 Cyclosporine
"Cyclosporine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
| Descriptor ID |
D016572
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| MeSH Number(s) |
D04.345.566.235.300 D12.644.641.235.300
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| Concept/Terms |
Cyclosporine- Cyclosporine
- Cyclosporin
- Cyclosporine A
- Ciclosporin
- Cyclosporin A
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Below are MeSH descriptors whose meaning is more general than "Cyclosporine".
Below are MeSH descriptors whose meaning is more specific than "Cyclosporine".
This graph shows the total number of publications written about "Cyclosporine" by people in UAMS Profiles by year, and whether "Cyclosporine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2019 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2015 | 3 | 1 | 4 | | 2014 | 5 | 0 | 5 | | 2013 | 2 | 0 | 2 | | 2012 | 1 | 2 | 3 | | 2011 | 1 | 2 | 3 | | 2007 | 0 | 4 | 4 | | 2006 | 1 | 0 | 1 | | 2005 | 2 | 0 | 2 | | 2004 | 1 | 0 | 1 | | 2003 | 1 | 2 | 3 | | 2002 | 0 | 2 | 2 | | 2001 | 3 | 2 | 5 | | 2000 | 2 | 1 | 3 | | 1999 | 0 | 1 | 1 | | 1998 | 2 | 1 | 3 | | 1996 | 0 | 1 | 1 | | 1993 | 1 | 0 | 1 | | 1991 | 0 | 2 | 2 |
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Below are the most recent publications written about "Cyclosporine" by people in Profiles over the past ten years.
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Fervenza FC, Appel GB, Barbour SJ, Rovin BH, Lafayette RA, Aslam N, Jefferson JA, Gipson PE, Rizk DV, Sedor JR, Simon JF, McCarthy ET, Brenchley P, Sethi S, Avila-Casado C, Beanlands H, Lieske JC, Philibert D, Li T, Thomas LF, Green DF, Juncos LA, Beara-Lasic L, Blumenthal SS, Sussman AN, Erickson SB, Hladunewich M, Canetta PA, Hebert LA, Leung N, Radhakrishnan J, Reich HN, Parikh SV, Gipson DS, Lee DK, da Costa BR, Jüni P, Cattran DC. Rituximab or Cyclosporine in the Treatment of Membranous Nephropathy. N Engl J Med. 2019 07 04; 381(1):36-46.
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Almario EE, Borlak J, Suzuki A, Chen M. Drug-Induced Liver Injury. Biomed Res Int. 2017; 2017:2461694.
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Wilken R, Fung MA, Shi VY, Cheng MY, Patel F, Sultani H, Maverakis E. Cyclosporine-induced sebaceous hyperplasia in a hematopoetic stem cell transplant patient: delayed onset of a common adverse event. Dermatol Online J. 2016 Jan 15; 22(1).
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Hu J, Ramshesh VK, McGill MR, Jaeschke H, Lemasters JJ. Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver. Toxicol Sci. 2016 Mar; 150(1):204-15.
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Fervenza FC, Canetta PA, Barbour SJ, Lafayette RA, Rovin BH, Aslam N, Hladunewich MA, Irazabal MV, Sethi S, Gipson DS, Reich HN, Brenchley P, Kretzler M, Radhakrishnan J, Hebert LA, Gipson PE, Thomas LF, McCarthy ET, Appel GB, Jefferson JA, Eirin A, Lieske JC, Hogan MC, Greene EL, Dillon JJ, Leung N, Sedor JR, Rizk DV, Blumenthal SS, Lasic LB, Juncos LA, Green DF, Simon J, Sussman AN, Philibert D, Cattran DC. A Multicenter Randomized Controlled Trial of Rituximab versus Cyclosporine in the Treatment of Idiopathic Membranous Nephropathy (MENTOR). Nephron. 2015; 130(3):159-68.
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Sereno J, Vala H, Nunes S, Rocha-Pereira P, Carvalho E, Alves R, Teixeira F, Reis F. Cyclosporine A-induced nephrotoxicity is ameliorated by dose reduction and conversion to sirolimus in the rat. J Physiol Pharmacol. 2015 Apr; 66(2):285-99.
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Fuchs GJ. Re-CYCLing Rotavirus. J Pediatr Gastroenterol Nutr. 2015 Jan; 60(1):1.
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Pereira MJ, Palming J, Rizell M, Aureliano M, Carvalho E, Svensson MK, Eriksson JW. Cyclosporine A and tacrolimus reduce the amount of GLUT4 at the cell surface in human adipocytes: increased endocytosis as a potential mechanism for the diabetogenic effects of immunosuppressive agents. J Clin Endocrinol Metab. 2014 Oct; 99(10):E1885-94.
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Lopes PC, Fuhrmann A, Carvalho F, Sereno J, Santos MR, Pereira MJ, Eriksson JW, Reis F, Carvalho E. Cyclosporine A enhances gluconeogenesis while sirolimus impairs insulin signaling in peripheral tissues after 3 weeks of treatment. Biochem Pharmacol. 2014 Sep 01; 91(1):61-73.
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Sereno J, Rodrigues-Santos P, Vala H, Rocha-Pereira P, Alves R, Fernandes J, Santos-Silva A, Carvalho E, Teixeira F, Reis F. Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an in vivo rat model. Int J Mol Sci. 2014 May 20; 15(5):8979-97.
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Lopes PC, Fuhrmann A, Sereno J, Espinoza DO, Pereira MJ, Eriksson JW, Reis F, Carvalho E. Short and long term in vivo effects of Cyclosporine A and Sirolimus on genes and proteins involved in lipid metabolism in Wistar rats. Metabolism. 2014 May; 63(5):702-15.
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Fuhrmann A, Lopes P, Sereno J, Pedro J, Espinoza DO, Pereira MJ, Reis F, Eriksson JW, Carvalho E. Molecular mechanisms underlying the effects of cyclosporin A and sirolimus on glucose and lipid metabolism in liver, skeletal muscle and adipose tissue in an in vivo rat model. Biochem Pharmacol. 2014 Mar 15; 88(2):216-28.
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Lopes P, Fuhrmann A, Sereno J, Pereira MJ, Nunes P, Pedro J, Melão A, Reis F, Carvalho E. Effects of cyclosporine and sirolimus on insulin-stimulated glucose transport and glucose tolerance in a rat model. Transplant Proc. 2013 Apr; 45(3):1142-8.
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Sereno J, Parada B, Rodrigues-Santos P, Lopes PC, Carvalho E, Vala H, Teixeira-Lemos E, Alves R, Figueiredo A, Mota A, Teixeira F, Reis F. Serum and renal tissue markers of nephropathy in rats under immunosuppressive therapy: cyclosporine versus sirolimus. Transplant Proc. 2013 Apr; 45(3):1149-56.
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Pereira MJ, Palming J, Rizell M, Aureliano M, Carvalho E, Svensson MK, Eriksson JW. The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue. Mol Cell Endocrinol. 2013 Jan 30; 365(2):260-9.
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Garcia-Saenz-de-Sicilia M, Mukherjee S. The adverse pharmacology of calcineurin inhibitors and their impact on hepatitis C recurrence after liver transplantation: implications for clinical practice. Expert Rev Clin Pharmacol. 2012 Sep; 5(5):587-93.
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Li Y, Couch L, Higuchi M, Fang JL, Guo L. Mitochondrial dysfunction induced by sertraline, an antidepressant agent. Toxicol Sci. 2012 Jun; 127(2):582-91.
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