 Caspase 1
"Caspase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.
| Descriptor ID |
D020170
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| MeSH Number(s) |
D08.811.277.656.262.500.126.550.100 D08.811.277.656.300.200.126.550.100 D12.644.360.075.405.550.100 D12.776.476.075.405.550.100
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| Concept/Terms |
Caspase 1- Caspase 1
- ICE Protease
- Interleukin-1beta Converting Enzyme
- Converting Enzyme, Interleukin-1beta
- Interleukin 1beta Converting Enzyme
- IL-1 beta-Converting Enzyme
- IL 1 beta Converting Enzyme
- beta-Converting Enzyme, IL-1
- IL1BC Enzyme
- Interleukin-1 Converting Enzyme
- Converting Enzyme, Interleukin-1
- Interleukin 1 Converting Enzyme
- CASP1 Caspase
- Caspase, CASP1
- IL-1 beta Convertase
- Convertase, IL-1 beta
- IL 1 beta Convertase
- beta Convertase, IL-1
Procaspase-1- Procaspase-1
- Procaspase 1
- Pro-Caspase-1
- Pro Caspase 1
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Below are MeSH descriptors whose meaning is more general than "Caspase 1".
Below are MeSH descriptors whose meaning is more specific than "Caspase 1".
This graph shows the total number of publications written about "Caspase 1" by people in UAMS Profiles by year, and whether "Caspase 1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2025 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 | | 2022 | 0 | 2 | 2 | | 2020 | 0 | 2 | 2 | | 2019 | 0 | 1 | 1 | | 2015 | 2 | 1 | 3 | | 2014 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 1997 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Caspase 1" by people in Profiles over the past ten years.
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Kirby CS, Islam N, Wier E, Alphonse MP, Sweren E, Wang G, Liu H, Kim D, Li A, Lee SS, Overmiller AM, Xue Y, Reddy S, Archer NK, Miller LS, Yu J, Huang W, Jones JW, Kim S, Kane MA, Silverman RH, Garza LA. RNase L represses hair follicle regeneration through altered innate immune signaling. J Clin Invest. 2025 Feb 04; 135(6).
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Ma J, Wang X, Gu R, Guo D, Shi C, Kollisch-Singule M, Suo L, Luo J, Meng Q, Cooney RN. PROPHYLACTIC n CMT-3 ATTENUATES SEPSIS-INDUCED ACUTE KIDNEY INJURY IN ASSOCIATION WITH NLRP3 INFLAMMASOME ACTIVATION AND APOPTOSIS. Shock. 2023 06 01; 59(6):922-929.
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Oh C, Li L, Verma A, Reuven AD, Miao EA, Bliska JB, Aachoui Y. Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins. Cell Rep. 2022 11 22; 41(8):111688.
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Meng Q, Wang X, Guo D, Shi C, Gu R, Ma J, Nieman G, Kollisch-Singule M, Luo J, Cooney RN. Nano-chemically Modified Tetracycline-3 (nCMT-3) Attenuates Acute Lung Injury via Blocking sTREM-1 Release and NLRP3 Inflammasome Activation. Shock. 2022 05 01; 57(5):749-758.
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Wang X, Li X, Liu S, Brickell AN, Zhang J, Wu Z, Zhou S, Ding Z. PCSK9 regulates pyroptosis via mtDNA damage in chronic myocardial ischemia. Basic Res Cardiol. 2020 11 12; 115(6):66.
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Oh C, Verma A, Aachoui Y. Caspase-11 Non-canonical Inflammasomes in the Lung. Front Immunol. 2020; 11:1895.
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Kovacs SB, Oh C, Maltez VI, McGlaughon BD, Verma A, Miao EA, Aachoui Y. Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium. Cell Rep. 2020 07 28; 32(4):107967.
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Allen J, Gyorke CE, Tripathy MK, Zhang Y, Lovett A, Montgomery SA, Nagarajan UM. Caspase-11 Contributes to Oviduct Pathology during Genital Chlamydia Infection in Mice. Infect Immun. 2019 08; 87(8).
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Maltez VI, Tubbs AL, Cook KD, Aachoui Y, Falcone EL, Holland SM, Whitmire JK, Miao EA. Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium. Immunity. 2015 Nov 17; 43(5):987-97.
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Aachoui Y, Kajiwara Y, Leaf IA, Mao D, Ting JP, Coers J, Aderem A, Buxbaum JD, Miao EA. Canonical Inflammasomes Drive IFN-? to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium. Cell Host Microbe. 2015 Sep 09; 18(3):320-32.
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