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Last Name
Institution

Gunnar Boysen

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentCollege of Public Health, College of Provost
DivisionEnvironmental & Occupational Health
Address1/1220 ED III College of Public Health
220 UAMS Campus Dr.
Mail Slot # 820
Little Rock AR 72205
Phone501-526-4956
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    Collapse Affiliation 
    Collapse member of
    American Chemistry Society
    American Association for Research on Cancer (AACR)
    American Society for Mass Spectrometry
    Society of Toxicology (SOT)
    Collapse collaborator
    University of Texas Medical Branch (UTMB)

    Collapse Research Funds 
    Collapse research overview
    Our research focus on the interplay between chemical exposure and nutritional or lifestyle habits, such as diet selection and physical activity. To achieve this we utilize DNA and protein adducts to study carcinogen metabolism, how it is modified by nutritional components and the underlying mechanisms regulating corresponding enzyme activities. In addition, studies investigate exposures related changes in common metabolic pathways, using targeted and un-targeted mass spectrometry based metabolomic approaches.

    A second line of research applies systems biology approaches such as metabolomics to improve diagnosis of lung cancer patients and to elucidate mechanism that can be targeted with common or novel drugs.

    Collapse principal investigator
    Funding Agency: NIH/Nat. Inst. of Environmental Health Sciences - Title: Effects of genetic diversity on carcinogen metabolism - Award Number: 1 R21 ES023046-01A1 - Start Date: 2014-05-07

    Funding Agency: NIH/Nat. Inst. of Environmental Health Sciences - Title: Effects of genetic diversity on carcinogen metabolism - Award Number: 5 R21 ES023046-02 - Start Date: 2014-05-07

    Funding Agency: NIH/Nat. Inst. of Environmental Health Sciences - Title: Effects of genetic diversity on carcinogen metabolism - Award Number: 5 R21 ES023046-02 - Total direct costs: $538,415 - Start Date: 2014-05-07

    Funding Agency: NIH/Nat. Inst. of Environmental Health Sciences - Title: Effects of genetic diversity on carcinogen metabolism - Award Number: 5 R21 ES023046-02 - Total direct costs: $125,000 - Start Date: 2014-05-07

    Funding Agency: UAMS, Translational Research Institute (TRI) - Title: Systems Biology Based Diagnosis of Lung Cancer - Award Number: n/a - Total Direct Cost: $10000 - Start Date: 04-01-2013 - End Date: 03-31-2014

    Pass Through Agency: The Health Effects Institute - Funding Agency: Environmental Protection Agency - Title: ProfilingDoses of Reactive Compounds Derived from various Air Pollutant Exposures - Award Number: CR-83234701 - Total direct costs: $81,167 - Start Date: 2012-04-01

    Funding Agency: National Institute for Environmental Health Sciences (NIEHS) - Title: The Role of N1-Inosine Adducts in Butadiene Mutagenesis - Award Number: 1F32ES013107 - Start Date: 11-16-2003 - End Date: 11-15-2005


