 Interleukin-1beta
"Interleukin-1beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.
| Descriptor ID |
D053583
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| MeSH Number(s) |
D12.644.276.374.465.501.600 D12.644.276.374.500.400.600 D12.776.467.374.465.501.600 D12.776.467.374.500.400.600 D23.529.374.465.501.600 D23.529.374.500.400.600
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| Concept/Terms |
Interleukin-1beta- Interleukin-1beta
- Interleukin 1beta
- Interleukin-1 beta
- Interleukin 1 beta
- Catabolin
- IL-1 beta
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Below are MeSH descriptors whose meaning is more general than "Interleukin-1beta".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-1beta".
This graph shows the total number of publications written about "Interleukin-1beta" by people in UAMS Profiles by year, and whether "Interleukin-1beta" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2025 | 2 | 1 | 3 | | 2024 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 | | 2021 | 3 | 1 | 4 | | 2020 | 3 | 2 | 5 | | 2019 | 1 | 1 | 2 | | 2018 | 0 | 1 | 1 | | 2016 | 1 | 3 | 4 | | 2015 | 2 | 4 | 6 | | 2014 | 4 | 4 | 8 | | 2013 | 0 | 2 | 2 | | 2012 | 0 | 3 | 3 | | 2011 | 1 | 2 | 3 | | 2010 | 1 | 1 | 2 | | 2009 | 3 | 1 | 4 | | 2008 | 0 | 1 | 1 | | 2007 | 2 | 1 | 3 | | 2006 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Interleukin-1beta" by people in Profiles over the past ten years.
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Narasimhappagari J, Liu L, Balasubramaniam M, Ayyadevara S, Griffin WST. When Two Worlds Collide: The Contribution and Association Between Genetics (APOEe4) and Neuroinflammation (IL-1?) in Alzheimer's Neuropathogenesis. Cells. 2025 Aug 07; 14(15).
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Narasimhappagari J, Liu L, Balasubramaniam M, Ayyadevara S, Aboud O, Griffin WST. The Seminal Role of the Proinflammatory Cytokine IL-1? and Its Signaling Cascade in Glioblastoma Pathogenesis and the Therapeutic Effect of Interleukin-1? Receptor Antagonist (IL-1RA) and Tolcapone. Int J Mol Sci. 2025 Jul 18; 26(14).
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Verma A, Azhar G, Patyal P, Zhang X, Wei JY. Porphyromonas gingivalis-Lipopolysaccharide Induced Caspase-4 Dependent Noncanonical Inflammasome Activation Drives Alzheimer's Disease Pathologies. Cells. 2025 05 30; 14(11).
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Makhanova A, Tolliver MDM, Buckner Z, Shields GS, Hunter CL, Mengelkoch S, Houpt JW, Belote AE, Hoose DV, Schulz TK. Immune response and intergroup bias: Vaccine-induced increases in cytokine activity are associated with worse evaluations of resume for Latina job applicant. Brain Behav Immun. 2024 Nov; 122:555-564.
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Jiang L, Krongbaramee T, Lin X, Zhu M, Zhu Y, Hong L. microRNA-126 inhibits vascular cell adhesion molecule-1 and interleukin-1beta in human dental pulp cells. J Clin Lab Anal. 2022 May; 36(5):e24371.
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Burbank AJ, Schworer SA, Sood A, Almond M, Chason K, Bean N, Zhou H, Hernandez ML. Airway IL-1? associates with IL-5 production following dust mite allergen inhalation in humans. Respir Res. 2021 Dec 07; 22(1):309.
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Kore RA, Wang X, Henson JC, Ding Z, Jamshidi-Parsian A, Mehta JL. Proteomic basis of modulation of postischemic fibrosis by MSC exosomes. Am J Physiol Regul Integr Comp Physiol. 2021 11 01; 321(5):R639-R654.
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Wang G, Sweren E, Liu H, Wier E, Alphonse MP, Chen R, Islam N, Li A, Xue Y, Chen J, Park S, Chen Y, Lee S, Wang Y, Wang S, Archer NK, Andrews W, Kane MA, Dare E, Reddy SK, Hu Z, Grice EA, Miller LS, Garza LA. Bacteria induce skin regeneration via IL-1? signaling. Cell Host Microbe. 2021 05 12; 29(5):777-791.e6.
