 Procollagen-Proline Dioxygenase
"Procollagen-Proline Dioxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl-containing-peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.
| Descriptor ID |
D011393
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| MeSH Number(s) |
D08.811.682.690.708.673
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| Concept/Terms |
Procollagen-Proline Dioxygenase- Procollagen-Proline Dioxygenase
- Dioxygenase, Procollagen-Proline
- Procollagen Proline Dioxygenase
- Procollagen Prolyl 4-Hydroxylase
- 4-Hydroxylase, Procollagen Prolyl
- Procollagen Prolyl 4 Hydroxylase
- Prolyl 4-Hydroxylase, Procollagen
- Protocollagen Prolyl Hydroxylase
- Hydroxylase, Protocollagen Prolyl
- Prolyl Hydroxylase, Protocollagen
- Proline,2-Oxoglutarate 4-Dioxygenase
- 4-Dioxygenase, Proline,2-Oxoglutarate
- Proline,2 Oxoglutarate 4 Dioxygenase
- Prolyl 4-Hydroxylase
- 4-Hydroxylase, Prolyl
- Prolyl 4 Hydroxylase
- Prolyl Hydroxylase
- Hydroxylase, Prolyl
- Peptidyl Prolyl Hydroxylase
- Hydroxylase, Peptidyl Prolyl
- Prolyl Hydroxylase, Peptidyl
- Proline Hydroxylase
- Hydroxylase, Proline
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Below are MeSH descriptors whose meaning is more general than "Procollagen-Proline Dioxygenase".
Below are MeSH descriptors whose meaning is more specific than "Procollagen-Proline Dioxygenase".
This graph shows the total number of publications written about "Procollagen-Proline Dioxygenase" by people in UAMS Profiles by year, and whether "Procollagen-Proline Dioxygenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2017 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 |
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Below are the most recent publications written about "Procollagen-Proline Dioxygenase" by people in Profiles over the past ten years.
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Hudson DM, Weis M, Rai J, Joeng KS, Dimori M, Lee BH, Morello R, Eyre DR. P3h3-null and Sc65-null Mice Phenocopy the Collagen Lysine Under-hydroxylation and Cross-linking Abnormality of Ehlers-Danlos Syndrome Type VIA. J Biol Chem. 2017 03 03; 292(9):3877-3887.
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Heard ME, Besio R, Weis M, Rai J, Hudson DM, Dimori M, Zimmerman SM, Kamykowski JA, Hogue WR, Swain FL, Burdine MS, Mackintosh SG, Tackett AJ, Suva LJ, Eyre DR, Morello R. Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation. PLoS Genet. 2016 Apr; 12(4):e1006002.
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