    Collapse Outreach 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Boysen G. The Glutathione Conundrum: Stoichiometric Disconnect between Its Formation and Oxidative Stress. Chem Res Toxicol. 2017 May 15; 30(5):1113-1116. PMID: 28426193.
      View in: PubMed
    2. Hartman JH, Miller GP, Caro AA, Byrum SD, Orr LM, Mackintosh SG, Tackett AJ, MacMillan-Crow LA, Hallberg LM, Ameredes BT, Boysen G. 1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice. Toxicology. 2017 Mar 01; 378:114-124. PMID: 28082109.
      View in: PubMed
    3. Sappington DR, Siegel ER, Hiatt G, Desai A, Penney RB, Jamshidi-Parsian A, Griffin RJ, Boysen G. Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines. Biochim Biophys Acta. 2016 Apr; 1860(4):836-43. PMID: 26825773; PMCID: PMC4768472 [Available on 04/01/17].
    4. Bogusiewicz A, Boysen G, Mock DM. In HepG2 cells, coexisting carnitine deficiency masks important indicators of marginal biotin deficiency. J Nutr. 2015 Jan; 145(1):32-40. PMID: 25527659; PMCID: PMC4264022.
    5. Pugh CP, Pouncey DL, Hartman JH, Nshimiyimana R, Desrochers LP, Goodwin TE, Boysen G, Miller GP. Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites. Arch Biochem Biophys. 2014 Dec 15; 564:244-53. PMID: 25447818; PMCID: PMC4258421.
    6. Hartman JH, Miller GP, Boysen G. Inhibitory potency of 4-carbon alkanes and alkenes toward CYP2E1 activity. Toxicology. 2014 Apr 06; 318:51-8. PMID: 24561005; PMCID: PMC4747242.
    7. Pianalto KM, Hartman JH, Boysen G, Miller GP. Differences in butadiene adduct formation between rats and mice not due to selective inhibition of CYP2E1 by butadiene metabolites. Toxicol Lett. 2013 Nov 25; 223(2):221-7. PMID: 24021170; PMCID: PMC3831829.
    8. Edavana VK, Dhakal IB, Williams S, Penney R, Boysen G, Yao-Borengasser A, Kadlubar S. Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics. Drug Metab Dispos. 2013 Apr; 41(4):870-7. PMID: 23371966; PMCID: PMC3608453.
    9. Hartman JH, Boysen G, Miller GP. Cooperative effects for CYP2E1 differ between styrene and its metabolites. Xenobiotica. 2013 Sep; 43(9):755-64. PMID: 23327532; PMCID: PMC3979932.
    10. Kim SY, Kang JY, Hartman JH, Park SH, Jones DR, Yun CH, Boysen G, Miller GP. Metabolism of R- and S-warfarin by CYP2C19 into four hydroxywarfarins. Drug Metab Lett. 2012 Sep 01; 6(3):157-64. PMID: 23331088; PMCID: PMC3713490.
    11. Bogusiewicz A, Horvath TD, Stratton SL, Mock DM, Boysen G. Measurement of acylcarnitine substrate to product ratios specific to biotin-dependent carboxylases offers a combination of indicators of biotin status in humans. J Nutr. 2012 Sep; 142(9):1621-5. PMID: 22833654; PMCID: PMC3417829.
    12. Hartman JH, Boysen G, Miller GP. CYP2E1 metabolism of styrene involves allostery. Drug Metab Dispos. 2012 Oct; 40(10):1976-83. PMID: 22807108; PMCID: PMC3463823.
    13. Stratton SL, Henrich CL, Matthews NI, Bogusiewicz A, Dawson AM, Horvath TD, Owen SN, Boysen G, Moran JH, Mock DM. Marginal biotin deficiency can be induced experimentally in humans using a cost-effective outpatient design. J Nutr. 2012 Jan; 142(1):22-6. PMID: 22157538; PMCID: PMC3237229.
    14. Boysen G, Georgieva NI, Bordeerat NK, Sram RJ, Vacek P, Albertini RJ, Swenberg JA. Formation of 1,2:3,4-diepoxybutane-specific hemoglobin adducts in 1,3-butadiene exposed workers. Toxicol Sci. 2012 Jan; 125(1):30-40. PMID: 22003190; PMCID: PMC3243749.
