Atorvastatin and simvastatin, but not pravastatin, up-regulate LPS-induced MMP-9 expression in macrophages by regulating phosphorylation of ERK and CREB.

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Atorvastatin and simvastatin, but not pravastatin, up-regulate LPS-induced MMP-9 expression in macrophages by regulating phosphorylation of ERK and CREB.

Lee DK, Park EJ, Kim EK, Jin J, Kim JS, Shin IJ, Kim BY, Lee H, Kim DE. Atorvastatin and simvastatin, but not pravastatin, up-regulate LPS-induced MMP-9 expression in macrophages by regulating phosphorylation of ERK and CREB. Cell Physiol Biochem. 2012; 30(3):499-511.

View in: PubMed

subject areas

Animals
Calcium
Cell Line
Cyclic AMP Response Element-Binding Protein
Extracellular Signal-Regulated MAP Kinases
Heptanoic Acids
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lipopolysaccharides
Macrophages
Matrix Metalloproteinase 9
Mice
Microglia
Phosphorylation
Polyisoprenyl Phosphates
Pravastatin
Pyrroles
Signal Transduction
Simvastatin
Up-Regulation

authors with profiles

Ikjae Shin