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Alicia Byrd

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentBiochemistry & Molecular Biology, College of Medicine
Address433-2 Biomedical Research II
325 S. Elm St.
Mail Slot # 516
Little Rock AR 72205
ORCID ORCID Icon0000-0001-5484-0759 Additional info
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    Collapse Overview 
    Collapse overview
    DNA damage occurs tens of thousands of times per day in human cells from both endogenous and environmental sources. In order to preserve the genetic material, cells have evolved multiple mechanisms to detect and repair DNA damage. However, inaccurate DNA repair can cause genomic instability such as chromosomal rearrangements and expansion of repetitive sequences which can lead to the development of cancer or diseases such as Fragile X Syndrome. One area my research focuses on is the enzymes that regulate the DNA damage response. In particular, I am interested in a family of enzymes called helicases which remove secondary structures from DNA and RNA. At least 10 different human helicases are involved in DNA repair.

    My research is focused on understanding the fundamental mechanisms of these enzymes using biophysical and biochemical techniques including ensemble and single molecule kinetics, proteomics, and genomics. The molecular mechanisms of these proteins, both individually and as components of multi-protein complexes, are of interest, as are the effects of posttranslational modifications on their activity.

    Collapse Affiliation 
    Collapse member of
    American Chemical Society
    American Association for the Advancement of Science
    American Association of Biochemistry and Molecular Biology

    Collapse Research 
    Collapse research activities and funding
    P20GM121293 Sub-Project 6782     (BYRD, ALICIA K)Jul 20, 2022 - Jun 30, 2027
    Role of HELB in the Replication Stress Response
    Role: Principal Investigator

    Hornick Endowment     (BYRD, ALICIA K)Jan 1, 2021 - Dec 31, 2022
    UAMS Internal Research Awards
    The effect of rs75770066, a stroke associated single nucleotide polymorphism, on enzyme activity
    Role: Principal Investigator

    ABCRP Pilot Award     (BYRD, ALICIA K)Sep 1, 2020 - Aug 31, 2022
    Arkansas Breast Cancer Research Program
    Identification of synthetic lethal targets for treating breast cancer
    Role: Principal Investigator

    Medical Research Endowment Fund     (BYRD, ALICIA K)Sep 1, 2020 - Aug 31, 2021
    UAMS Internal Research Awards
    The Role of DNA Helicase B in Response to DNA Replication Stress
    Role: Principal Investigator

    Seeds of Science FY19     (BYRD, ALICIA K)Feb 1, 2019 - Jan 31, 2020
    UAMS Internal Research Awards
    Seeds of Science Pilot award
    Role: Principal Investigator

    SeedsofScienceFY19     (BYRD, ALICIA K)Feb 1, 2019 - Jan 31, 2020
    UAMS Internal Research Awards
    Seeds of Science Pilot award
    Role: Principal Investigator

    R35GM122601     (RANEY, KEVIN DOUGLAS)May 1, 2017 - Apr 30, 2022
    Functions and Mechanisms of Helicases and G-Quadruplex Nucleic Acids
    Role: Co-Investigator

    R01GM117439     (RANEY, KEVIN DOUGLAS)Sep 21, 2015 - Jun 30, 2019
    G-quadruplex DNA as a chemical signaling agent
    Role: Co-Investigator

    1012716     (BYRD, ALICIA K)May 24, 2013 - Dec 31, 2014
    Burroughs Wellcome Fund
    Measurement of Helicase Diffusion and Cooperativity at the Single Molecule Level
    Role: Principal Investigator

    R01GM098922     (RANEY, KEVIN DOUGLAS)Sep 1, 2011 - Dec 31, 2019
    DNA Helicases: Mechanism and Function
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Belachew B, Gao J, Byrd AK, Raney KD. Hepatitis C virus nonstructural protein NS3 unfolds viral G-quadruplex RNA structures. J Biol Chem. 2022 11; 298(11):102486. PMID: 36108740.
      View in: PubMed
    2. Ozaslan D, Byrd AK, Belachew B, Raney KD. Alignment of helicases on single-stranded DNA increases activity. Methods Enzymol. 2022; 672:29-54. PMID: 35934480.
      View in: PubMed
    3. Malone EG, Thompson MD, Byrd AK. Role and Regulation of Pif1 Family Helicases at the Replication Fork. Int J Mol Sci. 2022 Mar 29; 23(7). PMID: 35409096.
      View in: PubMed
    4. Thompson MD, Malone EG, Byrd AK. Monitoring helicase-catalyzed unwinding of multiple duplexes simultaneously. Methods Enzymol. 2022; 672:1-27. PMID: 35934470.
      View in: PubMed
    5. Ziemba A, Reed M, Raney KD, Byrd AB, Ebbinghaus S. A bis-conjugated TFO inhibits target gene expression intracellularly and prevents triplex unwinding due to helicase activity. Biochemistry. 2003; 42(17):5013-5024.
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