 Protein Stability
"Protein Stability" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The ability of a protein to retain its structural conformation or its activity when subjected to physical or chemical manipulations.
| Descriptor ID |
D055550
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| MeSH Number(s) |
G02.111.700
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| Concept/Terms |
Protein Stability- Protein Stability
- Protein Stabilities
- Stabilities, Protein
- Stability, Protein
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Below are MeSH descriptors whose meaning is more general than "Protein Stability".
Below are MeSH descriptors whose meaning is more specific than "Protein Stability".
This graph shows the total number of publications written about "Protein Stability" by people in UAMS Profiles by year, and whether "Protein Stability" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 | | 2021 | 0 | 4 | 4 | | 2020 | 0 | 2 | 2 | | 2019 | 1 | 1 | 2 | | 2018 | 0 | 2 | 2 | | 2017 | 0 | 3 | 3 | | 2016 | 0 | 3 | 3 | | 2015 | 0 | 2 | 2 | | 2014 | 0 | 1 | 1 | | 2013 | 1 | 2 | 3 | | 2011 | 0 | 1 | 1 | | 2010 | 0 | 2 | 2 | | 2009 | 0 | 2 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Protein Stability" by people in Profiles over the past ten years.
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Klimtchuk ES, Prokaeva T, Spencer BH, Wong S, Ghosh S, Urdaneta A, Morgan G, Wales TE, Gursky O. Conformational Differences in the Light Chain Constant Domain of Immunoglobulin G and Free Light Chain May Influence Proteolysis in AL Amyloidosis. J Mol Biol. 2024 Dec 01; 436(23):168837.
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Yan NL, Nair R, Chu A, Wilson IA, Johnson KA, Morgan GJ, Kelly JW. Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site. Bioorg Med Chem Lett. 2022 03 15; 60:128571.
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Waldrip ZJ, Burdine L, Harrison DK, Azevedo-Pouly AC, Storey AJ, Moffett OG, Mackintosh SG, Burdine MS. DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells. J Biol Chem. 2021 10; 297(4):101209.
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Kundumani-Sridharan V, Subramani J, Owens C, Das KC. Nrg1? Released in Remote Ischemic Preconditioning Improves Myocardial Perfusion and Decreases Ischemia/Reperfusion Injury via ErbB2-Mediated Rescue of Endothelial Nitric Oxide Synthase and Abrogation of Trx2 Autophagy. Arterioscler Thromb Vasc Biol. 2021 08; 41(8):2293-2314.
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Xu Q, Liu Q, Chen Z, Yue Y, Liu Y, Zhao Y, Zhou DX. Histone deacetylases control lysine acetylation of ribosomal proteins in rice. Nucleic Acids Res. 2021 05 07; 49(8):4613-4628.
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Voisin N, Schnur RE, Douzgou S, Hiatt SM, Rustad CF, Brown NJ, Earl DL, Keren B, Levchenko O, Geuer S, Verheyen S, Johnson D, Zarate YA, Hanc?rov? M, Amor DJ, Bebin EM, Blatterer J, Brusco A, Cappuccio G, Charrow J, Chatron N, Cooper GM, Courtin T, Dadali E, Delafontaine J, Del Giudice E, Doco M, Douglas G, Eisenk?lbl A, Funari T, Giannuzzi G, Gruber-Sedlmayr U, Guex N, Heron D, Holla ?L, Hurst ACE, Juusola J, Kronn D, Lavrov A, Lee C, Lorrain S, Merckoll E, Mikhaleva A, Norman J, Pradervand S, Prchalov? D, Rhodes L, Sanders VR, Sedl?cek Z, Seebacher HA, Sellars EA, Sirchia F, Takenouchi T, Tanaka AJ, Taska-Tench H, T?nne E, Tveten K, Vitiello G, Vlckov? M, Uehara T, Nava C, Yalcin B, Kosaki K, Donnai D, Mundlos S, Brunetti-Pierri N, Chung WK, Reymond A. Variants in the degron of AFF3 are associated with intellectual disability, mesomelic dysplasia, horseshoe kidney, and epileptic encephalopathy. Am J Hum Genet. 2021 05 06; 108(5):857-873.
