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Cesar Compadre

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPharmaceutical Science, College of Pharmacy
DivisionPharmaceutical Science
Address246 Biomedical Research I
325 S. Elm St.
Mail Slot # 522-3
Little Rock AR 72205
Phone501-686-6493
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    Other Positions
    TitleAdjunct Clinical Assistant Professor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentInternal Medicine, College of Medicine
    DivisionPulmonary & Critical Care


    Collapse Research 
    Collapse research activities and funding
    1238     (COMPADRE, CESAR M)Jul 1, 2007 - Jun 30, 2008
    Arkansas Department of Health & Human Services - Pass Through: University of Arkansas at Pine Bluff
    Latino Smoke-Free Coalition
    Role: Principal Investigator
    17504     (COMPADRE, CESAR M)Apr 15, 2007 - Apr 14, 2008
    National Aeronautics & Space Administration - Pass Through: Arkansas Space Grant Consortium
    Developing Countermeasures for Acute Respiratory Distress Produced by Lunar Dust
    Role: Principal Investigator
    1192     (COMPADRE, CESAR M)Jul 1, 2006 - Jun 30, 2007
    Arkansas Department of Health & Human Services - Pass Through: University of Arkansas at Pine Bluff
    Latino Smoke-Free Coalition
    Role: Principal Investigator
    4600010227     (COMPADRE, CESAR M)Jul 1, 2006 - Jun 30, 2007
    Arkansas Department of Health & Human Services
    Unwed Birth Prevention for Teenagers of Hispanic Heritage in Sevier County
    Role: Principal Investigator
    1067     (COMPADRE, CESAR M)Jul 1, 2003 - Jun 30, 2006
    Arkansas Department of Health - Pass Through: University of Arkansas at Pine Bluff
    La Casa Latino Tobacco Free Coalition (subcontract with UAPB)
    Role: Principal Investigator
    P01AG012411     (GRIFFIN, SUE TILTON)Jun 1, 1995 - May 31, 2021
    NIH
    Early Events in Alzheimer Pathogenesis
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Shrum SA, Nukala U, Shrimali S, Pineda EN, Krager KJ, Thakkar S, Jones DE, Pathak R, Breen PJ, Aykin-Burns N, Compadre CM. Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects. Antioxidants (Basel). 2023 Nov 09; 12(11). PMID: 38001840.
      View in: PubMed
    2. LoBianco FV, Krager KJ, Johnson E, Godwin CO, Allen AR, Crooks PA, Compadre CM, Borrelli MJ, Aykin-Burns N. Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells. Front Toxicol. 2022; 4:936149. PMID: 36591540.
      View in: PubMed
    3. Mery DE, Compadre AJ, Ord??ez PE, Selvik EJ, Morocho V, Contreras J, Malag?n O, Jones DE, Breen PJ, Balick MJ, Gaudio FG, Guzman ML, Compadre CM. Analysis of Plant-Plant Interactions Reveals the Presence of Potent Antileukemic Compounds. Molecules. 2022 May 04; 27(9). PMID: 35566279.
      View in: PubMed
    4. Choi AN, Payakachat N, Harrington HP, Compadre C. Yoga therapy knowledge in third-year pharmacy students: An education intervention. Curr Pharm Teach Learn. 2021 06; 13(6):665-671. PMID: 33867062.
      View in: PubMed
    5. Ord??ez PE, Mery DE, Sharma KK, Nemu S, Reynolds WF, Enriquez RG, Burns DC, Malag?n O, Jones DE, Guzman ML, Compadre CM. Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine. Molecules. 2020 Oct 20; 25(20). PMID: 33092263.
      View in: PubMed
    6. Nukala U, Thakkar S, Krager KJ, Breen PJ, Compadre CM, Aykin-Burns N. Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans). Antioxidants (Basel). 2018 Feb 23; 7(2). PMID: 29473853.
      View in: PubMed
    7. Fil D, DeLoach A, Yadav S, Alkam D, MacNicol M, Singh A, Compadre CM, Goellner JJ, O'Brien CA, Fahmi T, Basnakian AG, Calingasan NY, Klessner JL, Beal FM, Peters OM, Metterville J, Brown RH, Ling KKY, Rigo F, Ozdinler PH, Kiaei M. Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease. Hum Mol Genet. 2017 02 15; 26(4):686-701. PMID: 28040732.
