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Jason Stumhofer

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentMicrobiology & Immunology, College of Medicine
DivisionMicrobiology & Immunology Faculty
Address521D Biomedical Research I
325 S. Elm St.
Mail Slot # 511
Little Rock AR 72205
Phone501-526-6180
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    Collapse Research Funds 
    Collapse research activities
    R21AI139797     (STUMHOFER, JASON)Jun 12, 2018 - May 31, 2021
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Understanding the contribution of atypical B cell progenitors to the humoral response
    Role: Principal Investigator

    R41AI138690     (ZHAROV, VLADIMIR)Apr 1, 2018 - Sep 30, 2020
    NIH/Nat. Cancer Institute - Pass Through: CytoAstra, LLC
    Multicolor photoacoustic malaria detector
    Role: Co-Investigator

    R01AI116653     (STUMHOFER, JASON)Dec 4, 2015 - Nov 30, 2020
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Regulation and function of B cells during malaria infection
    Role: Principal Investigator

    P20GM103625     (SMELTZER, MARK)Aug 15, 2012 - Apr 30, 2022
    NIH/Nat. Inst. of General Medical Sciences
    Microbial Pathogenesis and Host Inflammatory Responses
    Role: Co-Investigator

    R21AI090179     (STUMHOFER, JASON)Mar 1, 2012 - Feb 28, 2015
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    A protective role for IL-17 in blood-stage malaria
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Latham LE, Wikenheiser DJ, Stumhofer JS. ICOS signaling promotes a secondary humoral response after re-challenge with Plasmodium chabaudi chabaudi AS. PLoS Pathog. 2020 04; 16(4):e1008527. PMID: 32348365.
      View in: PubMed
    2. Tait Wojno ED, Hunter CA, Stumhofer JS. The Immunobiology of the Interleukin-12 Family: Room for Discovery. Immunity. 2019 04 16; 50(4):851-870. PMID: 30995503.
      View in: PubMed
    3. Wikenheiser DJ, Brown SL, Lee J, Stumhofer JS. NK1.1 Expression Defines a Population of CD4+ Effector T Cells Displaying Th1 and Tfh Cell Properties That Support Early Antibody Production During Plasmodium yoelii Infection. Front Immunol. 2018; 9:2277. PMID: 30374346.
      View in: PubMed
    4. Ghosh D, Brown SL, Stumhofer JS. IL-17 Promotes Differentiation of Splenic LSK- Lymphoid Progenitors into B Cells following Plasmodium yoelii Infection. J Immunol. 2017 09 01; 199(5):1783-1795. PMID: 28733485.
      View in: PubMed
    5. Menyaev YA, Carey KA, Nedosekin DA, Sarimollaoglu M, Galanzha EI, Stumhofer JS, Zharov VP. Preclinical photoacoustic models: application for ultrasensitive single cell malaria diagnosis in large vein and artery. Biomed Opt Express. 2016 Sep 01; 7(9):3643-3658. PMID: 27699126.
      View in: PubMed
    6. Wikenheiser DJ, Stumhofer JS. ICOS Co-Stimulation: Friend or Foe? Front Immunol. 2016; 7:304. PMID: 27559335.
      View in: PubMed
    7. Ghosh D, Wikenheiser DJ, Kennedy B, McGovern KE, Stuart JD, Wilson EH, Stumhofer JS. An Atypical Splenic B Cell Progenitor Population Supports Antibody Production during Plasmodium Infection in Mice. J Immunol. 2016 09 01; 197(5):1788-800. PMID: 27448588.
      View in: PubMed
    8. Cai C, Carey KA, Nedosekin DA, Menyaev YA, Sarimollaoglu M, Galanzha EI, Stumhofer JS, Zharov VP. In vivo photoacoustic flow cytometry for early malaria diagnosis. Cytometry A. 2016 06; 89(6):531-42. PMID: 27078044.
      View in: PubMed
    9. Wikenheiser DJ, Ghosh D, Kennedy B, Stumhofer JS. The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS Infection. J Immunol. 2016 Jan 15; 196(2):778-91. PMID: 26667167.
      View in: PubMed
    10. Liu FD, Kenngott EE, Schröter MF, Kühl A, Jennrich S, Watzlawick R, Hoffmann U, Wolff T, Norley S, Scheffold A, Stumhofer JS, Saris CJ, Schwab JM, Hunter CA, Debes GF, Hamann A. Timed action of IL-27 protects from immunopathology while preserving defense in influenza. PLoS Pathog. 2014 May; 10(5):e1004110. PMID: 24809349.