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Hong A, Piva M, Liu S, Hugo W, Lomeli SH, Zoete V, Randolph CE, Yang Z, Wang Y, Lee JJ, Lo SJ, Sun L, Vega-Crespo A, Garcia AJ, Shackelford DB, Dubinett SM, Scumpia PO, Byrum SD, Tackett AJ, Donahue TR, Michielin O, Holmen SL, Ribas A, Moriceau G, Lo RS. Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity. Cancer Discov. 2021 03; 11(3):714-735.
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Xia J, He Y, Meng B, Chen S, Zhang J, Wu X, Zhu Y, Shen Y, Feng X, Guan Y, Kuang C, Guo J, Lei Q, Wu Y, An G, Li G, Qiu L, Zhan F, Zhou W. NEK2 induces autophagy-mediated bortezomib resistance by stabilizing Beclin-1 in multiple myeloma. Mol Oncol. 2020 04; 14(4):763-778.
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Harkey T, Govind Kumar V, Hettige J, Tabari SH, Immadisetty K, Moradi M. The Role of a Crystallographically Unresolved Cytoplasmic Loop in Stabilizing the Bacterial Membrane Insertase YidC2. Sci Rep. 2019 10 08; 9(1):14451.
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Daniels JR, Cao Z, Maisha M, Schnackenberg LK, Sun J, Pence L, Schmitt TC, Kamlage B, Rogstad S, Beger RD, Yu LR. Stability of the Human Plasma Proteome to Pre-analytical Variability as Assessed by an Aptamer-Based Approach. J Proteome Res. 2019 10 04; 18(10):3661-3670.
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Franqui-Machin R, Hao M, Bai H, Gu Z, Zhan X, Habelhah H, Jethava Y, Qiu L, Frech I, Tricot G, Zhan F. Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma. J Clin Invest. 2018 07 02; 128(7):2877-2893.
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Zheng JH, Grace CR, Guibao CD, McNamara DE, Llambi F, Wang YM, Chen T, Moldoveanu T. Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis. Cell Rep. 2018 05 15; 23(7):2083-2094.e6.
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Kim Wiese A, Schluterman Burdine M, Turnage RH, Tackett AJ, Burdine LJ. DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes. PLoS One. 2017; 12(7):e0181608.
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Bawa-Khalfe T, Yang FM, Ritho J, Lin HK, Cheng J, Yeh ET. SENP1 regulates PTEN stability to dictate prostate cancer development. Oncotarget. 2017 Mar 14; 8(11):17651-17664.
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Ten Have GAM, Engelen MPKJ, Wolfe RR, Deutz NEP. Phenylalanine isotope pulse method to measure effect of sepsis on protein breakdown and membrane transport in the pig. Am J Physiol Endocrinol Metab. 2017 06 01; 312(6):E519-E529.
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Morgan GJ, Kelly JW. The Kinetic Stability of a Full-Length Antibody Light Chain Dimer Determines whether Endoproteolysis Can Release Amyloidogenic Variable Domains. J Mol Biol. 2016 10 23; 428(21):4280-4297.
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Willett R, Blackburn JB, Climer L, Pokrovskaya I, Kudlyk T, Wang W, Lupashin V. COG lobe B sub-complex engages v-SNARE GS15 and functions via regulated interaction with lobe A sub-complex. Sci Rep. 2016 07 07; 6:29139.
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Steiner E, Livne S, Kobinson-Katz T, Tal L, Pri-Tal O, Mosquna A, Tarkowsk? D, Mueller B, Tarkowski P, Weiss D. The Putative O-Linked N-Acetylglucosamine Transferase SPINDLY Inhibits Class I TCP Proteolysis to Promote Sensitivity to Cytokinin. Plant Physiol. 2016 06; 171(2):1485-94.
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Thakkar S, Wang X, Khaidakov M, Dai Y, Gokulan K, Mehta JL, Varughese KI. Structure-based Design Targeted at LOX-1, a Receptor for Oxidized Low-Density Lipoprotein. Sci Rep. 2015 Nov 18; 5:16740.
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Mcgill MR, Jaeschke H. A direct comparison of methods used to measure oxidized glutathione in biological samples: 2-vinylpyridine and N-ethylmaleimide. Toxicol Mech Methods. 2015; 25(8):589-95.
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