 Inhibitory Concentration 50
"Inhibitory Concentration 50" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.
| Descriptor ID |
D020128
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| MeSH Number(s) |
E05.940.350 G07.690.420
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Inhibitory Concentration 50".
Below are MeSH descriptors whose meaning is more specific than "Inhibitory Concentration 50".
This graph shows the total number of publications written about "Inhibitory Concentration 50" by people in UAMS Profiles by year, and whether "Inhibitory Concentration 50" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2020 | 0 | 3 | 3 | | 2019 | 0 | 1 | 1 | | 2018 | 0 | 2 | 2 | | 2017 | 0 | 2 | 2 | | 2015 | 0 | 2 | 2 | | 2014 | 0 | 5 | 5 | | 2013 | 0 | 4 | 4 | | 2012 | 0 | 3 | 3 | | 2011 | 0 | 5 | 5 | | 2010 | 0 | 5 | 5 | | 2009 | 0 | 2 | 2 | | 2008 | 0 | 2 | 2 | | 2007 | 0 | 2 | 2 | | 2006 | 0 | 2 | 2 | | 2005 | 0 | 2 | 2 | | 2004 | 0 | 5 | 5 | | 2003 | 0 | 3 | 3 | | 1999 | 0 | 1 | 1 |
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Below are the most recent publications written about "Inhibitory Concentration 50" by people in Profiles over the past ten years.
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Gujarathi S, Zafar MK, Liu X, Eoff RL, Zheng G. A Facile Semisynthesis and Evaluation of Garcinoic Acid and Its Analogs for the Inhibition of Human DNA Polymerase ?. Molecules. 2020 Dec 11; 25(24).
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Adderley JD, John von Freyend S, Jackson SA, Bird MJ, Burns AL, Anar B, Metcalf T, Semblat JP, Billker O, Wilson DW, Doerig C. Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention. Nat Commun. 2020 08 11; 11(1):4015.
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Urbaniak A, Jousheghany F, Pi?a-Oviedo S, Yuan Y, Majcher-Uchanska U, Klejborowska G, Moorjani A, Monzavi-Karbassi B, Huczynski A, Chambers TC. Carbamate derivatives of colchicine show potent activity towards primary acute lymphoblastic leukemia and primary breast cancer cells-in vitro and ex vivo study. J Biochem Mol Toxicol. 2020 Jun; 34(6):e22487.
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Ketkar A, Maddukuri L, Penthala NR, Reed MR, Zafar MK, Crooks PA, Eoff RL. Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms. ACS Chem Biol. 2019 06 21; 14(6):1337-1351.
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Leiva R, Phillips MB, Turcu AL, Gratac?s-Batlle E, Le?n-Garc?a L, Sureda FX, Soto D, Johnson JW, V?zquez S. Pharmacological and Electrophysiological Characterization of Novel NMDA Receptor Antagonists. ACS Chem Neurosci. 2018 11 21; 9(11):2722-2730.
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Kim SY, Jones DR, Kang JY, Yun CH, Miller GP. Regioselectivity significantly impacts microsomal glucuronidation efficiency of R/S-6, 7-, and 8-hydroxywarfarin. Xenobiotica. 2019 Apr; 49(4):397-403.
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Gannon BM, Galindo KI, Mesmin MP, Sulima A, Rice KC, Collins GT. Relative reinforcing effects of second-generation synthetic cathinones: Acquisition of self-administration and fixed ratio dose-response curves in rats. Neuropharmacology. 2018 05 15; 134(Pt A):28-35.
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Zolotarev KV, Belyaeva NF, Mikhailov AN, Mikhailova MV. Dependence between LD50 for Rodents and LC50 for Adult Fish and Fish Embryos. Bull Exp Biol Med. 2017 Feb; 162(4):445-450.
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Wang W, Qin Z, Zhu D, Wei Y, Li S, Duan L. Synthesis, Bioactivity Evaluation, and Toxicity Assessment of Novel Salicylanilide Ester Derivatives as Cercaricides against Schistosoma japonicum and Molluscicides against Oncomelania hupensis. Antimicrob Agents Chemother. 2016 01; 60(1):323-31.
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Alford SE, Kothari A, Loeff FC, Eichhorn JM, Sakurikar N, Goselink HM, Saylors RL, Jedema I, Falkenburg JH, Chambers TC. BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells. Cancer Res. 2015 Apr 01; 75(7):1366-75.
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