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Search Results to Vladimir Lupashin

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One or more keywords matched the following properties of Lupashin, Vladimir

overview Our laboratory is interested in understanding the molecular mechanisms responsible for the generation and maintenance of intra-cellular membrane-bounded compartments. In all eukaryotic cells intracellular membrane trafficking is critical for a range of important cellular functions including protein secretion, post-translational modifications, cell signalling, cell polarization, and cell maintenance. Defects in membrane trafficking can underline, or even exacerbate, a number of human diseases including cancer, diabetes mellitus, Alzheimer’s, cystic fibrosis, Hermansky-Pudlak syndrome and Congenital Disorders of Glycosylation. Our research directed towards the understanding of the basic mechanisms of intracellular vesicular trafficking using both yeast and mammalian tissue culture cell model systems. Our lab played a principal role in the discovery of a novel vesicle tethering factors, published more than 60 original papers in high-profile journals, including Journal of Cell Biology, PNAS, Science, Journal of Neuroscience, Molecular Biology of Cell and Nature Communications. My current research has been continuously supported by grants from both NSF and NIH. We have pioneered the functional analysis of the Conserved Oligomeric Golgi (COG), an evolutionarily conserved complex of eight gene products, each of which is critical for the membrane trafficking and protein modifications in the Golgi apparatus. The COG complex interacts with core fusion machinery components including SNAREs, SM proteins, Rabs, coiled-coil tethers and COPI coat to organize specific docking and fusion of transport intermediates with their acceptor membrane. By using state of the art biochemical, genetic and microscopy approaches (including mass-spectrometry, electron and super-resolution microscopy, CRISPR directed gene editing techniques) we would like to determine how the key components of intracellular membrane trafficking machinery work together to direct efficient protein trafficking in human cells in health and disease.

One or more keywords matched the following items that are connected to Lupashin, Vladimir