    15. Mock DM, Stratton SL, Horvath TD, Bogusiewicz A, Matthews NI, Henrich CL, Dawson AM, Spencer HJ, Owen SN, Boysen G, Moran JH. Urinary excretion of 3-hydroxyisovaleric acid and 3-hydroxyisovaleryl carnitine increases in response to a leucine challenge in marginally biotin-deficient humans. J Nutr. 2011 Nov; 141(11):1925-30. PMID: 21918059; PMCID: PMC3192457.
    16. Horvath TD, Matthews NI, Stratton SL, Mock DM, Boysen G. Measurement of 3-hydroxyisovaleric acid in urine from marginally biotin-deficient humans by UPLC-MS/MS. Anal Bioanal Chem. 2011 Nov; 401(9):2805-10. PMID: 21892638; PMCID: PMC3628633.
    17. Bhattacharyya D, Ramachandran S, Sharma S, Pathmasiri W, King CL, Baskerville-Abraham I, Boysen G, Swenberg JA, Campbell SL, Dokholyan NV, Chaney SG. Flanking bases influence the nature of DNA distortion by platinum 1,2-intrastrand (GG) cross-links. PLoS One. 2011; 6(8):e23582. PMID: 21853154; PMCID: PMC3154474.
    18. Begemann P, Boysen G, Georgieva NI, Sangaiah R, Koshlap KM, Koc H, Zhang D, Golding BT, Gold A, Swenberg JA. Identification and characterization of 2'-deoxyadenosine adducts formed by isoprene monoepoxides in vitro. Chem Res Toxicol. 2011 Jul 18; 24(7):1048-61. PMID: 21548641; PMCID: PMC3140868.
    19. Jones DR, Boysen G, Miller GP. Novel multi-mode ultra performance liquid chromatography-tandem mass spectrometry assay for profiling enantiomeric hydroxywarfarins and warfarin in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 May 01; 879(15-16):1056-62. PMID: 21470921.
      View in: PubMed
    20. Jones DR, Kim SY, Boysen G, Yun CH, Miller GP. Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin. Drug Metab Lett. 2010 Dec; 4(4):213-9. PMID: 20615193.
      View in: PubMed
    21. Swenberg JA, Bordeerat NK, Boysen G, Carro S, Georgieva NI, Nakamura J, Troutman JM, Upton PB, Albertini RJ, Vacek PM, Walker VE, Sram RJ, Goggin M, Tretyakova N. 1,3-Butadiene: Biomarkers and application to risk assessment. Chem Biol Interact. 2011 Jun 30; 192(1-2):150-4. PMID: 20974116; PMCID: PMC3501005.
    22. Georgieva NI, Boysen G, Bordeerat N, Walker VE, Swenberg JA. Exposure-response of 1,2:3,4-diepoxybutane-specific N-terminal valine adducts in mice and rats after inhalation exposure to 1,3-butadiene. Toxicol Sci. 2010 Jun; 115(2):322-9. PMID: 20176624; PMCID: PMC2871755.
    23. Boysen G, Collins LB, Liao S, Luke AM, Pachkowski BF, Watters JL, Swenberg JA. Analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine by ultra high pressure liquid chromatography-heat assisted electrospray ionization-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Feb 01; 878(3-4):375-80. PMID: 20022307.
      View in: PubMed
    24. Watters JL, Satia JA, da Costa KA, Boysen G, Collins LB, Morrow JD, Milne GL, Swenberg JA. Comparison of three oxidative stress biomarkers in a sample of healthy adults. Biomarkers. 2009 Dec; 14(8):587-95. PMID: 20001708; PMCID: PMC3290341.
    25. Bordeerat NK, Georgieva NI, Klapper DG, Collins LB, Cross TJ, Borchers CH, Swenberg JA, Boysen G. Accurate quantitation of standard peptides used for quantitative proteomics. Proteomics. 2009 Aug; 9(15):3939-44. PMID: 19637239; PMCID: PMC2766299.
    26. Kim S, Collins LB, Boysen G, Swenberg JA, Gold A, Ball LM, Bradford BU, Rusyn I. Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. Toxicology. 2009 Aug 21; 262(3):230-8. PMID: 19549554; PMCID: PMC2765814.
    27. Boysen G, Pachkowski BF, Nakamura J, Swenberg JA. The formation and biological significance of N7-guanine adducts. Mutat Res. 2009 Aug; 678(2):76-94. PMID: 19465146; PMCID: PMC2739241.
