 Dipeptidyl Peptidase 4
"Dipeptidyl Peptidase 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine protease that catalyses the release of an N-terminal dipeptide. Several biologically-active peptides have been identified as dipeptidyl peptidase 4 substrates including INCRETINS; NEUROPEPTIDES; and CHEMOKINES. The protein is also found bound to ADENOSINE DEAMINASE on the T-CELL surface and is believed to play a role in T-cell activation.
| Descriptor ID |
D018819
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| MeSH Number(s) |
D08.811.277.656.350.350.126 D08.811.277.656.959.250 D23.050.301.264.035.282 D23.050.301.264.894.160 D23.101.100.110.282 D23.101.100.894.160
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| Concept/Terms |
Dipeptidyl Peptidase 4- Dipeptidyl Peptidase 4
- Dipeptidyl-Peptidase IV
- Dipeptidyl Peptidase IV
- CD26 Antigen
- Antigen, CD26
- CD26 Antigens
- Adenosine Deaminase Complexing Protein 2
- Antigens, CD26
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Below are MeSH descriptors whose meaning is more general than "Dipeptidyl Peptidase 4".
Below are MeSH descriptors whose meaning is more specific than "Dipeptidyl Peptidase 4".
This graph shows the total number of publications written about "Dipeptidyl Peptidase 4" by people in UAMS Profiles by year, and whether "Dipeptidyl Peptidase 4" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2023 | 1 | 0 | 1 | | 2019 | 0 | 1 | 1 | | 2016 | 1 | 1 | 2 | | 2013 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2005 | 1 | 0 | 1 | | 2003 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dipeptidyl Peptidase 4" by people in Profiles over the past ten years.
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Wang C, Nistala R, Cao M, Pan Y, Behrens M, Doll D, Hammer RD, Nistala P, Chang HM, Yeh ETH, Kang X. Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells. Cell Rep. 2023 02 28; 42(2):112105.
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Kulcsar KA, Coleman CM, Beck SE, Frieman MB. Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection. JCI Insight. 2019 10 17; 4(20).
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Uchida T, Wakasugi M, Kitamura T, Yamamoto T, Asakura M, Fujiwara R, Itoh T, Fujii H, Hirono S. Exploration of DPP-IV inhibitors with a novel scaffold by multistep in silico screening. J Mol Graph Model. 2018 01; 79:254-263.
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Coleman CM, Sisk JM, Halasz G, Zhong J, Beck SE, Matthews KL, Venkataraman T, Rajagopalan S, Kyratsous CA, Frieman MB. CD8+ T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome. J Virol. 2017 Jan 01; 91(1).
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Asakura M, Fukami T, Nakajima M, Fujii H, Atsuda K, Itoh T, Fujiwara R. Hepatic Dipeptidyl Peptidase-4 Controls Pharmacokinetics of Vildagliptin In Vivo. Drug Metab Dispos. 2017 02; 45(2):237-245.
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Luke T, Wu H, Zhao J, Channappanavar R, Coleman CM, Jiao JA, Matsushita H, Liu Y, Postnikova EN, Ork BL, Glenn G, Flyer D, Defang G, Raviprakash K, Kochel T, Wang J, Nie W, Smith G, Hensley LE, Olinger GG, Kuhn JH, Holbrook MR, Johnson RF, Perlman S, Sullivan E, Frieman MB. Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo. Sci Transl Med. 2016 Feb 17; 8(326):326ra21.
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Asakura M, Fujii H, Atsuda K, Itoh T, Fujiwara R. Dipeptidyl peptidase-4 greatly contributes to the hydrolysis of vildagliptin in human liver. Drug Metab Dispos. 2015 Apr; 43(4):477-84.
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