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Marjan Boerma

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentCollege of Pharmacy, College of Provost
DivisionPharmaceutical Science
Address410-2 Biomedical Research II
200 South Cedar
Mail Slot # 522-10
Little Rock AR 72202
Phone501-686-6599
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    Collapse Research 
    Collapse research activities and funding
    R43AI155046     (BOERMA, MARJAN)Jul 1, 2020 - Jun 30, 2022
    NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: Nelson Scientific Labs, LLC
    Metabolomics Based Prediction of Delayed Effects of Acute Radiation Exposure
    Role: Principal Investigator
    U01A148308     (BOERMA, MARJAN)Feb 1, 2020 - Jan 31, 2025
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Development of a minimally invasive biomarker assay to detect delayed radiation injury
    Role: Principal Investigator
    U01AI148308     (BOERMA, MARJAN)Feb 1, 2020 - Jan 31, 2025
    NIH
    Development of a minimally invasive biomarker assay to detect delayed radiation injury
    Role: Principal Investigator
    W81XWH1910737     (PAWAR, SNEHALATA)Sep 15, 2019 - Sep 14, 2022
    US Department of Defense
    Role of TLR4 in Radiation-induced Cardiomyopathy
    Role: Co-Investigator
    80NSSC19K0437     (BOERMA, MARJAN)Jan 31, 2019 - Mar 31, 2022
    National Aeronautics & Space Administration
    Tocotrienol as a countermeasure against high-energy charged particle-induced carcinogenesis, cardiovascular disease, and central nervous system effects- Resubmission
    Role: Principal Investigator
    80NSSC19K0437 P00001     (BOERMA, MARJAN)Jan 31, 2019 - Mar 31, 2022
    National Aeronautics & Space Administration
    Tocotrienol as a countermeasure against high-energy charged particle-induced carcinogenesis, cardiovascular disease, and central nervous system effects- Resubmission
    Role: Principal Investigator
    80NSSC19K0437 P00002     (BOERMA, MARJAN)Jan 31, 2019 - Mar 31, 2022
    National Aeronautics & Space Administration
    Tocotrienol as a countermeasure against high-energy charged particle-induced carcinogenesis, cardiovascular disease, and central nervous system effects- Resubmission
    Role: Principal Investigator
    NNX16A069A     (ALLEN, ANTINO)Jan 1, 2019 - Dec 31, 2020
    National Aeronautics & Space Administration
    Photobiomodulation to Ameliorate Neuronal Degeneration and Cognitive Decline after Mixed Field Irradiation
    Role: Co-Investigator
    80NSSC17K0425     (BOERMA, MARJAN)Aug 7, 2017 - Jan 6, 2020
    National Aeronautics & Space Administration
    Effects of Chronic and Single-dose Charged Particle Exposure on Cardiac Function and Structure in Multiple Animal Models
    Role: Principal Investigator
    U01AI133561     (BOERMA, MARJAN)Jun 5, 2017 - May 31, 2022
    NIH
    The Protein C Pathway in Mitigation of Radiation-Induced Endothelial and Vascular Dysfunction
    Role: Principal Investigator
    242029-16-UAMS-02     (PATHAK, RUPAK)Jan 1, 2016 - Jan 31, 2017
    National Aeronautics & Space Administration - Pass Through: Arkansas Space Grant Consortium
    Effect of microgravity and GT3 on proton-induced genomic instability in endothelial cells
    Role: Co-Investigator
    P20GM109005     (BOERMA, MARJAN)Jun 24, 2015 - May 31, 2025
    NIH
    Center for Studies of Host Response to Cancer Therapy
    Role: Co-Investigator
    RE04001     (BOERMA, MARJAN)Sep 1, 2014 - May 31, 2017
    National Space Biomedical Research Institute - Pass Through: Baylor College of Medicine
    Team Leader for the Radiation Effects Team
    Role: Principal Investigator
    NCC 9-58 95     (BOERMA, MARJAN)Jun 1, 2014 - May 31, 2017
    National Space Biomedical Research Institute
    Center for Research on Cardiac and Vascular Effects of Space Radiation
    Role: Principal Investigator
    NCC9-58     (BOERMA, MARJAN)Jun 1, 2014 - May 31, 2017
    National Space Biomedical Research Institute
    Center for Research on Cardiac and Vascular Effects of Space Radiation
    Role: Principal Investigator
    NNX13AB29A     (PATHAK, RUPAK)Jul 1, 2013 - Nov 30, 2015
    Arkansas Space Grant Consortium - Pass Through: University of Arkansas at Little Rock
    Effect of microgravity and GT3 on radiation-induced genomic instability in endothelial cells
    Role: Co-Investigator
    P20GM103625     (SMELTZER, MARK S)Aug 15, 2012 - Apr 30, 2022
    NIH
    Center for Microbial Pathogenesis and Host Inflammatory Responses
    Role: Co-Investigator
    HHSO100201100045C     (HAUER-JENSEN, MARTIN)Sep 26, 2011 - Jun 30, 2017
    DHHS - Biomedical Advanced Research and Development Authority
    Advanced Development of SOM230 as a Radiation Mitigator
    Role: Co-Investigator
    R01CA148679     (BOERMA, MARJAN)Jul 1, 2010 - Apr 30, 2016
    NIH
    Radiation-Induced Heart Disease: Mechanisms and Interventions
    Role: Principal Investigator
    RSG-10-125-01-CCE     (BOERMA, MARJAN)Jul 1, 2010 - Feb 28, 2015
    American Cancer Society, Inc.
