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Ryan Porter

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentInternal Med, College of Medicine
DivisionInternal Med Endo
Address4301 W. Markham
Mail Slot # 587
Little Rock AR 72205
ORCID ORCID Icon0000-0002-0246-5747 Additional info
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    Other Positions
    TitleAssistant Professor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentOrthopaedics, College of Medicine


    Collapse Overview 
    Collapse overview
    The Porter lab focuses on developing strategies to prevent articular cartilage degeneration or stimulate cartilage repair. Currently, his group is pursuing two areas of research: one focused on improving the intra-articular delivery of therapeutics within synovial joints to prevent or treat osteoarthritis; the other on overcoming key bottlenecks to stimulating chondrogenesis within skeletal defects. These projects use mouse, rat, and rabbit models of bone and joint injury to help answer specific research questions. This work has been supported by grants from the National Institutes of Health, the Klarman Family Foundation, the UAMS Bone and Joint Initiative, and the Arkansas Biosciences Institute.


    Collapse Research 
    Collapse research activities and funding
    HT9425     (AMBROGINI, ELENA)Mar 1, 2024 - Feb 28, 2026
    US Department of Defense
    Role of subchondral bone osteocytes in post-traumatic osteoarthritis
    Role: Principal Investigator
    HT9425-24-1-0039     (AMBROGINI, ELENA)Mar 1, 2024 - Feb 28, 2026
    US Department of Defense
    Role of subchondral bone osteocytes in post-traumatic osteoarthritis
    Role: Co-Investigator
    P20GM125503     (OBRIEN, CHARLES A)Apr 1, 2023 - Jan 31, 2028
    NIH/Nat. Inst. of General Medical Sciences
    Center for Musculoskeletal Disease Research (CMDR)
    Role: Co-Investigator
    R01AR075121     (PORTER, RYAN)Sep 21, 2020 - Jul 31, 2025
    NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases - Pass Through: Northeastern University
    Intra-cartilage depot delivery of electrically-charged IL-1RA for targeting osteoarthritis-associated inflammation and catabolism in multiple joint tissues
    Role: Co-Investigator
    R21AR071560     (PORTER, RYAN MICHAEL)Apr 1, 2018 - Mar 31, 2021
    NIH
    Harnessing Extracellular Vesicles to Direct the Repair of Osseous Defects
    Role: Principal Investigator
    R21AR069253     (PORTER, RYAN MICHAEL)Feb 7, 2016 - Jan 31, 2019
    NIH
    A Transgenic Rat for Noninvasive Assessment of Chondrogenic Activity in vivo
    Role: Principal Investigator
    N/A     Sep 1, 2013 - Aug 31, 2015
    MIT Deshpande Center for Technological Innovation - Pass Through: Massachusetts Institute of Technology
    Drug Delivery System for Treating Post Traumatic Osteoarthritis in Human and Equine Populations
    Role: Co-Investigator

    Collapse Bibliographic 
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    The links below are provided by the researcher to provide access to external online bibliographies that they keep independently from the Profiles System.
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Warren A, Porter RM, Reyes-Castro O, Ali MM, Marques-Carvalho A, Kim HN, Gatrell LB, Schipani E, Nookaew I, O'Brien CA, Morello R, Almeida M. The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice. Nat Commun. 2023 06 17; 14(1):3616. PMID: 37330524.
      View in: PubMed
    2. Williams T, Salmanian G, Burns M, Maldonado V, Smith E, Porter RM, Song YH, Samsonraj RM. Versatility of mesenchymal stem cell-derived extracellular vesicles in tissue repair and regenerative applications. Biochimie. 2023 Apr; 207:33-48. PMID: 36427681.
      View in: PubMed
    3. Panos JA, Coenen MJ, Nagelli CV, McGlinch EB, Atasoy-Zeybek A, De Padilla CL, Coghlan RF, Johnstone B, Ferreira E, Porter RM, De la Vega RE, Evans CH. IL-1Ra gene transfer potentiates BMP2-mediated bone healing by redirecting osteogenesis toward endochondral ossification. Mol Ther. 2023 02 01; 31(2):420-434. PMID: 36245128.
