Item Type | Name |
Academic Article
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N-Aroyl indole thiobarbituric acids as inhibitors of DNA repair and replication stress response polymerases.
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Concept
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Bacterial Proteins
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Concept
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Carrier Proteins
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Concept
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Cytoskeletal Proteins
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Concept
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DNA-Binding Proteins
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Concept
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Membrane Proteins
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Concept
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Protein Disulfide Reductase (Glutathione)
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Concept
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Protein Subunits
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Concept
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Proteins
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Concept
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Protein Conformation
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Concept
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GTP-Binding Proteins
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Concept
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BRCA1 Protein
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Concept
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Recombinant Proteins
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Concept
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Mitogen-Activated Protein Kinase 9
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Concept
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Proto-Oncogene Proteins p21(ras)
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Concept
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Vesicular Monoamine Transport Proteins
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Concept
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Mitochondrial Proteins
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Concept
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Vesicular Biogenic Amine Transport Proteins
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Concept
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Protein Binding
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Concept
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Serotonin Plasma Membrane Transport Proteins
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Concept
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Protein Transport
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Concept
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Proteinuria
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Concept
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Tumor Suppressor Protein p53
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Concept
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BH3 Interacting Domain Death Agonist Protein
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Concept
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bcl-X Protein
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Concept
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Plasma Membrane Neurotransmitter Transport Proteins
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Concept
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Neurotransmitter Transport Proteins
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Concept
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Nucleic Acid Synthesis Inhibitors
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Concept
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Mutant Chimeric Proteins
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Concept
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Nerve Tissue Proteins
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Concept
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Norepinephrine Plasma Membrane Transport Proteins
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Concept
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Viral Nonstructural Proteins
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Concept
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Protein Biosynthesis
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Concept
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Intracellular Signaling Peptides and Proteins
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Concept
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Protein Structure, Secondary
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Concept
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I-kappa B Proteins
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Concept
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Membrane Transport Proteins
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Concept
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Dopamine Plasma Membrane Transport Proteins
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Concept
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bcl-2-Associated X Protein
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Concept
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Protein Structure, Tertiary
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Concept
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Neoplasm Proteins
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Concept
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Proto-Oncogene Proteins c-bcl-2
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Concept
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Oncogene Protein v-akt
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Concept
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Proto-Oncogene Proteins c-akt
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Concept
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Nuclear Proteins
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Concept
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Recombinant Fusion Proteins
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Academic Article
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Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway.
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Academic Article
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Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents.
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Academic Article
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Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4.
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Academic Article
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Carrier-mediated transport of the quaternary ammonium neuronal nicotinic receptor antagonist n,n'-dodecylbispicolinium dibromide at the blood-brain barrier.
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Academic Article
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NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols.
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Academic Article
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The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion.
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Academic Article
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N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2(*) and alpha7(*) neuronal nicotinic acetylcholine receptors.
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Academic Article
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meso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release.
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Academic Article
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A general procedure for the enantioselective synthesis of the minor tobacco alkaloids nornicotine, anabasine, and anatabine.
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Academic Article
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The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins.
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Academic Article
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Synthesis and antitubercular activity of a series of hydrazone and nitrovinyl analogs derived from heterocyclic aldehydes.
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Academic Article
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Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras.
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Academic Article
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Modeling multiple species of nicotine and deschloroepibatidine interacting with alpha4beta2 nicotinic acetylcholine receptor: from microscopic binding to phenomenological binding affinity.
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Academic Article
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Spectrophotometric and steady-state kinetic analysis of the biosynthetic arginine decarboxylase of Yersinia pestis utilizing arginine analogues as inhibitors and alternative substrates.
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Academic Article
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Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters.
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Academic Article
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Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands.
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Academic Article
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Active transport of high-affinity choline and nicotine analogs into the central nervous system by the blood-brain barrier choline transporter.
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Academic Article
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Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter.
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Academic Article
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3D-QSAR study of bis-azaaromatic quaternary ammonium analogs at the blood-brain barrier choline transporter.
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Academic Article
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N,N'-Alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: inhibition of nicotine-evoked dopamine release and hyperactivity.
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Academic Article
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Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6beta-naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents.
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Academic Article
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The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery.
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Academic Article
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An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells.
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Academic Article
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Introduction of unsaturation into the N-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: effect on affinity and selectivity.
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Academic Article
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Identification and synthesis of novel alkaloids from the root system of Nicotiana tabacum: affinity for neuronal nicotinic acetylcholine receptors.
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Academic Article
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Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature.
