Cross-Over Studies
"Cross-Over Studies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Descriptor ID |
D018592
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MeSH Number(s) |
E05.318.780.150 N05.715.360.780.150 N06.850.520.445.150
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Concept/Terms |
Cross-Over Studies- Cross-Over Studies
- Cross Over Studies
- Cross-Over Study
- Studies, Cross-Over
- Study, Cross-Over
- Crossover Studies
- Crossover Study
- Studies, Crossover
- Study, Crossover
- Cross-Over Trials
- Cross Over Trials
- Trial, Cross-Over
- Trials, Cross-Over
- Crossover Trials
- Trial, Crossover
- Trials, Crossover
Cross-Over Design- Cross-Over Design
- Cross Over Design
- Cross-Over Designs
- Design, Cross-Over
- Designs, Cross-Over
- Crossover Design
- Crossover Designs
- Design, Crossover
- Designs, Crossover
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Below are MeSH descriptors whose meaning is more general than "Cross-Over Studies".
Below are MeSH descriptors whose meaning is more specific than "Cross-Over Studies".
This graph shows the total number of publications written about "Cross-Over Studies" by people in UAMS Profiles by year, and whether "Cross-Over Studies" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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2020 | 0 | 3 | 3 | 2019 | 0 | 8 | 8 | 2018 | 0 | 8 | 8 | 2017 | 0 | 15 | 15 | 2016 | 0 | 10 | 10 | 2015 | 0 | 5 | 5 | 2014 | 0 | 3 | 3 | 2013 | 0 | 6 | 6 | 2012 | 0 | 9 | 9 | 2011 | 0 | 8 | 8 | 2010 | 0 | 4 | 4 | 2009 | 0 | 6 | 6 | 2008 | 0 | 5 | 5 | 2007 | 0 | 7 | 7 | 2006 | 0 | 5 | 5 | 2005 | 0 | 6 | 6 | 2004 | 0 | 10 | 10 | 2003 | 0 | 6 | 6 | 2002 | 0 | 2 | 2 | 2001 | 0 | 3 | 3 | 2000 | 0 | 4 | 4 | 1999 | 0 | 9 | 9 | 1998 | 0 | 5 | 5 | 1997 | 0 | 1 | 1 | 1996 | 0 | 1 | 1 | 1995 | 0 | 1 | 1 | 1994 | 0 | 2 | 2 |
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Below are the most recent publications written about "Cross-Over Studies" by people in Profiles over the past ten years.
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Park S, Church DD, Azhar G, Schutzler SE, Ferrando AA, Wolfe RR. Anabolic response to essential amino acid plus whey protein composition is greater than whey protein alone in young healthy adults. J Int Soc Sports Nutr. 2020 Feb 10; 17(1):9.
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Reisdorph NA, Hendricks AE, Tang M, Doenges KA, Reisdorph RM, Tooker BC, Quinn K, Borengasser SJ, Nkrumah-Elie Y, Frank DN, Campbell WW, Krebs NF. Nutrimetabolomics reveals food-specific compounds in urine of adults consuming a DASH-style diet. Sci Rep. 2020 01 24; 10(1):1157.
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Allman BR, Morrissey MC, Kim JS, Panton LB, Contreras RJ, Hickner RC, Ormsbee MJ. Lipolysis and Fat Oxidation Are Not Altered with Presleep Compared with Daytime Casein Protein Intake in Resistance-Trained Women. J Nutr. 2020 01 01; 150(1):47-54.
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Jansen LT, Suh H, Adams JD, Sprong CA, Seal AD, Scott DM, Butts CL, Melander O, Kirkland TW, Vanhaecke T, Dolci A, Lemetais G, Perrier ET, Kavouras SA. Osmotic stimulation of vasopressin acutely impairs glucose regulation: a counterbalanced, crossover trial. Am J Clin Nutr. 2019 12 01; 110(6):1344-1352.
