 Leptin
"Leptin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
| Descriptor ID |
D020738
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| MeSH Number(s) |
D06.472.699.042.500 D12.644.276.024.500 D12.644.548.011.500 D12.776.467.024.500 D23.529.024.500
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| Concept/Terms |
Leptin- Leptin
- Obese Protein
- Obese Gene Product
- Gene Product, Obese
- Ob Gene Product
- Gene Product, Ob
- Ob Protein
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Below are MeSH descriptors whose meaning is more general than "Leptin".
Below are MeSH descriptors whose meaning is more specific than "Leptin".
This graph shows the total number of publications written about "Leptin" by people in UAMS Profiles by year, and whether "Leptin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2022 | 2 | 0 | 2 | | 2021 | 2 | 5 | 7 | | 2020 | 1 | 1 | 2 | | 2019 | 1 | 4 | 5 | | 2018 | 2 | 3 | 5 | | 2017 | 2 | 3 | 5 | | 2016 | 2 | 3 | 5 | | 2015 | 1 | 0 | 1 | | 2014 | 3 | 1 | 4 | | 2013 | 2 | 1 | 3 | | 2012 | 2 | 2 | 4 | | 2011 | 2 | 1 | 3 | | 2010 | 3 | 4 | 7 | | 2009 | 2 | 2 | 4 | | 2008 | 1 | 4 | 5 | | 2007 | 3 | 4 | 7 | | 2006 | 3 | 1 | 4 | | 2005 | 0 | 1 | 1 | | 2004 | 2 | 0 | 2 | | 2003 | 1 | 1 | 2 | | 2002 | 0 | 1 | 1 |
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Below are the most recent publications written about "Leptin" by people in Profiles over the past ten years.
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Diaz EC, Williams DK, Cotter M, Sims CR, Wolfe RR, Andres A, Børsheim E. Breastfeeding duration modifies the association between maternal weight status and offspring dietary palmitate oxidation. Am J Clin Nutr. 2022 08 04; 116(2):404-414.
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Çakir I, Hadley CK, Pan PL, Bagchi RA, Ghamari-Langroudi M, Porter DT, Wang Q, Litt MJ, Jana S, Hagen S, Lee P, White A, Lin JD, McKinsey TA, Cone RD. Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity. Nat Metab. 2022 01; 4(1):44-59.
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Chen Y, Shimoni O, Huang G, Wen S, Liao J, Duong HTT, Maddahfar M, Su QP, Ortega DG, Lu Y, Campbell DH, Walsh BJ, Jin D. Upconversion nanoparticle-assisted single-molecule assay for detecting circulating antigens of aggressive prostate cancer. Cytometry A. 2022 05; 101(5):400-410.
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Jones LR, Emmett PM, Hays NP, Shahkhalili Y, Taylor CM. Association of Nutrition in Early Childhood with Body Composition and Leptin in Later Childhood and Early Adulthood. Nutrients. 2021 Sep 18; 13(9).
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Barbosa P, Melnyk S, Bennuri SC, Delhey L, Reis A, Moura GR, Børsheim E, Rose S, Carvalho E. Redox Imbalance and Methylation Disturbances in Early Childhood Obesity. Oxid Med Cell Longev. 2021; 2021:2207125.
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Francis EC, Dabelea D, Shankar K, Perng W. Maternal diet quality during pregnancy is associated with biomarkers of metabolic risk among male offspring. Diabetologia. 2021 11; 64(11):2478-2490.
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Odle AK, MacNicol MC, Childs GV, MacNicol AM. Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction. Int J Mol Sci. 2021 Mar 24; 22(7).
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Childs GV, Odle AK, MacNicol MC, MacNicol AM. The Importance of Leptin to Reproduction. Endocrinology. 2021 02 01; 162(2).
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Krishnan S, Adams SH, Witbracht MG, Woodhouse LR, Piccolo BD, Thomas AP, Souza EC, Horn WF, Gertz ER, Van Loan MD, Keim NL. Weight Loss, but Not Dairy Composition of Diet, Moderately Affects Satiety and Postprandial Gut Hormone Patterns in Adults. J Nutr. 2021 01 04; 151(1):245-254.
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Miles TK, Silva Moreira AR, Allensworth-James ML, Odle AK, Haney AC, MacNicol AM, MacNicol MC, Childs GV. Sex differences in somatotrope response to fasting: biphasic responses in male mice. J Endocrinol. 2020 12; 247(3):213-224.