    28. Ye W, Sangaiah R, Degen DE, Gold A, Jayaraj K, Koshlap KM, Boysen G, Williams J, Tomer KB, Mocanu V, Dicheva N, Parker CE, Schaaper RM, Ball LM. Iminohydantoin lesion induced in DNA by peracids and other epoxidizing oxidants. J Am Chem Soc. 2009 May 06; 131(17):6114-23. PMID: 19354244; PMCID: PMC2690081.
    29. Baskerville-Abraham IM, Boysen G, Troutman JM, Mutlu E, Collins L, Dekrafft KE, Lin W, King C, Chaney SG, Swenberg JA. Development of an ultraperformance liquid chromatography/mass spectrometry method to quantify cisplatin 1,2 intrastrand guanine-guanine adducts. Chem Res Toxicol. 2009 May; 22(5):905-12. PMID: 19323581; PMCID: PMC2728554.
    30. Esther CR, Boysen G, Olsen BM, Collins LB, Ghio AJ, Swenberg JW, Boucher RC. Mass spectrometric analysis of biomarkers and dilution markers in exhaled breath condensate reveals elevated purines in asthma and cystic fibrosis. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L987-93. PMID: 19304910; PMCID: PMC2692804.
    31. Lu K, Boysen G, Gao L, Collins LB, Swenberg JA. Formaldehyde-induced histone modifications in vitro. Chem Res Toxicol. 2008 Aug; 21(8):1586-93. PMID: 18656964.
      View in: PubMed
    32. Alderman JM, Flurkey K, Brooks NL, Naik SB, Gutierrez JM, Srinivas U, Ziara KB, Jing L, Boysen G, Bronson R, Klebanov S, Chen X, Swenberg JA, Stridsberg M, Parker CE, Harrison DE, Combs TP. Neuroendocrine inhibition of glucose production and resistance to cancer in dwarf mice. Exp Gerontol. 2009 Jan-Feb; 44(1-2):26-33. PMID: 18582556; PMCID: PMC2872123.
    33. Esther CR, Jasin HM, Collins LB, Swenberg JA, Boysen G. A mass spectrometric method to simultaneously measure a biomarker and dilution marker in exhaled breath condensate. Rapid Commun Mass Spectrom. 2008; 22(5):701-5. PMID: 18257110; PMCID: PMC2578813.
    34. Swenberg JA, Fryar-Tita E, Jeong YC, Boysen G, Starr T, Walker VE, Albertini RJ. Biomarkers in toxicology and risk assessment: informing critical dose-response relationships. Chem Res Toxicol. 2008 Jan; 21(1):253-65. PMID: 18161944.
      View in: PubMed
    35. Jiang J, Parker CE, Hoadley KA, Perou CM, Boysen G, Borchers CH. Development of an immuno tandem mass spectrometry (iMALDI) assay for EGFR diagnosis. Proteomics Clin Appl. 2007 Dec; 1(12):1651-9. PMID: 21136662.
      View in: PubMed
    36. Brooks NL, Trent CM, Raetzsch CF, Flurkey K, Boysen G, Perfetti MT, Jeong YC, Klebanov S, Patel KB, Khodush VR, Kupper LL, Carling D, Swenberg JA, Harrison DE, Combs TP. Low utilization of circulating glucose after food withdrawal in Snell dwarf mice. J Biol Chem. 2007 Nov 30; 282(48):35069-77. PMID: 17905742.
      View in: PubMed
    37. Wu Y, Bhattacharyya D, King CL, Baskerville-Abraham I, Huh SH, Boysen G, Swenberg JA, Temple B, Campbell SL, Chaney SG. Solution structures of a DNA dodecamer duplex with and without a cisplatin 1,2-d(GG) intrastrand cross-link: comparison with the same DNA duplex containing an oxaliplatin 1,2-d(GG) intrastrand cross-link. Biochemistry. 2007 Jun 05; 46(22):6477-87. PMID: 17497831; PMCID: PMC2129171.
    38. Swenberg JA, Boysen G, Georgieva N, Bird MG, Lewis RJ. Future directions in butadiene risk assessment and the role of cross-species internal dosimetry. Chem Biol Interact. 2007 Mar 20; 166(1-3):78-83. PMID: 17343837.
      View in: PubMed
    39. Boysen G, Scarlett CO, Temple B, Combs TP, Brooks NL, Borchers CH, Swenberg JA. Identification of covalent modifications in P450 2E1 by 1,2-epoxy-3-butene in vitro. Chem Biol Interact. 2007 Mar 20; 166(1-3):170-5. PMID: 17298833.
