 Iron
"Iron" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
| Descriptor ID |
D007501
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| MeSH Number(s) |
D01.268.556.412 D01.268.956.287 D01.552.544.412
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Iron".
Below are MeSH descriptors whose meaning is more specific than "Iron".
This graph shows the total number of publications written about "Iron" by people in UAMS Profiles by year, and whether "Iron" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2022 | 2 | 4 | 6 | | 2021 | 2 | 2 | 4 | | 2020 | 0 | 5 | 5 | | 2019 | 0 | 2 | 2 | | 2018 | 3 | 1 | 4 | | 2017 | 3 | 4 | 7 | | 2016 | 2 | 2 | 4 | | 2015 | 3 | 6 | 9 | | 2014 | 6 | 0 | 6 | | 2013 | 4 | 3 | 7 | | 2011 | 3 | 1 | 4 | | 2010 | 1 | 4 | 5 | | 2009 | 3 | 1 | 4 | | 2008 | 2 | 2 | 4 | | 2007 | 3 | 2 | 5 | | 2006 | 5 | 3 | 8 | | 2005 | 1 | 0 | 1 | | 2004 | 3 | 0 | 3 | | 2003 | 3 | 1 | 4 | | 2001 | 3 | 0 | 3 | | 2000 | 1 | 0 | 1 | | 1999 | 1 | 1 | 2 | | 1997 | 0 | 2 | 2 | | 1995 | 1 | 0 | 1 | | 1993 | 2 | 0 | 2 |
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Below are the most recent publications written about "Iron" by people in Profiles over the past ten years.
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Joffré E, Xiao X, Correia MSP, Nookaew I, Sasse S, Globisch D, Zhu B, Sjöling Å. Analysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors. Microbiol Spectr. 2022 08 31; 10(4):e0175521.
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Chumble A, Brush P, Muzaffar A, Tanaka T. The Effects of Preoperative Administration of Erythropoietin in Pediatric Patients Undergoing Cranial Vault Remodeling for Craniosynostosis. J Craniofac Surg. 2022 Jul-Aug 01; 33(5):1424-1427.
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Das BK, Wang L, Fujiwara T, Zhou J, Aykin-Burns N, Krager KJ, Lan R, Mackintosh SG, Edmondson R, Jennings ML, Wang X, Feng JQ, Barrientos T, Gogoi J, Kannan A, Gao L, Xing W, Mohan S, Zhao H. Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton. Elife. 2022 06 27; 11.
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Ippolito JR, Piccolo BD, Robeson MS, Barney DE, Ali J, Singh P, Hennigar SR. Iron deficient diets modify the gut microbiome and reduce the severity of enteric infection in a mouse model of S. Typhimurium-induced enterocolitis. J Nutr Biochem. 2022 09; 107:109065.
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Butt AT, Banyard CD, Haldipurkar SS, Agnoli K, Mohsin MI, Vitovski S, Paleja A, Tang Y, Lomax R, Ye F, Green J, Thomas MS. The Burkholderia cenocepacia iron starvation s factor, OrbS, possesses an on-board iron sensor. Nucleic Acids Res. 2022 04 22; 50(7):3709-3726.
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Uyoga MA, Mzembe G, Stoffel NU, Moretti D, Zeder C, Phiri K, Sabatier M, Hays NP, Zimmermann MB, Mwangi MN. Iron Bioavailability from Infant Cereals Containing Whole Grains and Pulses: A Stable Isotope Study in Malawian Children. J Nutr. 2022 03 03; 152(3):826-834.
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Yu YC, Luu HN, Wang R, Thomas CE, Glynn NW, Youk AO, Behari J, Yuan JM. Serum Biomarkers of Iron Status and Risk of Hepatocellular Carcinoma Development in Patients with Nonalcoholic Fatty Liver Disease. Cancer Epidemiol Biomarkers Prev. 2022 01; 31(1):230-235.
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Ali SA, Ali SA, Razzaq S, Khowaja N, Gutkind S, Raheman FU, Suhail N. Predictors of iron consumption for at least 90?days during pregnancy: Findings from National Demographic Health Survey, Pakistan (2017-2018). BMC Pregnancy Childbirth. 2021 May 03; 21(1):352.
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Adetola OY, Kruger J, Ferruzzi MG, Hamaker BR, Taylor JRN. Potential of moringa leaf and baobab fruit food-to-food fortification of wholegrain maize porridge to improve iron and zinc bioaccessibility. Int J Food Sci Nutr. 2022 Feb; 73(1):15-27.
