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Aliza Brown

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentNeurology, College of Medicine
DivisionNeurology Faculty
AddressS6/30 Shorey
501 Jack Stephens Drive
Mail Slot # 556
Little Rock AR 72205
Phone501-686-6769
ORCID ORCID Icon0000-0002-8308-4101 Additional info
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    Other Roles
    My research studies include data analysis of the UAMS stroke database and other clinical population health-based research on stroke patients in Arkansas. As the leader in program evaluation for the Institute of Digital Technology’s stroke telemedicine program, and as a consultant for the Arkansas Department of Health and MEMS in central Arkansas, I evaluate pre-hospital and hospital care for stroke patients across the state.

    Collapse Overview 
    Collapse overview
    Since 2006, my research has heavily focused on stroke, encompassing the pre-clinical and clinical examination of new neuroprotectives and thrombolytics. However, to determine the feasibility of clinical implementation of our new therapies, I began broadening my focus in 2014 to include stroke population research across Arkansas. This research led to my participation in the Institute for Digital Health’s Stroke Telemedicine Program and the Arkansas Department of Health’s population health research on strokes, which is part of the American Heart Association’s Get-With-The-Guidelines program. Most recently, I also assisted with data analysis for the UAMS Department of Neurology’s stroke section. My efforts in these areas led to multiple publications, grant funding and 100% funding of my salary.

    Thus far, I know of two instances in which my research studies on paramedic stroke education saved a life. My funded study on paramedic video education on pre-hospital stroke care and procedures for hospital diversion prompted two paramedics to deliver their stroke patients to stroke-qualified hospitals. The ability to impact lives directly is a phenomenal achievement for a biomedical researcher. Other noteworthy projects include data analysis across the state to improve emergency services and pre-hospital care of all stroke patients. This effort led to my participation on the governor-appointed Arkansas Acute Stroke Care Stroke Task Force Committee of which I recently was appointed Chair.

    Further research funded by the Center for Translational Neurosciences led to my design and publication of two mobile phone apps, “WeTrain911” for training rural dispatchers on basic medical knowledge and “iClick911” to improve the accuracy of location notification to emergency medical services. I determined that Arkansas’s emergency 911 response in the poor delta counties had connection problems and/or poor response times. Both apps were designed to improve public health and reduce mortality due to poor emergency response. I still am dedicated to this area of research.

    In summary, I have contributed importantly to funded studies at UAMS that span translational and clinical research, for example, from using animal models of stroke and vascular disease, to the search for medications, to (most recently) helping to lead stroke initiatives in Arkansas’ communities to lower stroke incidence in the State.

    Notably, the common thread of my research interests is improving healthcare and reducing mortality. The majority of my work is centered on the early (acute) treatment period for ischemic stroke patients. There is an intense need for studies in this area, because treatment of stroke with thrombolysis and reperfusion is highly time dependent. Because the rural areas of our state experience higher incidences of strokes with less healthcare coverage, delivering optimal care is a major concern. Our telestroke program has accomplished much in overcoming this burden in the last decade. It has reduced the door to treatment time from 120+ minutes to approximately 65 minutes, thereby greatly improving patient outcomes. This is remarkable as 40% of the rural hospitals in Arkansas have 25 beds or less and have minimal resources.

    My programmatic review of the telestroke program led to evaluation of the state’s EMS system, which revealed areas in Arkansas with delays in medical care. Rural populations were particularly at risk. Subsequently, I developed two mobile app’s to improve emergency training through “WeTrain911” and to improve emergency medical response with “iClick911”. Both app’s were funded by the Center for Translational Neurosciences and the NIGMS-funded IDeA program. Although both app’s currently are currently closed I am continuing to evaluate emergency services in Arkansas and look for ways to improve emergency response in rural areas of the state.

    Additionally, to improve outcomes for ischemic stroke patients, I am assisting NuvOx Pharma with protocol development for the NVX-208 Phase II trial, which will begin at UAMS. My previous collaborations with Dr. William C. Culp, Professor of Radiology at UAMS, investigated the preclinical work of NVX-208’s neuroprotective properties. The ensuing positive results led to completion of a Phase I clinical trial and the drug’s first use to alleviate human stroke. I am continuing this clinical trial by assisting NuvOx with the development and initiation of a Phase II trial at UAMS and at other trial sites across the United States.


