 Bile Acids and Salts
"Bile Acids and Salts" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.
| Descriptor ID |
D001647
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| MeSH Number(s) |
D04.808.105
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Bile Acids and Salts".
Below are MeSH descriptors whose meaning is more specific than "Bile Acids and Salts".
This graph shows the total number of publications written about "Bile Acids and Salts" by people in UAMS Profiles by year, and whether "Bile Acids and Salts" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2023 | 0 | 2 | 2 | | 2022 | 2 | 1 | 3 | | 2021 | 1 | 0 | 1 | | 2020 | 2 | 1 | 3 | | 2019 | 0 | 1 | 1 | | 2018 | 3 | 1 | 4 | | 2017 | 1 | 1 | 2 | | 2016 | 1 | 0 | 1 | | 2015 | 1 | 1 | 2 | | 2014 | 1 | 1 | 2 | | 2013 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2002 | 1 | 1 | 2 | | 2001 | 2 | 0 | 2 | | 1999 | 3 | 0 | 3 | | 1998 | 1 | 1 | 2 | | 1993 | 1 | 0 | 1 | | 1991 | 5 | 0 | 5 | | 1990 | 2 | 1 | 3 | | 1989 | 2 | 0 | 2 |
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Below are the most recent publications written about "Bile Acids and Salts" by people in Profiles over the past ten years.
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Luu HN, Tran CT, Wang R, Nguyen MV, Tran MT, Tuong TT, Tran QH, Le LC, Pham HT, Vu HH, Bui NC, Ha HT, Trinh DT, Thomas CE, Adams-Haduch J, Velikokhatnaya L, Schoen RE, Xie G, Jia W, Boffetta P, Clemente JC, Yuan JM. Associations between Ileal Juice Bile Acids and Colorectal Advanced Adenoma. Nutrients. 2023 Jun 28; 15(13).
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Golonka RM, Yeoh BS, Saha P, Gohara A, Tummala R, Stepkowski S, Tiwari AK, Joe B, Gonzalez FJ, Gewirtz AT, Vijay-Kumar M. Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor-deficient mice. Hepatol Commun. 2023 06 01; 7(6).
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Stierwalt HD, Morris EM, Maurer A, Apte U, Phillips K, Li T, Meers GME, Koch LG, Britton SL, Graf G, Rector RS, Mercer K, Shankar K, Thyfault JP. Rats with high aerobic capacity display enhanced transcriptional adaptability and upregulation of bile acid metabolism in response to an acute high-fat diet. Physiol Rep. 2022 08; 10(15):e15405.
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Manjar?n R, Dillard K, Coffin M, Hernandez GV, Smith VA, Noland-Lidell T, Gehani TR, Smart HJ, Wheeler K, Sprayberry KA, Edwards MS, Fanter RK, Glanz H, Immoos C, Santiago-Rodriguez TM, Blank JM, Burrin DG, Piccolo BD, Abo-Ismail M, La Frano MR, Maj M. Dietary fat composition shapes bile acid metabolism and severity of liver injury in a pig model of pediatric NAFLD. Am J Physiol Endocrinol Metab. 2022 09 01; 323(3):E187-E206.
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Adams SH, Wright R, Piccolo BD, Moody B, Sikes J, Avaritt N, Chintapalli SV, Ou X. C-section increases cecal abundance of the archetypal bile acid and glucocorticoid modifying Lachnoclostridium [clostridium] scindens in mice. Physiol Rep. 2022 07; 10(13):e15363.
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Lopez-Ruiz A, Juncos LA. Bile Acids are Important Contributors of AKI Associated with Liver Disease: COMMENTARY. Kidney360. 2022 01 27; 3(1):25-27.
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Mercer KE, Maurer A, Pack LM, Ono-Moore K, Spray BJ, Campbell C, Chandler CJ, Burnett D, Souza E, Casazza G, Keim N, Newman J, Hunter G, Fernadez J, Garvey WT, Harper ME, Hoppel C, Adams SH, Thyfault J. Exercise training and diet-induced weight loss increase markers of hepatic bile acid (BA) synthesis and reduce serum total BA concentrations in obese women. Am J Physiol Endocrinol Metab. 2021 05 01; 320(5):E864-E873.
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Maurer A, Ward JL, Dean K, Billinger SA, Lin H, Mercer KE, Adams SH, Thyfault JP. Divergence in aerobic capacity impacts bile acid metabolism in young women. J Appl Physiol (1985). 2020 10 01; 129(4):768-778.
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Hernandez GV, Smith VA, Melnyk M, Burd MA, Sprayberry KA, Edwards MS, Peterson DG, Bennet DC, Fanter RK, Columbus DA, Steibel JP, Glanz H, Immoos C, Rice MS, Santiago-Rodriguez TM, Blank J, VanderKelen JJ, Kitts CL, Piccolo BD, La Frano MR, Burrin DG, Maj M, Manjarin R. Dysregulated FXR-FGF19 signaling and choline metabolism are associated with gut dysbiosis and hyperplasia in a novel pig model of pediatric NASH. Am J Physiol Gastrointest Liver Physiol. 2020 03 01; 318(3):G582-G609.