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Ghaffarieh A, Ciolino JB. Potential of Application of Iron Chelating Agents in Ophthalmic Diseases. Semin Ophthalmol. 2021 May 19; 36(4):157-161.
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Ali SA, Abbasi Z, Shahid B, Moin G, Hambidge KM, Krebs NF, Westcott JE, McClure EM, Goldenberg RL, Saleem S. Prevalence and determinants of anemia among women of reproductive age in Thatta Pakistan: Findings from a cross-sectional study. PLoS One. 2020; 15(9):e0239320.
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Hawco NJ, Fu F, Yang N, Hutchins DA, John SG. Independent iron and light limitation in a low-light-adapted Prochlorococcus from the deep chlorophyll maximum. ISME J. 2021 01; 15(1):359-362.
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Kruger J, Taylor JRN, Ferruzzi MG, Debelo H. What is food-to-food fortification? A working definition and framework for evaluation of efficiency and implementation of best practices. Compr Rev Food Sci Food Saf. 2020 11; 19(6):3618-3658.
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Vorland CJ, Mestre LM, Mendis SS, Brown AW. Within-group comparisons led to unsubstantiated conclusions in "Low-phytate wholegrain bread instead of high-phytate wholegrain bread in a total diet context did not improve iron status of healthy Swedish females: a 12-week, randomized, parallel-design intervention Study". Eur J Nutr. 2020 09; 59(6):2813-2814.
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Scindia Y, Wlazlo E, Ghias E, Cechova S, Loi V, Leeds J, Ledesma J, Helen C, Swaminathan S. Modulation of iron homeostasis with hepcidin ameliorates spontaneous murine lupus nephritis. Kidney Int. 2020 07; 98(1):100-115.
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Menon LP, Weinstein RS. Iron replacement ameliorates hypophosphatemia in autosomal dominant hypophosphatemic rickets: A review of the role of iron. Bone. 2020 02; 131:115137.
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Agnoli K, Haldipurkar SS, Tang Y, Butt AT, Thomas MS. Distinct Modes of Promoter Recognition by Two Iron Starvation s Factors with Overlapping Promoter Specificities. J Bacteriol. 2019 02 01; 201(3).
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Qiu GW, Lou WJ, Sun CY, Yang N, Li ZK, Li DL, Zang SS, Fu FX, Hutchins DA, Jiang HB, Qiu BS. Outer Membrane Iron Uptake Pathways in the Model Cyanobacterium Synechocystis sp. Strain PCC 6803. Appl Environ Microbiol. 2018 10 01; 84(19).
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Urbaniak A, Basta P, Ast K, Woloszyn A, Kurianska-Woloszyn J, Latour E, Skarpanska-Stejnborn A. The impact of supplementation with pomegranate fruit (Punica granatum L.) juice on selected antioxidant parameters and markers of iron metabolism in rowers. J Int Soc Sports Nutr. 2018 Jul 24; 15(1):35.
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Wang L, Fang B, Fujiwara T, Krager K, Gorantla A, Li C, Feng JQ, Jennings ML, Zhou J, Aykin-Burns N, Zhao H. Deletion of ferroportin in murine myeloid cells increases iron accumulation and stimulates osteoclastogenesis in vitro and in vivo. J Biol Chem. 2018 06 15; 293(24):9248-9264.
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Dreval K, Tryndyak V, Kindrat I, Twaddle NC, Orisakwe OE, Mudalige TK, Beland FA, Doerge DR, Pogribny IP. Cellular and Molecular Effects of Prolonged Low-Level Sodium Arsenite Exposure on Human Hepatic HepaRG Cells. Toxicol Sci. 2018 04 01; 162(2):676-687.
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Peng Y, Shinde DN, Valencia CA, Mo JS, Rosenfeld J, Truitt Cho M, Chamberlin A, Li Z, Liu J, Gui B, Brockhage R, Basinger A, Alvarez-Leon B, Heydemann P, Magoulas PL, Lewis AM, Scaglia F, Gril S, Chong SC, Bower M, Monaghan KG, Willaert R, Plona MR, Dineen R, Milan F, Hoganson G, Powis Z, Helbig KL, Keller-Ramey J, Harris B, Anderson LC, Green T, Sukoff Rizzo SJ, Kaylor J, Chen J, Guan MX, Sellars E, Sparagana SP, Gibson JB, Reinholdt LG, Tang S, Huang T. Biallelic mutations in the ferredoxin reductase gene cause novel mitochondriopathy with optic atrophy. Hum Mol Genet. 2017 12 15; 26(24):4937-4950.