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Margolis LM, Wilson MA, Whitney CC, Carrigan CT, Murphy NE, Radcliffe PN, Gwin JA, Church DD, Wolfe RR, Ferrando AA, Young AJ, Pasiakos SM. Acute hypoxia reduces exogenous glucose oxidation, glucose turnover, and metabolic clearance rate during steady-state aerobic exercise. Metabolism. 2020 02; 103:154030.
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Goode GA, Wagh SJ, Irby DJ, Ma D, Jacobs RF, Kearns GL, Almoazen H. Bioavailability testing of a newly developed clindamycin oral suspension in a pediatric porcine model. Pharm Dev Technol. 2019 Oct; 24(8):1038-1043.
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Elton A, Dove S, Spencer CN, Robinson DL, Boettiger CA. Naltrexone Acutely Enhances Connectivity Between the Ventromedial Prefrontal Cortex and a Left Frontoparietal Network. Alcohol Clin Exp Res. 2019 05; 43(5):965-978.
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Stancil SL, Pearce RE, Tyndale RF, Kearns GL, Vyhlidal CA, Leeder JS, Abdel-Rahman S. Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults. Br J Clin Pharmacol. 2019 05; 85(5):960-969.
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Matlock DN, Bai S, Weisner MD, Comtois N, Beck J, Sinderby C, Courtney SE. Tidal volume transmission during non-synchronized nasal intermittent positive pressure ventilation via RAM® cannula. J Perinatol. 2019 05; 39(5):723-729.
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Adams JD, Scott DM, Brand NA, Suh HG, Seal AD, McDermott BP, Ganio MS, Kavouras SA. Mild hypohydration impairs cycle ergometry performance in the heat: A blinded study. Scand J Med Sci Sports. 2019 May; 29(5):686-695.
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Hamarsland H, Aas SN, Nordengen AL, Holte K, Garthe I, Paulsen G, Cotter M, Børsheim E, Benestad HB, Raastad T. Native Whey Induces Similar Post Exercise Muscle Anabolic Responses as Regular Whey, Despite Greater Leucinemia, in Elderly Individuals. J Nutr Health Aging. 2019; 23(1):42-50.
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Coker RH, Shin K, Scholten K, Johannsen M, Tsigonis J, Kim IY, Schutzler SE, Wolfe RR. Essential amino acid-enriched meal replacement promotes superior net protein balance in older, overweight adults. Clin Nutr. 2019 12; 38(6):2821-2826.
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Lovallo WR, Acheson A, Vincent AS, Sorocco KH, Cohoon AJ. Early life adversity diminishes the cortisol response to opioid blockade in women: Studies from the Family Health Patterns project. PLoS One. 2018; 13(10):e0205723.
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Jonker R, Deutz NEP, Schols AMWJ, Veley EA, Harrykissoon R, Zachria AJ, Engelen MPKJ. Whole body protein anabolism in COPD patients and healthy older adults is not enhanced by adding either carbohydrates or leucine to a serving of protein. Clin Nutr. 2019 08; 38(4):1684-1691.
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Schlienz NJ, Lee DC, Stitzer ML, Vandrey R. The effect of high-dose dronabinol (oral THC) maintenance on cannabis self-administration. Drug Alcohol Depend. 2018 06 01; 187:254-260.
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Fairman BJ, Anthony JC. Does Starting to Smoke Cigars Trigger Onset of Cannabis Blunt Smoking? Nicotine Tob Res. 2018 02 07; 20(3):355-361.
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Awad SM, Berlinski A. Crossover Evaluation of Compressors and Nebulizers Typically Used by Cystic Fibrosis Patients. Respir Care. 2018 Mar; 63(3):294-300.
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Bhardwaj R, Dod H, Sandhu MS, Bedi R, Dod S, Konat G, Chopra HK, Sharma R, Jain AC, Nanda N. Acute effects of diets rich in almonds and walnuts on endothelial function. Indian Heart J. 2018 Jul - Aug; 70(4):497-501.
