 Glutathione Transferase
"Glutathione Transferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.
| Descriptor ID |
D005982
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| MeSH Number(s) |
D08.811.913.225.500
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| Concept/Terms |
Glutathione Transferase- Glutathione Transferase
- Transferase, Glutathione
- Glutathione S-Alkyltransferase
- Glutathione S Alkyltransferase
- S-Alkyltransferase, Glutathione
- Glutathione S-Aryltransferase
- Glutathione S Aryltransferase
- S-Aryltransferase, Glutathione
- Glutathione S-Epoxidetransferase
- Glutathione S Epoxidetransferase
- S-Epoxidetransferase, Glutathione
- S-Hydroxyalkyl Glutathione Lyase
- Glutathione Lyase, S-Hydroxyalkyl
- Lyase, S-Hydroxyalkyl Glutathione
- S Hydroxyalkyl Glutathione Lyase
- Glutathione Transferases
- Transferases, Glutathione
- Heme Transfer Protein
- Protein, Heme Transfer
- Transfer Protein, Heme
- Ligandin
- Ligandins
- Glutathione Organic Nitrate Ester Reductase
- Glutathione S-Transferase
- Glutathione S Transferase
- S-Transferase, Glutathione
Glutathione S-Transferase 3- Glutathione S-Transferase 3
- Glutathione S Transferase 3
- S-Transferase 3, Glutathione
- Glutathione S-Transferase III
- Glutathione S Transferase III
- S-Transferase III, Glutathione
Glutathione S-Transferase P- Glutathione S-Transferase P
- Glutathione S Transferase P
- P, Glutathione S-Transferase
- S-Transferase P, Glutathione
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Below are MeSH descriptors whose meaning is more general than "Glutathione Transferase".
Below are MeSH descriptors whose meaning is more specific than "Glutathione Transferase".
This graph shows the total number of publications written about "Glutathione Transferase" by people in UAMS Profiles by year, and whether "Glutathione Transferase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2019 | 0 | 1 | 1 | | 2018 | 2 | 0 | 2 | | 2017 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2015 | 3 | 0 | 3 | | 2014 | 1 | 2 | 3 | | 2013 | 2 | 2 | 4 | | 2011 | 2 | 0 | 2 | | 2010 | 0 | 2 | 2 | | 2009 | 2 | 1 | 3 | | 2008 | 2 | 1 | 3 | | 2006 | 1 | 2 | 3 | | 2005 | 5 | 7 | 12 | | 2004 | 6 | 6 | 12 | | 2003 | 3 | 5 | 8 | | 2002 | 5 | 3 | 8 | | 2001 | 5 | 0 | 5 | | 2000 | 3 | 1 | 4 | | 1999 | 2 | 0 | 2 | | 1998 | 1 | 1 | 2 | | 1997 | 3 | 1 | 4 | | 1996 | 1 | 0 | 1 | | 1994 | 1 | 0 | 1 | | 1993 | 1 | 0 | 1 | | 1992 | 5 | 1 | 6 | | 1991 | 1 | 0 | 1 | | 1989 | 1 | 1 | 2 | | 1986 | 2 | 0 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Glutathione Transferase" by people in Profiles over the past ten years.
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Matlock MK, Tambe A, Elliott-Higgins J, Hines RN, Miller GP, Swamidass SJ. A Time-Embedding Network Models the Ontogeny of 23 Hepatic Drug Metabolizing Enzymes. Chem Res Toxicol. 2019 08 19; 32(8):1707-1721.
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Zhong G, James MO, Smeltz MG, Jahn SC, Langaee T, Simpson P, Stacpoole PW. Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1. Drug Metab Dispos. 2018 08; 46(8):1118-1128.
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Shearn CT, Pulliam CF, Pedersen K, Meredith K, Mercer KE, Saba LM, Orlicky DJ, Ronis MJ, Petersen DR. Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet. Alcohol Clin Exp Res. 2018 07; 42(7):1192-1205.
