZ, Singh SR, Aydin AM, Gokden N, Tam NNC, Leung YK, Langford T, Ho SM. Stem Cell Theory of Cancer: Clinical Implications of Epigenomic versus Genomic Biomarkers in Cancer Care. Cancers (Basel). 2023 Nov 22; 15(23). PMID: 38067237.
      View in: PubMed
    8. Wang X, DeFilippis RA, Leung YK, Shah NP, Li HY. N-(3-Methoxyphenyl)-6-(7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl)pyridin-2-amine is an inhibitor of the FLT3-ITD and BCR-ABL pathways, and potently inhibits FLT3-ITD/D835Y and FLT3-ITD/F691L secondary mutants. Bioorg Chem. 2024 Feb; 143:106966. PMID: 37995643.
      View in: PubMed
    9. Leung YK. A Silent Threat: Exploring the Impact of Endocrine Disruption on Human Health. Int J Mol Sci. 2023 Jun 06; 24(12). PMID: 37372939.
      View in: PubMed
    10. Zhang L, Moccia M, Briggs DC, Bharate JB, Lakkaniga NR, Knowles P, Yan W, Tran P, Kharbanda A, Wang X, Leung YK, Frett B, Santoro M, McDonald NQ, Carlomagno F, Li HY. Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose. J Med Chem. 2022 01 27; 65(2):1536-1551. PMID: 35081714.
      View in: PubMed
    11. McDermott A, Kim K, Kasper S, Ho SM, Leung YK. The androgen receptor inhibits transcription of GPER1 by preventing Sp1 and Sp3 from binding to the promoters in prostate cancer cells. Oncotarget. 2022; 13:46-60. PMID: 35018219.
      View in: PubMed
    12. Ho SM, Rao R, Ouyang B, Tam NNC, Schoch E, Song D, Ying J, Leung YK, Govindarajah V, Tarapore P. Three-Generation Study of Male Rats Gestationally Exposed to High Butterfat and Bisphenol A: Impaired Spermatogenesis, Penetrance with Reduced Severity. Nutrients. 2021 Oct 17; 13(10). PMID: 34684636.
      View in: PubMed
    13. Zhang L, Lakkaniga NR, Bharate JB, Mcconnell N, Wang X, Kharbanda A, Leung YK, Frett B, Shah NP, Li HY. Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor. Eur J Med Chem. 2021 Dec 05; 225:113776. PMID: 34479037.
      View in: PubMed
    14. Kharbanda A, Tran P, Zhang L, Leung YK, Li HY, Frett B. Discovery of 4-aminoquinolines as highly selective TGF?R1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology. Eur J Med Chem. 2021 Dec 05; 225:113763. PMID: 34419892.
      View in: PubMed
    15. Kharbanda A, Zhang L, Saha D, Tran P, Xu K, Li MO, Leung YK, Frett B, Li HY. Discovery and biological evaluation of phthalazines as novel non-kinase TGF? pathway inhibitors. Eur J Med Chem. 2021 Nov 05; 223:113660. PMID: 34246853.
      View in: PubMed
    16. Padala KP, Padala PR, Leung YK, Dennis RA, Ho SM. Untangling the Complex Interactions of Open Burn Pit Exposure and Health Outcomes: Response to Brumage et al. Prim Care Companion CNS Disord. 2021 04 22; 23(2). PMID: 34000124.
      View in: PubMed
    17. Leung YK, Biesiada J, Govindarajah V, Ying J, Kendler A, Medvedovic M, Ho SM. Low-Dose Bisphenol A in a Rat Model of Endometrial Cancer: A CLARITY-BPA Study. Environ Health Perspect. 2020 12; 128(12):127005. PMID: 33296240.
      View in: PubMed
    18. Padala KP, Padala PR, Leung YK, Dennis RA, Ho SM. Open Burn Pit Exposure and Concern About the COVID-19 Pandemic. Prim Care Companion CNS Disord. 2020 11 05; 22(6). PMID: 33166097.
      View in: PubMed
    19. Lakkaniga NR, Gunaganti N, Zhang L, Belachew B, Frett B, Leung YK, Li HY. Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation. Eur J Med Chem. 2020 Nov 15; 206:112691. PMID: 32823007.
      View in: PubMed
    20. Wongsurawat T, Jenjaroenpun P, De Loose A, Alkam D, Ussery DW, Nookaew I, Leung YK, Ho SM, Day JD, Rodriguez A. A novel Cas9-targeted long-read assay for simultaneous detection of IDH1/2 mutations and clinically relevant MGMT methylation in fresh biopsies of diffuse glioma. Acta Neuropathol Commun. 2020 06 20; 8(1):87. PMID: 32563269.