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Aryaie A, Tinsley G, Lee J, Watkins BA, Moore L, Alhaj-Saleh A, Shankar K, Wood SR, Wang R, Shen CL. Actions of annatto-extracted tocotrienol supplementation on obese postmenopausal women: study protocol for a double-blinded, placebo-controlled, randomised trial. BMJ Open. 2020 03 08; 10(3):e034338.
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Zheng F, Mu S, Rusch NJ. Leptin Activates Trpm7 Channels in the Carotid Body As a Mechanism of Obesity-Related Hypertension. Circ Res. 2019 11 08; 125(11):1003-1005.
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Zhao S, Zhu Y, Schultz RD, Li N, He Z, Zhang Z, Caron A, Zhu Q, Sun K, Xiong W, Deng H, Sun J, Deng Y, Kim M, Lee CE, Gordillo R, Liu T, Odle AK, Childs GV, Zhang N, Kusminski CM, Elmquist JK, Williams KW, An Z, Scherer PE. Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy. Cell Metab. 2019 10 01; 30(4):706-719.e6.
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Gibb FW, Dixon JM, Clarke C, Homer NZ, Faqehi AMM, Andrew R, Walker BR. Higher Insulin Resistance and Adiposity in Postmenopausal Women With Breast Cancer Treated With Aromatase Inhibitors. J Clin Endocrinol Metab. 2019 09 01; 104(9):3670-3678.
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Ronis MJ, Blackburn ML, Shankar K, Ferguson M, Cleves MA, Badger TM. Estradiol and NADPH oxidase crosstalk regulates responses to high fat feeding in female mice. Exp Biol Med (Maywood). 2019 07; 244(10):834-845.
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Huang YW, Chen JH, Rader JS, Aguilera-Barrantes I, Wang LS. Preventive Effects by Black Raspberries of Endometrial Carcinoma Initiation and Promotion Induced by a High-Fat Diet. Mol Nutr Food Res. 2019 06; 63(12):e1900013.
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Borengasser SJ, Baker PR, Kerns ME, Miller LV, Palacios AP, Kemp JF, Westcott JE, Morrison SD, Hernandez TL, Garces A, Figueroa L, Friedman JE, Hambidge KM, Krebs NF. Preconception Micronutrient Supplementation Reduced Circulating Branched Chain Amino Acids at 12 Weeks Gestation in an Open Trial of Guatemalan Women Who Are Overweight or Obese. Nutrients. 2018 Sep 11; 10(9).
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Wu B, Huang J, Zhang L, Kasukurthi MV, Huang F, Bian J, Fukuo K, Kazumi T. An integrative approach to investigate the association among high-sensitive C-reactive protein, body fat mass distribution, and other cardiometabolic risk factors in young healthy women. Methods. 2018 08 01; 145:60-66.
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Chouinard VA, Henderson DC, Dalla Man C, Valeri L, Gray BE, Ryan KP, Cypess AM, Cobelli C, Cohen BM, Öngür D. Impaired insulin signaling in unaffected siblings and patients with first-episode psychosis. Mol Psychiatry. 2019 10; 24(10):1513-1522.
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Perissinotti PP, Rivero-Echeto MC, Garcia-Rill E, Bisagno V, Urbano FJ. Leptin alters somatosensory thalamic networks by decreasing gaba release from reticular thalamic nucleus and action potential frequency at ventrobasal neurons. Brain Struct Funct. 2018 Jun; 223(5):2499-2514.
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Odle AK, Beneš H, Melgar Castillo A, Akhter N, Syed M, Haney A, Allensworth-James M, Hardy L, Winter B, Manoharan R, Syed R, MacNicol MC, MacNicol AM, Childs GV. Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression. Endocrinology. 2018 02 01; 159(2):883-894.
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Chondronikola M, Porter C, Malagaris I, Nella AA, Sidossis LS. Brown adipose tissue is associated with systemic concentrations of peptides secreted from the gastrointestinal system and involved in appetite regulation. Eur J Endocrinol. 2017 Jul; 177(1):33-40.
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Ruebel ML, Cotter M, Sims CR, Moutos DM, Badger TM, Cleves MA, Shankar K, Andres A. Obesity Modulates Inflammation and Lipid Metabolism Oocyte Gene Expression: A Single-Cell Transcriptome Perspective. J Clin Endocrinol Metab. 2017 06 01; 102(6):2029-2038.