      View in: PubMed
    40. Boysen G, Georgieva NI, Upton PB, Walker VE, Swenberg JA. N-terminal globin adducts as biomarkers for formation of butadiene derived epoxides. Chem Biol Interact. 2007 Mar 20; 166(1-3):84-92. PMID: 17084829.
      View in: PubMed
    41. Albertini RJ, Sram RJ, Vacek PM, Lynch J, Rossner P, Nicklas JA, McDonald JD, Boysen G, Georgieva N, Swenberg JA. Molecular epidemiological studies in 1,3-butadiene exposed Czech workers: female-male comparisons. Chem Biol Interact. 2007 Mar 20; 166(1-3):63-77. PMID: 16949064.
      View in: PubMed
    42. Meng Q, Walker DM, McDonald JD, Henderson RF, Carter MM, Cook DL, McCash CL, Torres SM, Bauer MJ, Seilkop SK, Upton PB, Georgieva NI, Boysen G, Swenberg JA, Walker VE. Age-, gender-, and species-dependent mutagenicity in T cells of mice and rats exposed by inhalation to 1,3-butadiene. Chem Biol Interact. 2007 Mar 20; 166(1-3):121-31. PMID: 16945358.
      View in: PubMed
    43. Georgieva NI, Boysen G, Upton PB, Jayaraj K, Gold A, Swenberg JA. Quantitative analysis of N-terminal valine peptide adducts specific for 1,2-epoxy-3-butene. Chem Biol Interact. 2007 Mar 20; 166(1-3):219-25. PMID: 16860298; PMCID: PMC2718720.
    44. Powell CL, Kosyk O, Ross PK, Schoonhoven R, Boysen G, Swenberg JA, Heinloth AN, Boorman GA, Cunningham ML, Paules RS, Rusyn I. Phenotypic anchoring of acetaminophen-induced oxidative stress with gene expression profiles in rat liver. Toxicol Sci. 2006 Sep; 93(1):213-22. PMID: 16751229; PMCID: PMC1805881.
    45. Stout MD, Jeong YC, Boysen G, Li Y, Sangaiah R, Ball LM, Gold A, Swenberg JA. LC/MS/MS method for the quantitation of trans-2-hexenal-derived exocyclic 1,N(2)-propanodeoxyguanosine in DNA. Chem Res Toxicol. 2006 Apr; 19(4):563-70. PMID: 16608168.
      View in: PubMed
    46. Ye W, Sangaiah R, Degen DE, Gold A, Jayaraj K, Koshlap KM, Boysen G, Williams J, Tomer KB, Ball LM. A 2-iminohydantoin from the oxidation of guanine. Chem Res Toxicol. 2006 Apr; 19(4):506-10. PMID: 16608161.
      View in: PubMed
    47. Li Y, Warren JT, Boysen G, Gilbert LI, Gold A, Sangaiah R, Ball LM, Swenberg JA. Profiling of ecdysteroids in complex biological samples using liquid chromatography/ion trap mass spectrometry. Rapid Commun Mass Spectrom. 2006; 20(2):185-92. PMID: 16345130.
      View in: PubMed
    48. Boysen G, Georgieva NI, Upton PB, Jayaraj K, Li Y, Walker VE, Swenberg JA. Analysis of diepoxide-specific cyclic N-terminal globin adducts in mice and rats after inhalation exposure to 1,3-butadiene. Cancer Res. 2004 Dec 01; 64(23):8517-20. PMID: 15574756.
      View in: PubMed
    49. Wu Y, Pradhan P, Havener J, Boysen G, Swenberg JA, Campbell SL, Chaney SG. NMR solution structure of an oxaliplatin 1,2-d(GG) intrastrand cross-link in a DNA dodecamer duplex. J Mol Biol. 2004 Aug 27; 341(5):1251-69. PMID: 15321720.
      View in: PubMed
    50. Boysen G, Kenney PM, Upadhyaya P, Wang M, Hecht SS. Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats. Carcinogenesis. 2003 Mar; 24(3):517-25. PMID: 12663513.
      View in: PubMed
    51. Boysen G, Hecht SS. Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods. Mutat Res. 2003 Jan; 543(1):17-30. PMID: 12510015.
      View in: PubMed
    52. Sticha KR, Kenney PM, Boysen G, Liang H, Su X, Wang M, Upadhyaya P, Hecht SS. Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. Carcinogenesis. 2002 Sep; 23(9):1433-9. PMID: 12189184.
      View in: PubMed
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