      View in: PubMed
    8. Liu X, Gujarathi S, Zhang X, Shao L, Boerma M, Compadre CM, Crooks PA, Hauer-Jensen M, Zhou D, Zheng G. Synthesis of (2R,8' S,3' E)-d-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to d-tocotrienol. Tetrahedron. 2016 Jul; 72(27-28):4001-4006. PMID: 27773949.
      View in: PubMed
    9. Ord??ez PE, Quave CL, Reynolds WF, Varughese KI, Berry B, Breen PJ, Malag?n O, Vidari G, Smeltzer MS, Compadre CM. Corrigendum to "Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity" [J. Ethnopharmacol. 137 (2011) 1055-1059]. J Ethnopharmacol. 2016 06 20; 186:392. PMID: 27165010.
      View in: PubMed
    10. Ord??ez PE, Sharma KK, Bystrom LM, Alas MA, Enriquez RG, Malag?n O, Jones DE, Guzman ML, Compadre CM. Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells. J Nat Prod. 2016 Apr 22; 79(4):691-6. PMID: 27057812.
      View in: PubMed
    11. Krager KJ, Pineda EN, Kharade SV, Kordsmeier M, Howard L, Breen PJ, Compadre CM, Hauer-Jensen M, Aykin-Burns N. Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity. Evid Based Complement Alternat Med. 2015; 2015:148791. PMID: 26425129.
      View in: PubMed
    12. Cardenas VM, Breen PJ, Compadre CM, Delongchamp RR, Barone CP, Phillips MM, Wheeler JG. The smoking habits of the family influence the uptake of e-cigarettes in US children. Ann Epidemiol. 2015 Jan; 25(1):60-2. PMID: 25453726.
      View in: PubMed
    13. Compadre CM, Singh A, Thakkar S, Zheng G, Breen PJ, Ghosh S, Kiaei M, Boerma M, Varughese KI, Hauer-Jensen M. Molecular dynamics guided design of tocoflexol: a new radioprotectant tocotrienol with enhanced bioavailability. Drug Dev Res. 2014 Feb; 75(1):10-22. PMID: 24648045.
      View in: PubMed
    14. Sridharan V, Tripathi P, Sharma S, Corry PM, Moros EG, Singh A, Compadre CM, Hauer-Jensen M, Boerma M. Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation. PLoS One. 2013; 8(7):e68762. PMID: 23894340.
      View in: PubMed
    15. Hobby GH, Quave CL, Nelson K, Compadre CM, Beenken KE, Smeltzer MS. Quercus cerris extracts limit Staphylococcus aureus biofilm formation. J Ethnopharmacol. 2012 Dec 18; 144(3):812-5. PMID: 23127649.
      View in: PubMed
    16. Quave CL, Est?vez-Carmona M, Compadre CM, Hobby G, Hendrickson H, Beenken KE, Smeltzer MS. Ellagic acid derivatives from Rubus ulmifolius inhibit Staphylococcus aureus biofilm formation and improve response to antibiotics. PLoS One. 2012; 7(1):e28737. PMID: 22242149.
      View in: PubMed
    17. Nowak G, Bakajsova D, Hayes C, Hauer-Jensen M, Compadre CM. ?-Tocotrienol protects against mitochondrial dysfunction and renal cell death. J Pharmacol Exp Ther. 2012 Feb; 340(2):330-8. PMID: 22040679.
      View in: PubMed
    18. Ord??ez PE, Quave CL, Reynolds WF, Varughese KI, Berry B, Breen PJ, Malag?n O, Smeltzer MS, Compadre CM. Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity. J Ethnopharmacol. 2011 09 02; 137(2):1055-9. PMID: 21782013.
      View in: PubMed
    19. Rodr?guez-Morales S, Compadre RL, Castillo R, Breen PJ, Compadre CM. 3D-QSAR, synthesis, and antimicrobial activity of 1-alkylpyridinium compounds as potential agents to improve food safety. Eur J Med Chem. 2005 Sep; 40(9):840-9. PMID: 16194718.
      View in: PubMed
    20. Rodr?guez-Morales S, Zhou X, Salari H, Castillo R, Breen PJ, Compadre CM. Liquid chromatography determination of residue levels on apples treated with cetylpyridinium chloride. J Chromatogr A. 2005 Jan 14; 1062(2):285-9. PMID: 15679166.
