 Osteocalcin
"Osteocalcin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
| Descriptor ID |
D015675
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| MeSH Number(s) |
D12.776.157.125.700
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| Concept/Terms |
Osteocalcin- Osteocalcin
- Bone gamma-Carboxyglutamic Acid Protein
- Bone gamma Carboxyglutamic Acid Protein
- Vitamin K-Dependent Bone Protein
- Vitamin K Dependent Bone Protein
- Calcium-Binding Protein, Vitamin K-Dependent
- Calcium Binding Protein, Vitamin K Dependent
- Gla Protein, Bone
- 4-Carboxyglutamic Protein, Bone
- 4 Carboxyglutamic Protein, Bone
- Bone 4-Carboxyglutamic Protein
- Protein, Bone 4-Carboxyglutamic
- Bone Gla Protein
- Protein, Bone Gla
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Below are MeSH descriptors whose meaning is more general than "Osteocalcin".
Below are MeSH descriptors whose meaning is more specific than "Osteocalcin".
This graph shows the total number of publications written about "Osteocalcin" by people in UAMS Profiles by year, and whether "Osteocalcin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2023 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 | | 2020 | 0 | 2 | 2 | | 2019 | 0 | 1 | 1 | | 2016 | 0 | 3 | 3 | | 2015 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2013 | 0 | 2 | 2 | | 2012 | 2 | 1 | 3 | | 2011 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2008 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 1996 | 0 | 1 | 1 | | 1993 | 0 | 1 | 1 |
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Below are the most recent publications written about "Osteocalcin" by people in Profiles over the past ten years.
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Chen JR, Samuel HA, Shlisky J, Sims CR, Lazarenko OP, Williams DK, Andres A, Badger TM. A longitudinal observational study of skeletal development between ages 3 mo and 6 y in children fed human milk, milk formula, or soy formula. Am J Clin Nutr. 2023 06; 117(6):1211-1218.
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Wagner BM, Robinson JW, Prickett TCR, Espiner EA, Khosla S, Gaddy D, Suva LJ, Potter LR. Guanylyl Cyclase-B Dependent Bone Formation in Mice is Associated with Youth, Increased Osteoblasts, and Decreased Osteoclasts. Calcif Tissue Int. 2022 11; 111(5):506-518.
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Manolagas SC. Osteocalcin promotes bone mineralization but is not a hormone. PLoS Genet. 2020 06; 16(6):e1008714.
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Fowlkes JL, Clay Bunn R, Kalaitzoglou E, Ray P, Popescu I, Thrailkill KM. Postnatal loss of the insulin receptor in osteoprogenitor cells does not impart a metabolic phenotype. Sci Rep. 2020 06 01; 10(1):8842.
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Rochester E, Wickman BE, Bell A, Simecka C, Clayton ZS, Hakkak R, Hooshmand S. A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model. Food Funct. 2019 Oct 16; 10(10):6851-6857.
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Atluri K, Lee J, Seabold D, Elangovan S, Salem AK. Gene-Activated Titanium Surfaces Promote In Vitro Osteogenesis. Int J Oral Maxillofac Implants. 2017 Mar/Apr; 32(2):e83?e96.
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Smith SS, Dole NS, Franceschetti T, Hrdlicka HC, Delany AM. MicroRNA-433 Dampens Glucocorticoid Receptor Signaling, Impacting Circadian Rhythm and Osteoblastic Gene Expression. J Biol Chem. 2016 Oct 07; 291(41):21717-21728.
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P?rez-Campo FM, May T, Zauers J, Sa?udo C, Delgado-Calle J, Arozamena J, Berciano MT, Lafarga M, Riancho JA. Generation and characterization of two immortalized human osteoblastic cell lines useful for epigenetic studies. J Bone Miner Metab. 2017 Mar; 35(2):150-160.
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Hinton PS, Shankar K, Eaton LM, Rector RS. Obesity-related changes in bone structural and material properties in hyperphagic OLETF rats and protection by voluntary wheel running. Metabolism. 2015 Aug; 64(8):905-16.
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Liu S, Song W, Boulanger JH, Tang W, Sabbagh Y, Kelley B, Gotschall R, Ryan S, Phillips L, Malley K, Cao X, Xia TH, Zhen G, Cao X, Ling H, Dechow PC, Bellido TM, Ledbetter SR, Schiavi SC. Role of TGF-? in a mouse model of high turnover renal osteodystrophy. J Bone Miner Res. 2014; 29(5):1141-57.
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