      View in: PubMed
    21. Lu Y, Liu X, Zhang E, Kopras EJ, Smith EP, Astreinidis A, Li C, Leung YK, Ho SM, Yu JJ. Estrogen activates pyruvate kinase M2 and increases the growth of TSC2-deficient cells. PLoS One. 2020; 15(2):e0228894. PMID: 32078667.
      View in: PubMed
    22. Langevin SM, Kuhnell D, Niu L, Biesiada J, Leung YK, Deka R, Chen A, Medvedovic M, Kelsey KT, Kasper S, Zhang X. Comprehensive mapping of the methylation landscape of 16 CpG-dense regions in oral and pharyngeal squamous cell carcinoma. Epigenomics. 2019 07; 11(9):987-1002. PMID: 31215230.
      View in: PubMed
    23. Khanal T, Leung YK, Jiang W, Timchenko N, Ho SM, Kim K. NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries. FASEB J. 2019 07; 33(7):8335-8348. PMID: 30991008.
      View in: PubMed
    24. Xie C, Leung YK, Chen A, Long DX, Hoyo C, Ho SM. Differential methylation values in differential methylation analysis. Bioinformatics. 2019 04 01; 35(7):1094-1097. PMID: 30184051.
      View in: PubMed
    25. Leung YK, Chan QK, Ng CF, Ma FM, Tse HM, To KF, Maranchie J, Ho SM, Lau KM. Correction: Hsa-miRNA-765 as a Key Mediator for Inhibiting Growth, Migration and Invasion in Fulvestrant-Treated Prostate Cancer. PLoS One. 2019; 14(3):e0214184. PMID: 30883603.
      View in: PubMed
    26. Dworatzek E, Mahmoodzadeh S, Schriever C, Kusumoto K, Kramer L, Santos G, Fliegner D, Leung YK, Ho SM, Zimmermann WH, Lutz S, Regitz-Zagrosek V. Sex-specific regulation of collagen I and III expression by 17?-Estradiol in cardiac fibroblasts: role of estrogen receptors. Cardiovasc Res. 2019 02 01; 115(2):315-327. PMID: 30016401.
      View in: PubMed
    27. Leung YK, Ouyang B, Niu L, Xie C, Ying J, Medvedovic M, Chen A, Weihe P, Valvi D, Grandjean P, Ho SM. Identification of sex-specific DNA methylation changes driven by specific chemicals in cord blood in a Faroese birth cohort. Epigenetics. 2018; 13(3):290-300. PMID: 29560787.
      View in: PubMed
    28. Alexander J, Teague AM, Chen J, Aston CE, Leung YK, Chernausek S, Simmons RA, Pinney SE. Offspring sex impacts DNA methylation and gene expression in placentae from women with diabetes during pregnancy. PLoS One. 2018; 13(2):e0190698. PMID: 29470513.
      View in: PubMed
    29. Khanal T, Choi K, Leung YK, Wang J, Kim D, Janakiram V, Cho SG, Puga A, Ho SM, Kim K. Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer. Sci Rep. 2017 09 06; 7(1):10662. PMID: 28878246.
      View in: PubMed
    30. Chen T, Lu L, Xu C, Lin X, Leung YK, Ho SM, Ruan XZ, Lian X. Inhibition Role of Atherogenic Diet on Ethyl Carbamate Induced Lung Tumorigenesis in C57BL/6J Mice. Sci Rep. 2017 07 05; 7(1):4723. PMID: 28680122.
      View in: PubMed
    31. Leung YK, Govindarajah V, Cheong A, Veevers J, Song D, Gear R, Zhu X, Ying J, Kendler A, Medvedovic M, Belcher S, Ho SM. Gestational high-fat diet and bisphenol A exposure heightens mammary cancer risk. Endocr Relat Cancer. 2017 07; 24(7):365-378. PMID: 28487351.
      View in: PubMed
    32. Tarapore P, Hennessy M, Song D, Ying J, Ouyang B, Govindarajah V, Leung YK, Ho SM. Data on spermatogenesis in rat males gestationally exposed to bisphenol A and high fat diets. Data Brief. 2016 Dec; 9:812-817. PMID: 27872877.
      View in: PubMed
    33. Tarapore P, Hennessy M, Song D, Ying J, Ouyang B, Govindarajah V, Leung YK, Ho SM. High butter-fat diet and bisphenol A additively impair male rat spermatogenesis. Reprod Toxicol. 2017 03; 68:191-199. PMID: 27658648.