    Collapse Affiliation 
    Collapse member of
    American Heart Association
    National Stroke Association
    North American Vascular Biological Organization
    Arkansas Acute Care Stroke Task Force
    Arkansas Chapter, American Public Health Association
    National Public Health Association
    Arkansas, Heart Disease and Stroke Prevention Coalition
    Collapse collaborator
    William Culp, MD
    Robert Skinner, PhD
    Chronic Disease Branch, Arkansas Dept of Health
    Paula Roberson, PhD
    Sanjeeva Onteddu, MD
    Krishna Nalleballe, MD
    Martin Radvany
    Marzella Backus
    Renee Joiner
    Lori Berry
    Nidhi Kapoor
    Bala Simon
    David Vrudny
    Margaret Tremwel
    Michael Borrelli
    Rohan Sharma
    Gwendolyn Bryant-Smith
    Gloria Richard-Davis

    Collapse Biography 
    Collapse Leadership and Administrative Roles
    My main leadership roles on campus, in the State, and nationally include incoming Chair of the Acute Stroke Care Task Force (ASCTF) Committee, American Heart Association council committee review, the UAMS Faculty Development Committee and other faculty volunteer activities (interviewing of medical school applicants).
    My credentials as a leader and dedication to providing administrative service on behalf of the College of Medicine and UAMS are exemplified by my position as the Chair of the Governor’s Task Force on Stroke for Arkansas, the Acute Stroke Care Task Force (ASCTF) committee.
    I also lead programmatic review and evaluation for the UAMS Institute for Digital Health & Innovation’s telestroke program (AR SAVES) and provide the impetus for implementing improvements in the nation’s largest in-state telestroke program.
    As a faculty member, I participate on faculty committees with distinct responsibilities, and additionally, I regularly interview medical school candidates (2007 – present), judge students’ science presentations on campus, and volunteer in several community service projects.
    I have a strong participative role in the American Heart Association’s (AHA) Council on Cardiovascular Radiology & Intervention, Stroke Council and Council on Quality of Care and Outcomes Research (QCOR), including webinar presentations and council demands for program review and meeting abstract reviews.
    As a component of AHA’s QCOR, I am a member of the Council on Epidemiology and Prevention Council on Cardiovascular Stroke Nursing Prevention Science Committee, providing the AHA updates on scientific statements on CVD and stroke, propose session planning, and develop education material for nurses on CVD and stroke.
    I have a strong history as a mentor of research and clinical fellows (2000 – 2007) and medical students (2004 – 2006; 2009 – 2016).
    As a UAMS faculty member, I have led initiatives in the Women’s Faculty Development Caucus, our Digital Health & Innovation’s Stroke Telemedicine program, the Faculty Development Committee, Clinical Stroke Board, Academic Affairs Committee, and Stroke Research Interest Group.

    Collapse education and training
    University of Central Arkansas, ConwayBS05/1988Nutrition/Dietetics
    University of Arkansas, FayettevillePhD12/1993Animal Sciences/Reproductive Physiology
    University of Arkansas for Medical Sciences, Little Rock05/2000Assistant Professor
    University of Arkansas for Medical Sciences, Little Rock07/2019Associate Professor
    Collapse awards and honors
    2016 - 2017Center for Translational Neuroscience Telemedicine Core Facility, P30 GM 110702; NIH/NIGMS/IDeA
    2016 - 2017Challenge Study to Improve Time to Thrombolysis in the AR SAVES Telestroke Spoke Sites, UAMS, COM, THE FUND TO CURE STROKE
    2015 - 2017Pilot study to validate a paramedic training video covering stroke recognition during patient triage, Genentech, CGN
    2018 - PresFellow, American Heart Association, American Heart Association
    20053rd Place presentation award at the 4th International Conference on Hyperhomocysteinemia in Saarbruc, International Conference on Hyperhomocysteinemia
    2009Award winning poster, 34th Annual Society of Interventional Radiology Meeting, San Diego, CA, Annual Society of Interventional Radiology Meeting
    2016ESRF Junior Travel Grant Award for the 25th European Stroke Conference in Venice Italy, April 13-15,, European Stroke Conference
    2017 - PresElected Member, Arkansas Acute Stroke Task Force, Government
    2017Interviewed, Arkansas Northwest news channel for ‘WeTrain911’, Local news station
    2017Website featured, ‘WeTrain911’ mobile phone App, University of Arkansas for Medical Sciences, Unversity of Arkansas for Medical Sciences
    2018Elected Vice-Chairman, Arkansas Acute Stroke Care Task Force, Government
    2019 - 2020Elected Chairman, Arkansas Acute Care Stroke Task Force , Government

    Collapse Teaching 

    Collapse Research 
    Collapse research overview
    My research studies include data analysis of the UAMS stroke database and other clinical population health-based research on stroke patients in Arkansas. As the leader in program evaluator for the Institute of Digital Technology’s stroke telemedicine program, and as a consultant for the Arkansas Department of Health and MEMS, I am evaluating pre-hospital and hospital care for stroke patients across Arkansas. In addition, as a member of the Center for Translational Neurosciences Telemedicine Core, I evaluate 911 emergency services in the state.

