 Farnesyl-Diphosphate Farnesyltransferase
"Farnesyl-Diphosphate Farnesyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway.
| Descriptor ID |
D013186
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| MeSH Number(s) |
D08.811.913.225.431
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| Concept/Terms |
Farnesyl-Diphosphate Farnesyltransferase- Farnesyl-Diphosphate Farnesyltransferase
- Farnesyl Diphosphate Farnesyltransferase
- Farnesyltransferase, Farnesyl-Diphosphate
- FPP-FPP Farnesyl Transferase
- FPP FPP Farnesyl Transferase
- Farnesyl Transferase, FPP-FPP
- Transferase, FPP-FPP Farnesyl
- Squalene Synthase
- Synthase, Squalene
- Squalene Synthetase
- Synthetase, Squalene
- Farnesyldiphosphate-Farnesyldiphosphate Farnesyltransferase
- Farnesyldiphosphate Farnesyldiphosphate Farnesyltransferase
- Farnesyltransferase, Farnesyldiphosphate-Farnesyldiphosphate
- Presqualene-Diphosphate Synthase
- Presqualene Diphosphate Synthase
- Synthase, Presqualene-Diphosphate
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Below are MeSH descriptors whose meaning is more general than "Farnesyl-Diphosphate Farnesyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Farnesyl-Diphosphate Farnesyltransferase".
This graph shows the total number of publications written about "Farnesyl-Diphosphate Farnesyltransferase" by people in UAMS Profiles by year, and whether "Farnesyl-Diphosphate Farnesyltransferase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Farnesyl-Diphosphate Farnesyltransferase" by people in Profiles over the past ten years.
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Stieglitz E, Ward AF, Gerbing RB, Alonzo TA, Arceci RJ, Liu YL, Emanuel PD, Widemann BC, Cheng JW, Jayaprakash N, Balis FM, Castleberry RP, Bunin NJ, Loh ML, Cooper TM. Phase II/III trial of a pre-transplant farnesyl transferase inhibitor in juvenile myelomonocytic leukemia: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2015 Apr; 62(4):629-36.
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