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Sherer ML, Lei J, Creisher PS, Jang M, Reddy R, Voegtline K, Olson S, Littlefield K, Park HS, Ursin RL, Ganesan A, Boyer T, Elsayed N, Brown DM, Walch SN, Antar AAR, Manabe YC, Jones-Beatty K, Golden WC, Satin AJ, Sheffield JS, Pekosz A, Klein SL, Burd I. Pregnancy alters interleukin-1 beta expression and antiviral antibody responses during severe acute respiratory syndrome coronavirus 2 infection. Am J Obstet Gynecol. 2021 09; 225(3):301.e1-301.e14.
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Li X, Brickell AN, Wang X, Zhou S, Ding Z. NADPH oxidase promotes PCSK9 secretion in macrophages. J Mol Cell Cardiol. 2021 04; 153:42-43.
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Gyorke CE, Kollipara A, Allen J, Zhang Y, Ezzell JA, Darville T, Montgomery SA, Nagarajan UM. IL-1a Is Essential for Oviduct Pathology during Genital Chlamydial Infection in Mice. J Immunol. 2020 12 01; 205(11):3037-3049.
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Kovacs SB, Oh C, Maltez VI, McGlaughon BD, Verma A, Miao EA, Aachoui Y. Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium. Cell Rep. 2020 07 28; 32(4):107967.
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Ding Z, Wang X, Liu S, Zhou S, Kore RA, Mu S, Deng X, Fan Y, Mehta JL. NLRP3 inflammasome via IL-1? regulates PCSK9 secretion. Theranostics. 2020; 10(16):7100-7110.
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Alkhuriji AF, Al Omar SY, Babay ZA, El-Khadragy MF, Mansour LA, Alharbi WG, Khalil MI. Association of IL-1?, IL-6, TNF-a, and TGF?1 Gene Polymorphisms with Recurrent Spontaneous Abortion in Polycystic Ovary Syndrome. Dis Markers. 2020; 2020:6076274.
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Balasubramaniam M, Parcon PA, Bose C, Liu L, Jones RA, Farlow MR, Mrak RE, Barger SW, Griffin WST. Interleukin-1? drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site. J Neuroinflammation. 2019 Dec 27; 16(1):275.
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Chen J, Del Valle L, Lin HY, Plaisance-Bonstaff K, Forrest JC, Post SR, Qin Z. Expression of PD-1 and PD-Ls in Kaposi's sarcoma and regulation by oncogenic herpesvirus lytic reactivation. Virology. 2019 10; 536:16-19.
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Nagarajan UM, Tripathy M, Kollipara A, Allen J, Goodwin A, Whittimore J, Wyrick PB, Rank RG. Differential signaling pathways are initiated in macrophages during infection depending on the intracellular fate of Chlamydia spp. Immunol Cell Biol. 2018 03; 96(3):246-256.
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Hirashima R, Itoh T, Tukey RH, Fujiwara R. Prediction of drug-induced liver injury using keratinocytes. J Appl Toxicol. 2017 07; 37(7):863-872.
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Farris RA, Price ET. Reverse Translational Study of Fenofibrate's Observed Effects in Diabetes-Associated Retinopathy. Clin Transl Sci. 2017 03; 10(2):110-116.
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Chen X, Chen X, Xu Y, Yang W, Wu N, Ye H, Yang JY, Hong Q, Xin Y, Yang MQ, Deng Y, Duan S. Association of six CpG-SNPs in the inflammation-related genes with coronary heart disease. Hum Genomics. 2016 07 25; 10 Suppl 2:21.
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Liu M, Verma N, Peng X, Srodulski S, Morris A, Chow M, Hersh LB, Chen J, Zhu H, Netea MG, Margulies KB, Despa S, Despa F. Hyperamylinemia Increases IL-1? Synthesis in the Heart via Peroxidative Sarcolemmal Injury. Diabetes. 2016 09; 65(9):2772-83.
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Liu M, Chen S, Yueh MF, Fujiwara R, Konopnicki C, Hao H, Tukey RH. Cadmium and arsenic override NF-?B developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia. Biochem Pharmacol. 2016 06 15; 110-111:37-46.
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Liu Y, Almeida M, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice. Am J Physiol Endocrinol Metab. 2016 May 01; 310(9):E762-73.
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