    Part of my efforts is dedicated to the clinical investigation of the neuroprotective NVX-208 drug for stroke patients. I developed the protocol for Phase II, with UAMS as the first site among nine in the study. The NuvOx pharmaceutical company awarded a contract to secure my assistance in development and initiation of the clinical Phase II trial in Arkansas.

    Collapse research activities and funding
    U3GRH40001     (LOWERY, CURTIS)Sep 1, 2020 - Aug 31, 2024
    Health Resources & Services Administration
    FORTE - Foundation for Objective Rural Telehealth Evaluation
    Role: Co-Investigator

    P30GM110702     (GARCIA-RILL, EDGAR E.)Jun 10, 2014 - Apr 30, 2020
    NIH
    Center for Translational Neuroscience
    Role: Co-Investigator

    R01HL082481     (CULP, WILLIAM C)Feb 15, 2006 - Jan 31, 2012
    NIH
    Ischemic Stroke Treatment with Microbubbles, a Novel Clot Lysis Therapeutic
    Role: Co-Investigator

    Collapse Outreach 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
    List All   |   Timeline
    1. Kapoor N, Sharma R, Iser C, Chaudhari K, Nalleballe K, Brown A, Veerapaneni P, Sheng S, Elkhider H, Veerapaneni K, Onteddu S, Sidorov E. Cost-Effectiveness of Emergent MRI during Stroke Alert to Diagnose Stroke Mimics: Single-Center Experience. J Neurosci Rural Pract. 2021 Jan; 12(1):102-105. PMID: 33531766.
      View in: PubMed
    2. Sheng S, Wang X, Tommee C, Arulprakash N, Kamran M, Jasti M, Yadala S, Brown A, Onteddu S, Nalleballe K. . Continued underutilization of stroke care during the COVID-19 pandemic. Brain Behav & Immun-Health. 2021; 15:100274.
    3. Onteddu S, Veerapaneni P, Nalleballe K, Elkhider H, Yadala S, Veerapaneni K, Wissler D, Sheng S, Skinner RD, Culp WC, Brown A. Stroke Transfers for Thrombectomy in the Era of Extended Time. Clinical Neurology and Neurosurgery. 2021; 200:106371.
    4. Brown A, Onteddu,S, Nalleballe K, Arthur MC, Backus M, Joiner R, Lowery C. Telemedicine and e-Health. No. 59; Telestroke Quality Assessment Surveys; Our Plan for System-Wide Assessment. Society for Education and the Advancement of Research in Connected Health (SEARCH). The National Telehealth Research Symposium Abstracts. 2020.
    5. Sharma R, Iser C, Chaudhari K, Nalleballe K, Brown A, Sheng S, Veerapaneni P, Elkhider H, Onteddu S, Sidorov E. Telestroke: A New Treatment Paradigm. Ischemic Stroke. 2020.
    6. Onteddu SR, Nalleballe K, Sharma R, Brown AT. Underutilization of health care for strokes during the COVID-19 outbreak. Int J Stroke. 2020 07; 15(5):NP9-NP10. PMID: 32478606.
      View in: PubMed
    7. Nalleballe K, Brown A, Sharma R, Sheng S, Veerapaneni P, Patrice KA, Shah V, Onteddu S, Culp W, Lowery C, Benton T, Joiner R, Kapoor N. When Telestroke Programs Work, Hospital Size Really Does Not Matter. J Neurosci Rural Pract. 2020 Jul; 11(3):403-406. PMID: 32753804.
      View in: PubMed
    8. Nalleballe K, Sheng S, Li C, Mahashabde R, Annapureddy AR, Mudassar K, Pothineni K, Veerapaneni P, Harada Y, Chilkulwar A, Ranabothu S, Brown A, Kapoor N, Onteddu S. Industry Payment to Vascular Neurologists: A 6-Year Analysis of the Open Payments Program From 2013 Through 2018. Stroke. 2020 04; 51(4):1339-1343. PMID: 32078482.
      View in: PubMed
    9. Brown A, Vrudny D, Marshall T, Onteddu S, Radvany M, Nalleballe K, Brown G, Joiner R, Backus M, Culp W, Adolph S, Balamurugan A. . Stroke. It’s all in the wrist – Integrating EMS, telestroke and stroke registry data systems. 2020; 51(1):TP251.
    10. Brown A, Backus M, Onteddu S, Nalleballe K, Sheng S, Haldal S, Joiner R, Kapoor N, Benton T, Lowery C. No need to ‘card’ here; Cocaine/opiod use in middle age and stroke. Stroke. v51. TP179. 2020.
