 Darin Jones
| Title | Associate Professor |
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| Institution | University of Arkansas for Medical Sciences |
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| Department | Pharmaceutical Science, College of Pharmacy |
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| Division | Pharmaceutical Science |
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| Address | 200 South Cedar
Mail Slot # 622
Little Rock AR 72202
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| Phone | 501-686-6496 |
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ORCID
.gif) | 0000-0003-1581-3453  |
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| vCard | Download vCard |
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 Research DE-AC02 (JONES, DARIN)Dec 15, 2023 - Sep 30, 2026 US Department of Energy - Pass Through: Lawrence Berkeley National Laboratory
A Plug and Play DOE Approach for Emerging Threats: Taskforce 5
Role: Principal Investigator |
| DE-AC02-05CH11231 (JONES, DARIN)Dec 15, 2023 - Sep 30, 2026 US Department of Energy - Pass Through: Lawrence Berkeley National Laboratory
A Plug and Play DOE Approach for Emerging Threats: Taskforce 5
Role: Principal Investigator |
| R01CA276837 (JONES, DARIN)Jun 1, 2023 - May 31, 2028 NIH/Nat. Cancer Institute - Pass Through: University of New Mexico
Targeting DNA ligase 1 in Ovarian Cancer
Role: Principal Investigator |
| P01CA092584 (JONES, DARIN)Sep 21, 2021 - Aug 31, 2026 NIH/Nat. Cancer Institute - Pass Through: Lawrence Berkeley National Laboratory
Structural Cell Biology of DNA Repair Machines Project 3 - PARP: PAR-dependent, phase-transitioned protein assemblies, and DNA repair.
Role: Principal Investigator |
| 80NSSC21M0323 (PATHAK, RUPAK)Aug 15, 2021 - Aug 14, 2025 National Aeronautics & Space Administration - Pass Through: Arkansas Space Grant Consortium
Preventing immune system dysregulation during deep-space missions by Tocofexol, a modified isomer of vitamin E - AA request
Role: Principal Investigator |
| R01CA200231 (JONES, DARIN)Sep 1, 2018 - Feb 28, 2021 NIH/Nat. Cancer Institute - Pass Through: University of Texas Health Science Center at Houston
Pharmacological Modulation of Poly (ADP-ribose) Metabolism
Role: Principal Investigator |
| R01GM047251 (JONES, DARIN)Aug 1, 2018 - Jul 31, 2022 NIH/Nat. Inst. of General Medical Sciences - Pass Through: University of New Mexico
Cellular Functions of Eukaryotic DNA Ligases - Continuation
Role: Principal Investigator |
| R01CA200231 (AHMED, ZAMAL)Mar 7, 2016 - Feb 28, 2021 NIH
PHARMACOLOGICAL MODULATION OF POLY(ADP-RIBOSE) METABOLISM
Role: Co-Principal Investigator |
Bibliographic The links below are provided by the researcher to provide access to external online bibliographies that they keep independently from the Profiles System.
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Shrum SA, Nukala U, Shrimali S, Pineda EN, Krager KJ, Thakkar S, Jones DE, Pathak R, Breen PJ, Aykin-Burns N, Compadre CM. Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects. Antioxidants (Basel). 2023 Nov 09; 12(11). PMID: 38001840.
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Mery DE, Compadre AJ, Ord??ez PE, Selvik EJ, Morocho V, Contreras J, Malag?n O, Jones DE, Breen PJ, Balick MJ, Gaudio FG, Guzman ML, Compadre CM. Analysis of Plant-Plant Interactions Reveals the Presence of Potent Antileukemic Compounds. Molecules. 2022 May 04; 27(9). PMID: 35566279.
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Moiani D, Link TM, Brosey CA, Katsonis P, Lichtarge O, Kim Y, Joachimiak A, Ma Z, Kim IK, Ahmed Z, Jones DE, Tsutakawa SE, Tainer JA. An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2. Methods Enzymol. 2021; 661:407-431. PMID: 34776222.
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Ye Z, Xu S, Shi Y, Bacolla A, Syed A, Moiani D, Tsai CL, Shen Q, Peng G, Leonard PG, Jones DE, Wang B, Tainer JA, Ahmed Z. GRB2 enforces homology-directed repair initiation by MRE11. Sci Adv. 2021 Aug; 7(32). PMID: 34348893.
