 Methionine
"Methionine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals.
| Descriptor ID |
D008715
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| MeSH Number(s) |
D02.886.030.676 D12.125.142.557 D12.125.154.549 D12.125.166.676
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| Concept/Terms |
Methionine- Methionine
- L-Methionine
- Methionine, L-Isomer
- L-Isomer Methionine
- Methionine, L Isomer
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Below are MeSH descriptors whose meaning is more general than "Methionine".
Below are MeSH descriptors whose meaning is more specific than "Methionine".
This graph shows the total number of publications written about "Methionine" by people in UAMS Profiles by year, and whether "Methionine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2022 | 0 | 1 | 1 | | 2021 | 2 | 0 | 2 | | 2020 | 6 | 1 | 7 | | 2019 | 1 | 1 | 2 | | 2018 | 1 | 1 | 2 | | 2017 | 1 | 3 | 4 | | 2016 | 1 | 1 | 2 | | 2015 | 0 | 1 | 1 | | 2014 | 1 | 2 | 3 | | 2013 | 1 | 0 | 1 | | 2012 | 0 | 2 | 2 | | 2011 | 0 | 3 | 3 | | 2010 | 2 | 0 | 2 | | 2009 | 2 | 1 | 3 | | 2008 | 2 | 3 | 5 | | 2006 | 3 | 1 | 4 | | 2005 | 2 | 1 | 3 | | 2004 | 2 | 1 | 3 | | 2003 | 1 | 0 | 1 | | 2002 | 3 | 1 | 4 | | 2001 | 0 | 1 | 1 | | 2000 | 1 | 0 | 1 | | 1999 | 0 | 1 | 1 | | 1998 | 0 | 2 | 2 | | 1997 | 1 | 0 | 1 | | 1996 | 1 | 0 | 1 | | 1993 | 0 | 1 | 1 | | 1991 | 0 | 1 | 1 | | 1988 | 0 | 1 | 1 |
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Below are the most recent publications written about "Methionine" by people in Profiles over the past ten years.
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Tripathi M, Singh BK, Zhou J, Tikno K, Widjaja A, Sandireddy R, Arul K, Abdul Ghani SAB, Bee GGB, Wong KA, Pei HJ, Shekeran SG, Sinha RA, Singh MK, Cook SA, Suzuki A, Lim TR, Cheah CC, Wang J, Xiao RP, Zhang X, Chow PKH, Yen PM. Vitamin B12 and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation. J Hepatol. 2022 11; 77(5):1246-1255.
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Wallis KF, Morehead LC, Bird JT, Byrum SD, Miousse IR. Differences in cell death in methionine versus cysteine depletion. Environ Mol Mutagen. 2021 03; 62(3):216-226.
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Binz RL, Sadhukhan R, Miousse IR, Garg S, Koturbash I, Zhou D, Hauer-Jensen M, Pathak R. Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells. Int J Mol Sci. 2021 Feb 27; 22(5).
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Rosa F, Osorio JS. Quantitative determination of histone methylation via fluorescence resonance energy transfer (FRET) technology in immortalized bovine mammary alveolar epithelial cells supplemented with methionine. PLoS One. 2020; 15(12):e0244135.
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Wan Z, Rosenbaum ER, Liu W, Song B, Yue X, Kong Y, Li T, Zhai Y, Ma Z, Cao Z. Benchmark Examination of Blood Amino Acids Patterns in Phenylketonuria Neonates and Young Children on Phenylalanine-Restricted Dietary Treatment. Fetal Pediatr Pathol. 2022 Jun; 41(3):443-450.
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Ligthart-Melis GC, Engelen MPKJ, Simbo SY, Ten Have GAM, Thaden JJ, Cynober L, Deutz NEP. Metabolic Consequences of Supplemented Methionine in a Clinical Context. J Nutr. 2020 10 01; 150(Suppl 1):2538S-2547S.
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Ewing LE, Skinner CM, Pathak R, Yee EU, Krager K, Gurley PC, Melnyk S, Boerma M, Hauer-Jensen M, Koturbash I. Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation. Int J Radiat Oncol Biol Phys. 2021 02 01; 109(2):581-593.
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Miousse IR, Tobacyk J, Quick CM, Jamshidi-Parsian A, Skinner CM, Kore R, Melnyk SB, Kutanzi KR, Xia F, Griffin RJ, Koturbash I. Reply to Flugge: the anti-metastatic potential of methionine restriction in melanoma. Carcinogenesis. 2020 05 14; 41(3):390-391.
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Huang JY, Luu HN, Butler LM, Midttun Ø, Ulvik A, Wang R, Jin A, Gao YT, Tan Y, Ueland PM, Koh WP, Yuan JM. A prospective evaluation of serum methionine-related metabolites in relation to pancreatic cancer risk in two prospective cohort studies. Int J Cancer. 2020 10 01; 147(7):1917-1927.
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Wallis KF, Melnyk SB, Miousse IR. Sex-Specific Effects of Dietary Methionine Restriction on the Intestinal Microbiome. Nutrients. 2020 Mar 16; 12(3).
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Miousse IR, Ewing LE, Skinner CM, Pathak R, Garg S, Kutanzi KR, Melnyk S, Hauer-Jensen M, Koturbash I. Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome. Am J Physiol Gastrointest Liver Physiol. 2020 03 01; 318(3):G439-G450.