    Phosphodiesterase inhibitors and tocols in radiation-induced heart disease
    Role: Principal Investigator
    RC1AI078515     (BURNETT, ALEXANDER FERGUSON)Sep 30, 2009 - Feb 28, 2011
    NIH
    Oral Interleukin 11 as a Countermeasure against Radiation Injury to Gut
    Role: Co-Investigator
    HU0001-07-1-0009     (HAUER-JENSEN, MARTIN)Aug 15, 2007 - Nov 30, 2010
    Uniformed Services University of the Health Sciences - Pass Through: Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Combined effect of Gamma-Tocotrienol and Pentoxifylline on Radiation Protection: Efficacy and Molecular Mechanisms
    Role: Co-Investigator
    600-105-00000-00-105538     (HAUER-JENSEN, MARTIN)Aug 15, 2007 - Jun 30, 2010
    Uniformed Services University of the Health Sciences - Pass Through: Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Combined effect of Gamma-Tocotrienol and Pentoxifylline on Radiation Protection: Efficacy and Molecular Mechanisms
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Park SS, Boerma M. Hypofractionated Irradiation and Immune Modulation Therapies: Let's Work Together! Int J Radiat Oncol Biol Phys. 2021 11 01; 111(3):589-591. PMID: 34560018.
      View in: PubMed
    2. Jun SR, Boerma M, Udaondo Z, Richardson S, Thrall KD, Miousse IR, Seng J, Pathak R, Hauer-Jensen M. Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure. Metabolites. 2021 Aug 13; 11(8). PMID: 34436481.
      View in: PubMed
    3. Wang J, Garg S, Landes RD, Liu L, Fu Q, Seng J, Boerma M, Thrall K, Hauer-Jensen M, Pathak R. Differential Recovery of Small Intestinal Segments after Partial-Body Irradiation in Non-Human Primates. Radiat Res. 2021 08 01; 196(2):204-212. PMID: 34043805.
      View in: PubMed
    4. Boerma M, Davis CM, Jackson IL, Schaue D, Williams JP. All for one, though not one for all: team players in normal tissue radiobiology. Int J Radiat Biol. 2021 Jul 01; 1-21. PMID: 34129427.
      View in: PubMed
    5. Sridharan V, Johnson KA, Landes RD, Cao M, Singh P, Wagoner G, Hayar A, Sprick ED, Eveld KA, Bhattacharyya A, Krager KJ, Aykin-Burns N, Weiler H, Fernández JA, Griffin JH, Boerma M. Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin. PLoS One. 2021; 16(5):e0252142. PMID: 34029348.
      View in: PubMed
    6. Swinton C, Kiffer F, McElroy T, Wang J, Sridharan V, Boerma M, Allen AR. Effects of 16O charged-particle irradiation on cognition, hippocampal morphology and mutagenesis in female mice. Behav Brain Res. 2021 06 11; 407:113257. PMID: 33794227.
      View in: PubMed
    7. Hritzo B, Aghdam SY, Legesse B, Kaur A, Cao M, Boerma M, Chakraborty N, Dimitrov G, Gautam A, Hammamieh R, Wilkins W, Tsioplaya A, Holmes-Hampton GP, Moroni M. Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling. Int J Mol Sci. 2021 Mar 23; 22(6). PMID: 33807089.
      View in: PubMed
    8. Gilreath C, Boerma M, Qin Z, Hudson MK, Wang S. The Hypoxic Microenvironment of Breast Cancer Cells Promotes Resistance in Radiation Therapy. Front Oncol. 2020; 10:629422. PMID: 33680952.
      View in: PubMed
    9. Apte N, Dherange P, Mustafa U, Ya'qoub L, Dawson D, Higginbotham K, Boerma M, Morin DP, Gupta D, McLarty J, Mansour R, Dominic P. Cancer Radiation Therapy May Be Associated With Atrial Fibrillation. Front Cardiovasc Med. 2021; 8:610915. PMID: 33553271.
      View in: PubMed
    10. Boerma M, Koturbash I. Manned space travel: from a race between nations to a race against the environmental stressors beyond earth. J Environ Sci Health C Toxicol Carcinog. 2021; 39(2):109-112. PMID: 33902390.
      View in: PubMed
    11. Bose C, Alves I, Singh P, Palade PT, Carvalho E, Børsheim E, Jun SR, Cheema A, Boerma M, Awasthi S, Singh SP. Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling. Aging Cell. 2020 11; 19(11):e13261. PMID: 33067900.
