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Youssef Aachoui

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentMicrobiology And Immunology, College of Medicine
Address506G BIOMED
4301 W. Markham
Mail Slot # 511
Little Rock AR 72205
ORCID ORCID Icon0000-0003-0878-5511 Additional info
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    Collapse Research 
    Collapse research activities and funding
    R21AI175731     (AACHOUI, YOUSSEF)Aug 25, 2023 - Jul 31, 2025
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Pyroptotic Macrophages Traps Against Shigella Infection
    Role: Principal Investigator
    K22AI132489     (AACHOUI, YOUSSEF)Aug 2, 2018 - Jul 31, 2020
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Mechanisms of Inflammasome Defense against Cytosol-invasive Bacteria - Continuation
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Oh C, Spears TJ, Aachoui Y. Inflammasome-mediated pyroptosis in defense against pathogenic bacteria. Immunol Rev. 2025 01; 329(1):e13408. PMID: 39404258.
      View in: PubMed
    2. Oh C, Li L, Verma A, Reuven AD, Miao EA, Bliska JB, Aachoui Y. Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins. Cell Rep. 2022 11 22; 41(8):111688. PMID: 36417874.
      View in: PubMed
    3. Oh C, Verma A, Hafeez M, Hogland B, Aachoui Y. Shigella OspC3 suppresses murine cytosolic LPS sensing. iScience. 2021 Aug 20; 24(8):102910. PMID: 34409271.
      View in: PubMed
    4. Kovacs SB, Oh C, Aachoui Y, Miao EA. Evaluating cytokine production by flow cytometry using brefeldin A in mice. STAR Protoc. 2021 03 19; 2(1):100244. PMID: 33458706.
      View in: PubMed
    5. Oh C, Verma A, Aachoui Y. Caspase-11 Non-canonical Inflammasomes in the Lung. Front Immunol. 2020; 11:1895. PMID: 32973786.
      View in: PubMed
    6. Kovacs SB, Oh C, Maltez VI, McGlaughon BD, Verma A, Miao EA, Aachoui Y. Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium. Cell Rep. 2020 07 28; 32(4):107967. PMID: 32726630.
      View in: PubMed
    7. Aachoui Y, Miao EA. Down with doublespeak: NAIP/NLRC4 inflammasomes get specific. J Exp Med. 2016 05 02; 213(5):646. PMID: 27140198.
      View in: PubMed
    8. Maltez VI, Tubbs AL, Cook KD, Aachoui Y, Falcone EL, Holland SM, Whitmire JK, Miao EA. Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium. Immunity. 2015 Nov 17; 43(5):987-97. PMID: 26572063.
      View in: PubMed
    9. Aachoui Y, Kajiwara Y, Leaf IA, Mao D, Ting JP, Coers J, Aderem A, Buxbaum JD, Miao EA. Canonical Inflammasomes Drive IFN-? to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium. Cell Host Microbe. 2015 Sep 09; 18(3):320-32. PMID: 26320999.
      View in: PubMed
    10. Hagar JA, Aachoui Y, Miao EA. WildCARDs: inflammatory caspases directly detect LPS. Cell Res. 2015 Feb; 25(2):149-50. PMID: 25267404.
      View in: PubMed
    11. Hagar JA, Powell DA, Aachoui Y, Ernst RK, Miao EA. Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. Science. 2013 Sep 13; 341(6151):1250-3. PMID: 24031018.
      View in: PubMed
    12. Aachoui Y, Sagulenko V, Miao EA, Stacey KJ. Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection. Curr Opin Microbiol. 2013 Jun; 16(3):319-26. PMID: 23707339.
      View in: PubMed
    13. Aachoui Y, Leaf IA, Hagar JA, Fontana MF, Campos CG, Zak DE, Tan MH, Cotter PA, Vance RE, Aderem A, Miao EA. Caspase-11 protects against bacteria that escape the vacuole. Science. 2013 Feb 22; 339(6122):975-8. PMID: 23348507.
      View in: PubMed
    14. Roy Chowdhury R, Aachoui Y, Ghosh SK. Effects of small intestinal submucosa (SIS) on the murine innate immune microenvironment induced by heat-killed Staphylococcus aureus. PLoS One. 2012; 7(11):e48724. PMID: 23189134.
      View in: PubMed
    15. Aachoui Y, Ghosh SK. Extracellular matrix from porcine small intestinal submucosa (SIS) as immune adjuvants. PLoS One. 2011; 6(11):e27083. PMID: 22087247.
      View in: PubMed
    16. Aachoui Y, Ghosh SK. Immune enhancement by novel vaccine adjuvants in autoimmune-prone NZB/W F1 mice: relative efficacy and safety. BMC Immunol. 2011 Oct 24; 12:61. PMID: 22024358.
      View in: PubMed
    17. Aachoui Y, Schulte ML, Fitch RW, Ghosh SK. Synthetic adjuvants for vaccine formulations: evaluation of new phytol derivatives in induction and persistence of specific immune response. Cell Immunol. 2011; 271(2):308-18. PMID: 21855057.
      View in: PubMed
    18. Aachoui Y, Chowdhury RR, Fitch RW, Ghosh SK. Molecular signatures of phytol-derived immunostimulants in the context of chemokine-cytokine microenvironment and enhanced immune response. Cell Immunol. 2011; 271(2):227-38. PMID: 21813116.
      View in: PubMed
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