 Metabolic Detoxication, Phase II
"Metabolic Detoxication, Phase II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The conjugation of exogenous substances with various hydrophilic substituents to form water soluble products that are excretable in URINE. Phase II modifications include GLUTATHIONE conjugation; ACYLATION; and AMINATION. Phase II enzymes include GLUTATHIONE TRANSFERASE and GLUCURONOSYLTRANSFERASE. In a sense these reactions detoxify phase I reaction products.
| Descriptor ID |
D050217
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| MeSH Number(s) |
G03.495.244.820.750 G07.690.812.097.600.750 G07.700.680.097.600.750
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| Concept/Terms |
Metabolic Detoxication, Phase II- Metabolic Detoxication, Phase II
- Phase II Detoxification
- Detoxification, Phase II
- Detoxifications, Phase II
- Phase II Detoxifications
- Metabolic Detoxication, Conjugative
- Conjugative Metabolic Detoxication
- Conjugative Metabolic Detoxications
- Detoxication, Conjugative Metabolic
- Detoxications, Conjugative Metabolic
- Metabolic Detoxications, Conjugative
- Metabolic Detoxification, Phase II
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Below are MeSH descriptors whose meaning is more general than "Metabolic Detoxication, Phase II".
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This graph shows the total number of publications written about "Metabolic Detoxication, Phase II" by people in UAMS Profiles by year, and whether "Metabolic Detoxication, Phase II" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 0 | 1 | 1 | | 2015 | 1 | 1 | 2 | | 2011 | 0 | 2 | 2 | | 2010 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 |
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Below are the most recent publications written about "Metabolic Detoxication, Phase II" by people in Profiles over the past ten years.
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Court MH, Zhu Z, Masse G, Duan SX, James LP, Harmatz JS, Greenblatt DJ. Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers. J Pharmacol Exp Ther. 2017 09; 362(3):431-440.
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Oda S, Fujiwara R, Kutsuno Y, Fukami T, Itoh T, Yokoi T, Nakajima M. Targeted screen for human UDP-glucuronosyltransferases inhibitors and the evaluation of potential drug-drug interactions with zafirlukast. Drug Metab Dispos. 2015 Jun; 43(6):812-8.
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Gupta PK, Barone G, Gurley BJ, Fifer EK, Hendrickson HP. Hydrastine pharmacokinetics and metabolism after a single oral dose of goldenseal (Hydrastis canadensis) to humans. Drug Metab Dispos. 2015 Apr; 43(4):534-52.
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