      View in: PubMed
    12. Sadhukhan R, Majumdar D, Garg S, Landes RD, McHargue V, Pawar SA, Chowdhury P, Griffin RJ, Narayanasamy G, Boerma M, Dobretsov M, Hauer-Jensen M, Pathak R. Simultaneous exposure to chronic irradiation and simulated microgravity differentially alters immune cell phenotype in mouse thymus and spleen. Life Sci Space Res (Amst). 2021 Feb; 28:66-73. PMID: 33612181.
      View in: PubMed
    13. Jun SR, Cheema A, Bose C, Boerma M, Palade PT, Carvalho E, Awasthi S, Singh SP. Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice. Microorganisms. 2020 Sep 29; 8(10). PMID: 33003447.
      View in: PubMed
    14. Ewing LE, Skinner CM, Pathak R, Yee EU, Krager K, Gurley PC, Melnyk S, Boerma M, Hauer-Jensen M, Koturbash I. Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation. Int J Radiat Oncol Biol Phys. 2021 02 01; 109(2):581-593. PMID: 33002540.
      View in: PubMed
    15. Mao XW, Nishiyama NC, Byrum SD, Stanbouly S, Jones T, Holley J, Sridharan V, Boerma M, Tackett AJ, Willey JS, Pecaut MJ, Delp MD. Spaceflight induces oxidative damage to blood-brain barrier integrity in a mouse model. FASEB J. 2020 11; 34(11):15516-15530. PMID: 32981077.
      View in: PubMed
    16. Kiffer F, Alexander T, Anderson J, Groves T, McElroy T, Wang J, Sridharan V, Bauer M, Boerma M, Allen A. Late Effects of 1H + 16O on Short-Term and Object Memory, Hippocampal Dendritic Morphology and Mutagenesis. Front Behav Neurosci. 2020; 14:96. PMID: 32670032.
      View in: PubMed
    17. Upadhyay M, Rajagopal M, Gill K, Li Y, Bansal S, Sridharan V, Tyburski JB, Boerma M, Cheema AK. Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model. Metabolites. 2020 Jun 17; 10(6). PMID: 32560360.
      View in: PubMed
    18. Sridharan V, Seawright JW, Landes RD, Cao M, Singh P, Davis CM, Mao XW, Singh SP, Zhang X, Nelson GA, Boerma M. Effects of single-dose protons or oxygen ions on function and structure of the cardiovascular system in male Long Evans rats. Life Sci Space Res (Amst). 2020 Aug; 26:62-68. PMID: 32718688.
      View in: PubMed
    19. Unger K, Li Y, Yeh C, Barac A, Srichai MB, Ballew EA, Girgis M, Jayatilake M, Sridharan V, Boerma M, Cheema AK. Plasma metabolite biomarkers predictive of radiation induced cardiotoxicity. Radiother Oncol. 2020 11; 152:133-145. PMID: 32360032.
      View in: PubMed
    20. Schlaak RA, SenthilKumar G, Boerma M, Bergom C. Advances in Preclinical Research Models of Radiation-Induced Cardiac Toxicity. Cancers (Basel). 2020 Feb 11; 12(2). PMID: 32053873.
      View in: PubMed
    21. Mao XW, Nishiyama NC, Byrum SD, Stanbouly S, Jones T, Drew A, Sridharan V, Boerma M, Tackett AJ, Zawieja D, Willey JS, Delp M, Pecaut MJ. Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations. Sci Rep. 2019 06 03; 9(1):8215. PMID: 31160660.
      View in: PubMed
    22. Miousse IR, Skinner CM, Sridharan V, Seawright JW, Singh P, Landes RD, Cheema AK, Hauer-Jensen M, Boerma M, Koturbash I. Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (16O). Life Sci Space Res (Amst). 2019 Aug; 22:8-15. PMID: 31421852.
      View in: PubMed
    23. Kiffer F, Boerma M, Allen A. Behavioral effects of space radiation: A comprehensive review of animal studies. Life Sci Space Res (Amst). 2019 May; 21:1-21. PMID: 31101151.
      View in: PubMed
    24. Kiffer F, Alexander T, Anderson JE, Groves T, Wang J, Sridharan V, Boerma M, Allen AR. Late Effects of 16O-Particle Radiation on Female Social and Cognitive Behavior and Hippocampal Physiology. Radiat Res. 2019 03; 191(3):278-294. PMID: 30664396.
      View in: PubMed
    25. Seawright JW, Sridharan V, Landes RD, Cao M, Singh P, Koturbash I, Mao XW, Miousse IR, Singh SP, Nelson GA, Hauer-Jensen M, Boerma M. Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice. Life Sci Space Res (Amst). 2019 Feb; 20:72-84. PMID: 30797436.
