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Shengyu Mu

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPharmacology & Toxicology, College of Medicine
Address4301 W Markham St.
Mail slot #611
Little Rock AR 72205
Phone501-603-1081
ORCID ORCID Icon0000-0001-9368-7881 Additional info
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    Collapse Research 
    Collapse research activities and funding
    1F31HL175932-01     (MU, SHENGYU)Sep 30, 2024 - Aug 31, 2026
    NIH/Nat. Heart, Lung & Blood Institute
    Kidney-resident memory CD8+ T cells promote hypertension and memorize salt sensitivity.
    Role: Principal Investigator
    2R01HL146713     (MU, SHENGYU)Apr 10, 2024 - Mar 31, 2029
    NIH/Nat. Heart, Lung & Blood Institute
    T cell homing to the kidney contributes to salt retention and blood pressure regulation - Continuation
    Role: Principal Investigator
    5R01HL146713-08     (MU, SHENGYU)Apr 1, 2024 - Mar 31, 2029
    NIH/Nat. Heart, Lung & Blood Institute
    T cell homing to the kidney contributes to salt retention and blood pressure regulation - Continuation
    Role: Principal Investigator
    5R01HL146713-09     (MU, SHENGYU)Apr 1, 2024 - Mar 31, 2029
    NIH/Nat. Heart, Lung & Blood Institute
    T cell homing to the kidney contributes to salt retention and blood pressure regulation - Continuation
    Role: Principal Investigator
    5R01HL146713-10     (MU, SHENGYU)Apr 1, 2024 - Mar 31, 2029
    NIH/Nat. Heart, Lung & Blood Institute
    T cell homing to the kidney contributes to salt retention and blood pressure regulation - Continuation
    Role: Principal Investigator
    2024-38821-42096     (MU, SHENGYU)Apr 1, 2024 - Mar 31, 2027
    US Department of Agriculture - Pass Through: University of Arkansas at Pine Bluff
    Determination of antihypertensive, anti-inflammatory and chymase inhibitory efficacy of sweet potato and rice bran extract
    Role: Principal Investigator
    N/A - Advance Account     (MU, SHENGYU)Apr 1, 2024 - Mar 31, 2027
    US Department of Agriculture - Pass Through: University of Arkansas at Pine Bluff
    Determination of antihypertensive, anti-inflammatory and chymase inhibitory efficacy of sweet potato and rice bran extract
    Role: Principal Investigator
    24PRE1198737     (MU, SHENGYU)Jan 1, 2024 - Dec 31, 2025
    American Heart Association
    AHA Pre-doc Fellowship Deck
    Role: Principal Investigator
    23TPA1076467     (MU, SHENGYU)Jul 1, 2023 - Jun 30, 2026
    American Heart Association
    Formation of CD8Trms in the kidney contributes to salt-memory of hypertension
    Role: Principal Investigator
    1R01HL162958     (Ding)Apr 1, 2022 - Jul 31, 2023
    NIH/Nat. Heart, Lung & Blood Institute
    Impact of hemodynamics on efferocytosis in endothelial cells
    Role: Principal Investigator
    5R01HL146713-07     (MU, SHENGYU)Apr 1, 2019 - Mar 31, 2029
    NIH/Nat. Heart, Lung & Blood Institute
    T cell homing to the kidney contributes to salt retention and blood pressure regulation - Continuation
    Role: Principal Investigator
    5R01HL146713-9     (MU, SHENGYU)Apr 1, 2019 - Mar 31, 2029
    NIH/Nat. Heart, Lung & Blood Institute
    T cell homing to the kidney contributes to salt retention and blood pressure regulation - Continuation
    Role: Principal Investigator
    R01HL146713     (MU, SHENGYU)Apr 1, 2019 - Mar 31, 2029
    NIH/Nat. Heart, Lung & Blood Institute
    T cell homing to the kidney contributes to salt retention and blood pressure regulation - Continuation
    Role: Principal Investigator
    Dept funds for Lab     (MU, SHENGYU)Mar 1, 2016 - Jun 30, 2016
    UAMS College of Medicine
    Mu Lab Funding
    Role: Principal Investigator
    DeptfundsforLab     (MU, SHENGYU)Mar 1, 2016 - Jun 30, 2016
    UAMS College of Medicine
    Mu Lab Funding
    Role: Principal Investigator
    15BGIA25730047     (MU, SHENGYU)Jul 1, 2015 - Jun 30, 2017
    American Heart Association (SouthWest Affiliate)
    Role of Immune Cells in kidney in the Development of Salt-Sensitive Hypertension
    Role: Principal Investigator
    P20GM109005     (BOERMA, MARJAN)Jun 24, 2015 - May 31, 2025
    NIH
    Center for Studies of Host Response to Cancer Therapy
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Pal S, Bagchi AK, Henry DS, Landes RD, Mu S, Rhee SW, Rusch NJ, Stolarz AJ. Rhythmic Contractions of Lymph Vessels and Lymph Flow Are Disrupted in Hypertensive Rats. Hypertension. 2025 Jan; 82(1):72-83. PMID: 39502071.
