 Insulin Receptor Substrate Proteins
"Insulin Receptor Substrate Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share in common an N-terminal PHOSPHOLIPID-binding domain, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation insulin receptor substrate proteins interact with specific SH2 DOMAIN-containing proteins that are involved in insulin receptor signaling.
| Descriptor ID |
D055504
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| MeSH Number(s) |
D12.644.360.024.301 D12.776.157.057.039 D12.776.476.024.382
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Insulin Receptor Substrate Proteins".
Below are MeSH descriptors whose meaning is more specific than "Insulin Receptor Substrate Proteins".
This graph shows the total number of publications written about "Insulin Receptor Substrate Proteins" by people in UAMS Profiles by year, and whether "Insulin Receptor Substrate Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 | | 2013 | 0 | 3 | 3 | | 2012 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2000 | 0 | 2 | 2 | | 1999 | 0 | 1 | 1 |
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Below are the most recent publications written about "Insulin Receptor Substrate Proteins" by people in Profiles over the past ten years.
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García-Casarrubios E, de Moura C, Arroba AI, Pescador N, Calderon-Dominguez M, Garcia L, Herrero L, Serra D, Cadenas S, Reis F, Carvalho E, Obregon MJ, Valverde ÁM. Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes. Biochim Biophys Acta. 2016 12; 1861(12 Pt A):1929-1941.
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Jaiswal N, Gunaganti N, Maurya CK, Narender T, Tamrakar AK. Free fatty acid induced impairment of insulin signaling is prevented by the diastereomeric mixture of calophyllic acid and isocalophyllic acid in skeletal muscle cells. Eur J Pharmacol. 2015 Jan 05; 746:70-7.
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Stuart CA, South MA, Lee ML, McCurry MP, Howell ME, Ramsey MW, Stone MH. Insulin responsiveness in metabolic syndrome after eight weeks of cycle training. Med Sci Sports Exerc. 2013 Nov; 45(11):2021-9.
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de Matos MA, Ottone Vde O, Duarte TC, Sampaio PF, Costa KB, Fonseca CA, Neves MP, Schneider SM, Moseley P, Coimbra CC, Magalhães Fde C, Rocha-Vieira E, Amorim FT. Exercise reduces cellular stress related to skeletal muscle insulin resistance. Cell Stress Chaperones. 2014 Mar; 19(2):263-70.
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