      View in: PubMed
    26. Ewing LE, Miousse IR, Pathak R, Skinner CM, Kosanke S, Boerma M, Hauer-Jensen M, Koturbash I. NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity. Int J Radiat Biol. 2020 01; 96(1):93-99. PMID: 30561233.
      View in: PubMed
    27. Howe A, Kiffer F, Alexander TC, Sridharan V, Wang J, Ntagwabira F, Rodriguez A, Boerma M, Allen AR. Long-Term Changes in Cognition and Physiology after Low-Dose 16O Irradiation. Int J Mol Sci. 2019 Jan 07; 20(1). PMID: 30621014.
      View in: PubMed
    28. Aykin-Burns N, Pathak R, Boerma M, Kim T, Hauer-Jensen M. Utilization of Vitamin E Analogs to Protect Normal Tissues While Enhancing Antitumor Effects. Semin Radiat Oncol. 2019 01; 29(1):55-61. PMID: 30573184.
      View in: PubMed
    29. Skinner CM, Miousse IR, Ewing LE, Sridharan V, Cao M, Lin H, Williams DK, Avula B, Haider S, Chittiboyina AG, Khan IA, ElSohly MA, Boerma M, Gurley BJ, Koturbash I. Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro™ (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments. Food Chem Toxicol. 2018 Dec; 122:21-32. PMID: 30282009.
      View in: PubMed
    30. Mao XW, Byrum S, Nishiyama NC, Pecaut MJ, Sridharan V, Boerma M, Tackett AJ, Shiba D, Shirakawa M, Takahashi S, Delp MD. Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic Analysis. Int J Mol Sci. 2018 Aug 28; 19(9). PMID: 30154332.
      View in: PubMed
    31. Kiffer F, Howe AK, Carr H, Wang J, Alexander T, Anderson JE, Groves T, Seawright JW, Sridharan V, Carter G, Boerma M, Allen AR. Late effects of 1H irradiation on hippocampal physiology. Life Sci Space Res (Amst). 2018 May; 17:51-62. PMID: 29753414.
      View in: PubMed
    32. Carr H, Alexander TC, Groves T, Kiffer F, Wang J, Price E, Boerma M, Allen AR. Early effects of 16O radiation on neuronal morphology and cognition in a murine model. Life Sci Space Res (Amst). 2018 May; 17:63-73. PMID: 29753415.
      View in: PubMed
    33. Bose C, Awasthi S, Sharma R, Beneš H, Hauer-Jensen M, Boerma M, Singh SP. Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model. PLoS One. 2018; 13(3):e0193918. PMID: 29518137.
      View in: PubMed
    34. Wang Y, Chang J, Li X, Pathak R, Sridharan V, Jones T, Mao XW, Nelson G, Boerma M, Hauer-Jensen M, Zhou D, Shao L. Low doses of oxygen ion irradiation cause long-term damage to bone marrow hematopoietic progenitor and stem cells in mice. PLoS One. 2017; 12(12):e0189466. PMID: 29232383.
      View in: PubMed
    35. Kiffer F, Carr H, Groves T, Anderson JE, Alexander T, Wang J, Seawright JW, Sridharan V, Carter G, Boerma M, Allen AR. Effects of 1H + 16O Charged Particle Irradiation on Short-Term Memory and Hippocampal Physiology in a Murine Model. Radiat Res. 2018 01; 189(1):53-63. PMID: 29136391.
      View in: PubMed
    36. Casero D, Gill K, Sridharan V, Koturbash I, Nelson G, Hauer-Jensen M, Boerma M, Braun J, Cheema AK. Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome. Microbiome. 2017 08 18; 5(1):105. PMID: 28821301.
      View in: PubMed
    37. Chang J, Wang Y, Pathak R, Sridharan V, Jones T, Mao XW, Nelson G, Boerma M, Hauer-Jensen M, Zhou D, Shao L. Whole body proton irradiation causes acute damage to bone marrow hematopoietic progenitor and stem cells in mice. Int J Radiat Biol. 2017 12; 93(12):1312-1320. PMID: 28782442.
      View in: PubMed
    38. Seawright JW, Samman Y, Sridharan V, Mao XW, Cao M, Singh P, Melnyk S, Koturbash I, Nelson GA, Hauer-Jensen M, Boerma M. Effects of low-dose rate ?-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart. PLoS One. 2017; 12(7):e0180594. PMID: 28678877.
      View in: PubMed
    39. Groves TR, Wang J, Boerma M, Allen AR. Assessment of Hippocampal Dendritic Complexity in Aged Mice Using the Golgi-Cox Method. J Vis Exp. 2017 06 22; (124). PMID: 28671647.
      View in: PubMed
    40. Miousse IR, Tobacyk J, Melnyk S, James SJ, Cheema AK, Boerma M, Hauer-Jensen M, Koturbash I. One-carbon metabolism and ionizing radiation: a multifaceted interaction. Biomol Concepts. 2017 May 24; 8(2):83-92. PMID: 28574375.
