 Caspase 1
"Caspase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.
| Descriptor ID |
D020170
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| MeSH Number(s) |
D08.811.277.656.262.500.126.550.100 D08.811.277.656.300.200.126.550.100 D12.644.360.075.405.550.100 D12.776.476.075.405.550.100
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| Concept/Terms |
Caspase 1- Caspase 1
- ICE Protease
- Interleukin-1beta Converting Enzyme
- Converting Enzyme, Interleukin-1beta
- Interleukin 1beta Converting Enzyme
- IL-1 beta-Converting Enzyme
- IL 1 beta Converting Enzyme
- beta-Converting Enzyme, IL-1
- IL1BC Enzyme
- Interleukin-1 Converting Enzyme
- Converting Enzyme, Interleukin-1
- Interleukin 1 Converting Enzyme
- CASP1 Caspase
- Caspase, CASP1
- IL-1 beta Convertase
- Convertase, IL-1 beta
- IL 1 beta Convertase
- beta Convertase, IL-1
Procaspase-1- Procaspase-1
- Procaspase 1
- Pro-Caspase-1
- Pro Caspase 1
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Below are MeSH descriptors whose meaning is more general than "Caspase 1".
Below are MeSH descriptors whose meaning is more specific than "Caspase 1".
This graph shows the total number of publications written about "Caspase 1" by people in UAMS Profiles by year, and whether "Caspase 1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2020 | 0 | 3 | 3 | | 2019 | 0 | 1 | 1 | | 2015 | 2 | 1 | 3 | | 2014 | 0 | 1 | 1 | | 2013 | 0 | 2 | 2 | | 2012 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 1998 | 0 | 1 | 1 | | 1997 | 0 | 2 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Caspase 1" by people in Profiles over the past ten years.
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Wang X, Li X, Liu S, Brickell AN, Zhang J, Wu Z, Zhou S, Ding Z. PCSK9 regulates pyroptosis via mtDNA damage in chronic myocardial ischemia. Basic Res Cardiol. 2020 11 12; 115(6):66.
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Oh C, Verma A, Aachoui Y. Caspase-11 Non-canonical Inflammasomes in the Lung. Front Immunol. 2020; 11:1895.
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Kovacs SB, Oh C, Maltez VI, McGlaughon BD, Verma A, Miao EA, Aachoui Y. Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium. Cell Rep. 2020 07 28; 32(4):107967.
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Allen J, Gyorke CE, Tripathy MK, Zhang Y, Lovett A, Montgomery SA, Nagarajan UM. Caspase-11 Contributes to Oviduct Pathology during Genital Chlamydia Infection in Mice. Infect Immun. 2019 08; 87(8).
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Maltez VI, Tubbs AL, Cook KD, Aachoui Y, Falcone EL, Holland SM, Whitmire JK, Miao EA. Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium. Immunity. 2015 Nov 17; 43(5):987-97.
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Aachoui Y, Kajiwara Y, Leaf IA, Mao D, Ting JP, Coers J, Aderem A, Buxbaum JD, Miao EA. Canonical Inflammasomes Drive IFN-? to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium. Cell Host Microbe. 2015 Sep 09; 18(3):320-32.
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Cieniewicz B, Dong Q, Li G, Forrest JC, Mounce BC, Tarakanova VL, van der Velden A, Krug LT. Murine Gammaherpesvirus 68 Pathogenesis Is Independent of Caspase-1 and Caspase-11 in Mice and Impairs Interleukin-1ß Production upon Extrinsic Stimulation in Culture. J Virol. 2015 Jul; 89(13):6562-74.
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Ding Z, Liu S, Wang X, Theus S, Fan Y, Deng X, Mehta JL. LOX-1 - dependent mitochondrial DNA damage and NLRP3 activation during systemic inflammation in mice. Biochem Biophys Res Commun. 2014 Sep 05; 451(4):637-43.
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Lin KM, Hu W, Troutman TD, Jennings M, Brewer T, Li X, Nanda S, Cohen P, Thomas JA, Pasare C. IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):775-80.
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Murphy SK, Yang H, Moylan CA, Pang H, Dellinger A, Abdelmalek MF, Garrett ME, Ashley-Koch A, Suzuki A, Tillmann HL, Hauser MA, Diehl AM. Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease. Gastroenterology. 2013 Nov; 145(5):1076-87.
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Negash AA, Ramos HJ, Crochet N, Lau DT, Doehle B, Papic N, Delker DA, Jo J, Bertoletti A, Hagedorn CH, Gale M. IL-1ß production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease. PLoS Pathog. 2013; 9(4):e1003330.
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