      View in: PubMed
    4. He T, Zhang C, Colombani T, Bencherif SA, Porter RM, Bajpayee AG. Intra-articular kinetics of a cartilage targeting cationic PEGylated protein for applications in drug delivery. Osteoarthritis Cartilage. 2023 02; 31(2):187-198. PMID: 36241136.
      View in: PubMed
    5. Ferreira E, Gatrell LB, Childress L, Wu H, Porter RM. A Transgenic Rat for Noninvasive Assessment of Chondrogenesis in Vivo. Cartilage. 2021 12; 13(2_suppl):1720S-1733S. PMID: 34809478.
      View in: PubMed
    6. Almeida M, Kim HN, Han L, Zhou D, Thostenson J, Porter RM, Ambrogini E, Manolagas SC, Jilka RL. Increased marrow adipogenesis does not contribute to age-dependent appendicular bone loss in female mice. Aging Cell. 2020 11; 19(11):e13247. PMID: 33048436.
      View in: PubMed
    7. He T, Zhang C, Vedadghavami A, Mehta S, Clark HA, Porter RM, Bajpayee AG. Multi-arm Avidin nano-construct for intra-cartilage delivery of small molecule drugs. J Control Release. 2020 02; 318:109-123. PMID: 31843642.
      View in: PubMed
    8. Mehta S, Akhtar S, Porter RM, ?nnerfjord P, Bajpayee AG. Interleukin-1 receptor antagonist (IL-1Ra) is more effective in suppressing cytokine-induced catabolism in cartilage-synovium co-culture than in cartilage monoculture. Arthritis Res Ther. 2019 11 13; 21(1):238. PMID: 31722745.
      View in: PubMed
    9. De la Vega RE, Scheu M, Brown LA, Evans CH, Ferreira E, Porter RM. Specific, Sensitive, and Stable Reporting of Human Mesenchymal Stromal Cell Chondrogenesis. Tissue Eng Part C Methods. 2019 03; 25(3):176-190. PMID: 30727864.
      View in: PubMed
    10. Almeida M, Porter RM. Sirtuins and FoxOs in osteoporosis and osteoarthritis. Bone. 2019 04; 121:284-292. PMID: 30738214.
      View in: PubMed
    11. Martin-Pena A, Porter RM, Plumton G, McCarrel TM, Morton AJ, Guijarro MV, Ghivizzani SC, Sharma B, Palmer GD. Lentiviral-based reporter constructs for profiling chondrogenic activity in primary equine cell populations. Eur Cell Mater. 2018 10 12; 36:156-170. PMID: 30311630.
      View in: PubMed
    12. Ferreira E, Porter RM. Harnessing extracellular vesicles to direct endochondral repair of large bone defects. Bone Joint Res. 2018 Apr; 7(4):263-273. PMID: 29922444.
      View in: PubMed
    13. Bajpayee AG, De la Vega RE, Scheu M, Varady NH, Yannatos IA, Brown LA, Krishnan Y, Fitzsimons TJ, Bhattacharya P, Frank EH, Grodzinsky AJ, Porter RM. Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis. Eur Cell Mater. 2017 12 05; 34:341-364. PMID: 29205258.
      View in: PubMed
    14. De La Vega RE, De Padilla CL, Trujillo M, Quirk N, Porter RM, Evans CH, Ferreira E. Contribution of Implanted, Genetically Modified Muscle Progenitor Cells Expressing BMP-2 to New Bone Formation in a Rat Osseous Defect. Mol Ther. 2018 01 03; 26(1):208-218. PMID: 29107477.
      View in: PubMed
    15. Liu F, Wells JW, Porter RM, Glatt V, Shen Z, Schinhan M, Ivkovic A, Vrahas MS, Evans CH, Ferreira E. Interaction between living bone particles and rhBMP-2 in large segmental defect healing in the rat femur. J Orthop Res. 2016 12; 34(12):2137-2145. PMID: 27037517.