      View in: PubMed
    41. Boerma M, Coyle EA, Dietrich MA, Dintzner MR, Drayton SJ, Early JL, Edginton AN, Horlen CK, Kirkwood CK, Lin AYF, Rager ML, Shah-Manek B, Welch AC, Williams NT. Point/Counterpoint: Are Outstanding Leaders Born or Made? Am J Pharm Educ. 2017 Apr; 81(3):58. PMID: 28496278.
      View in: PubMed
    42. Sharma S, Narayanasamy G, Clarkson R, Chao M, Moros EG, Zhang X, Yan Y, Boerma M, Paudel N, Morrill S, Corry P, Griffin RJ. Study of Image Qualities From 6D Robot-Based CBCT Imaging System of Small Animal Irradiator. Technol Cancer Res Treat. 2017 Dec; 16(6):811-818. PMID: 28355964.
      View in: PubMed
    43. Sridharan V, Seawright JW, Antonawich FJ, Garnett M, Cao M, Singh P, Boerma M. Late Administration of a Palladium Lipoic Acid Complex (POLY-MVA) Modifies Cardiac Mitochondria but Not Functional or Structural Manifestations of Radiation-Induced Heart Disease in a Rat Model. Radiat Res. 2017 03; 187(3):361-366. PMID: 28231026.
      View in: PubMed
    44. Boerma M, Freeman ML. Radiation Biology: Targeting CD47 in Cancer Growth Inhibition and Normal Tissue Protection. Int J Radiat Oncol Biol Phys. 2016 10 01; 96(2):245-247. PMID: 27598800.
      View in: PubMed
    45. Groves TR, Farris R, Anderson JE, Alexander TC, Kiffer F, Carter G, Wang J, Boerma M, Allen AR. 5-Fluorouracil chemotherapy upregulates cytokines and alters hippocampal dendritic complexity in aged mice. Behav Brain Res. 2017 01 01; 316:215-224. PMID: 27599618.
      View in: PubMed
    46. Boerma M, Sridharan V, Mao XW, Nelson GA, Cheema AK, Koturbash I, Singh SP, Tackett AJ, Hauer-Jensen M. Effects of ionizing radiation on the heart. Mutat Res Rev Mutat Res. 2016 Oct - Dec; 770(Pt B):319-327. PMID: 27919338.
      View in: PubMed
    47. Sharma S, Narayanasamy G, Przybyla B, Webber J, Boerma M, Clarkson R, Moros EG, Corry PM, Griffin RJ. Advanced Small Animal Conformal Radiation Therapy Device. Technol Cancer Res Treat. 2017 02; 16(1):45-56. PMID: 26792490.
      View in: PubMed
    48. Wang Y, Boerma M, Zhou D. Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases. Radiat Res. 2016 08; 186(2):153-61. PMID: 27387862.
      View in: PubMed
    49. Chang J, Luo Y, Wang Y, Pathak R, Sridharan V, Jones T, Mao XW, Nelson G, Boerma M, Hauer-Jensen M, Zhou D, Shao L. Low Doses of Oxygen Ion Irradiation Cause Acute Damage to Hematopoietic Cells in Mice. PLoS One. 2016; 11(7):e0158097. PMID: 27367604.
      View in: PubMed
    50. Pathak R, Bachri A, Ghosh SP, Koturbash I, Boerma M, Binz RK, Sawyer JR, Hauer-Jensen M. The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage. Pharm Res. 2016 09; 33(9):2117-25. PMID: 27216753.
      View in: PubMed
    51. Liu X, Gujarathi S, Zhang X, Shao L, Boerma M, Compadre CM, Crooks PA, Hauer-Jensen M, Zhou D, Zheng G. Synthesis of (2R,8' S,3' E)-d-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to d-tocotrienol. Tetrahedron. 2016 Jul; 72(27-28):4001-4006. PMID: 27773949.
      View in: PubMed
    52. Sridharan V, Thomas CJ, Cao M, Melnyk SB, Pavliv O, Joseph J, Singh SP, Sharma S, Moros EG, Boerma M. Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart. Radiother Oncol. 2016 05; 119(2):259-64. PMID: 27072940.
      View in: PubMed
    53. Koturbash I, Miousse IR, Sridharan V, Nzabarushimana E, Skinner CM, Melnyk SB, Pavliv O, Hauer-Jensen M, Nelson GA, Boerma M. Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart. Mutat Res. 2016 May; 787:43-53. PMID: 26963372.
      View in: PubMed
    54. Boerma M, Nelson GA, Sridharan V, Mao XW, Koturbash I, Hauer-Jensen M. Space radiation and cardiovascular disease risk. World J Cardiol. 2015 Dec 26; 7(12):882-8. PMID: 26730293.
      View in: PubMed
    55. Ramadan SS, Sridharan V, Koturbash I, Miousse IR, Hauer-Jensen M, Nelson GA, Boerma M. A priming dose of protons alters the early cardiac cellular and molecular response to (56)Fe irradiation. Life Sci Space Res (Amst). 2016 Feb; 8:8-13. PMID: 26948008.