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Academic Article
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Microwave assisted synthesis and in vitro cytotoxicities of substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones against human tumor cell lines.
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Academic Article
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Predictive screening model for potential vector-mediated transport of cationic substrates at the blood-brain barrier choline transporter.
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Academic Article
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N, N -disubstituted piperazines and homopiperazines: synthesis and affinities at alpha4beta2* and alpha7* neuronal nicotinic acetylcholine receptors.
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Academic Article
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Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier.
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Academic Article
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Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents.
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Academic Article
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The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization.
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Academic Article
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The vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse.
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Academic Article
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One-pot multicomponent synthesis of indole incorporated thiazolylcoumarins and their antibacterial, anticancer and DNA cleavage studies.
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Academic Article
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Synthesis and in vitro stability of amino acid prodrugs of 6-?-naltrexol for microneedle-enhanced transdermal delivery.
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Academic Article
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Synthesis of novel isoluminol probes and their use in rapid bacterial assays.
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Academic Article
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Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake.
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Academic Article
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The mechanism of L-canavanine cytotoxicity: arginyl tRNA synthetase as a novel target for anticancer drug discovery.
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Academic Article
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Pharmacokinetics of the novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide in the rat.
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Academic Article
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Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2.
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Academic Article
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Synthesis and evaluation of chromenyl barbiturates and thiobarbiturates as potential antitubercular agents.
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Academic Article
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Indirect trapping of the retroconjugate addition reaction intermediate involved in the epimerization of lobeline: application to the synthesis of (-)-sedamine.
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Academic Article
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Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters.
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Academic Article
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Vesicular monoamine transporter 2: role as a novel target for drug development.
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Academic Article
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Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters.
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Academic Article
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A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells.
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Academic Article
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Quinlobelane: a water-soluble lobelane analogue and inhibitor of VMAT2.
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Academic Article
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Phenyl ring-substituted lobelane analogs: inhibition of [?H]dopamine uptake at the vesicular monoamine transporter-2.
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Academic Article
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Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands.
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Academic Article
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Aplysinopsin analogs: Synthesis and anti-proliferative activity of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-diones.
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Academic Article
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Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter.
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Academic Article
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Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners.
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Academic Article
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The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN.
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Academic Article
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Nornicotine inhibition of dopamine transporter function in striatum via nicotinic receptor activation.
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Academic Article
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The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target.
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Academic Article
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Modeling subtype-selective agonists binding with alpha4beta2 and alpha7 nicotinic acetylcholine receptors: effects of local binding and long-range electrostatic interactions.
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Academic Article
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Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse.
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Academic Article
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Computational neural network analysis of the affinity of N-n-alkylnicotinium salts for the alpha4beta2* nicotinic acetylcholine receptor.
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Academic Article
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Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2.
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Academic Article
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Lobelane analogues as novel ligands for the vesicular monoamine transporter-2.
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Academic Article
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Synthesis and stability of two indomethacin prodrugs.
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Academic Article
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bis-Pyridinium cyclophanes: novel ligands with high affinity for the blood-brain barrier choline transporter.
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Academic Article
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The effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats.
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Academic Article
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Synthesis and in vitro screening of novel N-benzyl aplysinopsin analogs as potential anticancer agents.
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Academic Article
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Stereocontrolled synthesis and pharmacological evaluation of cis-2,6-diphenethyl-1-azabicyclo[2.2.2]octanes as lobelane analogues.
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Academic Article
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KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells.
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Academic Article
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An Eco-Friendly Improved Protocol for the Synthesis of Bis(3-indolyl)methanes Using Poly(4-vinylpyridinium)hydrogen Sulfate as Efficient, Heterogeneous, and Recyclable Solid Acid Catalyst.
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Academic Article
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Oral administration of GZ-793A, a VMAT2 inhibitor, decreases methamphetamine self-administration in rats.
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Academic Article
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Targeting nucleophosmin 1 represents a rational strategy for radiation sensitization.
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Academic Article
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The NF-kappaB inhibitor LC-1 has single agent activity in multiple myeloma cells and synergizes with bortezomib.
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Academic Article
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The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats.
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Academic Article
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GZ-793A, a lobelane analog, interacts with the vesicular monoamine transporter-2 to inhibit the effect of methamphetamine.
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Academic Article
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Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2).
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Academic Article
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Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2.
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Academic Article
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The effect of a novel VMAT2 inhibitor, GZ-793A, on methamphetamine reward in rats.
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Academic Article
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Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo.
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Academic Article
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Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2).
