 Metformin
"Metformin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
| Descriptor ID |
D008687
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| MeSH Number(s) |
D02.078.370.141.450
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| Concept/Terms |
Metformin- Metformin
- Dimethylguanylguanidine
- Dimethylbiguanidine
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Below are MeSH descriptors whose meaning is more general than "Metformin".
Below are MeSH descriptors whose meaning is more specific than "Metformin".
This graph shows the total number of publications written about "Metformin" by people in UAMS Profiles by year, and whether "Metformin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 1 | 0 | 1 | | 2023 | 3 | 0 | 3 | | 2022 | 4 | 0 | 4 | | 2021 | 4 | 0 | 4 | | 2020 | 3 | 1 | 4 | | 2019 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2017 | 2 | 0 | 2 | | 2016 | 1 | 0 | 1 | | 2015 | 5 | 0 | 5 | | 2014 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 | | 2009 | 1 | 0 | 1 | | 2008 | 0 | 2 | 2 | | 2007 | 1 | 1 | 2 | | 2006 | 0 | 2 | 2 | | 2005 | 2 | 2 | 4 | | 2003 | 1 | 0 | 1 |
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Below are the most recent publications written about "Metformin" by people in Profiles over the past ten years.
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Harmon DC, Levene JA, Rutlen CL, White ES, Freeman IR, Lapidus JA. Preadmission Metformin Use Is Associated with Reduced Mortality in Patients with Diabetes Mellitus Hospitalized with COVID-19. J Gen Intern Med. 2024 Dec; 39(16):3253-3260.
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Ararat E, Landes RD, Forno E, Tas E, Perry TT. Metformin use is associated with decreased asthma exacerbations in adolescents and young adults. Pediatr Pulmonol. 2024 Jan; 59(1):48-54.
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Melnyk S, Hakkak R. Effect of Metformin Treatment on Serum Metabolic Profile Changes in Lean and Obese Zucker Rat Model for Fatty Liver Disease. Biomolecules. 2023 08 10; 13(8).
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Masson R, Shih T, Jeong C, Shi VY, Hsiao JL. Hormonal Treatments in Hidradenitis Suppurativa: A Systematic Review. J Drugs Dermatol. 2023 Aug 01; 22(8):785-794.
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Lopez-Candales A, Monte S, Sawalha K, Norgard NB. Time to revisit the true role of metformin in type 2 diabetes mellitus. Postgrad Med. 2023 08; 135(6):539-542.
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Majety P, Lozada Orquera FA, Edem D, Hamdy O. Pharmacological approaches to the prevention of type 2 diabetes mellitus. Front Endocrinol (Lausanne). 2023; 14:1118848.
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Griffin H, Sullivan SC, Barger SW, Phelan KD, Baldini G. Liraglutide Counteracts Endoplasmic Reticulum Stress in Palmitate-Treated Hypothalamic Neurons without Restoring Mitochondrial Homeostasis. Int J Mol Sci. 2022 Dec 30; 24(1).
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Scarton L, Jo A, Xie Z, O'Neal LJ, Munoz Pena JM, George TJ, Bian J. Examining the relationship between metformin dose and cancer survival: A SEER-Medicare analysis. PLoS One. 2022; 17(10):e0275681.
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Hunt CM, Efird JT, Redding TS, Thompson AD, Press AM, Williams CD, Hostler CJ, Suzuki A. Medications Associated with Lower Mortality in a SARS-CoV-2 Positive Cohort of 26,508 Veterans. J Gen Intern Med. 2022 12; 37(16):4144-4152.
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Gerardo Gonz?lez-Gonz?lez J, Cesar Solis R, D?az Gonz?lez-Colmenero A, Raygoza-Cortez K, Moreno-Pe?a PJ, S?nchez AL, McCoy RG, Singh Ospina N, Maraka S, Brito JP, Rodriguez-Gutierrez R. Effect of metformin on microvascular outcomes in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Res Clin Pract. 2022 Apr; 186:109821.
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Park YM, Sandler DP. Making sense of associations between type 2 diabetes, metformin, and breast cancer risk. Br J Cancer. 2021 09; 125(7):909-910.
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Kopel J, Grooms A, Ganapathy V, Clothier J. Metformin, valproic acid, and starvation induce seizures in a patient with partial SLC13A5 deficiency: a case of pharmaco-synergistic heterozygosity. Psychiatr Genet. 2021 02 01; 31(1):32-35.
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Park YM, Bookwalter DB, O'Brien KM, Jackson CL, Weinberg CR, Sandler DP. A prospective study of type 2 diabetes, metformin use, and risk of breast cancer. Ann Oncol. 2021 03; 32(3):351-359.
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Long DE, Peck BD, Tuggle SC, Villasante Tezanos AG, Windham ST, Bamman MM, Kern PA, Peterson CA, Walton RG. Associations of muscle lipid content with physical function and resistance training outcomes in older adults: altered responses with metformin. Geroscience. 2021 04; 43(2):629-644.