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Khemakhem AM, Frye RE, El-Ansary A, Al-Ayadhi L, Bacha AB. Novel biomarkers of metabolic dysfunction is autism spectrum disorder: potential for biological diagnostic markers. Metab Brain Dis. 2017 12; 32(6):1983-1997.
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Ronis M, Mercer K, Engi B, Pulliam C, Zimniak P, Hennings L, Shearn C, Badger T, Petersen D. Global Deletion of Glutathione S-Transferase A4 Exacerbates Developmental Nonalcoholic Steatohepatitis. Am J Pathol. 2017 Feb; 187(2):418-430.
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Shearn CT, Fritz KS, Shearn AH, Saba LM, Mercer KE, Engi B, Galligan JJ, Zimniak P, Orlicky DJ, Ronis MJ, Petersen DR. Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice. Redox Biol. 2016 Apr; 7:68-77.
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Singhal SS, Singh SP, Singhal P, Horne D, Singhal J, Awasthi S. Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling. Toxicol Appl Pharmacol. 2015 Dec 15; 289(3):361-70.
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Boerma M, Singh P, Sridharan V, Tripathi P, Sharma S, Singh SP. Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model. Radiat Res. 2015 Jun; 183(6):610-9.
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Ronis MJ, Mercer KE, Gannon B, Engi B, Zimniak P, Shearn CT, Orlicky DJ, Albano E, Badger TM, Petersen DR. Increased 4-hydroxynonenal protein adducts in male GSTA4-4/PPAR-a double knockout mice enhance injury during early stages of alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2015 Mar 01; 308(5):G403-15.
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Hasan SK, Khan R, Ali N, Khan AQ, Rehman MU, Tahir M, Lateef A, Nafees S, Mehdi SJ, Rashid S, Shahid A, Sultana S. 18-ß Glycyrrhetinic acid alleviates 2-acetylaminofluorene-induced hepatotoxicity in Wistar rats: Role in hyperproliferation, inflammation and oxidative stress. Hum Exp Toxicol. 2015 Jun; 34(6):628-41.
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Mobasher MA, de Toro-Martín J, González-Rodríguez Á, Ramos S, Letzig LG, James LP, Muntané J, Álvarez C, Valverde ÁM. Essential role of protein-tyrosine phosphatase 1B in the modulation of insulin signaling by acetaminophen in hepatocytes. J Biol Chem. 2014 Oct 17; 289(42):29406-19.
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Beneš H, Vuong MK, Boerma M, McElhanon KE, Siegel ER, Singh SP. Protection from oxidative and electrophilic stress in the Gsta4-null mouse heart. Cardiovasc Toxicol. 2013 Dec; 13(4):347-56.
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Molina E, Pérez-Morales R, Rubio J, Petrosyan P, Cadena LH, Arlt VM, Phillips DH, Gonsebatt ME. The GSTM1null (deletion) and MGMT84 rs12917 (Phe/Phe) haplotype are associated with bulky DNA adduct levels in human leukocytes. Mutat Res. 2013 Dec 12; 758(1-2):62-8.
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Dietz BM, Hagos GK, Eskra JN, Wijewickrama GT, Anderson JR, Nikolic D, Guo J, Wright B, Chen SN, Pauli GF, van Breemen RB, Bolton JL. Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo. Mol Nutr Food Res. 2013 Jun; 57(6):1055-66.
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McGill MR, Jaeschke H. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res. 2013 Sep; 30(9):2174-87.
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Apidianakis Y, Que YA, Xu W, Tegos GP, Zimniak P, Hamblin MR, Tompkins RG, Xiao W, Rahme LG. Down-regulation of glutatione S-transferase a 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection. FASEB J. 2012 Feb; 26(2):730-7.
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Li W, Gu Y, James MO, Hines RN, Simpson P, Langaee T, Stacpoole PW. Prenatal and postnatal expression of glutathione transferase ? 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate. Drug Metab Dispos. 2012 Feb; 40(2):232-9.
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