 Metabolic Detoxication, Phase I
"Metabolic Detoxication, Phase I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
| Descriptor ID |
D050216
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| MeSH Number(s) |
G03.495.244.820.500 G07.690.812.097.600.500 G07.700.680.097.600.500
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| Concept/Terms |
Metabolic Detoxication, Phase I- Metabolic Detoxication, Phase I
- Metabolic Detoxication, Oxidative
- Detoxication, Oxidative Metabolic
- Detoxications, Oxidative Metabolic
- Metabolic Detoxications, Oxidative
- Oxidative Metabolic Detoxication
- Oxidative Metabolic Detoxications
- Phase I Detoxification
- Detoxification, Phase I
- Detoxifications, Phase I
- Metabolic Detoxification, Phase I
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Below are MeSH descriptors whose meaning is more general than "Metabolic Detoxication, Phase I".
Below are MeSH descriptors whose meaning is more specific than "Metabolic Detoxication, Phase I".
This graph shows the total number of publications written about "Metabolic Detoxication, Phase I" by people in UAMS Profiles by year, and whether "Metabolic Detoxication, Phase I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2011 | 1 | 1 | 2 | | 2008 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 |
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Below are the most recent publications written about "Metabolic Detoxication, Phase I" by people in Profiles over the past ten years.
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Court MH, Zhu Z, Masse G, Duan SX, James LP, Harmatz JS, Greenblatt DJ. Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers. J Pharmacol Exp Ther. 2017 09; 362(3):431-440.
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Gupta PK, Barone G, Gurley BJ, Fifer EK, Hendrickson HP. Hydrastine pharmacokinetics and metabolism after a single oral dose of goldenseal (Hydrastis canadensis) to humans. Drug Metab Dispos. 2015 Apr; 43(4):534-52.
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