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Zeng H, Larson KJ, Cheng WH, Bukowski MR, Safratowich BD, Liu Z, Hakkak R. Advanced liver steatosis accompanies an increase in hepatic inflammation, colonic, secondary bile acids and Lactobacillaceae/Lachnospiraceae bacteria in C57BL/6 mice fed a high-fat diet. J Nutr Biochem. 2020 04; 78:108336.
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Pedersen KB, Pulliam CF, Patel A, Del Piero F, Watanabe TTN, Wankhade UD, Shankar K, Hicks C, Ronis MJ. Liver tumorigenesis is promoted by a high saturated fat diet specifically in male mice and is associated with hepatic expression of the proto-oncogene Agap2 and enrichment of the intestinal microbiome with Coprococcus. Carcinogenesis. 2019 04 29; 40(2):349-359.
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Wankhade UD, Zhong Y, Kang P, Alfaro M, Chintapalli SV, Piccolo BD, Mercer KE, Andres A, Thakali KM, Shankar K. Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice. Sci Rep. 2018 11 07; 8(1):16502.
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MahmoudianDehkordi S, Arnold M, Nho K, Ahmad S, Jia W, Xie G, Louie G, Kueider-Paisley A, Moseley MA, Thompson JW, St John Williams L, Tenenbaum JD, Blach C, Baillie R, Han X, Bhattacharyya S, Toledo JB, Schafferer S, Klein S, Koal T, Risacher SL, Kling MA, Motsinger-Reif A, Rotroff DM, Jack J, Hankemeier T, Bennett DA, De Jager PL, Trojanowski JQ, Shaw LM, Weiner MW, Doraiswamy PM, van Duijn CM, Saykin AJ, Kastenm?ller G, Kaddurah-Daouk R. Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome. Alzheimers Dement. 2019 01; 15(1):76-92.
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Sedgeman LR, Beysen C, Allen RM, Ramirez Solano MA, Turner SM, Vickers KC. Intestinal bile acid sequestration improves glucose control by stimulating hepatic miR-182-5p in type 2 diabetes. Am J Physiol Gastrointest Liver Physiol. 2018 11 01; 315(5):G810-G823.
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Mercer KE, Bhattacharyya S, Diaz-Rubio ME, Piccolo BD, Pack LM, Sharma N, Chaudhury M, Cleves MA, Chintapalli SV, Shankar K, Ronis MJJ, Yeruva L. Infant Formula Feeding Increases Hepatic Cholesterol 7a Hydroxylase (CYP7A1) Expression and Fecal Bile Acid Loss in Neonatal Piglets. J Nutr. 2018 05 01; 148(5):702-711.
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Sun X, Winglee K, Gharaibeh RZ, Gauthier J, He Z, Tripathi P, Avram D, Bruner S, Fodor A, Jobin C. Microbiota-Derived Metabolic Factors Reduce Campylobacteriosis in Mice. Gastroenterology. 2018 05; 154(6):1751-1763.e2.
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Eggink HM, van Nierop FS, Schooneman MG, Boelen A, Kalsbeek A, Koehorst M, Ten Have GAM, de Brauw LM, Groen AK, Romijn JA, Deutz NEP, Soeters MR. Transhepatic bile acid kinetics in pigs and humans. Clin Nutr. 2018 08; 37(4):1406-1414.
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Panasevich MR, Schuster CM, Phillips KE, Meers GM, Chintapalli SV, Wankhade UD, Shankar K, Butteiger DN, Krul ES, Thyfault JP, Rector RS. Soy compared with milk protein in a Western diet changes fecal microbiota and decreases hepatic steatosis in obese OLETF rats. J Nutr Biochem. 2017 08; 46:125-136.
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Keune WJ, Hausmann J, Bolier R, Tolenaars D, Kremer A, Heidebrecht T, Joosten RP, Sunkara M, Morris AJ, Matas-Rico E, Moolenaar WH, Oude Elferink RP, Perrakis A. Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. Nat Commun. 2016 Apr 14; 7:11248.
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Zhang Y, Liu C, Barbier O, Smalling R, Tsuchiya H, Lee S, Delker D, Zou A, Hagedorn CH, Wang L. Bcl2 is a critical regulator of bile acid homeostasis by dictating Shp and lncRNA H19 function. Sci Rep. 2016 Feb 03; 6:20559.
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Woolbright BL, McGill MR, Yan H, Jaeschke H. Bile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes. Basic Clin Pharmacol Toxicol. 2016 Feb; 118(2):160-7.
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James L, Yan K, Pence L, Simpson P, Bhattacharyya S, Gill P, Letzig L, Kearns G, Beger R. Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity. PLoS One. 2015; 10(7):e0131010.
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