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Kulkarni AS, Peck BD, Walton RG, Kern PA, Mar JC, Windham ST, Bamman MM, Barzilai N, Peterson CA. Metformin alters skeletal muscle transcriptome adaptations to resistance training in older adults. Aging (Albany NY). 2020 10 18; 12(20):19852-19866.
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Acosta-Torres S, Murdock T, Matsuno R, Beavis AL, Stone RL, Wethington SL, Levinson K, Grumbine F, Ferriss JS, Tanner EJ, Fader AN. The addition of metformin to progestin therapy in the fertility-sparing treatment of women with atypical hyperplasia/endometrial intraepithelial neoplasia or endometrial cancer: Little impact on response and low live-birth rates. Gynecol Oncol. 2020 05; 157(2):348-356.
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Hacimuftuoglu A, Mohammadzadeh M, Taghizadehghalehjoughi A, Taspinar N, Togar B, Nalci KA, Okkay U, Gundogdu B. The analgesic effect of metformin on paclitaxel-induced neuropathic pain model in rats: By considering pathological results. J Cancer Res Ther. 2020 Jan-Mar; 16(1):34-39.
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Pabona JMP, Burnett AF, Brown DM, Quick CM, Simmen FA, Montales MTE, Liu SJ, Rose T, Alhallak I, Siegel ER, Simmen RC. Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells. Reprod Sci. 2020 01; 27(1):267-277.
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Walton RG, Dungan CM, Long DE, Tuggle SC, Kosmac K, Peck BD, Bush HM, Villasante Tezanos AG, McGwin G, Windham ST, Ovalle F, Bamman MM, Kern PA, Peterson CA. Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double-blind, placebo-controlled, multicenter trial: The MASTERS trial. Aging Cell. 2019 12; 18(6):e13039.
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Taghizadehghalehjoughi A, Hacimuftuoglu A, Cetin M, Ugur AB, Galateanu B, Mezhuev Y, Okkay U, Taspinar N, Taspinar M, Uyanik A, Gundogdu B, Mohammadzadeh M, Nalci KA, Stivaktakis P, Tsatsakis A, Jung TW, Jeong JH, Abd El-Aty AM. Effect of metformin/irinotecan-loaded poly-lactic-co-glycolic acid nanoparticles on glioblastoma: in vitro and in vivo studies. Nanomedicine (Lond). 2018 07; 13(13):1595-1606.
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Rivas E, Herndon DN, Porter C, Meyer W, Suman OE. Short-term metformin and exercise training effects on strength, aerobic capacity, glycemic control, and mitochondrial function in children with burn injury. Am J Physiol Endocrinol Metab. 2018 03 01; 314(3):E232-E240.
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Long DE, Peck BD, Martz JL, Tuggle SC, Bush HM, McGwin G, Kern PA, Bamman MM, Peterson CA. Metformin to Augment Strength Training Effective Response in Seniors (MASTERS): study protocol for a randomized controlled trial. Trials. 2017 04 26; 18(1):192.
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Luizon MR, Eckalbar WL, Wang Y, Jones SL, Smith RP, Laurance M, Lin L, Gallins PJ, Etheridge AS, Wright F, Zhou Y, Molony C, Innocenti F, Yee SW, Giacomini KM, Ahituv N. Genomic Characterization of Metformin Hepatic Response. PLoS Genet. 2016 Nov; 12(11):e1006449.
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Hall C, Stone RL, Gehlot A, Zorn KK, Burnett AF. Use of Metformin in Obese Women With Type I Endometrial Cancer Is Associated With a Reduced Incidence of Cancer Recurrence. Int J Gynecol Cancer. 2016 Feb; 26(2):313-7.
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Abualsuod A. Response to Letter to the Editor: Effects of New Antiplatelet Agents and Aldosterone Receptor Antagonists on Mortality in Patients with Myocardial Infarction. Cardiovasc Drugs Ther. 2015 Oct; 29(5):497.
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Williams ED, Rogers SC, Zhang X, Azhar G, Wei JY. Elevated oxygen consumption rate in response to acute low-glucose stress: Metformin restores rate to normal level. Exp Gerontol. 2015 Oct; 70:157-62.
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Xu G, Wu H, Zhang J, Li D, Wang Y, Wang Y, Zhang H, Lu L, Li C, Huang S, Xing Y, Zhou D, Meng A. Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice. Free Radic Biol Med. 2015 Oct; 87:15-25.
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Abualsuod A, Rutland JJ, Watts TE, Pandat S, Delongchamp R, Mehta JL. The Effect of Metformin Use on Left Ventricular Ejection Fraction and Mortality Post-Myocardial Infarction. Cardiovasc Drugs Ther. 2015 Jun; 29(3):265-75.
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Barreto-Torres G, Hernandez JS, Jang S, Rodr?guez-Mu?oz AR, Torres-Ramos CA, Basnakian AG, Javadov S. The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARa-cyclophilin D interaction in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2015 Apr 01; 308(7):H749-58.
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