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Darin Jones

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPharmaceutical Science, College of Pharmacy
DivisionPharmaceutical Science
Address200 South Cedar
Mail Slot # 622
Little Rock AR 72202
Phone501-686-6496
ORCID ORCID Icon0000-0003-1581-3453 Additional info
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    Collapse Research 
    Collapse research activities and funding
    DE-AC02     (JONES, DARIN)Dec 15, 2023 - Sep 30, 2026
    US Department of Energy - Pass Through: Lawrence Berkeley National Laboratory
    A Plug and Play DOE Approach for Emerging Threats: Taskforce 5
    Role: Principal Investigator

    DE-AC02-05CH11231     (JONES, DARIN)Dec 15, 2023 - Sep 30, 2026
    US Department of Energy - Pass Through: Lawrence Berkeley National Laboratory
    A Plug and Play DOE Approach for Emerging Threats: Taskforce 5
    Role: Principal Investigator

    R01CA276837     (JONES, DARIN)Jun 1, 2023 - May 31, 2028
    NIH/Nat. Cancer Institute - Pass Through: University of New Mexico
    Targeting DNA ligase 1 in Ovarian Cancer
    Role: Principal Investigator

    P01CA092584     (JONES, DARIN)Sep 21, 2021 - Aug 31, 2026
    NIH/Nat. Cancer Institute - Pass Through: Lawrence Berkeley National Laboratory
    Structural Cell Biology of DNA Repair Machines Project 3 - PARP: PAR-dependent, phase-transitioned protein assemblies, and DNA repair.
    Role: Principal Investigator

    80NSSC21M0323     (PATHAK, RUPAK)Aug 15, 2021 - Aug 14, 2025
    National Aeronautics & Space Administration - Pass Through: Arkansas Space Grant Consortium
    Preventing immune system dysregulation during deep-space missions by Tocofexol, a modified isomer of vitamin E - AA request
    Role: Principal Investigator

    R01CA200231     (JONES, DARIN)Sep 1, 2018 - Feb 28, 2021
    NIH/Nat. Cancer Institute - Pass Through: University of Texas Health Science Center at Houston
    Pharmacological Modulation of Poly (ADP-ribose) Metabolism
    Role: Principal Investigator

    R01GM047251     (JONES, DARIN)Aug 1, 2018 - Jul 31, 2022
    NIH/Nat. Inst. of General Medical Sciences - Pass Through: University of New Mexico
    Cellular Functions of Eukaryotic DNA Ligases - Continuation
    Role: Principal Investigator

    R01CA200231     (AHMED, ZAMAL)Mar 7, 2016 - Feb 28, 2021
    NIH
    PHARMACOLOGICAL MODULATION OF POLY(ADP-RIBOSE) METABOLISM
    Role: Co-Principal Investigator

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    1. Shrum SA, Nukala U, Shrimali S, Pineda EN, Krager KJ, Thakkar S, Jones DE, Pathak R, Breen PJ, Aykin-Burns N, Compadre CM. Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects. Antioxidants (Basel). 2023 Nov 09; 12(11). PMID: 38001840.
      View in: PubMed
    2. Mery DE, Compadre AJ, Ord??ez PE, Selvik EJ, Morocho V, Contreras J, Malag?n O, Jones DE, Breen PJ, Balick MJ, Gaudio FG, Guzman ML, Compadre CM. Analysis of Plant-Plant Interactions Reveals the Presence of Potent Antileukemic Compounds. Molecules. 2022 May 04; 27(9). PMID: 35566279.
      View in: PubMed
    3. Moiani D, Link TM, Brosey CA, Katsonis P, Lichtarge O, Kim Y, Joachimiak A, Ma Z, Kim IK, Ahmed Z, Jones DE, Tsutakawa SE, Tainer JA. An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2. Methods Enzymol. 2021; 661:407-431. PMID: 34776222.
      View in: PubMed
    4. Ye Z, Xu S, Shi Y, Bacolla A, Syed A, Moiani D, Tsai CL, Shen Q, Peng G, Leonard PG, Jones DE, Wang B, Tainer JA, Ahmed Z. GRB2 enforces homology-directed repair initiation by MRE11. Sci Adv. 2021 Aug; 7(32). PMID: 34348893.
      View in: PubMed
    5. Brosey CA, Houl JH, Katsonis P, Balapiti-Modarage LPF, Bommagani S, Arvai A, Moiani D, Bacolla A, Link T, Warden LS, Lichtarge O, Jones DE, Ahmed Z, Tainer JA. Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog Biophys Mol Biol. 2021 08; 163:171-186. PMID: 33636189.
      View in: PubMed
    6. Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 12824026.
      View in: PubMed
    7. Howes TRL, Sallmyr A, Brooks R, Greco GE, Jones DE, Matsumoto Y, Tomkinson AE. Erratum to "Structure-activity relationships among DNA ligase inhibitors; characterization of a selective uncompetitive DNA ligase I inhibitor" [DNA Repair 60C (2017) 29-39]. DNA Repair (Amst). 2018 01; 61:99. PMID: 29273192.
      View in: PubMed
    8. Ord??ez PE, Sharma KK, Bystrom LM, Alas MA, Enriquez RG, Malag?n O, Jones DE, Guzman ML, Compadre CM. Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells. J Nat Prod. 2016 Apr 22; 79(4):691-6. PMID: 27057812.
      View in: PubMed
    9. Franco FM, Jones DE, Harris PK, Han Z, Wildman SA, Jarvis CM, Janetka JW. Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets. Bioorg Med Chem. 2015 May 15; 23(10):2328-43. PMID: 25882520.
      View in: PubMed
    10. Han Z, Harris PK, Jones DE, Chugani R, Kim T, Agarwal M, Shen W, Wildman SA, Janetka JW. Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer. ACS Med Chem Lett. 2014 Nov 13; 5(11):1219-24. PMID: 25408834.
      View in: PubMed
    11. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 23260349.
      View in: PubMed
    12. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 33092263.
      View in: PubMed
    13. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 31827085.
      View in: PubMed
    14. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 29078112.
      View in: PubMed
    15. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 33675849.
      View in: PubMed
    16. Parlow JJ, Case BL, Dice TA, Fenton RL, Hayes MJ, Jones DE, Neumann WL, Wood RS, Lachance RM, Girard TJ, Nicholson NS, Clare M, Stegeman RA, Stevens AM, Stallings WC, Kurumbail RG, South MS. Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex. J Med Chem. 2003 Sep 11; 46(19):4050-62. PMID: 12954058.
      View in: PubMed
    17. Davis MO, Hata DJ, Johnson SA, Jones DE, Harmata MA, Evans ML, Walker JC, Smith DS. Cloning, sequence, and expression of a blood group B active recombinant alpha-D-galactosidase from pinto bean (Phaseolus vulgaris). Biochem Mol Biol Int. 1997 Jul; 42(3):453-67. PMID: 9247703.
      View in: PubMed
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