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Padala PR, Padala KP, Lensing SY, Jackson AN, Hunter CR, Parkes CM, Dennis RA, Bopp MM, Caceda R, Mennemeier MS, Roberson PK, Sullivan DH. Repetitive transcranial magnetic stimulation for apathy in mild cognitive impairment: A double-blind, randomized, sham-controlled, cross-over pilot study. Psychiatry Res. 2018 03; 261:312-318.
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Haynes T, Turner J, Smith J, Curran G, Bryant-Moore K, Ounpraseuth ST, Kramer T, Harris K, Hutchins E, Yeary KHK. Reducing depressive symptoms through behavioral activation in churches: A Hybrid-2 randomized effectiveness-implementation design. Contemp Clin Trials. 2018 01; 64:22-29.
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Hamarsland H, Nordengen AL, Nyvik Aas S, Holte K, Garthe I, Paulsen G, Cotter M, Børsheim E, Benestad HB, Raastad T. Native whey protein with high levels of leucine results in similar post-exercise muscular anabolic responses as regular whey protein: a randomized controlled trial. J Int Soc Sports Nutr. 2017; 14:43.
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Srivastava S, Mennemeier M, Pimple S. Effect of Alpinia galanga on Mental Alertness and Sustained Attention With or Without Caffeine: A Randomized Placebo-Controlled Study. J Am Coll Nutr. 2017 Nov-Dec; 36(8):631-639.
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Chopra S, Rathore A, Younas H, Pham LV, Gu C, Beselman A, Kim IY, Wolfe RR, Perin J, Polotsky VY, Jun JC. Obstructive Sleep Apnea Dynamically Increases Nocturnal Plasma Free Fatty Acids, Glucose, and Cortisol During Sleep. J Clin Endocrinol Metab. 2017 09 01; 102(9):3172-3181.
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Fray KJ. Fusional Amplitudes: Developing Testing Standards. Strabismus. 2017 09; 25(3):145-155.
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James GA, Thostenson JD, Brown G, Carter G, Hayes H, Tripathi SP, Dobry DJ, Govindan RB, Dornhoffer JL, Williams DK, Kilts CD, Mennemeier MS. Neural activity during attentional conflict predicts reduction in tinnitus perception following rTMS. Brain Stimul. 2017 Sep - Oct; 10(5):934-943.
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Hanlon CA, Dowdle LT, Correia B, Mithoefer O, Kearney-Ramos T, Lench D, Griffin M, Anton RF, George MS. Left frontal pole theta burst stimulation decreases orbitofrontal and insula activity in cocaine users and alcohol users. Drug Alcohol Depend. 2017 09 01; 178:310-317.
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Wells AJ, Jajtner AR, Varanoske AN, Church DD, Gonzalez AM, Townsend JR, Boone CH, Baker KM, Beyer KS, Mangine GT, Oliveira LP, Fukuda DH, Stout JR, Hoffman JR. Post-resistance exercise ingestion of milk protein attenuates plasma TNFa and TNFr1 expression on monocyte subpopulations. Amino Acids. 2017 08; 49(8):1415-1426.
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Mathis WS, Han X. The acute effect of pleasurable music on craving for alcohol: A pilot crossover study. J Psychiatr Res. 2017 07; 90:143-147.
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Stimson RH, Anderson AJ, Ramage LE, Macfarlane DP, de Beaux AC, Mole DJ, Andrew R, Walker BR. Acute physiological effects of glucocorticoids on fuel metabolism in humans are permissive but not direct. Diabetes Obes Metab. 2017 06; 19(6):883-891.
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Tolbert JA, Bai S, Abdel-Rahman SM, August KJ, Weir SJ, Kearns GL, Neville KA. Pharmacokinetics of two 6-mercaptopurine liquid formulations in children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2017 Aug; 64(8).
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Bai S, Dormer N, Shoults C, Meyer A, Pierce CD, Neville KA, Kearns GL. Palatability of a novel oral formulation of prednisone in healthy young adults. J Pharm Pharmacol. 2017 Apr; 69(4):489-496.