      View in: PubMed
    56. Lieblong BJ, Sridharan V, Srivastava AK, Moros EG, Sharma SK, Boerma M. Role of the bradykinin B2 receptor in a rat model of local heart irradiation. Int J Radiat Biol. 2015 Aug; 91(8):634-42. PMID: 25955317.
      View in: PubMed
    57. Boerma M, Singh P, Sridharan V, Tripathi P, Sharma S, Singh SP. Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model. Radiat Res. 2015 Jun; 183(6):610-9. PMID: 26010708.
      View in: PubMed
    58. Pathak R, Shao L, Ghosh SP, Zhou D, Boerma M, Weiler H, Hauer-Jensen M. Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice. PLoS One. 2015; 10(4):e0122511. PMID: 25860286.
      View in: PubMed
    59. Sridharan V, Tripathi P, Aykin-Burns N, Krager KJ, Sharma SK, Moros EG, Melnyk SB, Pavliv O, Hauer-Jensen M, Boerma M. A tocotrienol-enriched formulation protects against radiation-induced changes in cardiac mitochondria without modifying late cardiac function or structure. Radiat Res. 2015 Mar; 183(3):357-66. PMID: 25710576.
      View in: PubMed
    60. Das M, Boerma M, Goree JR, Lavoie EG, Fausther M, Gubrij IB, Pangle AK, Johnson LG, Dranoff JA. Pathological changes in pulmonary circulation in carbon tetrachloride (CCl4)-induced cirrhotic mice. PLoS One. 2014; 9(4):e96043. PMID: 24763616.
      View in: PubMed
    61. Pawar SA, Shao L, Chang J, Wang W, Pathak R, Zhu X, Wang J, Hendrickson H, Boerma M, Sterneck E, Zhou D, Hauer-Jensen M. C/EBPd deficiency sensitizes mice to ionizing radiation-induced hematopoietic and intestinal injury. PLoS One. 2014; 9(4):e94967. PMID: 24747529.
      View in: PubMed
    62. Garg S, Wang W, Prabath BG, Boerma M, Wang J, Zhou D, Hauer-Jensen M. Bone marrow transplantation helps restore the intestinal mucosal barrier after total body irradiation in mice. Radiat Res. 2014 Mar; 181(3):229-39. PMID: 24568131.
      View in: PubMed
    63. Sridharan V, Aykin-Burns N, Tripathi P, Krager KJ, Sharma SK, Moros EG, Corry PM, Nowak G, Hauer-Jensen M, Boerma M. Radiation-induced alterations in mitochondria of the rat heart. Radiat Res. 2014 Mar; 181(3):324-34. PMID: 24568130.
      View in: PubMed
    64. Sridharan V, Tripathi P, Sharma S, Moros EG, Zheng J, Hauer-Jensen M, Boerma M. Roles of sensory nerves in the regulation of radiation-induced structural and functional changes in the heart. Int J Radiat Oncol Biol Phys. 2014 Jan 01; 88(1):167-74. PMID: 24331664.
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    65. Compadre CM, Singh A, Thakkar S, Zheng G, Breen PJ, Ghosh S, Kiaei M, Boerma M, Varughese KI, Hauer-Jensen M. Molecular dynamics guided design of tocoflexol: a new radioprotectant tocotrienol with enhanced bioavailability. Drug Dev Res. 2014 Feb; 75(1):10-22. PMID: 24648045.
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    66. Beneš H, Vuong MK, Boerma M, McElhanon KE, Siegel ER, Singh SP. Protection from oxidative and electrophilic stress in the Gsta4-null mouse heart. Cardiovasc Toxicol. 2013 Dec; 13(4):347-56. PMID: 23690225.
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    67. Wondergem J, Boerma M, Kodama K, Stewart FA, Trott KR. Cardiovascular effects after low-dose exposure and radiotherapy: what research is needed? Radiat Environ Biophys. 2013 Nov; 52(4):425-34. PMID: 23999657.
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    68. Sharma S, Moros EG, Boerma M, Sridharan V, Han EY, Clarkson R, Hauer-Jensen M, Corry PM. A novel technique for image-guided local heart irradiation in the rat. Technol Cancer Res Treat. 2014 Dec; 13(6):593-603. PMID: 24000983.
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    69. Boerma M, Wang J, Sridharan V, Herbert JM, Hauer-Jensen M. Pharmacological induction of transforming growth factor-beta1 in rat models enhances radiation injury in the intestine and the heart. PLoS One. 2013; 8(7):e70479. PMID: 23936211.
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    70. Sridharan V, Tripathi P, Sharma S, Corry PM, Moros EG, Singh A, Compadre CM, Hauer-Jensen M, Boerma M. Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation. PLoS One. 2013; 8(7):e68762. PMID: 23894340.