      View in: PubMed
    2. Shahror RA, Shosha E, Morris C, Wild M, Mu S, Csanyi G, Boerma M, Rusch NJ, Fouda AY. Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury. J Neuroinflammation. 2024 Jul 12; 21(1):170. PMID: 38997746.
      View in: PubMed
    3. Andrews JT, Zhang Z, Prasad GVRK, Huey F, Nazarova EV, Wang J, Ranaraja A, Weinkopff T, Li LX, Mu S, Birrer MJ, Huang SC, Zhang N, Arg?ello RJ, Philips JA, Mattila JT, Huang L. Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis. Mucosal Immunol. 2024 Oct; 17(5):825-842. PMID: 38844208.
      View in: PubMed
    4. Hao J, Qiang P, Fan L, Xiong Y, Chang Y, Yang F, Wang X, Shimosawa T, Mu S, Xu Q. Eplerenone reduces lymphangiogenesis in the contralateral kidneys of UUO rats. Sci Rep. 2024 05 01; 14(1):9976. PMID: 38693148.
      View in: PubMed
    5. Benson LN, Deck KS, Mora CJ, Guo Y, Rafferty TM, Li LX, Huang L, Andrews JT, Qin Z, Trott DW, Hoover RS, Liu Y, Mu S. P2X7-Mediated Antigen-Independent Activation of CD8+ T Cells Promotes Salt-Sensitive Hypertension. Hypertension. 2024 Mar; 81(3):530-540. PMID: 38193292.
      View in: PubMed
    6. Benson LN, Mu S. Interferon gamma in the pathogenesis of hypertension - recent insights. Curr Opin Nephrol Hypertens. 2024 03 01; 33(2):154-160. PMID: 38164939.
      View in: PubMed
    7. Chen J, Lin Z, Song J, Plaisance-Bonstaff K, James J, Mu S, Post SR, Dai L, Qin Z. Echinomycin as a promising therapeutic agent against KSHV-related malignancies. J Hematol Oncol. 2023 05 04; 16(1):48. PMID: 37143124.
      View in: PubMed
    8. Chen J, Song J, Plaisance-Bonstaff K, Mu S, Post SR, Dai L, Qin Z. Role of Histamine and Related Signaling in Kaposi's Sarcoma-Associated Herpesvirus Pathogenesis and Oncogenesis. Viruses. 2023 04 20; 15(4). PMID: 37112991.
      View in: PubMed
    9. Benson LN, Guo Y, Deck K, Mora C, Liu Y, Mu S. The link between immunity and hypertension in the kidney and heart. Front Cardiovasc Med. 2023; 10:1129384. PMID: 36970367.
      View in: PubMed
    10. Qi X, Rusch NJ, Fan J, Mora CJ, Xie L, Mu S, Rabinovitch PS, Zhang H. Mitochondrial proton leak in cardiac aging. Geroscience. 2023 08; 45(4):2135-2143. PMID: 36856945.