    11. Brown A, McGonigle J, Graham K, Onteddu S, Radvany M, Culp W, Unger E. Stroke. Welcoming the New Kid on the Block; The phase IIb prospective, randomized, open-label, blinded endpoint (PROBE) study of NanO2™ neuroprotection in large vessel strokes. 2020; 51:WP120.
    12. Sheng S, Nalleballe K, Brown A, Ali S, Sharma R, Kapoor N, Kamran M, Patrice K-A, Onteddu S. . Stroke. Industry payments to vascular neurologists, a six-year analysis of the open payments program from 2013 to 2018. 2020; 51:WMMP96.
    13. Veerapaneni P, Nalleballe K, Sheng S, Rohan S, Onteddu SR, Brown A, Wissler D, Duncan C, Joiner R. Stroke. Lost opportunities in a telestroke network. 2020; 50:WP373.
    14. Onteddu S, Nalleballe K, Sharma R, Dandu V, Brown A, Jasti M, Yadala S, Veerapaneni K, Siddamreddy S, Avula A, Kapoor N, Mudassar K, Kovvuru S. . Spectrum of neuropsychiatric manifestations in COVID-19. Brain Behav Immun. 2020; 88:71-74.
    15. Culp WC, Onteddu SS, Brown A, Nalleballe K, Sharma R, Skinner RD, Witt T, Roberson PK, Marsh JD. Dodecafluoropentane Emulsion in Acute Ischemic Stroke: A Phase Ib/II Randomized and Controlled Dose-Escalation Trial. J Vasc Interv Radiol. 2019 Aug; 30(8):1244-1250.e1. PMID: 31349978.
      View in: PubMed
    16. Sheng S, Wu L, Nalleballe K, Sharma R, Brown A, Ranabothu S, Kapoor N, Onteddu S. Fabry's disease and stroke: Effectiveness of enzyme replacement therapy (ERT) in stroke prevention, a review with meta-analysis. J Clin Neurosci. 2019 Jul; 65:83-86. PMID: 30955952.
      View in: PubMed
    17. Brown A, Wells J, Onteddu S, Bryant-Smith G, Sharma R, Joiner R, Nalleballe K, Richard-Davis G, Sheng S, Benton T, Culp W, Lowery C. Women on Hormone Therapy with Ischemic Stroke, Effects on Deficits and Recovery. J Neurol Neurosurg Psychiatry Res. 2019 Jan-Jun; 1(1). PMID: 31008455.
      View in: PubMed
    18. Nalleballe K, Sharma R, Kovvuru S, Brown A, Sheng S, Gundapaneni S, Ranabothu S, Veerapaneni P, Joiner R, Kapoor N, Culp W, Onteddu S. Why are acute ischemic stroke patients not receiving thrombolysis in a telestroke network? J Telemed Telecare. 2020 Jul; 26(6):317-321. PMID: 30741084.
      View in: PubMed
    19. Brown A, Onteddu S, Nalleballe K, Joiner R, Benton T, Lowery C. . Stroke. Rural hospitals in telestroke: How effective are on-site mock drills and community education on stroke awareness?. 2019; 50:ATP4270.
    20. Joiner R, Brown A, Onteddu S, Nalleballe K, Joiner R, Benton T, Lowery C. . Stroke. When telestroke programs work, bed size really doesn’t matter. 2019; 50:ATP4690.
    21. Culp WC, Onteddu S, Brown A, Nalleballe K, Sharma R, Skinner RD, Witt T, Marsh J. . Stroke. Dodecafluoropentane emulsion in acute ischemic stroke, a phase 1b/2 randomized and controlled trial. 2019; 50:ATPTMP17.
    22. Brown A, Onteddu S, Sharma R, Kapoor N, Nalleballe K, Balamurugan A, Gundapaneni S, Bianchi N, Skinner R, Culp W. A Pilot Study Validating Video-Based Training on Pre-Hospital Stroke Recognition. J Neurol Neurosurg Psychiatry Res. 2019 Jan-Jun; 1(1). PMID: 30868141.
      View in: PubMed
    23. Nalleballe K, Sharma R, Brown A, Joiner R, Kapoor N, Morgan T, Benton T, Williamson C, Culp W, Lowery C, Onteddu S. Ideal telestroke time targets: Telestroke-based treatment times in the United States stroke belt. J Telemed Telecare. 2020 04; 26(3):174-179. PMID: 30352525.
      View in: PubMed
    24. Brown AT, Vrudny D, Adolph SS, Culp W, Balamurugan A. . Stroke. Can Pre-Hospital Intervention Improve Rural Stroke Care?. 2018; 49:ATP219.
    25. Morgan T, Brown AT, Onteddu S, Joiner R, Benton T, Culp W, Lowery C. . Stroke. Validation of an education gauge for measuring stroke outreach efforts. 2018; 49:ATMP60.