      View in: PubMed
    21. Joguparthi V, Breen P, Compadre C, Zhou X, Gann L, Hiller FC, Anderson P. Effect of propellant on the pharmacokinetics and pharmacodynamics of inhaled albuterol in asthmatic subjects. J Aerosol Med. 2003; 16(1):47-53. PMID: 12737684.
      View in: PubMed
    22. Raufman JP, Chen Y, Cheng K, Compadre C, Compadre L, Zimniak P. Selective interaction of bile acids with muscarinic receptors: a case of molecular mimicry. Eur J Pharmacol. 2002 Dec 20; 457(2-3):77-84. PMID: 12464352.
      View in: PubMed
    23. Mercer KE, Ahn CE, Coke A, Compadre CM, Drake RR. Mutation of herpesvirus thymidine kinase to generate ganciclovir-specific kinases for use in cancer gene therapies. Protein Eng. 2002 Nov; 15(11):903-11. PMID: 12538910.
      View in: PubMed
    24. Maleki SJ, Kopper RA, Shin DS, Park CW, Compadre CM, Sampson H, Burks AW, Bannon GA. Structure of the major peanut allergen Ara h 1 may protect IgE-binding epitopes from degradation. J Immunol. 2000 Jun 01; 164(11):5844-9. PMID: 10820263.
      View in: PubMed
    25. Cutter CN, Dorsa WJ, Handie A, Rodriguez-Morales S, Zhou X, Breen PJ, Compadre CM. Antimicrobial activity of cetylpyridinium chloride washes against pathogenic bacteria on beef surfaces. J Food Prot. 2000 May; 63(5):593-600. PMID: 10826715.
      View in: PubMed
    26. Hinds TA, Compadre C, Hurlburt BK, Drake RR. Conservative mutations of glutamine-125 in herpes simplex virus type 1 thymidine kinase result in a ganciclovir kinase with minimal deoxypyrimidine kinase activities. Biochemistry. 2000 Apr 11; 39(14):4105-11. PMID: 10747801.
      View in: PubMed
    27. Zhou X, Handie A, Salari H, Fifer EK, Breen PJ, Compadre CM. High-performance liquid chromatography determination of residue levels on chicken carcasses treated with cetylpyridinium chloride. J Chromatogr B Biomed Sci Appl. 1999 May 28; 728(2):273-7. PMID: 10406212.
      View in: PubMed
    28. Anderson PJ, Zhou X, Breen P, Gann L, Logsdon TW, Compadre CM, Hiller FC. Pharmacokinetics of (R,S)-Albuterol after aerosol inhalation in healthy adult volunteers. J Pharm Sci. 1998 Jul; 87(7):841-4. PMID: 9649352.
      View in: PubMed
    29. Shin DS, Compadre CM, Maleki SJ, Kopper RA, Sampson H, Huang SK, Burks AW, Bannon GA. Biochemical and structural analysis of the IgE binding sites on ara h1, an abundant and highly allergenic peanut protein. J Biol Chem. 1998 May 29; 273(22):13753-9. PMID: 9593717.
      View in: PubMed
    30. Fan M, Byrd C, Compadre CM, Compadre RL. Comparison of CoMFA models for Salmonella typhimurium TA98, TA100, TA98 + S9 and TA100 + S9 mutagenicity of nitroaromatics. SAR QSAR Environ Res. 1998; 9(3-4):187-215. PMID: 9933959.
      View in: PubMed
    31. Breen PJ, Salari H, Compadre CM. Elimination of Salmonella Contamination from Poultry Tissues by Cetylpyridinium Chloride Solutions. J Food Prot. 1997 Sep; 60(9):1019-1021. PMID: 31207819.
      View in: PubMed
    32. Logsdon TW, Zhou X, Breen P, Anderson P, Gann L, Hiller C, Compadre CM. Determination of albuterol in plasma after aerosol inhalation by gas chromatography-mass spectrometry with selected-ion monitoring. J Chromatogr B Biomed Sci Appl. 1997 May 09; 692(2):472-7. PMID: 9188839.
      View in: PubMed
    33. Marles RJ, Hudson JB, Graham EA, Soucy-Breau C, Morand P, Compadre RL, Compadre CM, Towers GH, Arnason JT. Structure-activity studies of photoactivated antiviral and cytotoxic tricyclic thiophenes. Photochem Photobiol. 1992 Oct; 56(4):479-87. PMID: 1333615.