Item TypeName
Academic Article Golgi tethering factors.
Academic Article Cog1p plays a central role in the organization of the yeast conserved oligomeric Golgi complex.
Academic Article Role of tethering factors in secretory membrane traffic.
Academic Article COG8 deficiency causes new congenital disorder of glycosylation type IIh.
Academic Article [The nature of N-terminal signal sequence determines the type of intracellular distribution and effectiveness of export of human growth hormone in Saccharomyces cerevisiae].
Academic Article Interaction of the conserved oligomeric Golgi complex with t-SNARE Syntaxin5a/Sed5 enhances intra-Golgi SNARE complex stability.
Academic Article Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter.
Academic Article Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation.
Academic Article Cog3p depletion blocks vesicle-mediated Golgi retrograde trafficking in HeLa cells.
Academic Article Chlamydia trachomatis hijacks intra-Golgi COG complex-dependent vesicle trafficking pathway.
Academic Article [Cell wall permeability and export of proteins into the culture broth of Saccharomyces cerevisiae].
Academic Article Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.
Academic Article Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis.
Academic Article Identification of a novel secreted glycoprotein of the yeast Saccharomyces cerevisiae stimulated by heat shock.
Academic Article The COG complex, Rab6 and COPI define a novel Golgi retrograde trafficking pathway that is exploited by SubAB toxin.
Academic Article Oxysterol-binding protein (OSBP) is required for the perinuclear localization of intra-Golgi v-SNAREs.
Academic Article COG complex-mediated recycling of Golgi glycosyltransferases is essential for normal protein glycosylation.
Academic Article Characterization of a novel yeast SNARE protein implicated in Golgi retrograde traffic.
Academic Article COG complexes form spatial landmarks for distinct SNARE complexes.
Academic Article The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network.
Academic Article Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene.
Academic Article Conserved oligomeric Golgi complex specifically regulates the maintenance of Golgi glycosylation machinery.
Academic Article Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.
Academic Article The Golgi puppet master: COG complex at center stage of membrane trafficking interactions.
Academic Article Sec35p, a novel peripheral membrane protein, is required for ER to Golgi vesicle docking.
Academic Article COG6 interacts with a subset of the Golgi SNAREs and is important for the Golgi complex integrity.
Academic Article t-SNARE activation through transient interaction with a rab-like guanosine triphosphatase.
Academic Article Fluorescent microscopy as a tool to elucidate dysfunction and mislocalization of Golgi glycosyltransferases in COG complex depleted mammalian cells.
Academic Article Mislocalization of large ARF-GEFs as a potential mechanism for BFA resistance in COG-deficient cells.
Academic Article Assembly of the ER to Golgi SNARE complex requires Uso1p.
Academic Article Identification of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery.
Academic Article [A new secreted protein from Saccharomyces cerevisiae, stimulated by heat shock].
Academic Article Biochemical requirements for the targeting and fusion of ER-derived transport vesicles with purified yeast Golgi membranes.
Academic Article Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p.
Academic Article Molecular insights into vesicle tethering at the Golgi by the conserved oligomeric Golgi (COG) complex and the golgin TATA element modulatory factor (TMF).
Academic Article The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins.
Concept Bacterial Proteins
Concept Microtubule-Associated Proteins
Concept Carrier Proteins
Concept Fungal Proteins
Concept DNA-Binding Proteins
Concept Chromosomal Proteins, Non-Histone
Concept Membrane Proteins
Concept Luminescent Proteins
Concept Molecular Motor Proteins
Concept Proteins
Concept Plant Proteins
Concept GTP-Binding Proteins
Concept Recombinant Proteins
Concept Cation Transport Proteins
Concept rab GTP-Binding Proteins
Concept Escherichia coli Proteins
Concept Serotonin Plasma Membrane Transport Proteins
Concept Proto-Oncogene Proteins c-myc
Concept SNARE Proteins
Concept Green Fluorescent Proteins
Concept Nerve Tissue Proteins
Concept Saccharomyces cerevisiae Proteins
Concept Heat-Shock Proteins
Concept Qc-SNARE Proteins
Concept GTPase-Activating Proteins
Concept Intracellular Signaling Peptides and Proteins
Concept Cell Cycle Proteins
Concept Membrane Transport Proteins
Concept rab4 GTP-Binding Proteins
Concept Qa-SNARE Proteins
Concept Qb-SNARE Proteins
Concept Munc18 Proteins
Concept Dystrophin-Associated Proteins
Concept R-SNARE Proteins
Concept Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins
Concept Adaptor Proteins, Vesicular Transport
Concept Recombinant Fusion Proteins
Concept Vesicular Transport Proteins
Academic Article Identification and characterization of novel proteins involved in the regulation of SNARE-complex assembly
Academic Article Yeast COG complex, a Ypt1 effector required for retrograde intra-Golgi trafficking COG interacts with the Golgi SNAREs and with COPI vesicle coat proteins
Academic Article Extracellular enzymes of microorganisms
Academic Article The Conserved Oligomeric Golgi complex functional interaction with SNARE and Rab proteins
Academic Article Localization and characterization of yeast secretory proteins stimulated by heat shock
Academic Article Glycosylation of secreted proteins in yeast
Academic Article Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex.
Academic Article Expression of functional Myc-tagged conserved oligomeric Golgi (COG) subcomplexes in mammalian cells.
Academic Article The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-? during Chlamydia trachomatis infection.
Academic Article COG lobe B sub-complex engages v-SNARE GS15 and functions via regulated interaction with lobe A sub-complex.
Academic Article Creating Knockouts of Conserved Oligomeric Golgi Complex Subunits Using CRISPR-Mediated Gene Editing Paired with a Selection Strategy Based on Glycosylation Defects Associated with Impaired COG Complex Function.
Academic Article Manganese-induced turnover of TMEM165.
Academic Article Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway.
Academic Article Galactose Supplementation in Patients With TMEM165-CDG Rescues the Glycosylation Defects.
Academic Article A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication.
Academic Article Conserved Oligomeric Golgi and Neuronal Vesicular Trafficking.
Academic Article Membrane detachment is not essential for COG complex function.
Academic Article More than just sugars: Conserved oligomeric Golgi complex deficiency causes glycosylation-independent cellular defects.
Academic Article Detailed Analysis of the Interaction of Yeast COG Complex.
Grant Characterization of mammalian COG complex-interacting Golgi trafficking machinery
Academic Article Dissection of TMEM165 function in Golgi glycosylation and its Mn2+ sensitivity.
Academic Article Fetal bovine serum impacts the observed N-glycosylation defects in TMEM165 KO HEK cells.
Academic Article Conserved Oligomeric Golgi (COG) Complex Proteins Facilitate Orthopoxvirus Entry, Fusion and Spread.
Academic Article Golgi inCOGnito: From vesicle tethering to human disease.
Academic Article Proteoglycan synthesis in conserved oligomeric Golgi subunit deficient HEK293T cells is affected differently, depending on the lacking subunit.
Academic Article The Golgi-associated retrograde protein (GARP) complex plays an essential role in the maintenance of the Golgi glycosylation machinery.
Academic Article Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation.
Academic Article Insights into the regulation of cellular Mn2+ homeostasis via TMEM165.
Academic Article GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins.
Academic Article Rapid COG Depletion in Mammalian Cell by Auxin-Inducible Degradation System.
Academic Article Generation and Analysis of hTERT-RPE1 VPS54 Knock-Out and Rescued Cell Lines.
Academic Article Acute COG complex inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra-Golgi recycling vesicles.
Academic Article Syntaxin-5's flexibility in SNARE pairing supports Golgi functions.
Academic Article Biallelic missense variants in COG3 cause a congenital disorder of glycosylation with impairment of retrograde vesicular trafficking.

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