      View in: PubMed
    16. Liu F, Ferreira E, Porter RM, Glatt V, Schinhan M, Shen Z, Randolph MA, Kirker-Head CA, Wehling C, Vrahas MS, Evans CH, Wells JW. Rapid and reliable healing of critical size bone defects with genetically modified sheep muscle. Eur Cell Mater. 2015 Sep 21; 30:118-30; discussion 130-1. PMID: 26388615.
      View in: PubMed
    17. Bajpayee AG, Scheu M, Grodzinsky AJ, Porter RM. A rabbit model demonstrates the influence of cartilage thickness on intra-articular drug delivery and retention within cartilage. J Orthop Res. 2015 May; 33(5):660-7. PMID: 25627105.
      View in: PubMed
    18. Sullivan CB, Porter RM, Evans CH, Ritter T, Shaw G, Barry F, Murphy JM. TNFa and IL-1? influence the differentiation and migration of murine MSCs independently of the NF-?B pathway. Stem Cell Res Ther. 2014 Aug 27; 5(4):104. PMID: 25163844.
      View in: PubMed
    19. Bajpayee AG, Scheu M, Grodzinsky AJ, Porter RM. Electrostatic interactions enable rapid penetration, enhanced uptake and retention of intra-articular injected avidin in rat knee joints. J Orthop Res. 2014 Aug; 32(8):1044-51. PMID: 24753019.
      View in: PubMed
    20. Ferreira E, Porter RM, Wehling N, O'Sullivan RP, Liu F, Boskey A, Estok DM, Harris MB, Vrahas MS, Evans CH, Wells JW. Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow. J Biol Chem. 2013 Oct 11; 288(41):29494-505. PMID: 23970554.
      View in: PubMed
    21. Florine EM, Miller RE, Porter RM, Evans CH, Kurz B, Grodzinsky AJ. Effects of Dexamethasone on Mesenchymal Stromal Cell Chondrogenesis and Aggrecanase Activity: Comparison of Agarose and Self-Assembling Peptide Scaffolds. Cartilage. 2013 Jan 01; 4(1):63-74. PMID: 24533173.
      View in: PubMed
    22. Evans CH, Liu F, Porter RM, O'Sullivan RP, Merghoub T, Lunsford EP, Robichaud K, Van Valen F, Lessnick SL, Gebhardt MC, Wells JW. EWS-FLI-1-targeted cytotoxic T-cell killing of multiple tumor types belonging to the Ewing sarcoma family of tumors. Clin Cancer Res. 2012 Oct 01; 18(19):5341-51. PMID: 22879388.
      View in: PubMed
    23. Sullivan C, Murphy JM, Griffin MD, Porter RM, Evans CH, O'Flatharta C, Shaw G, Barry F. Genetic mismatch affects the immunosuppressive properties of mesenchymal stem cells in vitro and their ability to influence the course of collagen-induced arthritis. Arthritis Res Ther. 2012 Jul 19; 14(4):R167. PMID: 22812502.
      View in: PubMed
    24. Majewski M, Porter RM, Betz OB, Betz VM, Clahsen H, Fl?ckiger R, Evans CH. Improvement of tendon repair using muscle grafts transduced with TGF-?1 cDNA. Eur Cell Mater. 2012 Feb 16; 23:94-101; discussion 101-2. PMID: 22354460.
      View in: PubMed
    25. Liu F, Porter RM, Wells J, Glatt V, Pilapil C, Evans CH. Evaluation of BMP-2 gene-activated muscle grafts for cranial defect repair. J Orthop Res. 2012 Jul; 30(7):1095-102. PMID: 22213093.
      View in: PubMed
    26. Ivkovic A, Marijanovic I, Hudetz D, Porter RM, Pecina M, Evans CH. Regenerative medicine and tissue engineering in orthopaedic surgery. Front Biosci (Elite Ed). 2011 06 01; 3(3):923-44. PMID: 21622102.