      View in: PubMed
    34. Compadre CM, Hansch C, Klein TE, Petridou-Fischer J, Selassie CD, Smith RN, Steinmetz W, Yang CZ, Yang GZ. Separation of electronic and hydrophobic effects for the papain hydrolysis of substituted N-benzoylglycine esters. Biochim Biophys Acta. 1991 Aug 09; 1079(1):43-52. PMID: 1888764.
      View in: PubMed
    35. Compadre CM, Hansch C, Klein TE, Langridge R. The structure-activity relationship of the papain hydrolysis of N-benzoylglycine esters. Biochim Biophys Acta. 1990 Apr 19; 1038(2):158-63. PMID: 2331480.
      View in: PubMed
    36. Fullas F, Kim J, Compadre CM, Kinghorn AD. Separation of natural product sweetening agents using overpressured layer chromatography. J Chromatogr. 1989 Feb 17; 464(1):213-9. PMID: 2715248.
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    37. Compadre CM, Hussain RA, Lopez de Compadre RL, Pezzuto JM, Kinghorn AD. Analysis of structural features responsible for the sweetness of the sesquiterpene, hernandulcin. Experientia. 1988 May 15; 44(5):447-9. PMID: 3371450.
      View in: PubMed
    38. Compadre CM, Hussain RA, Nanayakkara NP, Pezzuto JM, Kinghorn AD. Mass spectral analysis of some derivatives and in vitro metabolites of steviol, the aglycone of the natural sweeteners, stevioside, rebaudioside A, and rubusoside. Biomed Environ Mass Spectrom. 1988 Feb 15; 15(4):211-22. PMID: 3370361.
      View in: PubMed
    39. Compadre CM, Hussain RA, Leon I, Enr?quez RG. Volatile Constituents of Montanoa tomentosa and Lippia graveolens. Planta Med. 1987 Oct; 53(5):495-6. PMID: 17269076.
      View in: PubMed
    40. Nanayakkara NP, Klocke JA, Compadre CM, Hussain RA, Pezzuto JM, Kinghorn AD. Characterization and feeding deterrent effects on the aphid, Schizaphis graminum, of some derivatives of the sweet compounds, stevioside and rebaudioside A. J Nat Prod. 1987 May-Jun; 50(3):434-41. PMID: 3668559.
      View in: PubMed
    41. Pezzuto JM, Nanayakkara NP, Compadre CM, Swanson SM, Kinghorn AD, Guenthner TM, Sparnins VL, Lam LK. Characterization of bacterial mutagenicity mediated by 13-hydroxy-ent-kaurenoic acid (steviol) and several structurally-related derivatives and evaluation of potential to induce glutathione S-transferase in mice. Mutat Res. 1986 Mar; 169(3):93-103. PMID: 3512998.
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    42. Compadre CM, Robbins EF, Kinghorn AD. The intensely sweet herb, Lippia dulcis Trev.: historical uses, field inquiries, and constituents. J Ethnopharmacol. 1986 Jan; 15(1):89-106. PMID: 3520154.
      View in: PubMed
    43. Pezzuto JM, Compadre CM, Swanson SM, Nanayakkara D, Kinghorn AD. Metabolically activated steviol, the aglycone of stevioside, is mutagenic. Proc Natl Acad Sci U S A. 1985 Apr; 82(8):2478-82. PMID: 3887402.
      View in: PubMed
    44. Compadre CM, Pezzuto JM, Kinghorn AD, Kamath SK. Hernandulcin: an intensely sweet compound discovered by review of ancient literature. Science. 1985 Jan 25; 227(4685):417-9. PMID: 3880922.
      View in: PubMed
    45. Kinghorn AD, Soejarto DD, Nanayakkara NP, Compadre CM, Makapugay HC, Hovanec-Brown JM, Medon PJ, Kamath SK. A phytochemical screening procedure for sweet ent-kaurene glycosides in the genus Stevia. J Nat Prod. 1984 May-Jun; 47(3):439-44. PMID: 6481357.
      View in: PubMed
    46. Compadre CM, J?uregui JF, Nathan PJ, Enr?quez RG. Isolation of 6-O-(p-coumaroyl)-catalpol from Tabebuia rosea. Planta Med. 1982 Sep; 46(1):42-4. PMID: 17396938.
      View in: PubMed
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