Alicia Byrd
Title | Assistant Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Biochemistry & Molecular Biology, College of Medicine |
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Address | 433-2 Biomedical Research II 325 S. Elm St. Mail Slot # 516 Little Rock AR 72205
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Phone | 501-526-6488 |
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ORCID
.gif) | 0000-0001-5484-0759  |
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vCard | Download vCard |
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Overview DNA damage occurs tens of thousands of times per day in human cells from both endogenous and environmental sources. In order to preserve the genetic material, cells have evolved multiple mechanisms to detect and repair DNA damage. However, inaccurate DNA repair can cause genomic instability such as chromosomal rearrangements and expansion of repetitive sequences which can lead to the development of cancer or diseases such as Fragile X Syndrome. One area my research focuses on is the enzymes that regulate the DNA damage response. In particular, I am interested in a family of enzymes called helicases which remove secondary structures from DNA and RNA. At least 10 different human helicases are involved in DNA repair.
My research is focused on understanding the fundamental mechanisms of these enzymes using biophysical and biochemical techniques including ensemble and single molecule kinetics, proteomics, and genomics. The molecular mechanisms of these proteins, both individually and as components of multi-protein complexes, are of interest, as are the effects of posttranslational modifications on their activity.
Affiliation American Chemical Society American Association for the Advancement of Science American Association of Biochemistry and Molecular Biology
Research P20GM121293 Sub-Project 6782 (BYRD, ALICIA K)Jul 20, 2022 - Jun 30, 2027 NIH/NIGMS Role of HELB in the Replication Stress Response Role: Principal Investigator |
| Hornick Endowment (BYRD, ALICIA K)Jan 1, 2021 - Dec 31, 2022 UAMS Internal Research Awards The effect of rs75770066, a stroke associated single nucleotide polymorphism, on enzyme activity Role: Principal Investigator |
| ABCRP Pilot Award (BYRD, ALICIA K)Sep 1, 2020 - Aug 31, 2022 Arkansas Breast Cancer Research Program Identification of synthetic lethal targets for treating breast cancer Role: Principal Investigator |
| Medical Research Endowment Fund (BYRD, ALICIA K)Sep 1, 2020 - Aug 31, 2021 UAMS Internal Research Awards The Role of DNA Helicase B in Response to DNA Replication Stress Role: Principal Investigator |
| Seeds of Science FY19 (BYRD, ALICIA K)Feb 1, 2019 - Jan 31, 2020 UAMS Internal Research Awards Seeds of Science Pilot award Role: Principal Investigator |
| SeedsofScienceFY19 (BYRD, ALICIA K)Feb 1, 2019 - Jan 31, 2020 UAMS Internal Research Awards Seeds of Science Pilot award Role: Principal Investigator |
| R35GM122601 (RANEY, KEVIN DOUGLAS)May 1, 2017 - Apr 30, 2022 NIH Functions and Mechanisms of Helicases and G-Quadruplex Nucleic Acids Role: Co-Investigator |
| R01GM117439 (RANEY, KEVIN DOUGLAS)Sep 21, 2015 - Jun 30, 2019 NIH G-quadruplex DNA as a chemical signaling agent Role: Co-Investigator |
| 1012716 (BYRD, ALICIA K)May 24, 2013 - Dec 31, 2014 Burroughs Wellcome Fund Measurement of Helicase Diffusion and Cooperativity at the Single Molecule Level Role: Principal Investigator |
| R01GM098922 (RANEY, KEVIN DOUGLAS)Sep 1, 2011 - Dec 31, 2019 NIH DNA Helicases: Mechanism and Function Role: Co-Investigator |
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Belachew B, Gao J, Byrd AK, Raney KD. Hepatitis C virus nonstructural protein NS3 unfolds viral G-quadruplex RNA structures. J Biol Chem. 2022 11; 298(11):102486. PMID: 36108740.
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Ozaslan D, Byrd AK, Belachew B, Raney KD. Alignment of helicases on single-stranded DNA increases activity. Methods Enzymol. 2022; 672:29-54. PMID: 35934480.
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Malone EG, Thompson MD, Byrd AK. Role and Regulation of Pif1 Family Helicases at the Replication Fork. Int J Mol Sci. 2022 Mar 29; 23(7). PMID: 35409096.
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Thompson MD, Malone EG, Byrd AK. Monitoring helicase-catalyzed unwinding of multiple duplexes simultaneously. Methods Enzymol. 2022; 672:1-27. PMID: 35934470.
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Ziemba A, Reed M, Raney KD, Byrd AB, Ebbinghaus S. A bis-conjugated TFO inhibits target gene expression intracellularly and prevents triplex unwinding due to helicase activity. Biochemistry. 2003; 42(17):5013-5024.
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Year | Publications |
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2003 | 1 | 2022 | 4 |
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