      View in: PubMed
    11. Stumhofer JS, Loke P. Parasites: what are they good for? Curr Immunol Rev. 2013 Aug 01; 9(3):120-128. PMID: 24683385.
      View in: PubMed
    12. Ghosh D, Stumhofer JS. Do you see what I see: Recognition of protozoan parasites by Toll-like receptors. Curr Immunol Rev. 2013 Aug; 9(3):129-140. PMID: 25383072.
      View in: PubMed
    13. Stumhofer JS, Silver JS, Hunter CA. IL-21 is required for optimal antibody production and T cell responses during chronic Toxoplasma gondii infection. PLoS One. 2013; 8(5):e62889. PMID: 23667536.
      View in: PubMed
    14. Hall AO, Beiting DP, Tato C, John B, Oldenhove G, Lombana CG, Pritchard GH, Silver JS, Bouladoux N, Stumhofer JS, Harris TH, Grainger J, Wojno ED, Wagage S, Roos DS, Scott P, Turka LA, Cherry S, Reiner SL, Cua D, Belkaid Y, Elloso MM, Hunter CA. The cytokines interleukin 27 and interferon-? promote distinct Treg cell populations required to limit infection-induced pathology. Immunity. 2012 Sep 21; 37(3):511-23. PMID: 22981537.
      View in: PubMed
    15. Hall AO, Beiting DP, Tato C, John B, Oldenhove G, Lombana CG, Pritchard GH, Silver JS, Bouladoux N, Stumhofer JS, Harris TH, Grainger J, Wojno ED, Wagage S, Roos DS, Scott P, Turka LA, Cherry S, Reiner SL, Cua D, Belkaid Y, Elloso MM, Hunter CA. The cytokine interleukin 27 and interferon-gamma promote distinct Treg cell populations required to limit infection-induced pathology. Immunity. 2012; 21(37):511-23.
    16. Villegas-Mendez A, Greig R, Shaw TN, De Souza JB, Gwyer Findlay E, Stumhofer JS, Hafalla JC, Blount DG, Hunter CA, Riley EM, Couper KN. IFN-gamma-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain. J. Immunol. 2012; 189(2):968-79.
    17. Villegas-Mendez A, Greig R, Shaw TN, de Souza JB, Gwyer Findlay E, Stumhofer JS, Hafalla JC, Blount DG, Hunter CA, Riley EM, Couper KN. IFN-?-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain. J Immunol. 2012 Jul 15; 189(2):968-79. PMID: 22723523.
      View in: PubMed
    18. Wojno ED, Hosken N, Stumhofer JS, O'Hara AC, Mauldin E, Fang Q, Turka LA, Levin SD, Hunter CA. A role for IL-27 in limiting T regulatory cell populations. J Immunol. 2011 Jul 01; 187(1):266-73. PMID: 21622862.
      View in: PubMed
    19. Silver JS, Stumhofer JS, Passos S, Ernst M, Hunter CA. IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondii. J Immunol. 2011 Jul 01; 187(1):350-60. PMID: 21606248.
      View in: PubMed
    20. Aronson LR, Stumhofer JS, Drobatz KJ, Hunter CA. Effect of cyclosporine, dexamethasone, and human CTLA4-Ig on production of cytokines in lymphocytes of clinically normal cats and cats undergoing renal transplantation. Am J Vet Res. 2011 Apr; 72(4):541-9. PMID: 21453156.
      View in: PubMed
    21. Stumhofer JS, Tait ED, Quinn WJ, Hosken N, Spudy B, Goenka R, Fielding CA, O'Hara AC, Chen Y, Jones ML, Saris CJ, Rose-John S, Cua DJ, Jones SA, Elloso MM, Grötzinger J, Cancro MP, Levin SD, Hunter CA. A role for IL-27p28 as an antagonist of gp130-mediated signaling. Nat Immunol. 2010 Dec; 11(12):1119-26. PMID: 21057510.
      View in: PubMed
    22. Jones GW, Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, Williams AS, Hunter CA, Jenkins BJ, Wang EC, Jones SA. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. FASEB J. 2011 Jan; 25(1):409-19. PMID: 20826539.
      View in: PubMed
    23. Findlay EG, Greig R, Stumhofer JS, Hafalla JC, de Souza JB, Saris CJ, Hunter CA, Riley EM, Couper KN. Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection. J Immunol. 2010 Aug 15; 185(4):2482-92. PMID: 20631310.
      View in: PubMed
    24. Passos ST, Silver JS, O'Hara AC, Sehy D, Stumhofer JS, Hunter CA. IL-6 promotes NK cell production of IL-17 during toxoplasmosis. J Immunol. 2010 Feb 15; 184(4):1776-83. PMID: 20083665.
      View in: PubMed
