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Search Results to Peter Crooks

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One or more keywords matched the following items that are connected to Crooks, Peter

Item TypeName
Academic Article Multiple modes of a7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents.
Concept Cell Cycle
Concept Cell Movement
Concept Cell Membrane
Concept Cell Division
Concept Cell Adhesion
Concept Cells, Cultured
Concept Epithelial Cells
Concept Cell Nucleus
Concept Hematopoietic Stem Cells
Concept Vero Cells
Concept Cell Line
Concept Cell Survival
Concept Cell Shape
Concept HT29 Cells
Concept HCT116 Cells
Concept Cell Proliferation
Concept Leukemia, Lymphocytic, Chronic, B-Cell
Concept Cell Death
Concept HEK293 Cells
Concept Endothelial Cells
Concept Cell Line, Tumor
Concept Carcinoma, Non-Small-Cell Lung
Concept Human Umbilical Vein Endothelial Cells
Concept 3T3-L1 Cells
Concept Stem Cells
Concept Tumor Cells, Cultured
Concept Neoplastic Stem Cells
Concept Tumor Stem Cell Assay
Concept CHO Cells
Concept Lymphoma, Large-Cell, Anaplastic
Concept Primary Cell Culture
Concept Cell Growth Processes
Concept Precursor Cell Lymphoblastic Leukemia-Lymphoma
Concept Cell Cycle Checkpoints
Academic Article Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway.
Academic Article Heterocyclic aminoparthenolide derivatives modulate G(2)-M cell cycle progression during Xenopus oocyte maturation.
Academic Article Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents.
Academic Article Characterization of the intrinsic activity for a novel class of cannabinoid receptor ligands: Indole quinuclidine analogs.
Academic Article Heck products of parthenolide and melampomagnolide-B as anticancer modulators that modify cell cycle progression.
Academic Article Novel cytoprotective inhibitors for apoptotic endonuclease G.
Academic Article Novel high-throughput deoxyribonuclease 1 assay.
Academic Article Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4.
Academic Article L-Canavanine as a radiosensitization agent for human pancreatic cancer cells.
Academic Article NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols.
Academic Article N-n-alkylpyridinium analogs, a novel class of nicotinic receptor antagonists: selective inhibition of nicotine-evoked [3H] dopamine overflow from superfused rat striatal slices.
Academic Article The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins.
Academic Article Antileukemic activity of aminoparthenolide analogs.
Academic Article Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters.
Academic Article The antiproliferative and immunotoxic effects of L-canavanine and L-canaline.
Academic Article An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells.
Academic Article Novel substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one and (Z)-(+/-)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol derivatives as potent thermal sensitizing agents.
Academic Article Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature.
Academic Article Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents.
Academic Article Microwave assisted synthesis and in vitro cytotoxicities of substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones against human tumor cell lines.
Academic Article Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents.
Academic Article The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization.
Academic Article A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-?B and generating reactive oxygen species.
Academic Article One-pot multicomponent synthesis of indole incorporated thiazolylcoumarins and their antibacterial, anticancer and DNA cleavage studies.
Academic Article Discovery of 1,2,4-thiadiazolidine-3,5-dione analogs that exhibit unusual and selective rapid cell death kinetics against acute myelogenous leukemia cells in culture.
Academic Article Melampomagnolide B: a new antileukemic sesquiterpene.
Academic Article Effect of celecoxib and the novel anti-cancer agent, dimethylamino-parthenolide, in a developmental model of pancreatic cancer.
Academic Article Synthesis and evaluation of chromenyl barbiturates and thiobarbiturates as potential antitubercular agents.
Academic Article A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells.
Academic Article Aplysinopsin analogs: Synthesis and anti-proliferative activity of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-diones.
Academic Article Antiangiogenic properties of substituted (Z)-(?)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol/one analogs and their derivatives.
Academic Article Inhibition of NF-?B and DNA double-strand break repair by DMAPT sensitizes non-small-cell lung cancers to X-rays.
Academic Article Antihyperglycemic profile of erinidine isolated from Hunteria umbellata seed.
Academic Article The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN.
Academic Article The NADH oxidase ENOX1, a critical mediator of endothelial cell radiosensitization, is crucial for vascular development.
Academic Article The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target.
Academic Article Computational neural network analysis of the affinity of N-n-alkylnicotinium salts for the alpha4beta2* nicotinic acetylcholine receptor.
Academic Article Nuclear factor-kappaB as a potential therapeutic target for the novel cytotoxic agent LC-1 in acute myeloid leukaemia.