      View in: PubMed
    27. Steinert AF, Kunz M, Prager P, Barthel T, Jakob F, N?th U, Murray MM, Evans CH, Porter RM. Mesenchymal stem cell characteristics of human anterior cruciate ligament outgrowth cells. Tissue Eng Part A. 2011 May; 17(9-10):1375-88. PMID: 21247268.
      View in: PubMed
    28. Miller MA, Ivkovic A, Porter R, Harris MB, Estok DM, Smith RM, Evans CH, Vrahas MS. Autologous bone grafting on steroids: preliminary clinical results. A novel treatment for nonunions and segmental bone defects. Int Orthop. 2011 Apr; 35(4):599-605. PMID: 20414656.
      View in: PubMed
    29. Evans CH, Liu FJ, Glatt V, Hoyland JA, Kirker-Head C, Walsh A, Betz O, Wells JW, Betz V, Porter RM, Saad FA, Gerstenfeld LC, Einhorn TA, Harris MB, Vrahas MS. Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage. Eur Cell Mater. 2009 Dec 31; 18:96-111. PMID: 20073015.
      View in: PubMed
    30. Wehling N, Palmer GD, Pilapil C, Liu F, Wells JW, M?ller PE, Evans CH, Porter RM. Interleukin-1beta and tumor necrosis factor alpha inhibit chondrogenesis by human mesenchymal stem cells through NF-kappaB-dependent pathways. Arthritis Rheum. 2009 Mar; 60(3):801-12. PMID: 19248089.
      View in: PubMed
    31. Porter RM, Liu F, Pilapil C, Betz OB, Vrahas MS, Harris MB, Evans CH. Osteogenic potential of reamer irrigator aspirator (RIA) aspirate collected from patients undergoing hip arthroplasty. J Orthop Res. 2009 Jan; 27(1):42-9. PMID: 18655129.
      View in: PubMed
    32. Majewski M, Betz O, Ochsner PE, Liu F, Porter RM, Evans CH. Ex vivo adenoviral transfer of bone morphogenetic protein 12 (BMP-12) cDNA improves Achilles tendon healing in a rat model. Gene Ther. 2008 Aug; 15(16):1139-46. PMID: 18432278.
      View in: PubMed
    33. Palmer GD, Stoddart MJ, Gouze E, Gouze JN, Ghivizzani SC, Porter RM, Evans CH. A simple, lanthanide-based method to enhance the transduction efficiency of adenovirus vectors. Gene Ther. 2008 Mar; 15(5):357-63. PMID: 18283289.
      View in: PubMed
    34. Evans CH, Palmer GD, Pascher A, Porter R, Kwong FN, Gouze E, Gouze JN, Liu F, Steinert A, Betz O, Betz V, Vrahas M, Ghivizzani SC. Facilitated endogenous repair: making tissue engineering simple, practical, and economical. Tissue Eng. 2007 Aug; 13(8):1987-93. PMID: 17518747.
      View in: PubMed
    35. Porter RM, Akers RM, Howard RD, Forsten-Williams K. Alginate encapsulation impacts the insulin-like growth factor-I system of monolayer-expanded equine articular chondrocytes and cell response to interleukin-1beta. Tissue Eng. 2007 Jun; 13(6):1333-45. PMID: 17518712.
      View in: PubMed
    36. Porter RM, Akers RM, Howard RD, Forsten-Williams K. Transcriptional and proteolytic regulation of the insulin-like growth factor-I system of equine articular chondrocytes by recombinant equine interleukin-1beta. J Cell Physiol. 2006 Nov; 209(2):542-50. PMID: 16897751.
      View in: PubMed
    37. Porter RM, Huckle WR, Goldstein AS. Effect of dexamethasone withdrawal on osteoblastic differentiation of bone marrow stromal cells. J Cell Biochem. 2003 Sep 01; 90(1):13-22. PMID: 12938152.
      View in: PubMed
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