    26. Onteddu S, Brown AT, Kovvuru S, Chen Y-T, Joiner R, Morgan T, Benton T, Culp W, Lowery C. . Stroke. An analysis of thrombolysis in a large telestroke program in the stroke belt. 2018; 49:ATP233.
    27. Brown AT, Wei F, Onteddu S, Bianchi N, Skinner R, Culp W. . Stroke. A pilot study validating video-based training on pre-hospital stroke recognition. 2018; 49:AWP233.
    28. Brown AT, Im J, Hall RH, Garcia-Rill E. . Stroke. Mobile application, “WeTrain911” to decrease stroke mortality by enhancing emergency dispatcher training. 2018; 49:ATP306.
    29. Wells J, Brown AT, Bryant-Smith G, Onteddu S, Joiner R, Morgan T, Benton T, Culp W, Lowery C. . Stroke. Women on HRT with ischemic stroke, a positive effect on deficits and recovery?. 2018; 49:AWP149.
    30. Onteddu S, Brown A, Tan B, Nalleballe K, Skinner R, Carlson K, Culp WC. . Phase-1b clinical trial of Dodecafluoropentane emulsion as a neuroprotective agent in acute ischemic stroke. 2018; 49:CTP25.
    31. Onteddu S, Nalleballe K, Brown A, Kairamkonda S, Culp W, Joiner R, Gundapaneni S, Kovvuru S. . Stroke. Why are acute ischemic stroke patients not receiving IV tPA in telestroke networks. 2018; 49:AWP72.
    32. Brown A, Onteddu S, Joiner R, Benton T, Culp W, Lowery C. . Circulation: Cardiovascular Quality and Outcomes. Strokes worse in women at 24 hours but severity reduced in younger women with hormone therapy. 2017; 10:A226.
    33. Brown A, Bird T, Onteddu S, Balamurugan A, Skinner R, Culp W. . Stroke. Concordance of pre-hospital stroke recognition by medical dispatchers and paramedics in an urban county. 2017; 48:ATP241.
    34. Arthur MC, Culp WC, Brown A, Borrelli M, Skinner R, Song L, Hendrickson H. Tissue distribution of dodecafluoropentane (DDFP) following repeated IV administration in the New Zealand white rabbit stroke model. The AAPS Journal. 2017; 19:520-526.
    35. Arthur MC, Brown A, Carlson K, Lowery J, Skinner RD, Culp WC. Dodecafluoropentane Improves Neurological Function Following Anterior Ischemic Stroke. Mol Neurobiol. 2017 08; 54(6):4764-4770. PMID: 27501802.
      View in: PubMed
    36. Brown AT, Wei F, Culp WC, Brown G, Tyler R, Balamurugan A, Bianchi N. Emergency transport of stroke suspects in a rural state: opportunities for improvement. Am J Emerg Med. 2016 Aug; 34(8):1640-4. PMID: 27344100.
      View in: PubMed
    37. Fitzgerald RT, Ou X, Nix JS, Arthur MC, Brown AT, Skinner RD, Borrelli MJ, Culp WC. Magnetic Resonance Imaging. Dodecafluoropentane emulsion delays and reduces MRI markers of infarction in a rat stroke model. 2015; 33:236-239.
    38. Culp WC, Brown AT, Lowery JD, Arthur MC, Roberson PK, Skinner RD. Dodecafluoropentane Emulsion Extends Window for tPA Therapy in a Rabbit Stroke Model. Mol Neurobiol. 2015 Oct; 52(2):979-84. PMID: 26055229.
      View in: PubMed
    39. Brown AT, Arthur MC, Nix JS, Montgomery JA, Skinner RD, Roberson PK, Borrelli M, Culp WC. Dodecafluoropentane Emulsion (DDFPe) Decreases Stroke Size and Improves Neurological Scores in a Permanent Occlusion Rat Stroke Model. Open Neurol J. 2014; 8:27-33. PMID: 25674164.
      View in: PubMed
    40. Fitzgerald RT, Wright SM, Samant RS, Kumar M, Ramakrishnaiah RH, Van Hemert R, Brown AT, Angtuaco EJ. Elevation of serum lactate dehydrogenase at posterior reversible encephalopathy syndrome onset in chemotherapy-treated cancer patients. J Clin Neurosci. 2014 Sep; 21(9):1575-8. PMID: 24780237.
      View in: PubMed
    41. Brown A, Woods S, Skinner R, Hatton J, Lowery J, Roberson P, Hennings L, Culp WC. Neurological assessment scores in rabbit embolic stroke models. Open Neurol J. 2013; 7:38-43. PMID: 24265650.
      View in: PubMed