      View in: PubMed
    34. Xu Z, Taylor JA, Leung YK, Ho SM, Niu L. oxBS-MLE: an efficient method to estimate 5-methylcytosine and 5-hydroxymethylcytosine in paired bisulfite and oxidative bisulfite treated DNA. Bioinformatics. 2016 12 01; 32(23):3667-3669. PMID: 27522082.
      View in: PubMed
    35. Zhou Z, Kennell C, Lee JY, Leung YK, Tarapore P. Calcium phosphate-polymer hybrid nanoparticles for enhanced triple negative breast cancer treatment via co-delivery of paclitaxel and miR-221/222 inhibitors. Nanomedicine. 2017 02; 13(2):403-410. PMID: 27520723.
      View in: PubMed
    36. Cheong A, Zhang X, Cheung YY, Tang WY, Chen J, Ye SH, Medvedovic M, Leung YK, Prins GS, Ho SM. DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk. Epigenetics. 2016 09; 11(9):674-689. PMID: 27415467.
      View in: PubMed
    37. Ho SM, Cheong A, Adgent MA, Veevers J, Suen AA, Tam NNC, Leung YK, Jefferson WN, Williams CJ. Environmental factors, epigenetics, and developmental origin of reproductive disorders. Reprod Toxicol. 2017 03; 68:85-104. PMID: 27421580.
      View in: PubMed
    38. Rizzardi AE, Zhang X, Vogel RI, Kolb S, Geybels MS, Leung YK, Henriksen JC, Ho SM, Kwak J, Stanford JL, Schmechel SC. Quantitative comparison and reproducibility of pathologist scoring and digital image analysis of estrogen receptor ?2 immunohistochemistry in prostate cancer. Diagn Pathol. 2016 Jul 11; 11(1):63. PMID: 27401406.
      View in: PubMed
    39. Miller M, Bailey B, Govindarajah V, Levin L, Metzger T, Pinney SM, Leung YK, Ho SM. A community survey on knowledge of the impact of environmental and epigenetic factors on health and disease. Perspect Public Health. 2016 Nov; 136(6):345-352. PMID: 26941233.
      View in: PubMed
    40. Schade GR, Holt SK, Zhang X, Song D, Wright JL, Zhao S, Kolb S, Lam HM, Levin L, Leung YK, Ho SM, Stanford JL. Prostate Cancer Expression Profiles of Cytoplasmic ER?1 and Nuclear ER?2 are Associated with Poor Outcomes following Radical Prostatectomy. J Urol. 2016 06; 195(6):1760-6. PMID: 26804755.
      View in: PubMed
    41. Stevenson M, Alexander B, Baxter CS, Leung YK. Evaluating Endocrine Disruption Activity of Deposits on Firefighting Gear Using a Sensitive and High Throughput Screening Method. J Occup Environ Med. 2015 Dec; 57(12):e153-7. PMID: 26641839.
      View in: PubMed
    42. Govindarajah V, Leung YK, Ying J, Gear R, Bornschein RL, Medvedovic M, Ho SM. In utero exposure of rats to high-fat diets perturbs gene expression profiles and cancer susceptibility of prepubertal mammary glands. J Nutr Biochem. 2016 Mar; 29:73-82. PMID: 26895667.
      View in: PubMed
    43. Martinez AM, Cheong A, Ying J, Xue J, Kannan K, Leung YK, Thomas MA, Ho SM. Effects of High-Butterfat Diet on Embryo Implantation in Female Rats Exposed to Bisphenol A. Biol Reprod. 2015 Dec; 93(6):147. PMID: 26510865.
      View in: PubMed
    44. Panchanathan R, Liu H, Leung YK, Ho SM, Choubey D. Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells. Mol Cell Endocrinol. 2015 Nov 05; 415:45-55. PMID: 26277401.
      View in: PubMed
    45. Ho SM, Cheong A, Lam HM, Hu WY, Shi GB, Zhu X, Chen J, Zhang X, Medvedovic M, Leung YK, Prins GS. Exposure of Human Prostaspheres to Bisphenol A Epigenetically Regulates SNORD Family Noncoding RNAs via Histone Modification. Endocrinology. 2015 Nov; 156(11):3984-95. PMID: 26248216.
      View in: PubMed
    46. Zhou Z, Badkas A, Stevenson M, Lee JY, Leung YK. Herceptin conjugated PLGA-PHis-PEG pH sensitive nanoparticles for targeted and controlled drug delivery. Int J Pharm. 2015 Jun 20; 487(1-2):81-90. PMID: 25865568.