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Funk M, Fennie KP, Stephens KE, May JL, Winkler CG, Drew BJ. Association of Implementation of Practice Standards for Electrocardiographic Monitoring With Nurses' Knowledge, Quality of Care, and Patient Outcomes: Findings From the Practical Use of the Latest Standards of Electrocardiography (PULSE) Trial. Circ Cardiovasc Qual Outcomes. 2017 02; 10(2).
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Lieben CK, Blokland A, Deutz NE, Jansen W, Han G, Hupperts RM. Intake of tryptophan-enriched whey protein acutely enhances recall of positive loaded words in patients with multiple sclerosis. Clin Nutr. 2018 02; 37(1):321-328.
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Bhat R, Kelleher J, Ambalavanan N, Chatburn RL, Mireles-Cabodevila E, Carlo WA. Feasibility of Mid-Frequency Ventilation Among Infants With Respiratory Distress Syndrome. Respir Care. 2017 Apr; 62(4):481-488.
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Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Effectiveness of essential amino acid supplementation in stimulating whole body net protein anabolism is comparable between COPD patients and healthy older adults. Metabolism. 2017 Apr; 69:120-129.
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Berlinski A, von Hollen D, Hatley RHM, Hardaker LEA, Nikander K. Drug Delivery in Asthmatic Children Following Coordinated and Uncoordinated Inhalation Maneuvers: A Randomized Crossover Trial. J Aerosol Med Pulm Drug Deliv. 2017 Jun; 30(3):182-189.
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Luhring KE, Butts CL, Smith CR, Bonacci JA, Ylanan RC, Ganio MS, McDermott BP. Cooling Effectiveness of a Modified Cold-Water Immersion Method After Exercise-Induced Hyperthermia. J Athl Train. 2016 Nov; 51(11):946-951.
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Kinsey AW, Cappadona SR, Panton LB, Allman BR, Contreras RJ, Hickner RC, Ormsbee MJ. The Effect of Casein Protein Prior to Sleep on Fat Metabolism in Obese Men. Nutrients. 2016 Jul 27; 8(8).
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Anderson AJ, Andrew R, Homer NZ, Jones GC, Smith K, Livingstone DE, Walker BR, Stimson RH. Metformin Increases Cortisol Regeneration by 11ßHSD1 in Obese Men With and Without Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. 2016 10; 101(10):3787-3793.
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Wells AJ, Hoffman JR, Jajtner AR, Varanoske AN, Church DD, Gonzalez AM, Townsend JR, Boone CH, Baker KM, Beyer KS, Mangine GT, Oliveira LP, Fukuda DH, Stout JR. The Effect of Post-Resistance Exercise Amino Acids on Plasma MCP-1 and CCR2 Expression. Nutrients. 2016 Jul 02; 8(7).
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Church DD, Schwarz NA, Spillane MB, McKinley-Barnard SK, Andre TL, Ramirez AJ, Willoughby DS. l-Leucine Increases Skeletal Muscle IGF-1 but Does Not Differentially Increase Akt/mTORC1 Signaling and Serum IGF-1 Compared to Ursolic Acid in Response to Resistance Exercise in Resistance-Trained Men. J Am Coll Nutr. 2016 Sep-Oct; 35(7):627-638.
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Gibb FW, Homer NZ, Faqehi AM, Upreti R, Livingstone DE, McInnes KJ, Andrew R, Walker BR. Aromatase Inhibition Reduces Insulin Sensitivity in Healthy Men. J Clin Endocrinol Metab. 2016 05; 101(5):2040-6.
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Butts CL, McDermott BP, Buening BJ, Bonacci JA, Ganio MS, Adams JD, Tucker MA, Kavouras SA. Physiologic and Perceptual Responses to Cold-Shower Cooling After Exercise-Induced Hyperthermia. J Athl Train. 2016 Mar; 51(3):252-7.
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Arnaoutis G, Kavouras SA, Stratakis N, Likka M, Mitrakou A, Papamichael C, Sidossis LS, Stamatelopoulos K. The effect of hypohydration on endothelial function in young healthy adults. Eur J Nutr. 2017 Apr; 56(3):1211-1217.