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Trexler ET, Hirsch KR, Campbell BI, Smith-Ryan AE. Physiological Changes Following Competition in Male and Female Physique Athletes: A Pilot Study. Int J Sport Nutr Exerc Metab. 2017 Oct; 27(5):458-466.
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Bell A, Korourian S, Zeng H, Phelps J, Hakkak R. A diet containing a high- versus low-daidzein level does not protect against liver steatosis in the obese Zucker rat model. Food Funct. 2017 Mar 22; 8(3):1293-1298.
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Hirsch KR, Smith-Ryan AE, Blue MNM, Mock MG, Trexler ET. Influence of segmental body composition and adiposity hormones on resting metabolic rate and substrate utilization in overweight and obese adults. J Endocrinol Invest. 2017 Jun; 40(6):635-643.
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Gong Z, Tas E, Yakar S, Muzumdar R. Hepatic lipid metabolism and non-alcoholic fatty liver disease in aging. Mol Cell Endocrinol. 2017 Nov 05; 455:115-130.
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Hirsch KR, Smith-Ryan AE, Blue MN, Mock MG, Trexler ET, Ondrak KS. Metabolic characterization of overweight and obese adults. Phys Sportsmed. 2016 11; 44(4):362-372.
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Yu S, Wu X, Ferguson M, Simmen RC, Cleves MA, Simmen FA, Fang N. Diets Containing Shiitake Mushroom Reduce Serum Lipids and Serum Lipophilic Antioxidant Capacity in Rats. J Nutr. 2016 Dec; 146(12):2491-2496.
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Odle AK, Allensworth-James ML, Akhter N, Syed M, Haney AC, MacNicol M, MacNicol AM, Childs GV. A Sex-Dependent, Tropic Role for Leptin in the Somatotrope as a Regulator of POU1F1 and POU1F1-Dependent Hormones. Endocrinology. 2016 Oct; 157(10):3958-3971.
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Odle AK, Allensworth-James M, Haney A, Akhter N, Syed M, Childs GV. Adipocyte Versus Somatotrope Leptin: Regulation of Metabolic Functions in the Mouse. Endocrinology. 2016 Apr; 157(4):1443-56.
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Saber H, Himali JJ, Shoamanesh A, Beiser A, Pikula A, Harris TB, Roubenoff R, Romero JR, Kase CS, Vasan RS, Seshadri S. Serum Leptin Levels and the Risk of Stroke: The Framingham Study. Stroke. 2015 Oct; 46(10):2881-5.
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Odle AK, Haney A, Allensworth-James M, Akhter N, Childs GV. Adipocyte versus pituitary leptin in the regulation of pituitary hormones: somatotropes develop normally in the absence of circulating leptin. Endocrinology. 2014 Nov; 155(11):4316-28.
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Akhter N, CarlLee T, Syed MM, Odle AK, Cozart MA, Haney AC, Allensworth-James ML, Beneš H, Childs GV. Selective deletion of leptin receptors in gonadotropes reveals activin and GnRH-binding sites as leptin targets in support of fertility. Endocrinology. 2014 Oct; 155(10):4027-42.
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Thakali KM, Saben J, Faske JB, Lindsey F, Gomez-Acevedo H, Lowery CL, Badger TM, Andres A, Shankar K. Maternal pregravid obesity changes gene expression profiles toward greater inflammation and reduced insulin sensitivity in umbilical cord. Pediatr Res. 2014 Aug; 76(2):202-10.
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Bajpai G, Simmen RC, Stenken JA. In vivo microdialysis sampling of adipokines CCL2, IL-6, and leptin in the mammary fat pad of adult female rats. Mol Biosyst. 2014 Apr; 10(4):806-12.
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Hussain A, Olausson H, Nilsson S, Nookaew I, Khoomrung S, Andersson L, Koskela A, Tuukkanen J, Ohlsson C, Holmäng A. Maternal beef and postweaning herring diets increase bone mineral density and strength in mouse offspring. Exp Biol Med (Maywood). 2013 Dec; 238(12):1362-9.
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Beck P, Mahaffey S, Urbano FJ, Garcia-Rill E. Role of G-proteins in the effects of leptin on pedunculopontine nucleus neurons. J Neurochem. 2013 Sep; 126(6):705-14.
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