    42. Erdem E, Samant R, Malak SF, Culp WC, Brown A, Peterson L, Lensing S, Barlogie B. Vertebral augmentation in the treatment of pathologic compression fractures in 792 patients with multiple myeloma. Leukemia. 2013 Dec; 27(12):2391-3. PMID: 23728152.
      View in: PubMed
    43. Woods SD, Skinner RD, Ricca AM, Brown AT, Lowery JD, Borrelli MJ, Lay JO, Culp WC. Progress in dodecafluoropentane emulsion as a neuroprotective agent in a rabbit stroke model. Molecular Neurobiology. 2013; 48:363-367.
    44. Culp WC, Woods SD, Brown AT, Lowery JD, Hennings LJ, Skinner RD, Borrelli MJ, Roberson PK. Three variations in rabbit angiographic stroke models. J Neurosci Methods. 2013 Jan 30; 212(2):322-8. PMID: 23142182.
      View in: PubMed
    45. Chaudhuri S, McCullough SS, Hennings L, Brown AT, Li SH, Simpson PM, Hinson JA, James LP. Effect of trifluoperazine on toxicity, HIF-1alpha induction and hepatocyte regeneration in acetaminophen toxicity in mice. Toxicol Appl Pharmacol. 2012; 264(2):192-201.
    46. Berridge, MS, Hatton, JH, Apana, SM, Carpenter, C, Lowery, JD, Alpe, TL, Borrelli, MJ, Brown, AT, Culp, WC. F-18 labelled blood clots for measurement of therapeutic efficacy in a rabbit stroke model. World Molecular Imaging Congress. 2012.
    47. Brown AT, Woods, SD, Skinner, RD, Ricca, AM, Brown, AT, Lowery, JD, Borrelli, MJ, Culp, WC. Dodecafluoropentane emulsion decreases infarct volume in a rabbit model of acute ischemic stroke. 11th International Conference on Neuroprotective Agents. 2012.
    48. Culp WC, Woods SD, Skinner RD, Brown AT, Lowery JD, Johnson JL, Unger EC, Hennings LJ, Borrelli MJ, Roberson PK. Dodecafluoropentane emulsion decreases infarct volume in a rabbit ischemic stroke model. J Vasc Interv Radiol. 2012 Jan; 23(1):116-21. PMID: 22079515.
      View in: PubMed
    49. Milesi-Hallé A, McCullough S, Hinson JA, Kurten RC, Lamps LW, Brown A, James LP. Echinomycin decreases induction of vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity in mice. Basic Clin Pharmacol Toxicol. 2012 Apr; 110(4):327-34. PMID: 21985601.
      View in: PubMed
    50. Brown AT, Ou X, James LP, Jambhekar K, Pandey T, McCullough S, Chaudhuri S, Borrelli MJ. Correlation of MRI findings to histology of acetaminophen toxicity in the mouse. Magn Reson Imaging. 2012 Feb; 30(2):283-9. PMID: 22055850.
      View in: PubMed
    51. Nyalala JO, Brown AT, Luo S, Deng H, Moursi MM. Estrogen replacement attenuates exaggerated neointimal hyperplasia following carotid endarterectomy in rats. Vasc Endovascular Surg. 2011 Nov; 45(8):720-6. PMID: 22262116.
      View in: PubMed
    52. Hennings LJ, Flores R, Roberson PK, Brown A, Lowery J, Borrelli M, Culp WC. Persistent penumbra in a rabbit stroke model: incidence and histologic characteristics. Stroke Res Treat. 2011; 2011:764830. PMID: 21776366.
      View in: PubMed
    53. Flores R, Hennings LJ, Lowery JD, Brown AT, Culp WC. Microbubble-augmented ultrasound sonothrombolysis decreases intracranial hemorrhage in a rabbit model of acute ischemic stroke. Invest Radiol. 2011 Jul; 46(7):419-24. PMID: 21343824.
      View in: PubMed
    54. Culp WC, Flores R, Brown AT, Lowery JD, Roberson PK, Hennings LJ, Woods SD, Hatton JH, Culp BC, Skinner RD, Borrelli MJ. Successful microbubble sonothrombolysis without tissue-type plasminogen activator in a rabbit model of acute ischemic stroke. Stroke. 2011 Aug; 42(8):2280-5. PMID: 21700942.
      View in: PubMed
    55. Caldwell B, Flores R, Lowery J, Brown AT, Culp WC. Variations in the circle of Willis in the New Zealand white rabbit. J Vasc Interv Radiol. 2011 Aug; 22(8):1188-92. PMID: 21507678.
      View in: PubMed