Academic Article Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1).
Academic Article Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways.
Academic Article Synthesis and in vitro screening of novel N-benzyl aplysinopsin analogs as potential anticancer agents.
Academic Article KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells.
Academic Article Targeting nucleophosmin 1 represents a rational strategy for radiation sensitization.
Academic Article The NF-kappaB inhibitor LC-1 has single agent activity in multiple myeloma cells and synergizes with bortezomib.
Academic Article The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats.
Academic Article Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells.
Academic Article Dimers of Melampomagnolide B Exhibit Potent Anticancer Activity against Hematological and Solid Tumor Cells.
Academic Article Anti-cancer activity of carbamate derivatives of melampomagnolide B.
Academic Article Dimethylamino parthenolide enhances the inhibitory effects of gemcitabine in human pancreatic cancer cells.
Academic Article 5-((1-Aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones as potential anticancer agents with anti-inflammatory properties.
Academic Article Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents.
Academic Article Synthesis and anti-proliferative activity of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione analogs against human tumor cell lines.
Academic Article Development and validation of a novel assay to identify radiosensitizers that target nucleophosmin 1.
Academic Article Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes.
Academic Article A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFkappaB and generating reactive oxygen species.
Academic Article 1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: Anti-cancer agents that target nucleophosmin 1 (NPM1).
Academic Article Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo.
Academic Article Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
Academic Article Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells.
Academic Article Targeting Enox1 in tumor stroma increases the efficacy of fractionated radiotherapy.
Academic Article N-[11CH3]Dimethylaminoparthenolide (DMAPT) uptake into orthotopic 9LSF glioblastoma tumors in the rat.
Academic Article Rational design of a parthenolide-based drug regimen that selectively eradicates acute myelogenous leukemia stem cells.
Academic Article Identification of resveratrol analogs as potent anti-dengue agents using a cell-based assay.
Academic Article GZ-793A inhibits the neurochemical effects of methamphetamine via a selective interaction with the vesicular monoamine transporter-2.
Academic Article Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia.
Academic Article Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
Academic Article Antinociceptive effects of the 6-O-sulfate ester of morphine in normal and diabetic rats: Comparative role of mu- and delta-opioid receptors.
Academic Article Succinamide derivatives of melampomagnolide B and their anti-cancer activities.
Academic Article Persistent Activation of NF-?B in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage.
Academic Article Characterization of structurally novel G protein biased CB1 agonists: Implications for drug development.
Academic Article DMAPT inhibits NF-?B activity and increases sensitivity of prostate cancer cells to X-rays in vitro and in tumor xenografts in vivo.
Academic Article Pharmacological Dual Inhibition of Tumor and Tumor-Induced Functional Limitations in a Transgenic Model of Breast Cancer.
Academic Article Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer Agents.
Academic Article A Small-Molecule Inhibitor of Human DNA Polymerase ? Potentiates the Effects of Cisplatin in Tumor Cells.
Academic Article Parthenolide and DMAPT induce cell death in primitive CML cells through reactive oxygen species.
Academic Article Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells.
Academic Article MMB triazole analogs are potent NF-?B inhibitors and anti-cancer agents against both hematological and solid tumor cells.
Academic Article Actinomycin-D and dimethylamino-parthenolide synergism in treating human pancreatic cancer cells.
Academic Article A novel tetrazole analogue of resveratrol is a potent anticancer agent.
Grant Regulation of hepatic stellate cells by intracellular calcium
Grant Novel melampomagnolide B-based prodrugs for the treatment of leukemia
Grant Use of precision deuteration to determine the contribution of norbuprenorphine to buprenorphine-associated neonatal abstinence syndrome
Academic Article Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of A? Self-Aggregation and Metal Chelation-Induced A? Aggregation.
Academic Article Targeting NPM1 in irradiated cells inhibits NPM1 binding to RAD51, RAD51 foci formation and radiosensitizes NSCLC.
Academic Article Antitumor properties of novel sesquiterpene lactone analogs as NF?B inhibitors that bind to the IKK? ubiquitin-like domain (ULD).
Academic Article Biobanked Glioblastoma Patient-Derived Organoids as a Precision Medicine Model to Study Inhibition of Invasion.
Academic Article Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells.

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