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Nguyen MT, Moiani D, Ahmed Z, Arvai AS, Namjoshi S, Shin DS, Fedorov Y, Selvik EJ, Jones DE, Pink J, Yan Y, Laverty DJ, Nagel ZD, Tainer JA, Gerson SL. An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation. Prog Biophys Mol Biol. 2021 08; 163:143-159. PMID: 33675849.
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Brosey CA, Houl JH, Katsonis P, Balapiti-Modarage LPF, Bommagani S, Arvai A, Moiani D, Bacolla A, Link T, Warden LS, Lichtarge O, Jones DE, Ahmed Z, Tainer JA. Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog Biophys Mol Biol. 2021 08; 163:171-186. PMID: 33636189.
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Ord??ez PE, Mery DE, Sharma KK, Nemu S, Reynolds WF, Enriquez RG, Burns DC, Malag?n O, Jones DE, Guzman ML, Compadre CM. Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine. Molecules. 2020 Oct 20; 25(20). PMID: 33092263.
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Houl JH, Ye Z, Brosey CA, Balapiti-Modarage LPF, Namjoshi S, Bacolla A, Laverty D, Walker BL, Pourfarjam Y, Warden LS, Babu Chinnam N, Moiani D, Stegeman RA, Chen MK, Hung MC, Nagel ZD, Ellenberger T, Kim IK, Jones DE, Ahmed Z, Tainer JA. Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nat Commun. 2019 12 11; 10(1):5654. PMID: 31827085.
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Howes TRL, Sallmyr A, Brooks R, Greco GE, Jones DE, Matsumoto Y, Tomkinson AE. Erratum to "Structure-activity relationships among DNA ligase inhibitors; characterization of a selective uncompetitive DNA ligase I inhibitor" [DNA Repair 60C (2017) 29-39]. DNA Repair (Amst). 2018 01; 61:99. PMID: 29273192.
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Howes TRL, Sallmyr A, Brooks R, Greco GE, Jones DE, Matsumoto Y, Tomkinson AE. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017 12; 60:29-39. PMID: 29078112.
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Ord??ez PE, Sharma KK, Bystrom LM, Alas MA, Enriquez RG, Malag?n O, Jones DE, Guzman ML, Compadre CM. Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells. J Nat Prod. 2016 Apr 22; 79(4):691-6. PMID: 27057812.
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Franco FM, Jones DE, Harris PK, Han Z, Wildman SA, Jarvis CM, Janetka JW. Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets. Bioorg Med Chem. 2015 May 15; 23(10):2328-43. PMID: 25882520.
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Han Z, Harris PK, Jones DE, Chugani R, Kim T, Agarwal M, Shen W, Wildman SA, Janetka JW. Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer. ACS Med Chem Lett. 2014 Nov 13; 5(11):1219-24. PMID: 25408834.
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Arhancet GB, Walker DP, Metz S, Fobian YM, Heasley SE, Carter JS, Springer JR, Jones DE, Hayes MJ, Shaffer AF, Jerome GM, Baratta MT, Zweifel B, Moore WM, Masferrer JL, Vazquez ML. Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation. Bioorg Med Chem Lett. 2013 Feb 15; 23(4):1114-9. PMID: 23260349.
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Parlow JJ, Case BL, Dice TA, Fenton RL, Hayes MJ, Jones DE, Neumann WL, Wood RS, Lachance RM, Girard TJ, Nicholson NS, Clare M, Stegeman RA, Stevens AM, Stallings WC, Kurumbail RG, South MS. Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex. J Med Chem. 2003 Sep 11; 46(19):4050-62. PMID: 12954058.
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South MS, Case BL, Wood RS, Jones DE, Hayes MJ, Girard TJ, Lachance RM, Nicholson NS, Clare M, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, Parlow JJ. Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex. Bioorg Med Chem Lett. 2003 Jul 21; 13(14):2319-25. PMID: 12824026.
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Davis MO, Hata DJ, Johnson SA, Jones DE, Harmata MA, Evans ML, Walker JC, Smith DS. Cloning, sequence, and expression of a blood group B active recombinant alpha-D-galactosidase from pinto bean (Phaseolus vulgaris). Biochem Mol Biol Int. 1997 Jul; 42(3):453-67. PMID: 9247703.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 1997 | 1 | | 2003 | 2 | | 2012 | 1 | | 2014 | 1 | | 2015 | 1 | | 2016 | 1 | | 2017 | 2 | | 2019 | 1 | | 2020 | 1 | | 2021 | 4 | | 2022 | 1 | | 2023 | 1 |
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