      View in: PubMed
    11. Benson LN, Liu Y, Deck K, Mora C, Mu S. IFN-? Contributes to the Immune Mechanisms of Hypertension. Kidney360. 2022 12 29; 3(12):2164-2173. PMID: 36591357.
      View in: PubMed
    12. Stolarz AJ, Mu S, Zhang H, Fouda AY, Rusch NJ, Ding Z. Opinion: Endothelial Cells - Macrophage-Like Gatekeepers? Front Immunol. 2022; 13:902945. PMID: 35619719.
      View in: PubMed
    13. Deck KS, Mu S. uEVs: A Potential Tool for Examining Renal Epithelial Cells. Kidney360. 2022 05 26; 3(5):796-798. PMID: 36128488.
      View in: PubMed
    14. Dai L, Lu YC, Chen J, Plaisance-Bonstaff K, Mu S, Forrest JC, Whitby D, Post SR, Qin Z. Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients. Front Microbiol. 2022; 13:882520. PMID: 35516440.
      View in: PubMed
    15. Benson LN, Liu Y, Wang X, Xiong Y, Rhee SW, Guo Y, Deck KS, Mora CJ, Li LX, Huang L, Andrews JT, Qin Z, Hoover RS, Ko B, Williams RM, Heller DA, Jaimes EA, Mu S. The IFN?-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension. Circ Res. 2022 05 13; 130(10):1550-1564. PMID: 35430873.
      View in: PubMed
    16. Chen J, Barrett L, Lin Z, Kendrick S, Mu S, Dai L, Qin Z. Identification of natural compounds tubercidin and lycorine HCl against small-cell lung cancer and BCAT1 as a therapeutic target. J Cell Mol Med. 2022 05; 26(9):2557-2565. PMID: 35318805.
      View in: PubMed
    17. Shoeib AM, Benson LN, Mu S, MacMillan-Crow LA, Prather PL. Non-Canonical Cannabinoid Receptors with Distinct Binding and Signaling Properties in Prostate and Other Cancer Cell Types Mediate Cell Death. Int J Mol Sci. 2022 Mar 11; 23(6). PMID: 35328467.
      View in: PubMed
    18. Pal S, Rahman J, Mu S, Rusch NJ, Stolarz AJ. Drug-Related Lymphedema: Mysteries, Mechanisms, and Potential Therapies. Front Pharmacol. 2022; 13:850586. PMID: 35308247.
      View in: PubMed
    19. Ding Z, Wang X, Liu S, Zhou S, Kore RA, Mu S, Deng X, Fan Y, Mehta JL. Erratum: NLRP3 inflammasome via IL-1? regulates PCSK9 secretion: Erratum. Theranostics. 2022; 12(1):418. PMID: 34987654.
      View in: PubMed
    20. Shoeib AM, Yarbrough AL, Ford BM, Franks LN, Urbaniak A, Hensley LL, Benson LN, Mu S, Radominska-Pandya A, Prather PL. Characterization of cannabinoid receptors expressed in Ewing sarcoma TC-71 and A-673 cells as potential targets for anti-cancer drug development. Life Sci. 2021 Nov 15; 285:119993. PMID: 34592231.
      View in: PubMed
    21. Van S, Pal S, Garner BR, Steed K, Sridharan V, Mu S, Rusch NJ, Stolarz AJ. Dantrolene Prevents the Lymphostasis Caused by Doxorubicin in the Rat Mesenteric Circulation. Front Pharmacol. 2021; 12:727526. PMID: 34483938.
      View in: PubMed
    22. Xiong Y, Chang Y, Hao J, Zhang C, Yang F, Wang Z, Liu Y, Wang X, Mu S, Xu Q. Eplerenone Attenuates Fibrosis in the Contralateral Kidney of UUO Rats by Preventing Macrophage-to-Myofibroblast Transition. Front Pharmacol. 2021; 12:620433. PMID: 33716747.
      View in: PubMed
    23. Garner BR, Stolarz AJ, Stuckey D, Sarimollaoglu M, Liu Y, Palade PT, Rusch NJ, Mu S. KATP Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema. J Pharmacol Exp Ther. 2021 01; 376(1):40-50. PMID: 33100270.