    56. Brown AT, Flores R, Hamilton E, Roberson PK, Borrelli MJ, Culp WC. Microbubbles improve sonothrombolysis in vitro and decrease hemorrhage in vivo in a rabbit stroke model. Invest Radiol. 2011 Mar; 46(3):202-7. PMID: 21150788.
      View in: PubMed
    57. Culp WC, Flores R, Lowery JD, Brown AT, Hennings LJ, Roberson PK, Woods SD, Hatton JH, Culp BC, Skinner RD, Borrelli MJ. Successful micrbubble sonothromolysis without tissue plaminogen activator in a rabbit model of acute ischemic stroke. Stroke. 2011; 42(8):2280-2285.
    58. Atherton ME, Culp WC, Brown AT, Erdem E. Successful intravascular ultrasound thrombolysis of dural sinus thrombosis with pre-existing subarachnoid and intraparenchymal hemorrhages. Interv Neuroradiol. 2010 Dec; 16(4):455-8. PMID: 21162778.
      View in: PubMed
    59. Milesi-Hallé A, Abdel-Rahman SM, Brown A, McCullough SS, Letzig L, Hinson JA, James LP. Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity. Chem Biol Interact. 2011 Feb 01; 189(3):222-9. PMID: 21145883.
      View in: PubMed
    60. Nyalala JO, Luo S, Campbell DN, Brown AT, Moursi MM. The effects of acarbose treatment on intimal hyperplasia in a rat carotid endarterectomy model of diet-induced insulin resistance. Vasc Endovascular Surg. 2010 Oct; 44(7):560-7. PMID: 20675317.
      View in: PubMed
    61. Brown AT, Skinner RD, Flores R, Hennings L, Borrelli MJ, Lowery J, Culp WC. Stroke location and brain function in an embolic rabbit stroke model. J Vasc Interv Radiol. 2010 Jun; 21(6):903-9. PMID: 20417119.
      View in: PubMed
    62. Nyalala JO, Luo S, Campbell DN, Brown AT, Moursi MM. The effects of acarbose treatment on intimal hyperplasia in a rat carotid edarterectomy model of diet induced insulin resistence. Vasc Endovacular Surg. 2010; 44:560-67.
    63. Brown AT, Skinner RD, Flores R, Hennings L, Lowery J, Culp WC. Correlation of stroke volume, brain structures and functional recovery in an embolic rabbit stroke model. J Vasc Interv Radiol. 2009; 20(Suppl 1):599.
    64. Kalapatapu VR, Satterfield L, Brown AT, Ercal N, Price TO, Ibrahim K, Moursi MM. The effects of Toradol on postoperative intimal hyperplasia in a rat carotid endarterectomy model: laboratory research. Vasc Endovascular Surg. 2007 Oct-Nov; 41(5):402-8. PMID: 17942855.
      View in: PubMed
    65. Culp WC, Brown AT, Hennings L, Lowery J, Culp BC, Erdem E, Roberson P, Matsunaga TO. Safety of high dose microbubbles and transcranial ultrasound in rabbits. 6th International Symposium on Therapeutic Ultrasound. 2007; 911:542-546.
    66. Culp BC, Brown AT, Erdem E, Lowery J, Culp WC. Selective intracranial magnification angiography of the rabbit: basic techniques and anatomy. J Vasc Interv Radiol. 2007 Feb; 18(2):187-92. PMID: 17327550.
      View in: PubMed
    67. Bledsoe SL, Barr JC, Fitzgerald RT, Brown AT, Faas FH, Eidt JF, Moursi MM. Pravastatin and clopidogrel combined inhibit intimal hyperplasia in a rat carotid endarterectomy model. Vasc Endovascular Surg. 2006 Jan-Feb; 40(1):49-57. PMID: 16456606.
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    68. Qureshi I, Chen H, Brown AT, Fitzgerald R, Zhang X, Breckenridge J, Kazi R, Crocker AJ, Stühlinger MC, Lin K, Cooke JP, Eidt JF, Moursi MM. Homocysteine-induced vascular dysregulation is mediated by the NMDA receptor. Vasc Med. 2005 Aug; 10(3):215-23. PMID: 16235775.
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    69. Chen H, Fitzgerald R, Brown AT, Qureshi I, Breckenridge J, Kazi R, Wang Y, Wu Y, Zhang X, Mukunyadzi P, Eidt J, Moursi MM. Identification of a homocysteine receptor in the peripheral endothelium and its role in proliferation. J Vasc Surg. 2005 May; 41(5):853-60. PMID: 15886671.