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Butt AT, Thomas MS. Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species. Front Cell Infect Microbiol. 2017; 7:460.
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Kindrat I, Dreval K, Shpyleva S, Tryndyak V, de Conti A, Mudalige TK, Chen T, Erstenyuk AM, Beland FA, Pogribny IP. Effect of methapyrilene hydrochloride on hepatic intracellular iron metabolism in vivo and in vitro. Toxicol Lett. 2017 Nov 05; 281:65-73.
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Liu Z, Nemec-Bakk A, Khaper N, Chen A. Sensitive Electrochemical Detection of Nitric Oxide Release from Cardiac and Cancer Cells via a Hierarchical Nanoporous Gold Microelectrode. Anal Chem. 2017 08 01; 89(15):8036-8043.
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McKee SG, Close R, Lowenthal E. Evaluation of Iron Deficiency Anemia in a Pediatric Clinic in the Dominican Republic. Ann Glob Health. 2017 May - Aug; 83(3-4):550-556.
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Xia J, Xu H, Zhang X, Allamargot C, Coleman KL, Nessler R, Frech I, Tricot G, Zhan F. Multiple Myeloma Tumor Cells are Selectively Killed by Pharmacologically-dosed Ascorbic Acid. EBioMedicine. 2017 Apr; 18:41-49.
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Chakravarti A, Camp K, McNabb DS, Pinto I. The Iron-Dependent Regulation of the Candida albicans Oxidative Stress Response by the CCAAT-Binding Factor. PLoS One. 2017; 12(1):e0170649.
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Juvvadi PR. Balancing iron and calcium: Flavin carrier family proteins in Aspergillus fumigatus virulence. Virulence. 2017 08 18; 8(6):621-624.
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Swaminathan S. Gadolinium toxicity: Iron and ferroportin as central targets. Magn Reson Imaging. 2016 Dec; 34(10):1373-1376.
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Swaminathan S. Iron, hormesis, and protection in acute kidney injury. Kidney Int. 2016 07; 90(1):16-7.
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Charlton JR, Pearl VM, Denotti AR, Lee JB, Swaminathan S, Scindia YM, Charlton NP, Baldelomar EJ, Beeman SC, Bennett KM. Biocompatibility of ferritin-based nanoparticles as targeted MRI contrast agents. Nanomedicine. 2016 08; 12(6):1735-45.
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Raber J, Allen AR, Sharma S, Allen B, Rosi S, Olsen RH, Davis MJ, Eiwaz M, Fike JR, Nelson GA. Effects of Proton and Combined Proton and (56)Fe Radiation on the Hippocampus. Radiat Res. 2016 Jan; 185(1):20-30.
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Allen AR, Raber J, Chakraborti A, Sharma S, Fike JR. (56)Fe Irradiation Alters Spine Density and Dendritic Complexity in the Mouse Hippocampus. Radiat Res. 2015 Dec; 184(6):586-94.
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Mohd-Shukri NA, Duncan A, Denison FC, Forbes S, Walker BR, Norman JE, Reynolds RM. Health Behaviours during Pregnancy in Women with Very Severe Obesity. Nutrients. 2015 Oct 07; 7(10):8431-43.
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Bose C, Megyesi JK, Shah SV, Hiatt KM, Hall KA, Karaduta O, Swaminathan S. Evidence Suggesting a Role of Iron in a Mouse Model of Nephrogenic Systemic Fibrosis. PLoS One. 2015; 10(8):e0136563.
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Nzabarushimana E, Prior S, Miousse IR, Pathak R, Allen AR, Latendresse J, Olsen RH, Raber J, Hauer-Jensen M, Nelson GA, Koturbash I. Combined exposure to protons and (56)Fe leads to overexpression of Il13 and reactivation of repetitive elements in the mouse lung. Life Sci Space Res (Amst). 2015 Nov; 7:1-8.
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Bertrand EM, McCrow JP, Moustafa A, Zheng H, McQuaid JB, Delmont TO, Post AF, Sipler RE, Spackeen JL, Xu K, Bronk DA, Hutchins DA, Allen AE. Phytoplankton-bacterial interactions mediate micronutrient colimitation at the coastal Antarctic sea ice edge. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):9938-43.
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Casper C, Chaturvedi S, Munshi N, Wong R, Qi M, Schaffer M, Bandekar R, Hall B, van de Velde H, Vermeulen J, Reddy M, van Rhee F. Analysis of Inflammatory and Anemia-Related Biomarkers in a Randomized, Double-Blind, Placebo-Controlled Study of Siltuximab (Anti-IL6 Monoclonal Antibody) in Patients With Multicentric Castleman Disease. Clin Cancer Res. 2015 Oct 01; 21(19):4294-304.