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    71. Pathak R, Pawar SA, Fu Q, Gupta PK, Berbée M, Garg S, Sridharan V, Wang W, Biju PG, Krager KJ, Boerma M, Ghosh SP, Cheema AK, Hendrickson HP, Aykin-Burns N, Hauer-Jensen M. Characterization of transgenic Gfrp knock-in mice: implications for tetrahydrobiopterin in modulation of normal tissue radiation responses. Antioxid Redox Signal. 2014 Mar 20; 20(9):1436-46. PMID: 23521531.
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    72. Sridharan V, Sharma SK, Moros EG, Corry PM, Tripathi P, Lieblong BJ, Guha C, Hauer-Jensen M, Boerma M. Effects of radiation on the epidermal growth factor receptor pathway in the heart. Int J Radiat Biol. 2013 Jul; 89(7):539-47. PMID: 23488537.
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    73. Sridharan V, Tripathi P, Sharma SK, Moros EG, Corry PM, Lieblong BJ, Kaschina E, Unger T, Thöne-Reineke C, Hauer-Jensen M, Boerma M. Cardiac inflammation after local irradiation is influenced by the kallikrein-kinin system. Cancer Res. 2012 Oct 01; 72(19):4984-92. PMID: 22865451.
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    74. Shaffer VA, Boerma M, Buonanno M, Costes S, Criswell T, Gonon G, Pandey BN, Pinto M, Rockwell S. Broadcasting in the airways: the fifth anniversary of the Radiation Research Podcast (1). Radiat Res. 2012 Jul; 178(1):99-100. PMID: 22686863.
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    75. Boerma M. Experimental radiation-induced heart disease: past, present, and future. Radiat Res. 2012 Jul; 178(1):1-6. PMID: 22663150.
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    76. Fu Q, Berbée M, Wang W, Boerma M, Wang J, Schmid HA, Hauer-Jensen M. Preclinical evaluation of Som230 as a radiation mitigator in a mouse model: postexposure time window and mechanisms of action. Radiat Res. 2011 Jun; 175(6):728-35. PMID: 21529145.
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    77. Berbée M, Fu Q, Boerma M, Sree Kumar K, Loose DS, Hauer-Jensen M. Mechanisms underlying the radioprotective properties of ?-tocotrienol: comparative gene expression profiling in tocol-treated endothelial cells. Genes Nutr. 2012 Jan; 7(1):75-81. PMID: 21516479.
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    78. Boerma M, Hauer-Jensen M. Potential targets for intervention in radiation-induced heart disease. Curr Drug Targets. 2010 Nov; 11(11):1405-12. PMID: 20583977.
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    79. Berbee M, Fu Q, Boerma M, Pathak R, Zhou D, Kumar KS, Hauer-Jensen M. Reduction of radiation-induced vascular nitrosative stress by the vitamin E analog ?-tocotrienol: evidence of a role for tetrahydrobiopterin. Int J Radiat Oncol Biol Phys. 2011 Mar 01; 79(3):884-91. PMID: 20950957.
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    80. Wang J, Boerma M, Kulkarni A, Hollenberg MD, Hauer-Jensen M. Activation of protease activated receptor 2 by exogenous agonist exacerbates early radiation injury in rat intestine. Int J Radiat Oncol Biol Phys. 2010 Jul 15; 77(4):1206-12. PMID: 20610041.
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    81. Garg S, Boerma M, Wang J, Fu Q, Loose DS, Kumar KS, Hauer-Jensen M. Influence of sublethal total-body irradiation on immune cell populations in the intestinal mucosa. Radiat Res. 2010 Apr; 173(4):469-78. PMID: 20334519.
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    82. Darby SC, Cutter DJ, Boerma M, Constine LS, Fajardo LF, Kodama K, Mabuchi K, Marks LB, Mettler FA, Pierce LJ, Trott KR, Yeh ET, Shore RE. Radiation-related heart disease: current knowledge and future prospects. Int J Radiat Oncol Biol Phys. 2010 Mar 01; 76(3):656-65. PMID: 20159360.
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    83. Owings RA, Boerma M, Wang J, Berbee M, Laderoute KR, Soderberg LS, Vural E, Jensen MH. Selective deficiency of HIF-1alpha in myeloid cells influences secondary intention wound healing in mouse skin. In Vivo. 2009 Nov-Dec; 23(6):879-84. PMID: 20023228.
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    84. Fu Q, Berbée M, Boerma M, Wang J, Schmid HA, Hauer-Jensen M. The somatostatin analog SOM230 (pasireotide) ameliorates injury of the intestinal mucosa and increases survival after total-body irradiation by inhibiting exocrine pancreatic secretion. Radiat Res. 2009 Jun; 171(6):698-707. PMID: 19580476.
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    85. Berbée M, Fu Q, Boerma M, Wang J, Kumar KS, Hauer-Jensen M. gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism. Radiat Res. 2009 May; 171(5):596-605. PMID: 19580495.