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Rajan S, Khanna A, Argalious M, Kimatian SJ, Mascha EJ, Makarova N, Nada EM, Elsharkawy H, Firoozbakhsh F, Avitsian R. Comparison of 2 resident learning tools-interactive screen-based simulated case scenarios versus problem-based learning discussions: a prospective quasi-crossover cohort study. J Clin Anesth. 2016 Feb; 28:4-11.
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Church DD, Hoffman JR, LaMonica MB, Riffe JJ, Hoffman MW, Baker KM, Varanoske AN, Wells AJ, Fukuda DH, Stout JR. The effect of an acute ingestion of Turkish coffee on reaction time and time trial performance. J Int Soc Sports Nutr. 2015; 12:37.
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Mansouri K, Medeiros FA, Weinreb RN. Effect of glaucoma medications on 24-hour intraocular pressure-related patterns using a contact lens sensor. Clin Exp Ophthalmol. 2015 Dec; 43(9):787-95.
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Hanson SJ, Havens PL, Simpson PM, Nugent ML, Wells RG. Intrapleural alteplase decreases parapneumonic effusion volume in children more than saline irrigation. Pediatr Pulmonol. 2015 Dec; 50(12):1328-35.
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Luiking YC, Abrahamse E, Ludwig T, Boirie Y, Verlaan S. Protein type and caloric density of protein supplements modulate postprandial amino acid profile through changes in gastrointestinal behaviour: A randomized trial. Clin Nutr. 2016 Feb; 35(1):48-58.
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Morgan G, Palumbo A, Dhanasiri S, Lee D, Weisel K, Facon T, Delforge M, Oriol A, Zaki M, Yu X, Sternas L, Jacques C, Akehurst R, Offner F, Dimopoulos MA. Overall survival of relapsed and refractory multiple myeloma patients after adjusting for crossover in the MM-003 trial for pomalidomide plus low-dose dexamethasone. Br J Haematol. 2015 Mar; 168(6):820-3.
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Azzalini L, Khan R, Al-Hawwas M, Hatem R, Fortier A, L'Allier PL, Ly HQ. Effect of radial-to-femoral access crossover on adverse outcomes in primary percutaneous coronary intervention. Am J Cardiol. 2014 Oct 15; 114(8):1165-73.
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Yates CC, Mitchell AJ, Booth MY, Williams DK, Lowe LM, Whit Hall R. The effects of massage therapy to induce sleep in infants born preterm. Pediatr Phys Ther. 2014; 26(4):405-10.
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Stimson RH, Mohd-Shukri NA, Bolton JL, Andrew R, Reynolds RM, Walker BR. The postprandial rise in plasma cortisol in men is mediated by macronutrient-specific stimulation of adrenal and extra-adrenal cortisol production. J Clin Endocrinol Metab. 2014 Jan; 99(1):160-168.
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Bardis CN, Kavouras SA, Arnaoutis G, Panagiotakos DB, Sidossis LS. Mild dehydration and cycling performance during 5-kilometer hill climbing. J Athl Train. 2013 Nov-Dec; 48(6):741-7.
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Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Hydrolyzed casein and whey protein meals comparably stimulate net whole-body protein synthesis in COPD patients with nutritional depletion without an additional effect of leucine co-ingestion. Clin Nutr. 2014 Apr; 33(2):211-20.
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Piccirillo JF, Kallogjeri D, Nicklaus J, Wineland A, Spitznagel EL, Vlassenko AG, Benzinger T, Mathews J, Garcia KS. Low-frequency repetitive transcranial magnetic stimulation to the temporoparietal junction for tinnitus: four-week stimulation trial. JAMA Otolaryngol Head Neck Surg. 2013 Apr; 139(4):388-95.
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Engelen MP, Com G, Wolfe RR, Deutz NE. Dietary essential amino acids are highly anabolic in pediatric patients with cystic fibrosis. J Cyst Fibros. 2013 Sep; 12(5):445-53.