      View in: PubMed
    47. Yang WS, Chadalapaka G, Cho SG, Lee SO, Jin UH, Jutooru I, Choi K, Leung YK, Ho SM, Safe S, Kim K. The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis. Neoplasia. 2014 Dec; 16(12):1059-69. PMID: 25499219.
      View in: PubMed
    48. Leung YK, Chan QK, Ng CF, Ma FM, Tse HM, To KF, Maranchie J, Ho SM, Lau KM. Hsa-miRNA-765 as a key mediator for inhibiting growth, migration and invasion in fulvestrant-treated prostate cancer. PLoS One. 2014; 9(5):e98037. PMID: 24837491.
      View in: PubMed
    49. Knower KC, To SQ, Leung YK, Ho SM, Clyne CD. Endocrine disruption of the epigenome: a breast cancer link. Endocr Relat Cancer. 2014 Apr; 21(2):T33-55. PMID: 24532474.
      View in: PubMed
    50. Langevin SM, Pinney SM, Leung YK, Ho SM. Does epigenetic drift contribute to age-related increases in breast cancer risk? Epigenomics. 2014; 6(4):367-9. PMID: 25333845.
      View in: PubMed
    51. Lee MT, Ho SM, Tarapore P, Chung I, Leung YK. Estrogen receptor ? isoform 5 confers sensitivity of breast cancer cell lines to chemotherapeutic agent-induced apoptosis through interaction with Bcl2L12. Neoplasia. 2013 Nov; 15(11):1262-71. PMID: 24339738.
      View in: PubMed
    52. Lee MT, Leung YK, Chung I, Tarapore P, Ho SM. Estrogen receptor ? (ER?1) transactivation is differentially modulated by the transcriptional coregulator Tip60 in a cis-acting element-dependent manner. J Biol Chem. 2013 Aug 30; 288(35):25038-25052. PMID: 23857583.
      View in: PubMed
    53. Lee MT, Ouyang B, Ho SM, Leung YK. Differential expression of estrogen receptor beta isoforms in prostate cancer through interplay between transcriptional and translational regulation. Mol Cell Endocrinol. 2013 Aug 25; 376(1-2):125-35. PMID: 23806560.
      View in: PubMed
    54. Brunst KJ, Leung YK, Ryan PH, Khurana Hershey GK, Levin L, Ji H, Lemasters GK, Ho SM. Forkhead box protein 3 (FOXP3) hypermethylation is associated with diesel exhaust exposure and risk for childhood asthma. J Allergy Clin Immunol. 2013 Feb; 131(2):592-4.e1-3. PMID: 23260754.
      View in: PubMed
    55. Leung YK, Lee MT, Lam HM, Tarapore P, Ho SM. Estrogen receptor-beta and breast cancer: translating biology into clinical practice. Steroids. 2012 Jun; 77(7):727-37. PMID: 22465878.
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    56. Lam HM, Suresh Babu CV, Wang J, Yuan Y, Lam YW, Ho SM, Leung YK. Phosphorylation of human estrogen receptor-beta at serine 105 inhibits breast cancer cell migration and invasion. Mol Cell Endocrinol. 2012 Jul 06; 358(1):27-35. PMID: 22370157.
      View in: PubMed
    57. Ho SM, Johnson A, Tarapore P, Janakiram V, Zhang X, Leung YK. Environmental epigenetics and its implication on disease risk and health outcomes. ILAR J. 2012; 53(3-4):289-305. PMID: 23744968.
      View in: PubMed
    58. Ho SM, Lee MT, Lam HM, Leung YK. Estrogens and prostate cancer: etiology, mediators, prevention, and management. Endocrinol Metab Clin North Am. 2011 Sep; 40(3):591-614, ix. PMID: 21889723.
      View in: PubMed
    59. Leung YK, Ho SM. Estrogen receptor ?: switching to a new partner and escaping from estrogen. Sci Signal. 2011 Apr 12; 4(168):pe19. PMID: 21487104.
      View in: PubMed
    60. Ouyang B, Leung YK, Wang V, Chung E, Levin L, Bracken B, Cheng L, Ho SM. a-Methylacyl-CoA racemase spliced variants and their expression in normal and malignant prostate tissues. Urology. 2011 Jan; 77(1):249.e1-7. PMID: 21195844.
      View in: PubMed
    61. Leung YK, Lam HM, Wu S, Song D, Levin L, Cheng L, Wu CL, Ho SM. Estrogen receptor beta2 and beta5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion. Endocr Relat Cancer. 2010 Sep; 17(3):675-89. PMID: 20501637.