      View in: PubMed
    24. Ding Z, Wang X, Liu S, Zhou S, Kore RA, Mu S, Deng X, Fan Y, Mehta JL. NLRP3 inflammasome via IL-1? regulates PCSK9 secretion. Theranostics. 2020; 10(16):7100-7110. PMID: 32641981.
      View in: PubMed
    25. Dai L, Chen J, Lin Z, Wang Z, Mu S, Qin Z. Targeting Sphingosine Kinase by ABC294640 against Diffuse Intrinsic Pontine Glioma (DIPG). J Cancer. 2020; 11(16):4683-4691. PMID: 32626514.
      View in: PubMed
    26. Cozart MA, Phelan KD, Wu H, Mu S, Birnbaumer L, Rusch NJ, Zheng F. Vascular smooth muscle TRPC3 channels facilitate the inverse hemodynamic response during status epilepticus. Sci Rep. 2020 01 21; 10(1):812. PMID: 31964991.
      View in: PubMed
    27. Zheng F, Mu S, Rusch NJ. Leptin Activates Trpm7 Channels in the Carotid Body As a Mechanism of Obesity-Related Hypertension. Circ Res. 2019 11 08; 125(11):1003-1005. PMID: 31697634.
      View in: PubMed
    28. Mu S, Fantegrossi WE, Rusch NJ. Cocaine-Responsive miRNA and Blood Pressure Elevation. Hypertension. 2018 04; 71(4):561-562. PMID: 29483229.
      View in: PubMed
    29. Sims CR, Singh SP, Mu S, Gokden N, Zakaria D, Nguyen TC, Mayeux PR. Rolipram Improves Outcome in a Rat Model of Infant Sepsis-Induced Cardiorenal Syndrome. Front Pharmacol. 2017; 8:237. PMID: 28515693.
      View in: PubMed
    30. Liu Y, Rafferty TM, Rhee SW, Webber JS, Song L, Ko B, Hoover RS, He B, Mu S. CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension. Nat Commun. 2017 01 09; 8:14037. PMID: 28067240.
      View in: PubMed
    31. Jimbo R, Kawakami-Mori F, Mu S, Hirohama D, Majtan B, Shimizu Y, Yatomi Y, Fukumoto S, Fujita T, Shimosawa T. Fibroblast growth factor 23 accelerates phosphate-induced vascular calcification in the absence of Klotho deficiency. Kidney Int. 2014 May; 85(5):1103-11. PMID: 24088960.
      View in: PubMed
    32. Ogura S, Shimosawa T, Mu S, Sonobe T, Kawakami-Mori F, Wang H, Uetake Y, Yoshida K, Yatomi Y, Shirai M, Fujita T. Oxidative stress augments pulmonary hypertension in chronically hypoxic mice overexpressing the oxidized LDL receptor. Am J Physiol Heart Circ Physiol. 2013 Jul 15; 305(2):H155-62. PMID: 23686713.
      View in: PubMed
    33. Shimosawa T, Mu S, Shibata S, Fujita T. The kidney and hypertension: pathogenesis of salt-sensitive hypertension. Curr Hypertens Rep. 2012 Oct; 14(5):468-72. PMID: 22752520.
      View in: PubMed
    34. Shibata S, Mu S, Kawarazaki H, Muraoka K, Ishizawa K, Yoshida S, Kawarazaki W, Takeuchi M, Ayuzawa N, Miyoshi J, Takai Y, Ishikawa A, Shimosawa T, Ando K, Nagase M, Fujita T. Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway. J Clin Invest. 2011 Aug; 121(8):3233-43. PMID: 21765214.
      View in: PubMed
    35. Mu S, Shimosawa T, Ogura S, Wang H, Uetake Y, Kawakami-Mori F, Marumo T, Yatomi Y, Geller DS, Tanaka H, Fujita T. Epigenetic modulation of the renal ?-adrenergic-WNK4 pathway in salt-sensitive hypertension. Nat Med. 2011 May; 17(5):573-80. PMID: 21499270.
      View in: PubMed
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