 Benzo(a)pyrene
"Benzo(a)pyrene" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
| Descriptor ID |
D001564
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| MeSH Number(s) |
D02.455.426.559.847.799.306.300 D04.615.799.306.300
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| Concept/Terms |
Benzo(a)pyrene- Benzo(a)pyrene
- 3,4-Benzpyrene
- 3,4 Benzpyrene
- 3,4-Benzopyrene
- 3,4 Benzopyrene
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Below are MeSH descriptors whose meaning is more general than "Benzo(a)pyrene".
Below are MeSH descriptors whose meaning is more specific than "Benzo(a)pyrene".
This graph shows the total number of publications written about "Benzo(a)pyrene" by people in UAMS Profiles by year, and whether "Benzo(a)pyrene" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2020 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2018 | 3 | 1 | 4 | | 2016 | 3 | 0 | 3 | | 2015 | 3 | 1 | 4 | | 2014 | 2 | 2 | 4 | | 2013 | 0 | 2 | 2 | | 2012 | 5 | 0 | 5 | | 2011 | 2 | 0 | 2 | | 2008 | 1 | 1 | 2 | | 2007 | 2 | 0 | 2 | | 2006 | 2 | 0 | 2 | | 2005 | 1 | 1 | 2 | | 2003 | 2 | 0 | 2 | | 1997 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Benzo(a)pyrene" by people in Profiles over the past ten years.
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Reed L, Jarvis IWH, Phillips DH, Arlt VM. Enhanced DNA adduct formation by benzo[a]pyrene in human liver cells lacking cytochrome P450 oxidoreductase. Mutat Res Genet Toxicol Environ Mutagen. 2020 Apr; 852:503162.
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Reed L, Jarvis IWH, Phillips DH, Arlt VM. Deletion of cytochrome P450 oxidoreductase enhances metabolism and DNA adduct formation of benzo[a]pyrene in Hepa1c1c7 cells. Mutagenesis. 2019 12 19; 34(5-6):413-420.
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Tryndyak V, Kindrat I, Dreval K, Churchwell MI, Beland FA, Pogribny IP. Effect of aflatoxin B1, benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov; 121:214-223.
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Reed L, Arlt VM, Phillips DH. The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo-in vitro paradox. Carcinogenesis. 2018 07 03; 39(7):851-859.
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Willis AJ, Indra R, Wohak LE, Sozeri O, Feser K, Mrizova I, Phillips DH, Stiborova M, Arlt VM. The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cells. Toxicology. 2018 04 01; 398-399:1-12.
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Reed L, Mrizova I, Barta F, Indra R, Moserova M, Kopka K, Schmeiser HH, Wolf CR, Henderson CJ, Stiborova M, Phillips DH, Arlt VM. Cytochrome b 5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b 5 /P450 reductase null (HBRN) mice. Arch Toxicol. 2018 Apr; 92(4):1625-1638.
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Stiborov? M, Indra R, Moserov? M, Frei E, Schmeiser HH, Kopka K, Phillips DH, Arlt VM. NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene. Chem Res Toxicol. 2016 08 15; 29(8):1325-34.
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Imanikia S, Galea F, Nagy E, Phillips DH, St?rzenbaum SR, Arlt VM. The application of the comet assay to assess the genotoxicity of environmental pollutants in the nematode Caenorhabditis elegans. Environ Toxicol Pharmacol. 2016 Jul; 45:356-61.
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Chepelev NL, Long AS, Bowers WJ, Gagn? R, Williams A, Kuo B, Phillips DH, Arlt VM, White PA, Yauk CL. Transcriptional profiling of the mouse hippocampus supports an NMDAR-mediated neurotoxic mode of action for benzo[a]pyrene. Environ Mol Mutagen. 2016 06; 57(5):350-63.
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Marrone AK, Tryndyak V, Beland FA, Pogribny IP. MicroRNA Responses to the Genotoxic Carcinogens Aflatoxin B1 and Benzo[a]pyrene in Human HepaRG Cells. Toxicol Sci. 2016 Feb; 149(2):496-502.
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Krais AM, Speksnijder EN, Melis JP, Indra R, Moserova M, Godschalk RW, van Schooten FJ, Seidel A, Kopka K, Schmeiser HH, Stiborova M, Phillips DH, Luijten M, Arlt VM. The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice. Arch Toxicol. 2016 Apr; 90(4):839-51.
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Arlt VM, Krais AM, Godschalk RW, Riffo-Vasquez Y, Mrizova I, Roufosse CA, Corbin C, Shi Q, Frei E, Stiborova M, van Schooten FJ, Phillips DH, Spina D. Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene. Toxicol Sci. 2015 Aug; 146(2):213-25.
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Kucab JE, van Steeg H, Luijten M, Schmeiser HH, White PA, Phillips DH, Arlt VM. TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts. Mutat Res. 2015 Mar; 773:48-62.
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Wohak LE, Krais AM, Kucab JE, Stertmann J, ?vreb? S, Seidel A, Phillips DH, Arlt VM. Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism. Arch Toxicol. 2016 Feb; 90(2):291-304.
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Zuo J, Brewer DS, Arlt VM, Cooper CS, Phillips DH. Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice. BMC Genomics. 2014 Oct 08; 15:880.
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Krais AM, M?hlbauer KR, Kucab JE, Chinbuah H, Cornelius MG, Wei QX, Hollstein M, Phillips DH, Arlt VM, Schmeiser HH. Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts. Toxicol In Vitro. 2015 Feb; 29(1):34-43.
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