      View in: PubMed
    62. Zhang X, Wu M, Xiao H, Lee MT, Levin L, Leung YK, Ho SM. Methylation of a single intronic CpG mediates expression silencing of the PMP24 gene in prostate cancer. Prostate. 2010 May 15; 70(7):765-76. PMID: 20054818.
      View in: PubMed
    63. Haynes EN, Heckel P, Ryan P, Roda S, Leung YK, Sebastian K, Succop P. Environmental manganese exposure in residents living near a ferromanganese refinery in Southeast Ohio: a pilot study. Neurotoxicology. 2010 Sep; 31(5):468-74. PMID: 19879291.
      View in: PubMed
    64. Hess-Wilson JK, Webb SL, Daly HK, Leung YK, Boldison J, Comstock CE, Sartor MA, Ho SM, Knudsen KE. Unique bisphenol A transcriptome in prostate cancer: novel effects on ERbeta expression that correspond to androgen receptor mutation status. Environ Health Perspect. 2007 Nov; 115(11):1646-53. PMID: 18007998.
      View in: PubMed
    65. Mak P, Leung YK, Tang WY, Harwood C, Ho SM. Apigenin suppresses cancer cell growth through ERbeta. Neoplasia. 2006 Nov; 8(11):896-904. PMID: 17132221.
      View in: PubMed
    66. Ho SM, Leung YK, Chung I. Estrogens and antiestrogens as etiological factors and therapeutics for prostate cancer. Ann N Y Acad Sci. 2006 Nov; 1089:177-93. PMID: 17261766.
      View in: PubMed
    67. Leung YK, Mak P, Hassan S, Ho SM. Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling. Proc Natl Acad Sci U S A. 2006 Aug 29; 103(35):13162-7. PMID: 16938840.
      View in: PubMed
    68. Leung YK, Gao Y, Lau KM, Zhang X, Ho SM. ICI 182,780-regulated gene expression in DU145 prostate cancer cells is mediated by estrogen receptor-beta/NFkappaB crosstalk. Neoplasia. 2006 Apr; 8(4):242-9. PMID: 16756716.
      View in: PubMed
    69. Leung YK, Ho JW. Deciphering signaling control by phosphoproteome using mass spectrometry. Protein Pept Lett. 2006; 13(5):467-9. PMID: 16800799.
      View in: PubMed
    70. Leung YK, Lau KM, Mobley J, Jiang Z, Ho SM. Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis. Cancer Res. 2005 May 01; 65(9):3726-34. PMID: 15867368.
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    71. Ho JW, Song JZ, Leung YK. Activation of p53 by specific agents in potential cancer therapy. Curr Med Chem Anticancer Agents. 2005 Mar; 5(2):131-5. PMID: 15777220.
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    72. Leung YK, Wong KF, Lee HK, Ho JW. Cloning and characterization of chironomidae ferrochelatase: copper activation of the purified ferrochelatase. Mol Cell Biochem. 2004 Jul; 262(1-2):225-31. PMID: 15532727.
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    73. Zhu X, Leav I, Leung YK, Wu M, Liu Q, Gao Y, McNeal JE, Ho SM. Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis. Am J Pathol. 2004 Jun; 164(6):2003-12. PMID: 15161636.
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    74. Tam NN, Gao Y, Leung YK, Ho SM. Androgenic regulation of oxidative stress in the rat prostate: involvement of NAD(P)H oxidases and antioxidant defense machinery during prostatic involution and regrowth. Am J Pathol. 2003 Dec; 163(6):2513-22. PMID: 14633623.
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    75. Leung YK, Ng TB, Ho JW. Transcriptional regulation of fosl-1 by licorice in rat Clone 9 cells. Life Sci. 2003 Oct 31; 73(24):3109-21. PMID: 14550851.
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    76. Lau KM, Tam NN, Thompson C, Cheng RY, Leung YK, Ho SM. Age-associated changes in histology and gene-expression profile in the rat ventral prostate. Lab Invest. 2003 May; 83(5):743-57. PMID: 12746483.
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    77. Ho JW, Leung YK, Chan CP. Herbal medicine in the treatment of cancer. Curr Med Chem Anticancer Agents. 2002 Mar; 2(2):209-14. PMID: 12678744.
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    78. Leung YK, Ho JW. Induction of UDP-glucuronosyltransferase 1A8 mRNA by 3-methylcholanthene in rat hepatoma cells. Biochem Pharmacol. 2002 Feb 15; 63(4):767-75. PMID: 11992647.
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