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    70. Bledsoe SL, Brown AT, Davis JA, Chen H, Eidt JF, Moursi MM. Effect of clopidogrel on platelet aggregation and intimal hyperplasia following carotid endarterectomy in the rat. Vascular. 2005 Jan-Feb; 13(1):43-9. PMID: 15895674.
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    71. Davis JA, Brown AT, Alshafie T, Poirier LA, Cruz CP, Wang Y, Eidt JF, Moursi MM. Saratin (an inhibitor of platelet-collagen interaction) decreases platelet aggregation and homocysteine-mediated postcarotid endarterectomy intimal hyperplasia in a dose-dependent manner. Am J Surg. 2004 Dec; 188(6):778-85. PMID: 15619499.
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    73. Davis JA, Brown AT, Chen H, Wang Y, Poirier LA, Eidt JF, Cruz CP, Moursi MM. Cigarette smoke increases intimal hyperplasia and homocysteine in a rat carotid endarterectomy. J Surg Res. 2004 Sep; 121(1):69-75. PMID: 15313378.
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    74. Cruz CP, Eidt JF, Brown AT, Moursi M. Correlation between preoperative and postoperative duplex vein measurements of the greater saphenous vein used for infrainguinal arterial reconstruction. Vasc Endovascular Surg. 2004 Jan-Feb; 38(1):57-62. PMID: 14760478.
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    75. Smith TP, Alshafie TA, Cruz CP, Fan CY, Brown AT, Wang Y, Eidt JF, Moursi MM. Saratin, an inhibitor of collagen-platelet interaction, decreases venous anastomotic intimal hyperplasia in a canine dialysis access model. Vasc Endovascular Surg. 2003 Jul-Aug; 37(4):259-69. PMID: 12894368.
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    76. Brown AT, Smith TP, Cruz CP, Poirier LA, Simmons D, Williams DK, Wang Y, Eidt JF, Moursi MM. Intimal hyperplasia following carotid endarterectomy in an insulin-resistant rat model. Metabolism. 2003 Jul; 52(7):834-9. PMID: 12870157.
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    77. Fonseca V, Keebler M, Dicker-Brown A, Desouza C, Poirier LA, Murthy SN, McNamara DB. The effect of troglitazone on plasma homocysteine, hepatic and red blood cell S-adenosyl methionine, and S-adenosyl homocysteine and enzymes in homocysteine metabolism in Zucker rats. Metabolism. 2002; 51:783-786.
    78. Kern PA, Fishman RB, Song W, Dicker-Brown AT, Fonseca VA. The effect of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on oxidative enzymes in adipocytes and liver. Toxicology. 2002; 171:117-125.
    79. Cruz CP, Eidt JF, Brown AT, Moursi MM. Saratin: (A specific inhibitor of platelet to collagen adhesion) decreases platelet aggregation and neointimal hyperplasia in a rat carotid endarterectomy model. J Vasc Surg. 2001; 34:724-729.
    80. Dicker-Brown AT, Fonseca VA, Fink L, Kern PA. The effect of glucose and insulin on the activity of methylene tetrahydrofolate reductase and cystathionine-B-synthase: studies in hepatocytes. Atherosclerosis. 2001; 158:297-301.
    81. Cao W, McGraw DW, Lee TT, Dicker-Brown A, Hiller FC, Cornett LE, Jones SM. Expression of functional beta 2-adrenergic receptors in a rat airway epithelial cell line (SPOC1) and cell density-dependent induction by glucocorticoids. Exp Lung Res. 2000 Sep; 26(6):421-35. PMID: 11033766.
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    82. Fonseca V, Dicker-Brown A, Ranganathan S, Song W, Barnard RJ, Fink L, Kern PA, A BROWN. Effects of a high fat sucrose diet on enzymes of homocysteine metabolism in the rat. Metabolism. 2000; 49:736-741.
    83. Bottje W, Kreider D, Graupner W, Dicker L, Enkvetchakul B. Elevated corticosterone levels following hepatic glutathionine depletion in rats. Med Sci Res. 1992; 20:48.
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