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Alharthi AS, Coleman DN, Liang Y, Batistel F, Elolimy AA, Yambao RC, Abdel-Hamied E, Pan YX, Parys C, Alhidary IA, Abdelrahman MM, Loor JJ. Hepatic 1-carbon metabolism enzyme activity, intermediate metabolites, and growth in neonatal Holstein dairy calves are altered by maternal supply of methionine during late pregnancy. J Dairy Sci. 2019 Nov; 102(11):10291-10303.
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Lapa C, Kircher M, Da Via M, Schreder M, Rasche L, Kortüm KM, Einsele H, Buck AK, Hänscheid H, Samnick S. Comparison of 11C-Choline and 11C-Methionine PET/CT in Multiple Myeloma. Clin Nucl Med. 2019 Aug; 44(8):620-624.
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Coleman DN, Vailati-Riboni M, Elolimy AA, Cardoso FC, Rodriguez-Zas SL, Miura M, Pan YX, Loor JJ. Hepatic betaine-homocysteine methyltransferase and methionine synthase activity and intermediates of the methionine cycle are altered by choline supply during negative energy balance in Holstein cows. J Dairy Sci. 2019 Sep; 102(9):8305-8318.
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Miousse IR, Skinner CM, Sridharan V, Seawright JW, Singh P, Landes RD, Cheema AK, Hauer-Jensen M, Boerma M, Koturbash I. Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (16O). Life Sci Space Res (Amst). 2019 Aug; 22:8-15.
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Batistel F, Alharthi AS, Yambao RRC, Elolimy AA, Pan YX, Parys C, Loor JJ. Methionine Supply During Late-Gestation Triggers Offspring Sex-Specific Divergent Changes in Metabolic and Epigenetic Signatures in Bovine Placenta. J Nutr. 2019 01 01; 149(1):6-17.
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Miousse IR, Tobacyk J, Quick CM, Jamshidi-Parsian A, Skinner CM, Kore R, Melnyk SB, Kutanzi KR, Xia F, Griffin RJ, Koturbash I. Modulation of dietary methionine intake elicits potent, yet distinct, anticancer effects on primary versus metastatic tumors. Carcinogenesis. 2018 09 21; 39(9):1117-1126.
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Miousse IR, Ewing LE, Kutanzi KR, Griffin RJ, Koturbash I. DNA Methylation in Radiation-Induced Carcinogenesis: Experimental Evidence and Clinical Perspectives. Crit Rev Oncog. 2018; 23(1-2):1-11.
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Stingone JA, Luben TJ, Carmichael SL, Aylsworth AS, Botto LD, Correa A, Gilboa SM, Langlois PH, Nembhard WN, Richmond-Bryant J, Shaw GM, Olshan AF. Maternal Exposure to Nitrogen Dioxide, Intake of Methyl Nutrients, and Congenital Heart Defects in Offspring. Am J Epidemiol. 2017 Sep 15; 186(6):719-729.
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Deutz NE, Simbo SY, Ligthart-Melis GC, Cynober L, Smriga M, Engelen MP. Tolerance to increased supplemented dietary intakes of methionine in healthy older adults. Am J Clin Nutr. 2017 Aug; 106(2):675-683.
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Miousse IR, Tobacyk J, Melnyk S, James SJ, Cheema AK, Boerma M, Hauer-Jensen M, Koturbash I. One-carbon metabolism and ionizing radiation: a multifaceted interaction. Biomol Concepts. 2017 May 24; 8(2):83-92.
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Wankhade UD, Zhong Y, Kang P, Alfaro M, Chintapalli SV, Thakali KM, Shankar K. Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations. PLoS One. 2017; 12(4):e0175675.
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Vargason T, Howsmon DP, Melnyk S, James SJ, Hahn J. Mathematical modeling of the methionine cycle and transsulfuration pathway in individuals with autism spectrum disorder. J Theor Biol. 2017 03 07; 416:28-37.
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Koturbash I, Miousse IR, Sridharan V, Nzabarushimana E, Skinner CM, Melnyk SB, Pavliv O, Hauer-Jensen M, Nelson GA, Boerma M. Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart. Mutat Res. 2016 May; 787:43-53.
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Wong D, Tortorelli S, Bishop L, Sellars EA, Schimmenti LA, Gallant N, Prada CE, Hopkin RJ, Leslie ND, Berry SA, Rosenblatt DS, Fair AL, Matern D, Raymond K, Oglesbee D, Rinaldo P, Gavrilov D. Outcomes of four patients with homocysteine remethylation disorders detected by newborn screening. Genet Med. 2016 Feb; 18(2):162-7.
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Aissa AF, Tryndyak V, de Conti A, Melnyk S, Gomes TD, Bianchi ML, James SJ, Beland FA, Antunes LM, Pogribny IP. Effect of methionine-deficient and methionine-supplemented diets on the hepatic one-carbon and lipid metabolism in mice. Mol Nutr Food Res. 2014 Jul; 58(7):1502-12.
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Wang F, Singh S, Zhang J, Huber TD, Helmich KE, Sunkara M, Hurley KA, Goff RD, Bingman CA, Morris AJ, Thorson JS, Phillips GN. Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus. FEBS J. 2014 Sep; 281(18):4224-39.
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Brioli A, Morgan GJ, Durie B, Zamagni E. The utility of newer imaging techniques as predictors of clinical outcomes in multiple myeloma. Expert Rev Hematol. 2014 Feb; 7(1):13-6.
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Gupta S, Melnyk SB, Kruger WD. Cystathionine ß-synthase-deficient mice thrive on a low-methionine diet. FASEB J. 2014 Feb; 28(2):781-90.
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