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    86. Richter GT, Bowen T, Boerma M, Fan CY, Hauer-Jensen M, Vural E. Impact of vascular endothelial growth factor on skin graft survival in irradiated rats. Arch Facial Plast Surg. 2009 Mar-Apr; 11(2):110-3. PMID: 19289683.
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    87. Boerma M, Fu Q, Wang J, Loose DS, Bartolozzi A, Ellis JL, McGonigle S, Paradise E, Sweetnam P, Fink LM, Vozenin-Brotons MC, Hauer-Jensen M. Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin. Blood Coagul Fibrinolysis. 2008 Oct; 19(7):709-18. PMID: 18832915.
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    88. Boerma M, Wang J, Kulkarni A, Roberto KA, Qiu X, Kennedy RH, Hauer-Jensen M. Influence of endothelin 1 receptor inhibition on functional, structural and molecular changes in the rat heart after irradiation. Radiat Res. 2008 Sep; 170(3):275-83. PMID: 18763854.
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    89. Boerma M, Roberto KA, Hauer-Jensen M. Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol. Int J Radiat Oncol Biol Phys. 2008 Sep 01; 72(1):170-7. PMID: 18632215.
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    90. Fu Q, Wang J, Boerma M, Berbée M, Qiu X, Fink LM, Hauer-Jensen M. Involvement of heat shock factor 1 in statin-induced transcriptional upregulation of endothelial thrombomodulin. Circ Res. 2008 Aug 15; 103(4):369-77. PMID: 18599869.
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    91. Boerma M, Wang J, Burnett AF, Santin AD, Roman JJ, Hauer-Jensen M. Local administration of interleukin-11 ameliorates intestinal radiation injury in rats. Cancer Res. 2007 Oct 01; 67(19):9501-6. PMID: 17909060.
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    92. Wang J, Boerma M, Fu Q, Kulkarni A, Fink LM, Hauer-Jensen M. Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism. Int J Radiat Oncol Biol Phys. 2007 Aug 01; 68(5):1483-90. PMID: 17674978.
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    93. Wang J, Boerma M, Fu Q, Hauer-Jensen M. Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy. World J Gastroenterol. 2007 Jun 14; 13(22):3047-55. PMID: 17589919.
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    94. Hauer-Jensen M, Wang J, Boerma M, Fu Q, Denham JW. Radiation damage to the gastrointestinal tract: mechanisms, diagnosis, and management. Curr Opin Support Palliat Care. 2007 Apr; 1(1):23-9. PMID: 18660720.
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    95. Boerma M, Fiser WP, Hoyt G, Berry GJ, Joseph L, Joseph J, Wang J, Crew MD, Robbins RC, Hauer-Jensen M. Influence of mast cells on outcome after heterotopic cardiac transplantation in rats. Transpl Int. 2007 Mar; 20(3):256-65. PMID: 17291219.
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    96. Wang J, Boerma M, Fu Q, Hauer-Jensen M. Radiation responses in skin and connective tissues: effect on wound healing and surgical outcome. Hernia. 2006 Dec; 10(6):502-6. PMID: 17047884.
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    97. Boerma M, Wang J, Richter KK, Hauer-Jensen M. Orazipone, a locally acting immunomodulator, ameliorates intestinal radiation injury: a preclinical study in a novel rat model. Int J Radiat Oncol Biol Phys. 2006 Oct 01; 66(2):552-9. PMID: 16965997.
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    98. Kennedy RH, Owings R, Joseph J, Melchert RB, Hauer-Jensen M, Boerma M. Acute dilatory and negative inotropic effects of homocysteine are inhibited by an adenosine blocker. Clin Exp Pharmacol Physiol. 2006 Apr; 33(4):340-4. PMID: 16620298.
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    99. Boerma M, Burton GR, Wang J, Fink LM, McGehee RE, Hauer-Jensen M. Comparative expression profiling in primary and immortalized endothelial cells: changes in gene expression in response to hydroxy methylglutaryl-coenzyme A reductase inhibition. Blood Coagul Fibrinolysis. 2006 Apr; 17(3):173-80. PMID: 16575254.
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    100. Boerma M, Wang J, Wondergem J, Joseph J, Qiu X, Kennedy RH, Hauer-Jensen M. Influence of mast cells on structural and functional manifestations of radiation-induced heart disease. Cancer Res. 2005 Apr 15; 65(8):3100-7. PMID: 15833839.
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    101. Boerma M, van der Wees CG, Vrieling H, Svensson JP, Wondergem J, van der Laarse A, Mullenders LH, van Zeeland AA. Microarray analysis of gene expression profiles of cardiac myocytes and fibroblasts after mechanical stress, ionising or ultraviolet radiation. BMC Genomics. 2005 Jan 18; 6:6. PMID: 15656902.
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    102. Boerma M, Kruse JJ, van Loenen M, Klein HR, Bart CI, Zurcher C, Wondergem J. Increased deposition of von Willebrand factor in the rat heart after local ionizing irradiation. Strahlenther Onkol. 2004 Feb; 180(2):109-16. PMID: 14762664.
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