 Smad3 Protein
"Smad3 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. Activated Smad3 can bind directly to DNA, and it regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.
| Descriptor ID |
D051900
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| MeSH Number(s) |
D12.644.360.024.334.500.300 D12.776.157.057.170.500.300 D12.776.260.713.500.300 D12.776.476.024.417.500.300 D12.776.744.741.875 D12.776.930.806.500.300
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Smad3 Protein".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- Adaptor Proteins, Signal Transducing [D12.644.360.024]
- Smad Proteins [D12.644.360.024.334]
- Smad Proteins, Receptor-Regulated [D12.644.360.024.334.500]
- Smad3 Protein [D12.644.360.024.334.500.300]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Adaptor Proteins, Signal Transducing [D12.776.157.057]
- Smad Proteins [D12.776.157.057.170]
- Smad Proteins, Receptor-Regulated [D12.776.157.057.170.500]
- Smad3 Protein [D12.776.157.057.170.500.300]
- DNA-Binding Proteins [D12.776.260]
- Smad Proteins [D12.776.260.713]
- Smad Proteins, Receptor-Regulated [D12.776.260.713.500]
- Smad3 Protein [D12.776.260.713.500.300]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- Adaptor Proteins, Signal Transducing [D12.776.476.024]
- Smad Proteins [D12.776.476.024.417]
- Smad Proteins, Receptor-Regulated [D12.776.476.024.417.500]
- Smad3 Protein [D12.776.476.024.417.500.300]
- Phosphoproteins [D12.776.744]
- Smad Proteins, Receptor-Regulated [D12.776.744.741]
- Smad3 Protein [D12.776.744.741.875]
- Transcription Factors [D12.776.930]
- Smad Proteins [D12.776.930.806]
- Smad Proteins, Receptor-Regulated [D12.776.930.806.500]
- Smad3 Protein [D12.776.930.806.500.300]
Below are MeSH descriptors whose meaning is more specific than "Smad3 Protein".
This graph shows the total number of publications written about "Smad3 Protein" by people in UAMS Profiles by year, and whether "Smad3 Protein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 | | 2019 | 1 | 1 | 2 | | 2016 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Smad3 Protein" by people in Profiles over the past ten years.
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Mady B, Ibrahim HF, ElAziz Mm A, Basta M, Assem S, Ahmed Ali M, El Mottelib LMMAA. The potential ameliorating effect of vitamin E on bleomycin - induced lung fibrosis in adult albino rats. Int Immunopharmacol. 2024 Jul 30; 136:112375.
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Monteiro DA, Dole NS, Campos JL, Kaya S, Schurman CA, Belair CD, Alliston T. Fluid shear stress generates a unique signaling response by activating multiple TGF? family type I receptors in osteocytes. FASEB J. 2021 03; 35(3):e21263.
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Heo SY, Jeong MS, Lee HS, Kim YJ, Park SH, Jung WK. Phlorofucofuroeckol A from Ecklonia cava ameliorates TGF-?1-induced fibrotic response of human tracheal fibroblasts via the downregulation of MAPKs and SMAD 2/3 pathways inactivated TGF-? receptor. Biochem Biophys Res Commun. 2020 Feb 12; 522(3):626-632.
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Richter JE, Samreen A, Vadlamudi C, Helmi H, Mohammad AN, Wierenga K, Hines S, Atwal PS, Caulfield TR. Genomic Observations of a Rare/Pathogenic SMAD3 Variant in Loeys?Dietz Syndrome 3 Confirmed by Protein Informatics and Structural Investigations. Medicina (Kaunas). 2019 05 15; 55(5).
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Bagchi RA, Roche P, Aroutiounova N, Espira L, Abrenica B, Schweitzer R, Czubryt MP. The transcription factor scleraxis is a critical regulator of cardiac fibroblast phenotype. BMC Biol. 2016 Mar 17; 14:21.
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Subathra M, Korrapati M, Howell LA, Arthur JM, Shayman JA, Schnellmann RG, Siskind LJ. Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells. Am J Physiol Renal Physiol. 2015 Aug 01; 309(3):F204-15.
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