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Academic Article
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The novel small molecule a9a10 nicotinic acetylcholine receptor antagonist ZZ-204G is analgesic.
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Academic Article
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Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferents.
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Academic Article
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Quinolyl analogues of norlobelane: novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2.
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Academic Article
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Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents.
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Academic Article
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Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release.
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Academic Article
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Synthesis and anti-proliferative activity of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione analogs against human tumor cell lines.
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Academic Article
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Development and validation of a novel assay to identify radiosensitizers that target nucleophosmin 1.
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Academic Article
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A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFkappaB and generating reactive oxygen species.
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Academic Article
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1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: Anti-cancer agents that target nucleophosmin 1 (NPM1).
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Academic Article
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1,4-Diphenalkylpiperidines: A new scaffold for the design of potent inhibitors of the vesicular monoamine transporter-2.
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Academic Article
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Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2.
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Academic Article
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Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2.
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Academic Article
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Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin.
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Academic Article
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Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells.
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Academic Article
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Efficient synthesis of cis-2,6-di-(2- quinolylpiperidine).
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Academic Article
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Synthesis of symmetrical 1,5-disubstituted granatanines.
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Academic Article
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Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents.
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Academic Article
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Synthesis of Lobeline, Lobelane and their Analogues. A Review.
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Academic Article
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Synthesis of thiazolidine-2,4-dione derivatives: anticancer, antimicrobial and DNA cleavage studies.
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Academic Article
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Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents.
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Academic Article
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L-Proline catalyzed one-step synthesis of 4,5-diaryl-2H-1,2,3-triazoles from heteroaryl cyanostilbenes via [3+2] cycloaddition of azide.
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Academic Article
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Expeditious synthesis of cis-1-methyl-2, 3,3a,4,5,9b-hexahydro-1H-pyrrolo-[3,2h]isoquinoline / [2,3-f]quinoline via azomethine ylide-alkene [3+2] cycloaddition.
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Academic Article
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Synthesis of (2R,8' S,3' E)-d-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to d-tocotrienol.
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Academic Article
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Identification of resveratrol analogs as potent anti-dengue agents using a cell-based assay.
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Academic Article
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Efficacy of dimethylaminoparthenolide and sulindac in combination with gemcitabine in a genetically engineered mouse model of pancreatic cancer.
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Academic Article
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GZ-793A inhibits the neurochemical effects of methamphetamine via a selective interaction with the vesicular monoamine transporter-2.
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Academic Article
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Succinamide derivatives of melampomagnolide B and their anti-cancer activities.
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Academic Article
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Persistent Activation of NF-?B in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage.
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Academic Article
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Characterization of structurally novel G protein biased CB1 agonists: Implications for drug development.
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Academic Article
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DMAPT inhibits NF-?B activity and increases sensitivity of prostate cancer cells to X-rays in vitro and in tumor xenografts in vivo.
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Academic Article
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Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [3H]dopamine uptake at the vesicular monoamine transporter-2.
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Academic Article
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Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer Agents.
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Academic Article
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New Scaffold for Lead Compounds to Treat Methamphetamine Use Disorders.
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Academic Article
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Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats.
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Academic Article
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N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3.
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Grant
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Early Events in Alzheimer Pathogenesis
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Academic Article
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Reduced Tolerance and Asymmetrical Crosstolerance to Effects of the Indole Quinuclidinone Analog PNR-4-20, a G Protein-Biased Cannabinoid 1 Receptor Agonist in Mice: Comparisons with ?9-Tetrahydrocannabinol and JWH-018.
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Academic Article
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GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine.
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Academic Article
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Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases.
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Academic Article
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A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer's Disease.
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Academic Article
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Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of A? Self-Aggregation and Metal Chelation-Induced A? Aggregation.
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Academic Article
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Binding Modes and Selectivity of Cannabinoid 1 (CB1) and Cannabinoid 2 (CB2) Receptor Ligands.
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Academic Article
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Structural modeling of GSK3? implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs.
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Academic Article
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Targeting NPM1 in irradiated cells inhibits NPM1 binding to RAD51, RAD51 foci formation and radiosensitizes NSCLC.
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Academic Article
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Implementing KDOQI CKD definition and staging guidelines in Southern California Kaiser Permanente.
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Academic Article
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Antitumor properties of novel sesquiterpene lactone analogs as NF?B inhibitors that bind to the IKK? ubiquitin-like domain (ULD).
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Academic Article
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Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer's disease.
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Academic Article
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High flux novel polymeric membrane for renal applications.
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