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Gu Z, Wang H, Xia J, Yang Y, Jin Z, Xu H, Shi J, De Domenico I, Tricot G, Zhan F. Decreased ferroportin promotes myeloma cell growth and osteoclast differentiation. Cancer Res. 2015 Jun 01; 75(11):2211-21.
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Scindia Y, Dey P, Thirunagari A, Liping H, Rosin DL, Floris M, Okusa MD, Swaminathan S. Hepcidin Mitigates Renal Ischemia-Reperfusion Injury by Modulating Systemic Iron Homeostasis. J Am Soc Nephrol. 2015 Nov; 26(11):2800-14.
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Ellwood MJ, Hutchins DA, Lohan MC, Milne A, Nasemann P, Nodder SD, Sander SG, Strzepek R, Wilhelm SW, Boyd PW. Iron stable isotopes track pelagic iron cycling during a subtropical phytoplankton bloom. Proc Natl Acad Sci U S A. 2015 Jan 06; 112(1):E15-20.
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Shpyleva S, Pogribna M, Cozart C, Bryant MS, Muskhelishvili L, Tryndyak VP, Ross SA, Beland FA, Pogribny IP. Interstrain differences in the progression of nonalcoholic steatohepatitis to fibrosis in mice are associated with altered hepatic iron metabolism. J Nutr Biochem. 2014 Dec; 25(12):1235-42.
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Garcia NS, Fu F, Sedwick PN, Hutchins DA. Iron deficiency increases growth and nitrogen-fixation rates of phosphorus-deficient marine cyanobacteria. ISME J. 2015 Jan; 9(1):238-45.
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Miousse IR, Shao L, Chang J, Feng W, Wang Y, Allen AR, Turner J, Stewart B, Raber J, Zhou D, Koturbash I. Exposure to low-dose (56)Fe-ion radiation induces long-term epigenetic alterations in mouse bone marrow hematopoietic progenitor and stem cells. Radiat Res. 2014 Jul; 182(1):92-101.
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Kim JH, Bothe JR, Frederick RO, Holder JC, Markley JL. Role of IscX in iron-sulfur cluster biogenesis in Escherichia coli. J Am Chem Soc. 2014 Jun 04; 136(22):7933-42.
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Nzabarushimana E, Miousse IR, Shao L, Chang J, Allen AR, Turner J, Stewart B, Raber J, Koturbash I. Long-term epigenetic effects of exposure to low doses of 56Fe in the mouse lung. J Radiat Res. 2014 Jul; 55(4):823-8.
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Vega DE, Young KD. Accumulation of periplasmic enterobactin impairs the growth and morphology of Escherichia coli tolC mutants. Mol Microbiol. 2014 Feb; 91(3):508-21.
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Zhou J, Ye S, Fujiwara T, Manolagas SC, Zhao H. Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation. J Biol Chem. 2013 Oct 18; 288(42):30064-30074.
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Chekhun VF, Lukyanova NY, Burlaka CA, Bezdenezhnykh NA, Shpyleva SI, Tryndyak VP, Beland FA, Pogribny IP. Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin. Int J Oncol. 2013 Nov; 43(5):1481-6.
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Jacobus JA, Duda CG, Coleman MC, Martin SM, Mapuskar K, Mao G, Smith BJ, Aykin-Burns N, Guida P, Gius D, Domann FE, Knudson CM, Spitz DR. Low-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and gender. Radiat Res. 2013 Aug; 180(2):156-65.
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Hayflick SJ, Kruer MC, Gregory A, Haack TB, Kurian MA, Houlden HH, Anderson J, Boddaert N, Sanford L, Harik SI, Dandu VH, Nardocci N, Zorzi G, Dunaway T, Tarnopolsky M, Skinner S, Holden KR, Frucht S, Hanspal E, Schrander-Stumpel C, Mignot C, Héron D, Saunders DE, Kaminska M, Lin JP, Lascelles K, Cuno SM, Meyer E, Garavaglia B, Bhatia K, de Silva R, Crisp S, Lunt P, Carey M, Hardy J, Meitinger T, Prokisch H, Hogarth P. ß-Propeller protein-associated neurodegeneration: a new X-linked dominant disorder with brain iron accumulation. Brain. 2013 Jun; 136(Pt 6):1708-17.
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