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Fray KJ. Fusional amplitudes: exploring where fusion falters. Am Orthopt J. 2013; 63:41-54.
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Foster L, Allan MC, Khan A, Moore P, Williams DK, Hubbard M, Dixon L, Gurley BJ. Multiple dosing of ephedra-free dietary supplements: hemodynamic, electrocardiographic, and bacterial contamination effects. Clin Pharmacol Ther. 2013 Mar; 93(3):267-74.
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Deepmala D, Franz L, Aponte C, Agrawal M, Jiang W. Identification of provider characteristics influencing prescription of analgesics: a systematic literature review. Pain Pract. 2013 Jul; 13(6):504-13.
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Carter LP, Kleykamp BA, Griffiths RR, Mintzer MZ. Cognitive effects of intramuscular ketamine and oral triazolam in healthy volunteers. Psychopharmacology (Berl). 2013 Mar; 226(1):53-63.
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James LP, Chiew A, Abdel-Rahman SM, Letzig L, Graudins A, Day P, Roberts D. Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations. Eur J Clin Pharmacol. 2013 Apr; 69(4):851-7.
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Vandrey R, Stitzer ML, Mintzer MZ, Huestis MA, Murray JA, Lee D. The dose effects of short-term dronabinol (oral THC) maintenance in daily cannabis users. Drug Alcohol Depend. 2013 Feb 01; 128(1-2):64-70.
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Ranganathan M, Schnakenberg A, Skosnik PD, Cohen BM, Pittman B, Sewell RA, D'Souza DC. Dose-related behavioral, subjective, endocrine, and psychophysiological effects of the ? opioid agonist Salvinorin A in humans. Biol Psychiatry. 2012 Nov 15; 72(10):871-9.
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Redwine K, Howard L, Simpson P, Li SH, Yan K, James L, Blumer J, Sullivan J, Ward R, Wells T. Effect of placebo on ambulatory blood pressure monitoring in children. Pediatr Nephrol. 2012 Oct; 27(10):1937-42.
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Mennemeier M, Munn T, Allensworth M, Lenow JK, Brown G, Allen S, Dornhoffer J, Williams DK. Laterality, frequency and replication of rTMS treatment for chronic tinnitus: pilot studies and a review of maintenance treatment. Hear Res. 2013 Jan; 295:30-7.
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Mpabanzi L, Deutz N, Hayes PC, Dejong CH, Olde Damink SW, Jalan R. Overnight glucose infusion suppresses renal ammoniagenesis and reduces hyperammonaemia induced by a simulated bleed in cirrhotic patients. Aliment Pharmacol Ther. 2012 Apr; 35(8):921-8.
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Clement KC, Thurman TL, Holt SJ, Heulitt MJ. Neurally triggered breaths reduce trigger delay and improve ventilator response times in ventilated infants with bronchiolitis. Intensive Care Med. 2011 Nov; 37(11):1826-32.
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Froehlich TE, Epstein JN, Nick TG, Melguizo Castro MS, Stein MA, Brinkman WB, Graham AJ, Langberg JM, Kahn RS. Pharmacogenetic predictors of methylphenidate dose-response in attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2011 Nov; 50(11):1129-1139.e2.
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Ishak KJ, Caro JJ, Drayson MT, Dimopoulos M, Weber D, Augustson B, Child JA, Knight R, Iqbal G, Dunn J, Shearer A, Morgan G. Adjusting for patient crossover in clinical trials using external data: a case study of lenalidomide for advanced multiple myeloma. Value Health. 2011 Jul-Aug; 14(5):672-8.
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Ferguson-Stegall L, McCleave EL, Ding Z, Doerner PG, Wang B, Liao YH, Kammer L, Liu Y, Hwang J, Dessard BM, Ivy JL. Postexercise carbohydrate-protein supplementation improves subsequent exercise performance and intracellular signaling for protein synthesis. J Strength Cond Res. 2011 May; 25(5):1210-24.
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