    25. Anderson CF, Stumhofer JS, Hunter CA, Sacks D. IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection. J Immunol. 2009 Oct 01; 183(7):4619-27. PMID: 19748991.
      View in: PubMed
    26. Diveu C, McGeachy MJ, Boniface K, Stumhofer JS, Sathe M, Joyce-Shaikh B, Chen Y, Tato CM, McClanahan TK, de Waal Malefyt R, Hunter CA, Cua DJ, Kastelein RA. IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. J Immunol. 2009 May 01; 182(9):5748-56. PMID: 19380822.
      View in: PubMed
    27. Stumhofer JS, Hunter CA. IL-27: Advances in understanding the anti-inflammatory properties of IL-27. Immunol Lett. 2008; 117(2):123-30.
    28. LaRosa DF, Stumhofer JS, Gelman AE, Rahman AH, Taylor DK, Hunter CA, Turka LA. T cell expression of myeloid protein 88 is required for resistance to Toxoplasma gondii. Proc Natl Acad Sci USA. 2008; 105(10):3855-60.
    29. Stumhofer JS, Hunter CA. Advances in understanding the anti-inflammatory properties of IL-27. Immunol Lett. 2008 May 15; 117(2):123-30. PMID: 18378322.
      View in: PubMed
    30. LaRosa DF, Stumhofer JS, Gelman AE, Rahman AH, Taylor DK, Hunter CA, Turka LA. T cell expression of MyD88 is required for resistance to Toxoplasma gondii. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3855-60. PMID: 18308927.
      View in: PubMed
    31. Stumhofer JS, Silver J, Hunter CA. Negative regulation of Th17 responses. Semin Immunol. 2007 Dec; 19(6):394-9. PMID: 18221887.
      View in: PubMed
    32. Stumhofer JS, Silver JS, Laurence A, Porrett PM, Harris TH, Turka LA, Ernst M, Saris CJ, O'Shea JJ, Hunter CA. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat Immunol. 2007 Dec; 8(12):1363-71. PMID: 17994025.
      View in: PubMed
    33. Dzierszinski F, Pepper M, Stumhofer JS, LaRosa DF, Wilson EH, Turka LA, Halonen SK, Hunter CA, Roos DS. Presentation of Toxoplasma gondii antigejns via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells. Infect Immun. 2007; 75(11):5200-9.
    34. Dzierszinski F, Pepper M, Stumhofer JS, LaRosa DF, Wilson EH, Turka LA, Halonen SK, Hunter CA, Roos DS. Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells. Infect Immun. 2007 Nov; 75(11):5200-9. PMID: 17846116.
      View in: PubMed
    35. Villarino AV, Tato CM, Stumhofer JS, Yao Z, Cui YK, Hennighausen L, O'Shea JJ, Hunter CA. Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals. J Exp Med. 2007 Jan 22; 204(1):65-71. PMID: 17227909.
      View in: PubMed
    36. Stumhofer JS, Laurence A, Wilson EH, Huang E, Tato CM, Johnson LM, Villarino AV, Huang Q, Sehy D, Saris CJ, O'Shea JJ, Hennighausen L, Ernst M, Hunter CA. A role for IL-27 as a negative regulator of TH-17 responses during infection-induced chronic CNS inflammation. Nat Immunol. 2006; 7(9):937-45.
    37. Stumhofer JS, Laurence A, Wilson EH, Huang E, Tato CM, Johnson LM, Villarino AV, Huang Q, Yoshimura A, Sehy D, Saris CJ, O'Shea JJ, Hennighausen L, Ernst M, Hunter CA. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol. 2006 Sep; 7(9):937-45. PMID: 16906166.
      View in: PubMed
    38. Chen Y, Langrish CL, McKenzie B, Joyce-Shaikh B, Stumhofer JS, McClanahan T, Blumenschein W, Churakovsa T, Low J, Presta L, Hunter CA, Kastelein RA, Cua DJ. Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J Clin Invest. 2006 May; 116(5):1317-26. PMID: 16670771.
      View in: PubMed
    39. Chen Y, Langrish CL, McKenzie B, Joyce-Shaikh B, Stumhofer JS, McClanahan T, Blumenschein W, Churakovsa T, Low J, Presta L, Hunter CA, Kastelein RA, Cua DJ. Anti-IL-23 therapy inhibits multiple inflammatory pathways and amerliorates autoimmune encephalomyelitis. J Clin Invest. 2006; 116(5):1317-26.
    40. Villarino AV, Stumhofer JS, Saris CJ, Kastelein RA, de Sauvage FJ, Hunter CA. IL-27 limits IL-2 production during Th1 differentiation. J Immunol. 2006 Jan 01; 176(1):237-47. PMID: 16365415.
      View in: PubMed
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