Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene.

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Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene.

Koturbash I, Melnyk S, James SJ, Beland FA, Pogribny IP. Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene. Mol Carcinog. 2013 Apr; 52(4):318-27.

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subject areas

2-Acetylaminofluorene
Acetylation
Animals
Carcinogens
Cell Line
DNA Methylation
Down-Regulation
Epigenesis, Genetic
Female
Gene Expression Regulation, Neoplastic
Histones
Liver
Liver Neoplasms, Experimental
Male
Methionine Adenosyltransferase
Methylenetetrahydrofolate Reductase (NADPH2)
MicroRNAs
Promoter Regions, Genetic
Rats
Rats, Sprague-Dawley
S-Adenosylhomocysteine
S-Adenosylmethionine

authors with profiles

Igor Koturbash